The 5′ binding MID domain of human argonaute2 tolerates chemically modified nucleotide analogues

Nucleic Acid Therapeutics

Volumn 23, Issue 1, 2013, Pages 81-87

  Deleavey, Glen F ^a   Frank, Filipp ^a   Hassler, Matthew ^a   Wisnovsky, Simon ^a   Nagar, Bhushan ^a   Damha, Masad J ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 2' FLUOROARABINO NUCLEIC ACID; 2' DEOXY 2' FLUORORIBONUCLEIC ACID; ARGONAUTE 2 PROTEIN; NUCLEOTIDE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ARGONAUTE PROTEIN; EIF2C2 PROTEIN, HUMAN; FIREFLY LUCIFERASE; MESSENGER RNA;

5' UNTRANSLATED REGION; ARTICLE; BINDING COMPETITION; CHEMICAL MODIFICATION; CONFORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSOCIATION CONSTANT; FEMALE; GENE SILENCING; HELA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE;

ARGONAUTE PROTEINS; BASE SEQUENCE; BINDING SITES; HELA CELLS; HUMANS; LUCIFERASES, FIREFLY; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84873958353     PISSN: 21593337     EISSN: None     Source Type: Journal    
DOI: 10.1089/nat.2012.0393     Document Type: Article

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