Evaluation of siRNAs that contain internal variable-length spacer linkages

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5590-5594

  Efthymiou, Tim C ^a   Peel, Brandon ^a   Huynh, Vanthi ^a   Desaulniers, Jean Paul ^a  

^a UNIVERSITY OF ONTARIO INSTITUTE OF TECHNOLOGY   (Canada)

Author keywords

Alkyl linker; Destabilization; Gene silencing; RNA; Short interfering RNA

Indexed keywords

COMPLEMENTARY RNA; INTERNAL TRANSCRIBED SPACER; SMALL INTERFERING RNA;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DISSOCIATION; RNA CLEAVAGE; RNA INTERFERENCE; RNA STABILITY; SUBSTITUTION REACTION;

ANIMALS; BASE SEQUENCE; HELA CELLS; HUMANS; LUCIFERASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-INDUCED SILENCING COMPLEX;

EID: 84865139258     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.07.006     Document Type: Article

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