-
1
-
-
80052348254
-
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
-
T.P. Alastalo, M. Li, J. Perez Vde, D. Pham, H. Sawada, J.K. Wang, M. Koskenvuo, L. Wang, B.A. Freeman, H.Y. Chang, and M. Rabinovitch Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival J. Clin. Invest. 121 2011 3735 3746
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 3735-3746
-
-
Alastalo, T.P.1
Li, M.2
Perez Vde, J.3
Pham, D.4
Sawada, H.5
Wang, J.K.6
Koskenvuo, M.7
Wang, L.8
Freeman, B.A.9
Chang, H.Y.10
Rabinovitch, M.11
-
2
-
-
84871320315
-
P53 orchestrates the PGC-1alpha-mediated antioxidant response upon mild redox and metabolic imbalance
-
K. Aquilano, S. Baldelli, B. Pagliei, S.M. Cannata, G. Rotilio, and M.R. Ciriolo p53 orchestrates the PGC-1alpha-mediated antioxidant response upon mild redox and metabolic imbalance Antioxid. Redox. Signal. 18 2013 386 399
-
(2013)
Antioxid. Redox. Signal.
, vol.18
, pp. 386-399
-
-
Aquilano, K.1
Baldelli, S.2
Pagliei, B.3
Cannata, S.M.4
Rotilio, G.5
Ciriolo, M.R.6
-
3
-
-
39149106144
-
Mitochondrial metabolism, redox signaling, and fusion: A mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer
-
S.L. Archer, M. Gomberg-Maitland, M.L. Maitland, S. Rich, J.G. Garcia, and E.K. Weir Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer Am. J. Physiol. Heart Circ. Physiol. 294 2008 H570 H578
-
(2008)
Am. J. Physiol. Heart Circ. Physiol.
, vol.294
, pp. H570-H578
-
-
Archer, S.L.1
Gomberg-Maitland, M.2
Maitland, M.L.3
Rich, S.4
Garcia, J.G.5
Weir, E.K.6
-
4
-
-
77954083190
-
Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target
-
S.L. Archer, G. Marsboom, G.H. Kim, H.J. Zhang, P.T. Toth, E.C. Svensson, J.R. Dyck, M. Gomberg-Maitland, B. Thébaud, and A.N. Husain Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target Circulation 121 2010 2661 2671
-
(2010)
Circulation
, vol.121
, pp. 2661-2671
-
-
Archer, S.L.1
Marsboom, G.2
Kim, G.H.3
Zhang, H.J.4
Toth, P.T.5
Svensson, E.C.6
Dyck, J.R.7
Gomberg-Maitland, M.8
Thébaud, B.9
Husain, A.N.10
-
5
-
-
0037046175
-
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
-
C. Atkinson, S. Stewart, P.D. Upton, R. Machado, J.R. Thomson, R.C. Trembath, and N.W. Morrell Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor Circulation 105 2002 1672 1678
-
(2002)
Circulation
, vol.105
, pp. 1672-1678
-
-
Atkinson, C.1
Stewart, S.2
Upton, P.D.3
Machado, R.4
Thomson, J.R.5
Trembath, R.C.6
Morrell, N.W.7
-
6
-
-
33745155785
-
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
-
S. Bonnet, E.D. Michelakis, C.J. Porter, M.A. Andrade-Navarro, B. Thébaud, S. Bonnet, A. Haromy, G. Harry, R. Moudgil, and M.S. McMurtry An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension Circulation 113 2006 2630 2641
-
(2006)
Circulation
, vol.113
, pp. 2630-2641
-
-
Bonnet, S.1
Michelakis, E.D.2
Porter, C.J.3
Andrade-Navarro, M.A.4
Thébaud, B.5
Bonnet, S.6
Haromy, A.7
Harry, G.8
Moudgil, R.9
McMurtry, M.S.10
-
7
-
-
80055086869
-
Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II
-
V.J. Burton, A.M. Holmes, L.I. Ciuclan, A. Robinson, J.S. Roger, G. Jarai, A.C. Pearce, and D.C. Budd Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II Blood 118 2011 4750 4758
-
(2011)
Blood
, vol.118
, pp. 4750-4758
-
-
Burton, V.J.1
Holmes, A.M.2
Ciuclan, L.I.3
Robinson, A.4
Roger, J.S.5
Jarai, G.6
Pearce, A.C.7
Budd, D.C.8
-
8
-
-
78651281751
-
The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer
-
T. Chen, J. He, L. Shen, H. Fang, H. Nie, T. Jin, X. Wei, Y. Xin, Y. Jiang, and H. Li The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer BMC Med. Genet. 12 2011 8
-
(2011)
BMC Med. Genet.
, vol.12
, pp. 8
-
-
Chen, T.1
He, J.2
Shen, L.3
Fang, H.4
Nie, H.5
Jin, T.6
Wei, X.7
Xin, Y.8
Jiang, Y.9
Li, H.10
-
9
-
-
84881076472
-
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
-
Y. Cheng, X. Ren, A.S. Gowda, Y. Shan, L. Zhang, Y.S. Yuan, R. Patel, H. Wu, K. Huber-Keener, and J.W. Yang Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress Cell Death Dis. 4 2013 e731
-
(2013)
Cell Death Dis.
, vol.4
, pp. e731
-
-
Cheng, Y.1
Ren, X.2
Gowda, A.S.3
Shan, Y.4
Zhang, L.5
Yuan, Y.S.6
Patel, R.7
Wu, H.8
Huber-Keener, K.9
Yang, J.W.10
-
10
-
-
55849094397
-
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
-
H.J. Chun, Z.A. Ali, Y. Kojima, R.K. Kundu, A.Y. Sheikh, R. Agrawal, L. Zheng, N.J. Leeper, N.E. Pearl, and A.J. Patterson Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis J. Clin. Invest. 118 2008 3343 3354
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3343-3354
-
-
Chun, H.J.1
Ali, Z.A.2
Kojima, Y.3
Kundu, R.K.4
Sheikh, A.Y.5
Agrawal, R.6
Zheng, L.7
Leeper, N.J.8
Pearl, N.E.9
Patterson, A.J.10
-
11
-
-
0030873452
-
Energy turnover of vascular endothelial cells
-
O. Culic, M.L. Gruwel, and J. Schrader Energy turnover of vascular endothelial cells Am. J. Physiol. 273 1997 C205 C213
-
(1997)
Am. J. Physiol.
, vol.273
, pp. C205-C213
-
-
Culic, O.1
Gruwel, M.L.2
Schrader, J.3
-
12
-
-
84863280800
-
BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta in pulmonary artery smooth muscle cells: Role of proinflammatory cytokines
-
R.J. Davies, A.M. Holmes, J. Deighton, L. Long, X. Yang, L. Barker, C. Walker, D.C. Budd, P.D. Upton, and N.W. Morrell BMP type II receptor deficiency confers resistance to growth inhibition by TGF-beta in pulmonary artery smooth muscle cells: role of proinflammatory cytokines Am. J. Physiol. Lung Cell. Mol. Physiol. 302 2012 L604 L615
-
(2012)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.302
, pp. L604-L615
-
-
Davies, R.J.1
Holmes, A.M.2
Deighton, J.3
Long, L.4
Yang, X.5
Barker, L.6
Walker, C.7
Budd, D.C.8
Upton, P.D.9
Morrell, N.W.10
-
13
-
-
0033838125
-
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
Z. Deng, J.H. Morse, S.L. Slager, N. Cuervo, K.J. Moore, G. Venetos, S. Kalachikov, E. Cayanis, S.G. Fischer, and R.J. Barst Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene Am. J. Hum. Genet. 67 2000 737 744
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 737-744
-
-
Deng, Z.1
Morse, J.H.2
Slager, S.L.3
Cuervo, N.4
Moore, K.J.5
Venetos, G.6
Kalachikov, S.7
Cayanis, E.8
Fischer, S.G.9
Barst, R.J.10
-
14
-
-
66949125400
-
Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2
-
I. Diebold, T. Djordjevic, A. Petry, A. Hatzelmann, H. Tenor, J. Hess, and A. Görlach Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2 Circ. Res. 104 2009 1169 1177
-
(2009)
Circ. Res.
, vol.104
, pp. 1169-1177
-
-
Diebold, I.1
Djordjevic, T.2
Petry, A.3
Hatzelmann, A.4
Tenor, H.5
Hess, J.6
Görlach, A.7
-
15
-
-
33845976357
-
Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology
-
S. Duvezin-Caubet, R. Jagasia, J. Wagener, S. Hofmann, A. Trifunovic, A. Hansson, A. Chomyn, M.F. Bauer, G. Attardi, and N.G. Larsson Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology J. Biol. Chem. 281 2006 37972 37979
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 37972-37979
-
-
Duvezin-Caubet, S.1
Jagasia, R.2
Wagener, J.3
Hofmann, S.4
Trifunovic, A.5
Hansson, A.6
Chomyn, A.7
Bauer, M.F.8
Attardi, G.9
Larsson, N.G.10
-
16
-
-
84887080883
-
Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension
-
J.P. Fessel, C.R. Flynn, L.J. Robinson, N.L. Penner, S. Gladson, C.J. Kang, D.H. Wasserman, A.R. Hemnes, and J.D. West Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension Am. J. Respir. Cell Mol. Biol. 49 2013 778 787
-
(2013)
Am. J. Respir. Cell Mol. Biol.
, vol.49
, pp. 778-787
-
-
Fessel, J.P.1
Flynn, C.R.2
Robinson, L.J.3
Penner, N.L.4
Gladson, S.5
Kang, C.J.6
Wasserman, D.H.7
Hemnes, A.R.8
West, J.D.9
-
17
-
-
77749291806
-
Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells
-
I. Fijalkowska, W. Xu, S.A. Comhair, A.J. Janocha, L.A. Mavrakis, B. Krishnamachary, L. Zhen, T. Mao, A. Richter, S.C. Erzurum, and R.M. Tuder Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells Am. J. Pathol. 176 2010 1130 1138
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 1130-1138
-
-
Fijalkowska, I.1
Xu, W.2
Comhair, S.A.3
Janocha, A.J.4
Mavrakis, L.A.5
Krishnamachary, B.6
Zhen, L.7
Mao, T.8
Richter, A.9
Erzurum, S.C.10
Tuder, R.M.11
-
18
-
-
0035487808
-
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
-
S. Frank, B. Gaume, E.S. Bergmann-Leitner, W.W. Leitner, E.G. Robert, F. Catez, C.L. Smith, and R.J. Youle The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis Dev. Cell 1 2001 515 525
-
(2001)
Dev. Cell
, vol.1
, pp. 515-525
-
-
Frank, S.1
Gaume, B.2
Bergmann-Leitner, E.S.3
Leitner, W.W.4
Robert, E.G.5
Catez, F.6
Smith, C.L.7
Youle, R.J.8
-
19
-
-
84855462583
-
Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: Role of nitric oxide and reactive oxygen species
-
R.J. Giedt, C. Yang, J.L. Zweier, A. Matzavinos, and B.R. Alevriadou Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species Free Radic. Biol. Med. 52 2012 348 356
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 348-356
-
-
Giedt, R.J.1
Yang, C.2
Zweier, J.L.3
Matzavinos, A.4
Alevriadou, B.R.5
-
20
-
-
84895523990
-
Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo
-
S.E. Gill, R. Taneja, M. Rohan, L. Wang, and S. Mehta Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo PLoS ONE 9 2014 e88501
-
(2014)
PLoS ONE
, vol.9
, pp. e88501
-
-
Gill, S.E.1
Taneja, R.2
Rohan, M.3
Wang, L.4
Mehta, S.5
-
21
-
-
71949120983
-
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
-
C. Guignabert, C.M. Alvira, T.P. Alastalo, H. Sawada, G. Hansmann, M. Zhao, L. Wang, N. El-Bizri, and M. Rabinovitch Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization Am. J. Physiol. Lung Cell. Mol. Physiol. 297 2009 L1082 L1090
-
(2009)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.297
, pp. L1082-L1090
-
-
Guignabert, C.1
Alvira, C.M.2
Alastalo, T.P.3
Sawada, H.4
Hansmann, G.5
Zhao, M.6
Wang, L.7
El-Bizri, N.8
Rabinovitch, M.9
-
22
-
-
43049092988
-
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
-
G. Hansmann, V.A. de Jesus Perez, T.P. Alastalo, C.M. Alvira, C. Guignabert, J.M. Bekker, S. Schellong, T. Urashima, L. Wang, N.W. Morrell, and M. Rabinovitch An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension J. Clin. Invest. 118 2008 1846 1857
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1846-1857
-
-
Hansmann, G.1
De Jesus Perez, V.A.2
Alastalo, T.P.3
Alvira, C.M.4
Guignabert, C.5
Bekker, J.M.6
Schellong, S.7
Urashima, T.8
Wang, L.9
Morrell, N.W.10
Rabinovitch, M.11
-
23
-
-
79959442340
-
PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
-
K.S. Heo, H. Lee, P. Nigro, T. Thomas, N.T. Le, E. Chang, C. McClain, C.A. Reinhart-King, M.R. King, and B.C. Berk PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation J. Cell Biol. 193 2011 867 884
-
(2011)
J. Cell Biol.
, vol.193
, pp. 867-884
-
-
Heo, K.S.1
Lee, H.2
Nigro, P.3
Thomas, T.4
Le, N.T.5
Chang, E.6
McClain, C.7
Reinhart-King, C.A.8
King, M.R.9
Berk, B.C.10
-
24
-
-
0034972978
-
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
-
J.R. Howe, J.L. Bair, M.G. Sayed, M.E. Anderson, F.A. Mitros, G.M. Petersen, V.E. Velculescu, G. Traverso, and B. Vogelstein Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis Nat. Genet. 28 2001 184 187
-
(2001)
Nat. Genet.
, vol.28
, pp. 184-187
-
-
Howe, J.R.1
Bair, J.L.2
Sayed, M.G.3
Anderson, M.E.4
Mitros, F.A.5
Petersen, G.M.6
Velculescu, V.E.7
Traverso, G.8
Vogelstein, B.9
-
25
-
-
84871961385
-
High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms
-
F.N. Jilwan, P. Escourrou, G. Garcia, X. Jaïs, M. Humbert, and G. Roisman High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms Chest 143 2013 47 55
-
(2013)
Chest
, vol.143
, pp. 47-55
-
-
Jilwan, F.N.1
Escourrou, P.2
Garcia, G.3
Jaïs, X.4
Humbert, M.5
Roisman, G.6
-
26
-
-
84881506336
-
Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells
-
M.W. Julian, G. Shao, Z.C. Vangundy, T.L. Papenfuss, and E.D. Crouser Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells PLoS ONE 8 2013 e72354
-
(2013)
PLoS ONE
, vol.8
, pp. e72354
-
-
Julian, M.W.1
Shao, G.2
Vangundy, Z.C.3
Papenfuss, T.L.4
Crouser, E.D.5
-
27
-
-
80052864064
-
Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions
-
Y.M. Kim, L. Haghighat, E. Spiekerkoetter, H. Sawada, C.M. Alvira, L. Wang, S. Acharya, G. Rodriguez-Colon, A. Orton, M. Zhao, and M. Rabinovitch Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions Am. J. Pathol. 179 2011 1560 1572
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 1560-1572
-
-
Kim, Y.M.1
Haghighat, L.2
Spiekerkoetter, E.3
Sawada, H.4
Alvira, C.M.5
Wang, L.6
Acharya, S.7
Rodriguez-Colon, G.8
Orton, A.9
Zhao, M.10
Rabinovitch, M.11
-
28
-
-
84872078405
-
An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
-
J. Kim, Y. Kang, Y. Kojima, J.K. Lighthouse, X. Hu, M.A. Aldred, D.L. McLean, H. Park, S.A. Comhair, and D.M. Greif An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension Nat. Med. 19 2013 74 82
-
(2013)
Nat. Med.
, vol.19
, pp. 74-82
-
-
Kim, J.1
Kang, Y.2
Kojima, Y.3
Lighthouse, J.K.4
Hu, X.5
Aldred, M.A.6
McLean, D.L.7
Park, H.8
Comhair, S.A.9
Greif, D.M.10
-
29
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
-
International PPH Consortium
-
K.B. Lane, R.D. Machado, M.W. Pauciulo, J.R. Thomson, J.A. Phillips 3rd, J.E. Loyd, W.C. Nichols, R.C. Trembath International PPH Consortium Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension Nat. Genet. 26 2000 81 84
-
(2000)
Nat. Genet.
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
Machado, R.D.2
Pauciulo, M.W.3
Thomson, J.R.4
Phillips, J.A.5
Loyd, J.E.6
Nichols, W.C.7
Trembath, R.C.8
-
30
-
-
84863249942
-
Oxidative injury is a common consequence of BMPR2 mutations
-
K.L. Lane, M. Talati, E. Austin, A.R. Hemnes, J.A. Johnson, J.P. Fessel, T. Blackwell, R.L. Mernaugh, L. Robinson, and C. Fike Oxidative injury is a common consequence of BMPR2 mutations Pulm. Circ. 1 2011 72 83
-
(2011)
Pulm. Circ.
, vol.1
, pp. 72-83
-
-
Lane, K.L.1
Talati, M.2
Austin, E.3
Hemnes, A.R.4
Johnson, J.A.5
Fessel, J.P.6
Blackwell, T.7
Mernaugh, R.L.8
Robinson, L.9
Fike, C.10
-
31
-
-
0031930319
-
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
-
N.G. Larsson, J. Wang, H. Wilhelmsson, A. Oldfors, P. Rustin, M. Lewandoski, G.S. Barsh, and D.A. Clayton Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice Nat. Genet. 18 1998 231 236
-
(1998)
Nat. Genet.
, vol.18
, pp. 231-236
-
-
Larsson, N.G.1
Wang, J.2
Wilhelmsson, H.3
Oldfors, A.4
Rustin, P.5
Lewandoski, M.6
Barsh, G.S.7
Clayton, D.A.8
-
32
-
-
80052667354
-
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension
-
M. Li, S.R. Riddle, M.G. Frid, K.C. El Kasmi, T.A. McKinsey, R.J. Sokol, D. Strassheim, B. Meyrick, M.E. Yeager, and A.R. Flockton Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension J. Immunol. 187 2011 2711 2722
-
(2011)
J. Immunol.
, vol.187
, pp. 2711-2722
-
-
Li, M.1
Riddle, S.R.2
Frid, M.G.3
El Kasmi, K.C.4
McKinsey, T.A.5
Sokol, R.J.6
Strassheim, D.7
Meyrick, B.8
Yeager, M.E.9
Flockton, A.R.10
-
33
-
-
34548433880
-
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
-
F.A. Masri, W. Xu, S.A. Comhair, K. Asosingh, M. Koo, A. Vasanji, J. Drazba, B. Anand-Apte, and S.C. Erzurum Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension Am. J. Physiol. Lung Cell. Mol. Physiol. 293 2007 L548 L554
-
(2007)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.293
, pp. L548-L554
-
-
Masri, F.A.1
Xu, W.2
Comhair, S.A.3
Asosingh, K.4
Koo, M.5
Vasanji, A.6
Drazba, J.7
Anand-Apte, B.8
Erzurum, S.C.9
-
34
-
-
0031888469
-
Upregulation of postbacteremic TNF-alpha and IL-1alpha gene expression by alveolar hypoxia/reoxygenation in perfused rat lungs
-
G.M. Matuschak, C.F. Munoz, C.A. Johanns, R. Rahman, and A.J. Lechner Upregulation of postbacteremic TNF-alpha and IL-1alpha gene expression by alveolar hypoxia/reoxygenation in perfused rat lungs Am. J. Respir. Crit. Care Med. 157 1998 629 637
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.157
, pp. 629-637
-
-
Matuschak, G.M.1
Munoz, C.F.2
Johanns, C.A.3
Rahman, R.4
Lechner, A.J.5
-
35
-
-
6344257102
-
Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
-
M.S. McMurtry, S. Bonnet, X. Wu, J.R. Dyck, A. Haromy, K. Hashimoto, and E.D. Michelakis Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis Circ. Res. 95 2004 830 840
-
(2004)
Circ. Res.
, vol.95
, pp. 830-840
-
-
McMurtry, M.S.1
Bonnet, S.2
Wu, X.3
Dyck, J.R.4
Haromy, A.5
Hashimoto, K.6
Michelakis, E.D.7
-
36
-
-
0037188928
-
Diversity in mitochondrial function explains differences in vascular oxygen sensing
-
E.D. Michelakis, V. Hampl, A. Nsair, X. Wu, G. Harry, A. Haromy, R. Gurtu, and S.L. Archer Diversity in mitochondrial function explains differences in vascular oxygen sensing Circ. Res. 90 2002 1307 1315
-
(2002)
Circ. Res.
, vol.90
, pp. 1307-1315
-
-
Michelakis, E.D.1
Hampl, V.2
Nsair, A.3
Wu, X.4
Harry, G.5
Haromy, A.6
Gurtu, R.7
Archer, S.L.8
-
37
-
-
0037080541
-
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels
-
E.D. Michelakis, M.S. McMurtry, X.C. Wu, J.R. Dyck, R. Moudgil, T.A. Hopkins, G.D. Lopaschuk, L. Puttagunta, R. Waite, and S.L. Archer Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels Circulation 105 2002 244 250
-
(2002)
Circulation
, vol.105
, pp. 244-250
-
-
Michelakis, E.D.1
McMurtry, M.S.2
Wu, X.C.3
Dyck, J.R.4
Moudgil, R.5
Hopkins, T.A.6
Lopaschuk, G.D.7
Puttagunta, L.8
Waite, R.9
Archer, S.L.10
-
38
-
-
79955772507
-
P53 gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice
-
S. Mizuno, H.J. Bogaard, D. Kraskauskas, A. Alhussaini, J. Gomez-Arroyo, N.F. Voelkel, and T. Ishizaki p53 gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice Am. J. Physiol. Lung Cell. Mol. Physiol. 300 2011 L753 L761
-
(2011)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.300
, pp. L753-L761
-
-
Mizuno, S.1
Bogaard, H.J.2
Kraskauskas, D.3
Alhussaini, A.4
Gomez-Arroyo, J.5
Voelkel, N.F.6
Ishizaki, T.7
-
39
-
-
84876577725
-
Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension
-
N. Mouraret, E. Marcos, S. Abid, G. Gary-Bobo, M. Saker, A. Houssaini, J.L. Dubois-Rande, L. Boyer, J. Boczkowski, and G. Derumeaux Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension Circulation 127 2013 1664 1676
-
(2013)
Circulation
, vol.127
, pp. 1664-1676
-
-
Mouraret, N.1
Marcos, E.2
Abid, S.3
Gary-Bobo, G.4
Saker, M.5
Houssaini, A.6
Dubois-Rande, J.L.7
Boyer, L.8
Boczkowski, J.9
Derumeaux, G.10
-
40
-
-
77953532933
-
P53-mediated induction of Noxa and p53AIP1 requires NFkappaB
-
J. O'Prey, D. Crighton, A.G. Martin, K.H. Vousden, H.O. Fearnhead, and K.M. Ryan p53-mediated induction of Noxa and p53AIP1 requires NFkappaB Cell Cycle 9 2010 947 952
-
(2010)
Cell Cycle
, vol.9
, pp. 947-952
-
-
O'Prey, J.1
Crighton, D.2
Martin, A.G.3
Vousden, K.H.4
Fearnhead, H.O.5
Ryan, K.M.6
-
41
-
-
84879082926
-
Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs
-
K.H. Park, T.H. Lee, C.W. Kim, and J. Kim Enhancement of CCL15 expression and monocyte adhesion to endothelial cells (ECs) after hypoxia/reoxygenation and induction of ICAM-1 expression by CCL15 via the JAK2/STAT3 pathway in ECs J. Immunol. 190 2013 6550 6558
-
(2013)
J. Immunol.
, vol.190
, pp. 6550-6558
-
-
Park, K.H.1
Lee, T.H.2
Kim, C.W.3
Kim, J.4
-
42
-
-
84905831453
-
Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension
-
F. Potus, S. Malenfant, C. Graydon, V. Mainguy, È. Tremblay, S. Breuils-Bonnet, F. Ribeiro, A. Porlier, F. Maltais, S. Bonnet, and S. Provencher Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 190 2014 318 328
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.190
, pp. 318-328
-
-
Potus, F.1
Malenfant, S.2
Graydon, C.3
Mainguy, V.4
Tremblay È.5
Breuils-Bonnet, S.6
Ribeiro, F.7
Porlier, A.8
Maltais, F.9
Bonnet, S.10
Provencher, S.11
-
43
-
-
0019482038
-
Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery
-
M. Rabinovitch, W.J. Gamble, O.S. Miettinen, and L. Reid Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery Am. J. Physiol. 240 1981 H62 H72
-
(1981)
Am. J. Physiol.
, vol.240
, pp. H62-H72
-
-
Rabinovitch, M.1
Gamble, W.J.2
Miettinen, O.S.3
Reid, L.4
-
44
-
-
77958021516
-
PGC-1 coactivators in cardiac development and disease
-
G.C. Rowe, A. Jiang, and Z. Arany PGC-1 coactivators in cardiac development and disease Circ. Res. 107 2010 825 838
-
(2010)
Circ. Res.
, vol.107
, pp. 825-838
-
-
Rowe, G.C.1
Jiang, A.2
Arany, Z.3
-
45
-
-
84876848950
-
PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension
-
J.J. Ryan, G. Marsboom, Y.H. Fang, P.T. Toth, E. Morrow, N. Luo, L. Piao, Z. Hong, K. Ericson, and H.J. Zhang PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension Am. J. Respir. Crit. Care Med. 187 2013 865 878
-
(2013)
Am. J. Respir. Crit. Care Med.
, vol.187
, pp. 865-878
-
-
Ryan, J.J.1
Marsboom, G.2
Fang, Y.H.3
Toth, P.T.4
Morrow, E.5
Luo, N.6
Piao, L.7
Hong, Z.8
Ericson, K.9
Zhang, H.J.10
-
46
-
-
73949089232
-
Endothelial cells and pulmonary arterial hypertension: Apoptosis, proliferation, interaction and transdifferentiation
-
S. Sakao, K. Tatsumi, and N.F. Voelkel Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation Respir. Res. 10 2009 95
-
(2009)
Respir. Res.
, vol.10
, pp. 95
-
-
Sakao, S.1
Tatsumi, K.2
Voelkel, N.F.3
-
47
-
-
84893783838
-
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension
-
H. Sawada, T. Saito, N.P. Nickel, T.P. Alastalo, J.P. Glotzbach, R. Chan, L. Haghighat, G. Fuchs, M. Januszyk, and A. Cao Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension J. Exp. Med. 211 2014 263 280
-
(2014)
J. Exp. Med.
, vol.211
, pp. 263-280
-
-
Sawada, H.1
Saito, T.2
Nickel, N.P.3
Alastalo, T.P.4
Glotzbach, J.P.5
Chan, R.6
Haghighat, L.7
Fuchs, G.8
Januszyk, M.9
Cao, A.10
-
48
-
-
84893480253
-
Endothelial PGC-1α mediates vascular dysfunction in diabetes
-
N. Sawada, A. Jiang, F. Takizawa, A. Safdar, A. Manika, Y. Tesmenitsky, K.T. Kang, J. Bischoff, H. Kalwa, and J.L. Sartoretto Endothelial PGC-1α mediates vascular dysfunction in diabetes Cell Metab. 19 2014 246 258
-
(2014)
Cell Metab.
, vol.19
, pp. 246-258
-
-
Sawada, N.1
Jiang, A.2
Takizawa, F.3
Safdar, A.4
Manika, A.5
Tesmenitsky, Y.6
Kang, K.T.7
Bischoff, J.8
Kalwa, H.9
Sartoretto, J.L.10
-
49
-
-
42049114034
-
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
-
R.C. Scarpulla Transcriptional paradigms in mammalian mitochondrial biogenesis and function Physiol. Rev. 88 2008 611 638
-
(2008)
Physiol. Rev.
, vol.88
, pp. 611-638
-
-
Scarpulla, R.C.1
-
50
-
-
84884819273
-
Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics
-
Y. Shimasaki, N. Pan, L.M. Messina, C. Li, K. Chen, L. Liu, M.P. Cooper, J.A. Vita, and J.F. Keaney Jr. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics Circ. Res. 113 2013 891 901
-
(2013)
Circ. Res.
, vol.113
, pp. 891-901
-
-
Shimasaki, Y.1
Pan, N.2
Messina, L.M.3
Li, C.4
Chen, K.5
Liu, L.6
Cooper, M.P.7
Vita, J.A.8
Keaney, Jr.J.F.9
-
51
-
-
84881240287
-
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension
-
E. Spiekerkoetter, X. Tian, J. Cai, R.K. Hopper, D. Sudheendra, C.G. Li, N. El-Bizri, H. Sawada, R. Haghighat, and R. Chan FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension J. Clin. Invest. 123 2013 3600 3613
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 3600-3613
-
-
Spiekerkoetter, E.1
Tian, X.2
Cai, J.3
Hopper, R.K.4
Sudheendra, D.5
Li, C.G.6
El-Bizri, N.7
Sawada, H.8
Haghighat, R.9
Chan, R.10
-
52
-
-
84897568503
-
The metabolic basis of pulmonary arterial hypertension
-
G. Sutendra, and E.D. Michelakis The metabolic basis of pulmonary arterial hypertension Cell Metab. 19 2014 558 573
-
(2014)
Cell Metab.
, vol.19
, pp. 558-573
-
-
Sutendra, G.1
Michelakis, E.D.2
-
53
-
-
77955635790
-
Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension
-
G. Sutendra, S. Bonnet, G. Rochefort, A. Haromy, K.D. Folmes, G.D. Lopaschuk, J.R. Dyck, and E.D. Michelakis Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension Sci. Transl. Med. 2 2010 44ra58
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 44ra58
-
-
Sutendra, G.1
Bonnet, S.2
Rochefort, G.3
Haromy, A.4
Folmes, K.D.5
Lopaschuk, G.D.6
Dyck, J.R.7
Michelakis, E.D.8
-
54
-
-
80052459025
-
Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension
-
G. Sutendra, P. Dromparis, S. Bonnet, A. Haromy, M.S. McMurtry, R.C. Bleackley, and E.D. Michelakis Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension J. Mol. Med. (Berl.) 89 2011 771 783
-
(2011)
J. Mol. Med. (Berl.)
, vol.89
, pp. 771-783
-
-
Sutendra, G.1
Dromparis, P.2
Bonnet, S.3
Haromy, A.4
McMurtry, M.S.5
Bleackley, R.C.6
Michelakis, E.D.7
-
55
-
-
17744393686
-
Mitochondrial DNA mutations in human disease
-
R.W. Taylor, and D.M. Turnbull Mitochondrial DNA mutations in human disease Nat. Rev. Genet. 6 2005 389 402
-
(2005)
Nat. Rev. Genet.
, vol.6
, pp. 389-402
-
-
Taylor, R.W.1
Turnbull, D.M.2
-
56
-
-
33644865928
-
Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
-
K. Teichert-Kuliszewska, M.J. Kutryk, M.A. Kuliszewski, G. Karoubi, D.W. Courtman, L. Zucco, J. Granton, and D.J. Stewart Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension Circ. Res. 98 2006 209 217
-
(2006)
Circ. Res.
, vol.98
, pp. 209-217
-
-
Teichert-Kuliszewska, K.1
Kutryk, M.J.2
Kuliszewski, M.A.3
Karoubi, G.4
Courtman, D.W.5
Zucco, L.6
Granton, J.7
Stewart, D.J.8
-
57
-
-
77956713444
-
Validation of high-resolution echocardiography and magnetic resonance imaging vs. High-fidelity catheterization in experimental pulmonary hypertension
-
D. Urboniene, I. Haber, Y.H. Fang, T. Thenappan, and S.L. Archer Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension Am. J. Physiol. Lung Cell. Mol. Physiol. 299 2010 L401 L412
-
(2010)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.299
, pp. L401-L412
-
-
Urboniene, D.1
Haber, I.2
Fang, Y.H.3
Thenappan, T.4
Archer, S.L.5
-
58
-
-
84870544267
-
P53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: Role in chronic left ventricular dysfunction in mice
-
C. Villeneuve, C. Guilbeau-Frugier, P. Sicard, O. Lairez, C. Ordener, T. Duparc, D. De Paulis, B. Couderc, O. Spreux-Varoquaux, and F. Tortosa p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice Antioxid. Redox Signal. 18 2013 5 18
-
(2013)
Antioxid. Redox Signal.
, vol.18
, pp. 5-18
-
-
Villeneuve, C.1
Guilbeau-Frugier, C.2
Sicard, P.3
Lairez, O.4
Ordener, C.5
Duparc, T.6
De Paulis, D.7
Couderc, B.8
Spreux-Varoquaux, O.9
Tortosa, F.10
-
59
-
-
0028011017
-
Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
-
J.V. Virbasius, and R.C. Scarpulla Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis Proc. Natl. Acad. Sci. USA 91 1994 1309 1313
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 1309-1313
-
-
Virbasius, J.V.1
Scarpulla, R.C.2
-
61
-
-
33846614655
-
Alterations of cellular bioenergetics in pulmonary artery endothelial cells
-
W. Xu, T. Koeck, A.R. Lara, D. Neumann, F.P. DiFilippo, M. Koo, A.J. Janocha, F.A. Masri, A.C. Arroliga, and C. Jennings Alterations of cellular bioenergetics in pulmonary artery endothelial cells Proc. Natl. Acad. Sci. USA 104 2007 1342 1347
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 1342-1347
-
-
Xu, W.1
Koeck, T.2
Lara, A.R.3
Neumann, D.4
Difilippo, F.P.5
Koo, M.6
Janocha, A.J.7
Masri, F.A.8
Arroliga, A.C.9
Jennings, C.10
-
62
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, and C.J. Hauser Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 2010 104 107
-
(2010)
Nature
, vol.464
, pp. 104-107
-
-
Zhang, Q.1
Raoof, M.2
Chen, Y.3
Sumi, Y.4
Sursal, T.5
Junger, W.6
Brohi, K.7
Itagaki, K.8
Hauser, C.J.9
|