메뉴 건너뛰기




Volumn 19, Issue 1, 2013, Pages 74-82

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MICRORNA; MICRORNA 424; MICRORNA 503; UNCLASSIFIED DRUG;

EID: 84872078405     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3040     Document Type: Article
Times cited : (316)

References (38)
  • 2
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • Humbert, M. et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43, 13S-24S (2004).
    • (2004) J. Am. Coll. Cardiol , vol.43
    • Humbert, M.1
  • 3
    • 67649844313 scopus 로고    scopus 로고
    • Inflammation, growth factors, and pulmonary vascular remodeling
    • Hassoun, P.M. et al. Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 54, S10-S19 (2009).
    • (2009) J. Am. Coll. Cardiol , vol.54
    • Hassoun, P.M.1
  • 5
    • 65649128937 scopus 로고    scopus 로고
    • Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
    • Izikki, M. et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J. Clin. Invest. 119, 512-523 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 512-523
    • Izikki, M.1
  • 6
    • 33646201514 scopus 로고    scopus 로고
    • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: Critical role for serotonin-induced smooth muscle hyperplasia
    • Eddahibi, S. et al. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 113, 1857-1864 (2006).
    • (2006) Circulation , vol.113 , pp. 1857-1864
    • Eddahibi, S.1
  • 7
    • 33750580874 scopus 로고    scopus 로고
    • Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension
    • Dewachter, L. et al. Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. Am. J. Respir. Crit. Care Med. 174, 1025-1033 (2006).
    • (2006) Am. J. Respir. Crit. Care Med , vol.174 , pp. 1025-1033
    • Dewachter, L.1
  • 8
    • 79953750062 scopus 로고    scopus 로고
    • Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension
    • Chandra, S.M. et al. Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. 31, 814-820 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol , vol.31 , pp. 814-820
    • Chandra, S.M.1
  • 9
    • 80052348254 scopus 로고    scopus 로고
    • Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    • Alastalo, T.P. et al. Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J. Clin. Invest. 121, 3735-3746 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 3735-3746
    • Alastalo, T.P.1
  • 10
    • 38149051165 scopus 로고    scopus 로고
    • In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure
    • Sheikh, A.Y. et al. In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am. J. Physiol. Heart Circ. Physiol. 294, H88-H98 (2008).
    • (2008) Am. J. Physiol. Heart Circ. Physiol , vol.294
    • Sheikh, A.Y.1
  • 11
    • 0034647520 scopus 로고    scopus 로고
    • Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin
    • Hosoya, M. et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J. Biol. Chem. 275, 21061-21067 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 21061-21067
    • Hosoya, M.1
  • 12
    • 54549087794 scopus 로고    scopus 로고
    • Anatomical profiling of G protein-coupled receptor expression
    • Regard, J.B., Sato, I.T. & Coughlin, S.R. Anatomical profiling of G protein-coupled receptor expression. Cell 135, 561-571 (2008).
    • (2008) Cell , vol.135 , pp. 561-571
    • Regard, J.B.1    Sato, I.T.2    Coughlin, S.R.3
  • 13
    • 29244471763 scopus 로고    scopus 로고
    • Apelin: A new plasma marker of cardiopulmonary disease
    • Goetze, J.P. et al. Apelin: a new plasma marker of cardiopulmonary disease. Regul. Pept. 133, 134-138 (2006).
    • (2006) Regul. Pept , vol.133 , pp. 134-138
    • Goetze, J.P.1
  • 14
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder, R.M., Groves, B., Badesch, D.B. & Voelkel, N.F. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am. J. Pathol. 144, 275-285 (1994).
    • (1994) Am. J. Pathol , vol.144 , pp. 275-285
    • Tuder, R.M.1    Groves, B.2    Badesch, D.B.3    Voelkel, N.F.4
  • 15
    • 34548433880 scopus 로고    scopus 로고
    • Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
    • Masri, F.A. et al. Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L548-L554 (2007).
    • (2007) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.293
    • Masri, F.A.1
  • 16
    • 6344285687 scopus 로고    scopus 로고
    • Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension
    • Benisty, J.I. et al. Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension. Chest 126, 1255-1261 (2004).
    • (2004) Chest , vol.126 , pp. 1255-1261
    • Benisty, J.I.1
  • 17
    • 66949148740 scopus 로고    scopus 로고
    • Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension
    • Falcão-Pires, I. et al. Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension. Am. J. Physiol. Heart Circ. Physiol. 296, H2007-H2014 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol , vol.296
    • Falcão-Pires, I.1
  • 18
    • 70350462121 scopus 로고    scopus 로고
    • Endogenous regulation of cardiovascular function by apelin-APJ
    • Charo, D.N. et al. Endogenous regulation of cardiovascular function by apelin-APJ. Am. J. Physiol. Heart Circ. Physiol. 297, H1904-H1913 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol , vol.297
    • Charo, D.N.1
  • 19
    • 0032826034 scopus 로고    scopus 로고
    • Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
    • Habata, Y. et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim. Biophys. Acta 1452, 25-35 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1452 , pp. 25-35
    • Habata, Y.1
  • 20
    • 80054919770 scopus 로고    scopus 로고
    • MicroRNA-16 and microRNA-424 regulate cell-Autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1
    • Chamorro-Jorganes, A. et al. MicroRNA-16 and microRNA-424 regulate cell-Autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler. Thromb. Vasc. Biol. 31, 2595-2606 (2011).
    • (2011) Arterioscler. Thromb. Vasc. Biol , vol.31 , pp. 2595-2606
    • Chamorro-Jorganes, A.1
  • 21
    • 55849150964 scopus 로고    scopus 로고
    • The FGF system has a key role in regulating vascular integrity
    • Murakami, M. et al. The FGF system has a key role in regulating vascular integrity. J. Clin. Invest. 118, 3355-3366 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 3355-3366
    • Murakami, M.1
  • 22
  • 23
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart, L. et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J. 15, 427-438 (2001).
    • (2001) FASEB J , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1
  • 24
    • 80051615782 scopus 로고    scopus 로고
    • Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension
    • Tu, L. et al. Autocrine fibroblast growth factor-2 signaling contributes to altered endothelial phenotype in pulmonary hypertension. Am. J. Respir. Cell Mol. Biol. 45, 311-322 (2011).
    • (2011) Am. J. Respir. Cell Mol. Biol , vol.45 , pp. 311-322
    • Tu, L.1
  • 25
    • 10044296019 scopus 로고    scopus 로고
    • Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells
    • Masri, B., Morin, N., Cornu, M., Knibiehler, B. & Audigier, Y. Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J. 18, 1909-1911 (2004).
    • (2004) FASEB J , vol.18 , pp. 1909-1911
    • Masri, B.1    Morin, N.2    Cornu, M.3    Knibiehler, B.4    Audigier, Y.5
  • 26
    • 50949099615 scopus 로고    scopus 로고
    • Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis
    • Eyries, M. et al. Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis. Circ. Res. 103, 432-440 (2008).
    • (2008) Circ. Res , vol.103 , pp. 432-440
    • Eyries, M.1
  • 27
    • 34247591454 scopus 로고    scopus 로고
    • Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis
    • Kälin, R.E. et al. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis. Dev. Biol. 305, 599-614 (2007).
    • (2007) Dev. Biol , vol.305 , pp. 599-614
    • Kälin, R.E.1
  • 28
    • 78149422176 scopus 로고    scopus 로고
    • Identification and functional analysis of endothelial tip cell-enriched genes
    • del Toro, R. et al. Identification and functional analysis of endothelial tip cell-enriched genes. Blood 116, 4025-4033 (2010).
    • (2010) Blood , vol.116 , pp. 4025-4033
    • Del Toro, R.1
  • 29
    • 78149284948 scopus 로고    scopus 로고
    • Apelin is a crucial factor for hypoxia-induced retinal angiogenesis
    • Kasai, A. et al. Apelin is a crucial factor for hypoxia-induced retinal angiogenesis. Arterioscler. Thromb. Vasc. Biol. 30, 2182-2187 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol , vol.30 , pp. 2182-2187
    • Kasai, A.1
  • 30
    • 53449098316 scopus 로고    scopus 로고
    • Retardation of retinal vascular development in apelin-deficient mice
    • Kasai, A. et al. Retardation of retinal vascular development in apelin-deficient mice. Arterioscler. Thromb. Vasc. Biol. 28, 1717-1722 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol , vol.28 , pp. 1717-1722
    • Kasai, A.1
  • 31
    • 77951078472 scopus 로고    scopus 로고
    • Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia
    • Kidoya, H., Naito, H. & Takakura, N. Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia. Blood 115, 3166-3174 (2010).
    • (2010) Blood , vol.115 , pp. 3166-3174
    • Kidoya, H.1    Naito, H.2    Takakura, N.3
  • 32
    • 77950878463 scopus 로고    scopus 로고
    • Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline
    • Caruso, P. et al. Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler. Thromb. Vasc. Biol. 30, 716-723 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol , vol.30 , pp. 716-723
    • Caruso, P.1
  • 33
    • 76749170274 scopus 로고    scopus 로고
    • Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation
    • Forrest, A.R. et al. Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia 24, 460-466 (2010).
    • (2010) Leukemia , vol.24 , pp. 460-466
    • Forrest, A.R.1
  • 34
    • 77954210384 scopus 로고    scopus 로고
    • MiR-322/424 and-503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A
    • Sarkar, S., Dey, B.K. & Dutta, A. MiR-322/424 and-503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A. Mol. Biol. Cell 21, 2138-2149 (2010).
    • (2010) Mol. Biol. Cell , vol.21 , pp. 2138-2149
    • Sarkar, S.1    Dey, B.K.2    Dutta, A.3
  • 35
    • 78049424494 scopus 로고    scopus 로고
    • Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-Alpha isoforms and promotes angiogenesis
    • Ghosh, G. et al. Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-Alpha isoforms and promotes angiogenesis. J. Clin. Invest. 120, 4141-4154 (2010).
    • (2010) J. Clin. Invest , vol.120 , pp. 4141-4154
    • Ghosh, G.1
  • 36
    • 84861779723 scopus 로고    scopus 로고
    • Human primary lung endothelial cells in culture
    • Comhair, S.A. et al. Human primary lung endothelial cells in culture. Am. J. Respir. Cell Mol. Biol. 46, 723-730 (2012).
    • (2012) Am. J. Respir. Cell Mol. Biol , vol.46 , pp. 723-730
    • Comhair, S.A.1
  • 37
    • 57049104201 scopus 로고    scopus 로고
    • High levels of hyaluronan in idiopathic pulmonary arterial hypertension
    • Aytekin, M. et al. High levels of hyaluronan in idiopathic pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L789-L799 (2008).
    • (2008) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.295
    • Aytekin, M.1
  • 38
    • 55849094397 scopus 로고    scopus 로고
    • Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
    • Chun, H.J. et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J. Clin. Invest. 118, 3343-3354 (2008).
    • (2008) J. Clin. Invest , vol.118 , pp. 3343-3354
    • Chun, H.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.