Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension

Journal of Molecular Medicine

Volumn 89, Issue 8, 2011, Pages 771-783

  Sutendra, Gopinath ^a   Dromparis, Peter ^a   Bonnet, Sébastien ^b   Haromy, Alois ^a   McMurtry, Michael S ^a   Bleackley, R Chris ^a   Michelakis, Evangelos D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Apoptosis; Inflammation; Metabolism; Mitochondria; Vascular disease

Indexed keywords

ETANERCEPT; MONOCROTALINE; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYPERPOLARIZATION; NONHUMAN; PATHOGENESIS; PHENOTYPE; POTASSIUM CURRENT; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; T LYMPHOCYTE;

ANIMALS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPERTENSION, PULMONARY; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; ION CHANNEL GATING; KETONE OXIDOREDUCTASES; KV1.5 POTASSIUM CHANNEL; MODELS, BIOLOGICAL; MONOCROTALINE; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; PULMONARY ARTERY; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80052459025     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0762-2     Document Type: Article

References (36)

1. P Dromparis G Sutendra ED Michelakis 2010 The role of mitochondria in pulmonary vascular remodeling J Mol Med 88 1003 1010 20734021 10.1007/s00109-010-0670-x 1:CAS:528:DC%2BC3cXhtFyjur3M
2. MS McMurtry S Bonnet X Wu JR Dyck A Haromy K Hashimoto ED Michelakis 2004 Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis Circ Res 95 830 840 15375007 10.1161/01.RES.0000145360.16770.9f 1:CAS:528:DC%2BD2cXot1aitr8%3D (Pubitemid 39390586)
3. ED Michelakis G Sutendra P Dromparis L Webster A Haromy E Niven C Maguire TL Gammer JR Mackey D Fulton, et al. 2010 Metabolic modulation of glioblastoma with dichloroacetate Sci Transl Med 2 31ra34 20463368 1:CAS:528: DC%2BC3cXhtVansrzF
4. G Sutendra S Bonnet G Rochefort A Haromy KD Folmes GD Lopaschuck JRB Dyck ED Michelakis 2010 Fatty acid oxidation and malonyl-CoA decarboxylase in vascular remodeling of pulmonary hypertension Sci Transl Med 2 44ra58 20702857
5. JW Kim CV Dang 2005 Multifaceted roles of glycolytic enzymes Trends Biochem Sci 30 142 150 15752986 10.1016/j.tibs.2005.01.005 1:CAS:528: DC%2BD2MXitVejurY%3D (Pubitemid 40332530)
6. S Bonnet SL Archer J Allalunis-Turner A Haromy C Beaulieu R Thompson CT Lee GD Lopaschuk L Puttagunta S Bonnet, et al. 2007 A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth Cancer Cell 11 37 51 17222789 10.1016/j.ccr.2006.10.020 1:CAS:528:DC%2BD2sXhtFClsLg%3D (Pubitemid 46054520)
7. C Guignabert L Tu M Izikki L Dewachter P Zadigue M Humbert S Adnot E Fadel S Eddahibi 2009 Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter FASEB J 23 4135 4147 19679640 10.1096/fj.09-131664 1:CAS:528:DC%2BD1MXhsFCgur%2FN
8. N Zamzami G Kroemer 2001 The mitochondrion in apoptosis: how Pandora's box opens Nat Rev Mol Cell Biol 2 67 71 11413468 10.1038/35048073 1:CAS:528:DC%2BD3MXivVWmsLw%3D (Pubitemid 33676964)
9. SL Archer E Souil AT Dinh-Xuan B Schremmer JC Mercier A El Yaagoubi L Nguyen-Huu HL Reeve V Hampl 1998 Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes J Clin Invest 101 2319 2330 9616203 10.1172/JCI333 1:CAS:528:DyaK1cXjvVWrtLw%3D (Pubitemid 28270426)
10. O Platoshyn VA Golovina CL Bailey A Limsuwan S Krick M Juhaszova JE Seiden LJ Rubin JX Yuan 2000 Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation Am J Physiol Cell Physiol 279 C1540 C1549 11029301 1:CAS:528:DC%2BD3cXotFarurk%3D
11. CV Remillard JX Yuan 2004 Activation of K+ channels: an essential pathway in programmed cell death Am J Physiol Lung Cell Mol Physiol 286 L49 L67 14656699 10.1152/ajplung.00041.2003 1:CAS:528:DC%2BD2cXot1WqsQ%3D%3D
12. JG Pastorino JB Hoek N Shulga 2005 Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity Cancer Res 65 10545 10554 16288047 10.1158/0008-5472.CAN-05-1925 1:CAS:528:DC%2BD2MXht1Wgu7zP (Pubitemid 41743749)
13. S Bonnet G Rochefort G Sutendra SL Archer A Haromy L Webster K Hashimoto SN Bonnet ED Michelakis 2007 The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted Proc Natl Acad Sci USA 104 11418 11423 17596340 10.1073/pnas.0610467104 1:CAS:528: DC%2BD2sXnvFOms7g%3D (Pubitemid 47175155)
14. L Taraseviciene-Stewart MR Nicolls D Kraskauskas R Scerbavicius N Burns C Cool K Wood JE Parr SA Boackle NF Voelkel 2007 Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling Am J Respir Crit Care Med 175 1280 1289 17413127 10.1164/rccm.200608-1189OC 1:CAS:528:DC%2BD2sXnvFaku74%3D (Pubitemid 46905754)
15. RM Tuder B Groves DB Badesch NF Voelkel 1994 Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension Am J Pathol 144 275 285 7508683 1:STN:280: DyaK2c7ksVKktQ%3D%3D (Pubitemid 24165948)
16. AW Caslin D Heath B Madden M Yacoub JR Gosney P Smith 1990 The histopathology of 36 cases of plexogenic pulmonary arteriopathy Histopathology 16 9 19 2307421 10.1111/j.1365-2559.1990.tb01054.x 1:STN:280: DyaK3c7mvFyrsA%3D%3D (Pubitemid 20123330)
17. CD Cool PR Rai ME Yeager D Hernandez-Saavedra AE Serls TM Bull MW Geraci KK Brown JM Routes RM Tuder, et al. 2003 Expression of human herpesvirus 8 in primary pulmonary hypertension N Engl J Med 349 1113 1122 13679525 10.1056/NEJMoa035115 1:CAS:528:DC%2BD3sXnsV2jtLY%3D (Pubitemid 37122323)
18. JC Marecki CD Cool JE Parr VE Beckey PA Luciw AF Tarantal A Carville RP Shannon A Cota-Gomez RM Tuder, et al. 2006 HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques Am J Respir Crit Care Med 174 437 445 16728715 10.1164/rccm.200601-005OC 1:CAS:528: DC%2BD28XpsVeqsr4%3D (Pubitemid 44223125)
19. VV McLaughlin KW Presberg RL Doyle SH Abman DC McCrory T Fortin G Ahearn 2004 Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines Chest 126 78S 92S 15249497 10.1378/chest.126.1-suppl.78S (Pubitemid 38932344)
20. E Soon AM Holmes CM Treacy NJ Doughty L Southgate RD Machado RC Trembath S Jennings L Barker P Nicklin, et al. 2010 Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension Circulation 122 920 927 20713898 10.1161/CIRCULATIONAHA.109.933762 1:CAS:528:DC%2BC3cXhtV2hsbzN
21. R Zell P Geck K Werdan P Boekstegers 1997 TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of mitochondrial function Mol Cell Biochem 177 61 67 9450646 10.1023/A:1006896832582 1:CAS:528: DyaK1cXivFGjsg%3D%3D
22. EA Atkinson M Barry AJ Darmon I Shostak PC Turner RW Moyer RC Bleackley 1998 Cytotoxic T lymphocyte-assisted suicide. Caspase 3 activation is primarily the result of the direct action of granzyme B J Biol Chem 273 21261 21266 9694885 10.1074/jbc.273.33.21261 1:CAS:528:DyaK1cXlsFOrt78%3D (Pubitemid 28385418)
23. MM Bowker-Kinley WI Davis P Wu RA Harris KM Popov 1998 Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex Biochem J 329 Pt 1 191 196 9405293 1:CAS:528:DyaK1cXltFegtw%3D%3D (Pubitemid 28022308)
24. P Barath MC Fishbein J Cao J Berenson RH Helfant JS Forrester 1990 Tumor necrosis factor gene expression in human vascular intimal smooth muscle cells detected by in situ hybridization Am J Pathol 137 503 509 1698022 1:CAS:528:DyaK3cXlvV2msro%3D (Pubitemid 20280979)
25. DW Wilson HJ Segall LC Pan SK Dunston 1989 Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats Microvasc Res 38 57 80 2503687 10.1016/0026-2862(89)90017-4 1:CAS:528: DyaL1MXhvV2nug%3D%3D (Pubitemid 19188539)
26. DJ Lovell EH Giannini A Reiff GD Cawkwell ED Silverman JJ Nocton LD Stein A Gedalia NT Ilowite CA Wallace, et al. 2000 Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group N Engl J Med 342 763 769 10717011 10.1056/ NEJM200003163421103 1:CAS:528:DC%2BD3cXit1Smu7k%3D (Pubitemid 30151920)
27. S Bonnet ED Michelakis CJ Porter MA Andrade-Navarro B Thebaud S Bonnet A Haromy G Harry R Moudgil MS McMurtry, et al. 2006 An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension Circulation 113 2630 2641 16735674 10.1161/CIRCULATIONAHA.105.609008 1:CAS:528:DC%2BD28XltFWgtbk%3D (Pubitemid 43948012)
28. I Papandreou RA Cairns L Fontana AL Lim NC Denko 2006 HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab 3 187 197 16517406 10.1016/j.cmet.2006.01.012 1:CAS:528:DC%2BD28Xislyhtr0%3D
29. E Daley C Emson C Guignabert MR de Waal J Louten VP Kurup C Hogaboam L Taraseviciene-Stewart NF Voelkel M Rabinovitch, et al. 2008 Pulmonary arterial remodeling induced by a Th2 immune response J Exp Med 205 361 372 18227220 10.1084/jem.20071008 1:CAS:528:DC%2BD1cXisVehtL8%3D (Pubitemid 351281602)
30. T Henriques-Coelho A Brandao-Nogueira D Moreira-Goncalves J Correia-Pinto AF Leite-Moreira 2008 Effects of TNF-alpha blockade in monocrotaline-induced pulmonary hypertension Rev Port Cardiol 27 341 348 18551920 1:STN:280: DC%2BD1czosFCnsw%3D%3D (Pubitemid 351631803)
31. E Bargagli M Galeazzi F Bellisai L Volterrani P Rottoli 2008 Infliximab treatment in a patient with systemic sclerosis associated with lung fibrosis and pulmonary hypertension Respiration 75 346 349 16369127 10.1159/000090248 (Pubitemid 351450408)
32. M Fujita JM Shannon CG Irvin KA Fagan C Cool A Augustin RJ Mason 2001 Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 280 L39 L49 11133493 1:CAS:528:DC%2BD3MXjtVWltrg%3D
33. NF Voelkel RM Tuder J Bridges WP Arend 1994 Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline Am J Respir Cell Mol Biol 11 664 675 7946395 1:CAS:528: DyaK2MXisVGgurk%3D
34. N Clausell S Molossi S Sett M Rabinovitch 1994 In vivo blockade of tumor necrosis factor-alpha in cholesterol-fed rabbits after cardiac transplant inhibits acute coronary artery neointimal formation Circulation 89 2768 2779 8205691 1:CAS:528:DyaK2cXltlWqur4%3D (Pubitemid 24173698)
35. T Stevens S Phan MG Frid D Alvarez E Herzog KR Stenmark 2008 Lung vascular cell heterogeneity: endothelium, smooth muscle, and fibroblasts Proc Am Thorac Soc 5 783 791 18757318 10.1513/pats.200803-027HR 1:CAS:528: DC%2BD1cXhtFOrsLvL
36. W Xu T Koeck AR Lara D Neumann FP DiFilippo M Koo AJ Janocha FA Masri AC Arroliga C Jennings, et al. 2007 Alterations of cellular bioenergetics in pulmonary artery endothelial cells Proc Natl Acad Sci USA 104 1342 1347 17227868 10.1073/pnas.0605080104 1:CAS:528:DC%2BD2sXht12hs7o%3D (Pubitemid 46184006)