Upregulation of postbacteremic TNF-α and IL-1α gene expression by alveolar hypoxia/reoxygenation in perfused rat lungs

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 2, 1998, Pages 629-637

  Matuschak, George M ^a   Munoz, Cesar F ^b   Johanns, Cheryl A ^b   Rahman, Rashid ^b   Lechner, Andrew J ^b  

^a SAINT LOUIS UNIVERSITY HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTAGLANDIN SYNTHASE; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL PNEUMONIA; GENE EXPRESSION REGULATION; GRAM NEGATIVE INFECTION; HYPOXIA; IMMUNOPATHOGENESIS; LUNG ALVEOLUS OXYGEN TENSION; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RAT; REPERFUSION INJURY;

EID: 0031888469     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.2.9707120     Document Type: Article

References (35)

1. Suter, P. M., S. Suter, E. Girardin, R. Roux-Lombard, G. E. Grau, and J. Dayer. 1992. High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome alter trauma, shock or sepsis. Am. Rev. Respir. Dis. 145:1016-1022.
2. Pugin, J., H. Ricou, K. P. Steinberg, P. M. Suter, and T. R. Martin. 1996. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS: a prominent role for interleukin-1. Am. J. Respir. Crit. Care Med. 153:1850-1856.
3. Meduri, G. U., G. Kohler, S. Headley, E. Tolley, F. Stentz, and A. Postlethwaite. 1995. Inflammatory cytokines in the BAL of patients with ARDS: persistent elevation over time predicts poor outcome. Chest 108:1303-1314.
4. Matuschak, G. M., M. E. Mattingly, T. L. Tredway, and A. J. Lechner. 1994. Liver-lung interactions during E. coli endotoxemia. TNF-α:leukotriene axis. Am. J. Respir. Crit. Care Med. 149:41-49.
5. Douzinas, E. E., P. D. Tsidemiadou, M. T. Pitaridis, I. Andrianakis, A. Bobota-Chloraki, K. Katsouyanni, D. Sfyras, K. Malagari, and C. Roussos. 1997. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am. J. Respir. Crit. Care Med. 155:53-59.
6. Perrella, M. A., C. M. Hsieh, W. S. Lee, S. Shieh, J. C. Tsai, C. Patterson, C. J. Lowenstein, N. C. Long, E. Haber, S. Shore, and M. E. Lee. 1996. Arrest of endotoxin-induced hypotension by transforming growth factor beta 1. Proc. Natl. Acad. Sci. U.S.A. 93:2054-2059.
7. Bone, R. C. 1996. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome and the multiple organ dysfunction syndrome (MODS). Ann. Intern. Med. 125:680-687.
8. Feng, L., Y. Xia, D. Hwang, and C. B. Wilson. 1995. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J. Clin. Invest. 95:1669-1675.
9. Hempel, S. L., M. M. Monnick, and G. W. Hunninghake. 1996. Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 14:170-176.
10. Kisala, J. M., A. Ayala, R. N. Stephan, and I. H. Chaudry. 1993. A model of pulmonary atelectasis in rats: activation of alveolar macrophage and cytokine release. Am. J. Physiol. 264:R610-R614.
11. Matuschak, G. M. 1996. Lung-liver interactions in sepsis and multiple organ failure syndrome. Clin. Chest Med. 17:83-98.
12. Wibbenmeyer, L. A., A. J. Lechner, C. F. Munoz, and G. M. Matuschak. 1995. Downregulation of E. coli-induced TNF-α expression in perfused liver by hypoxia-reoxygenation. Am. J. Physiol. 268:G311-G319.
13. Matuschak, G. M., C. A. Johanns, Z. Chen, J. Gaynor, and A. J. Lechner. 1996. Brief hypoxic stress downregulates E. coli-induced IL-1α and IL-1β gene expression in perfused liver. Am. J. Physiol. 271:R1I311-R1318.
14. Ikegami, K., C. Lalonde, Y. K. Young, L. Picard, and R. Demling. 1994. Comparison of plasma reduced glutathione and oxidized glutathione with lung and liver tissue oxidant and antioxidant activity during acute inflammation. Shock 1:307-312.
15. Drake, R., K. A. Gaar, and A. E. Taylor. 1978. Estimation of the filtration coefficient of pulmonary exchange vessels. Am. J. Physiol. 234: H266-H274.
16. Zanaboni, P. B., J. D. Bradley, R. O. Webster, and T. E. Dahms. 1990. Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs. J. Appl. Physiol. 69:1494-1514.
17. Ohar, J. A., K. S. Waller, and T. E. Dahms. 1993. Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. Am. Rev. Respir. Dis. 148:158-163.
18. Epperly, N. A., A. J. Lechner, C. H. Johanns, R. O. Webster, and G. M. Matuschak. 1996. Bidirectional effects of hepatic ischemia/reperfusion on E. coli-induced TNF-α gene expression. Am. J. Physiol. 270:R289-R297.
19. Cannon, J. G., J. W. M. van der Meer, D. Kwiakowski, S. Endres, G. Lonnemann, J. F. Burke, and C. A. Dinarello. 1988. Interleukin-1 beta in human plasma: optimization of blood collection, plasma extraction, and radioimmunoassay methods. Lymphokine Res. 7:457-467.
20. Derynck, R., J. A. Jarrett, E. Y. Chen, D. H. Eaton, J. R. Bell, R. K. Assoian, A. B. Roberts, M. B. Sporn, and D. V. Goeddel. 1985. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature 316:701-705.
21. VanOttern, G. M., T. J. Standiford, S. L. Kunkel, J. M. Danforth, and R. M. Strieter. 1995. Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 13:399-409.
22. Matuschak, G. M., C. A. Klein, T. L. Tredway, D. R. Schilly, and A. J. Lechner. 1993. TNF-α and cyclooxygenase metabolites do not modulate C. albicans septic shock with disseminated candidiasis. J. Appl. Physiol. 74:2432-2442.
23. Mitomo, K., K. Nakayama, K. Fujimoto, X. Sun, S. Seki, and K. Yamamoto. 1994. Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-κB in vitro. Gene 145:197-203.
24. Koong, A. C., E. Y. Chen, and A. J. Giaccia. 1994. Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα residues. Cancer Res. 54:1425-1430.
25. Galter, D., S. Mihm, and W. Droge. 1994. Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1. Eur. J. Biochem. 221:639-648.
26. Sen, C. K., and L. Packer. 1996. Antioxidant and redox regulation of gene transcription. FASEB J. 10:709-720.
27. Muller, J. M., R. A. Rupee, and P. A. Baeuerle. 1997. Study of gene regulation by NF-κB and AP-1 in response to reactive oxygen intermediates. Methods 11:301-312.
28. Matuschak, G. M., Z. Chen, C. Munoz, and A. J. Lechner. 1996. Organ-specific differences in hepatic vs. pulmonary TNF-α expression following sequential E. coli bacteremia and hypoxia/reoxygenation (abstract). Am. J. Respir. Crit. Care Med. 153:A251.
29. Loftis, L., C. Johanns, A. J. Lechner, and G. M. Matuschak. 1997. Effect of sequential E. coli bacteremia and brief hypoxic stress on NF-κB activation and TNF-α production in perfused rat liver (abstract). Crit. Care Med. (In press)
30. Madan, A., and P. T. Curtin. 1993. A 24-hase-pair sequence 3′ to the human erythropoetin gene contains a hypoxia-responsive transcriptional enhancer. Proc. Natl. Acad. Sci. U.S.A. 90:3928-3932.
31. Schwartz, M. D., J. E. Repine, and E. Abraham. 1995. Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock. Am. J. Respir. Cell Mol. Biol. 12:434-440.
32. Shenkar, R., and E. Abraham. 1996. Plasma from hemorrhaged mice activates CREB and increases cytokine expression in lung mononuclear cells through a xanthine oxidase-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 14:198-206.
33. Chavez, V. M., A. J. Lechner, and G. M. Matuschak. 1997. Brief hypoxic stress decreases circulating TNF-α after E. coli bacteremia in conscious rats (abstract). Am. J. Respir. Crit. Care Med. 155:A707.
34. 2 synthesis after oxidant stress is dependent on cell glutathione content. Am. J. Physiol. C1392-C1399.
35. 2 in isolated perfused rat lungs. Int. J. Microcirc.: Clin. Exp. 11:85-93.