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Volumn 9, Issue 2, 2014, Pages

Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CASPASE; CD18 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; CYCLOPHOSPHAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; LECTIN; PHOSPHATIDYLSERINE; ALBUMINOID;

EID: 84895523990     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0088501     Document Type: Article
Times cited : (77)

References (66)
  • 1
    • 70350463588 scopus 로고    scopus 로고
    • Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study
    • Ferrer R, Artigas A, Suarez D, Palencia E, Levy MM, et al. (2009) Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. AmJRespirCrit Care Med 180: 861-866.
    • (2009) AmJRespirCrit Care Med , vol.180 , pp. 861-866
    • Ferrer, R.1    Artigas, A.2    Suarez, D.3    Palencia, E.4    Levy, M.M.5
  • 2
    • 79952202283 scopus 로고    scopus 로고
    • National analysis of sepsis hospitalizations and factors contributing to sepsis in-hospital mortality in Canada
    • Husak L, Marcuzzi A, Herring J, Wen E, Yin L, et al. (2010) National analysis of sepsis hospitalizations and factors contributing to sepsis in-hospital mortality in Canada. HealthcQ 13 Spec No: 35-41.
    • (2010) HealthcQ , vol.13 , Issue.SPEC. NO , pp. 35-41
    • Husak, L.1    Marcuzzi, A.2    Herring, J.3    Wen, E.4    Yin, L.5
  • 3
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, et al. (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine 29: 1303-1310. (Pubitemid 32641789)
    • (2001) Critical Care Medicine , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 4
    • 0029941532 scopus 로고    scopus 로고
    • The sepsis syndrome. Definition and general approach to management
    • Bone RC (1996) The sepsis syndrome. Definition and general approach to management. Clinics in Chest Medicine 17: 175-181.
    • (1996) Clinics in Chest Medicine , vol.17 , pp. 175-181
    • Bone, R.C.1
  • 5
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • DOI 10.1056/NEJMra021333
    • Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. New England Journal of Medicine 348: 138-150. (Pubitemid 36056721)
    • (2003) New England Journal of Medicine , vol.348 , Issue.2 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 7
    • 0033810383 scopus 로고    scopus 로고
    • Pathophysiologic basis of sepsis: Considerations for future strategies of intervention
    • Glauser MP (2000) Pathophysiologic basis of sepsis: considerations for future strategies of intervention. Critical Care Medicine 28: S4-S8.
    • (2000) Critical Care Medicine , vol.28
    • Glauser, M.P.1
  • 8
    • 0033590515 scopus 로고    scopus 로고
    • Treating patients with severe sepsis
    • DOI 10.1056/NEJM199901213400307
    • Wheeler AP, Bernard GR (1999) Treating patients with severe sepsis. New England Journal of Medicine 340: 207-214. (Pubitemid 29063218)
    • (1999) New England Journal of Medicine , vol.340 , Issue.3 , pp. 207-214
    • Wheeler, A.P.1    Bernard, G.R.2
  • 9
    • 3242764396 scopus 로고    scopus 로고
    • Pulmonary neutrophil infiltration in murine sepsis: Role of inducible nitric oxide synthase
    • Razavi HM, Wang le F, Weicker S, Rohan M, Law C, et al. (2004) Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase. Am J Respir Crit Care Med 170: 227-233.
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 227-233
    • Razavi, H.M.1    Wang, L.F.2    Weicker, S.3    Rohan, M.4    Law, C.5
  • 10
    • 84984564151 scopus 로고    scopus 로고
    • Specific role of neutrophil inducible nitric oxide synthase in murine sepsis-induced lung injury in vivo
    • Wang L, Taneja R, Razavi HM, Law C, Gillis C, et al. (2012) Specific role of neutrophil inducible nitric oxide synthase in murine sepsis-induced lung injury in vivo. Shock 37: 539-547.
    • (2012) Shock , vol.37 , pp. 539-547
    • Wang, L.1    Taneja, R.2    Razavi, H.M.3    Law, C.4    Gillis, C.5
  • 12
    • 0036254948 scopus 로고    scopus 로고
    • Endothelial cell dysfunction and abnormal tissue perfusion
    • Vallet B (2002) Endothelial cell dysfunction and abnormal tissue perfusion. Critical Care Medicine 30: S229-234.
    • (2002) Critical Care Medicine , vol.30
    • Vallet, B.1
  • 13
  • 14
    • 0028214238 scopus 로고
    • The microcirculation and inflammation: Modulation of leukocyte- endothelial cell adhesion
    • Granger DN, Kubes P (1994) The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J Leukoc Biol 55: 662-675. (Pubitemid 24171735)
    • (1994) Journal of Leukocyte Biology , vol.55 , Issue.5 , pp. 662-675
    • Granger, D.N.1    Kubes, P.2
  • 15
    • 79551616910 scopus 로고    scopus 로고
    • Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis
    • Tyml K (2011) Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis. Microcirculation 18: 152-162.
    • (2011) Microcirculation , vol.18 , pp. 152-162
    • Tyml, K.1
  • 17
    • 0028053865 scopus 로고
    • Microvascular perfusion is impaired in a rat model of normotensive sepsis
    • Lam C, Tyml K, Martin C, Sibbald W (1994) Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94: 2077-2083. (Pubitemid 24348249)
    • (1994) Journal of Clinical Investigation , vol.94 , Issue.5 , pp. 2077-2083
    • Lam, C.1    Tyml, K.2    Martin, C.3    Sibbald, W.4
  • 18
    • 34247171377 scopus 로고    scopus 로고
    • Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis
    • DOI 10.1097/01.CCM.0000259527.89927.F9
    • Boerma EC, van der Voort PH, Spronk PE, Ince C (2007) Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Critical Care Medicine 35: 1055-1060. (Pubitemid 46598955)
    • (2007) Critical Care Medicine , vol.35 , Issue.4 , pp. 1055-1060
    • Boerma, E.C.1    Van Der, V.P.H.J.2    Spronk, P.E.3    Ince, C.4
  • 20
    • 33845872563 scopus 로고    scopus 로고
    • Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: Relationship to hemodynamics, oxygen transport, and survival
    • Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, et al. (2007) Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. AnnEmergMed 49: 88-98, 98.
    • (2007) AnnEmergMed , vol.49
    • Trzeciak, S.1    Dellinger, R.P.2    Parrillo, J.E.3    Guglielmi, M.4    Bajaj, J.5
  • 21
    • 4444233598 scopus 로고    scopus 로고
    • Persistent-microcirculatory alterations are associated with organ failure and death in patients with septic shock
    • DOI 10.1097/01.CCM.0000138558.16257.3F
    • Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL (2004) Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Critical Care Medicine 32: 1825-1831. (Pubitemid 39202356)
    • (2004) Critical Care Medicine , vol.32 , Issue.9 , pp. 1825-1831
    • Sakr, Y.1    Dubois, M.-J.2    De Backer, D.3    Creteur, J.4    Vincent, J.-L.5
  • 24
    • 0036255482 scopus 로고    scopus 로고
    • Markers of endothelial damage in organ dysfunction and sepsis
    • Reinhart K, Bayer O, Brunkhorst F, Meisner M (2002) Markers of endothelial damage in organ dysfunction and sepsis. Critical Care Medicine 30: S302-S312. (Pubitemid 34508007)
    • (2002) Critical Care Medicine , vol.30 , Issue.5 SUPPL.
    • Reinhart, K.1    Bayer, O.2    Brunkhorst, F.3    Meisner, M.4
  • 27
    • 27844491903 scopus 로고    scopus 로고
    • The effects of nitric oxide in acute lung injury
    • Mehta S (2005) The effects of nitric oxide in acute lung injury. Vascul Pharmacol 43: 390-403.
    • (2005) Vascul Pharmacol , vol.43 , pp. 390-403
    • Mehta, S.1
  • 28
    • 0032915279 scopus 로고    scopus 로고
    • Porcine endotoxemic shock is associated with increased expired nitric oxide
    • Mehta S, Javeshghani D, Datta P, Levy RD, Magder S (1999) Porcine endotoxemic shock is associated with increased expired nitric oxide. Critical Care Medicine 27: 385-393. (Pubitemid 29113550)
    • (1999) Critical Care Medicine , vol.27 , Issue.2 , pp. 385-393
    • Mehta, S.1    Javeshghani, D.2    Datta, P.3    Levy, R.D.4    Magder, S.5
  • 30
  • 32
    • 49949098205 scopus 로고    scopus 로고
    • Human neutrophil-pulmonary microvascular endothelial cell interactions in vitro: Differential effects of nitric oxide vs. Peroxynitrite
    • Shelton JL, Wang L, Cepinskas G, Inculet R, Mehta S (2008) Human neutrophil-pulmonary microvascular endothelial cell interactions in vitro: differential effects of nitric oxide vs. peroxynitrite. MicrovascRes 76: 80-88.
    • (2008) MicrovascRes , vol.76 , pp. 80-88
    • Shelton, J.L.1    Wang, L.2    Cepinskas, G.3    Inculet, R.4    Mehta, S.5
  • 33
    • 31744448251 scopus 로고    scopus 로고
    • Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions
    • DOI 10.1016/j.mvr.2005.11.003, PII S0026286205001196
    • Shelton JL, Wang L, Cepinskas G, Sandig M, Inculet R, et al. (2006) Albumin leak across human pulmonary microvascular vs. umbilical vein endothelial cells under septic conditions. Microvascular Research 71: 40-47. (Pubitemid 43175847)
    • (2006) Microvascular Research , vol.71 , Issue.1 , pp. 40-47
    • Shelton, J.L.1    Wang, L.2    Cepinskas, G.3    Sandig, M.4    Inculet, R.5    McCormack, D.G.6    Mehta, S.7
  • 34
    • 34249915081 scopus 로고    scopus 로고
    • Inducible NO synthase (iNOS) in human neutrophils but not pulmonary microvascular endothelial cells (PMVEC) mediates septic protein leak in vitro
    • DOI 10.1016/j.mvr.2007.02.008, PII S0026286207000234
    • Shelton JL, Wang L, Cepinskas G, Sandig M, Scott JA, et al. (2007) Inducible NO synthase (iNOS) in human neutrophils but not pulmonary microvascular endothelial cells (PMVEC) mediates septic protein leak in vitro. MicrovascRes 74: 23-31. (Pubitemid 46863364)
    • (2007) Microvascular Research , vol.74 , Issue.1 , pp. 23-31
    • Shelton, J.L.1    Wang, L.2    Cepinskas, G.3    Sandig, M.4    Scott, J.A.5    North, M.L.6    Inculet, R.7    Mehta, S.8
  • 36
    • 84984563960 scopus 로고    scopus 로고
    • Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase
    • Wang L, Mehta S, Gillis C, Law C, Taneja R (2010) Modulation of neutrophil apoptosis by murine pulmonary microvascular endothelial cell inducible nitric oxide synthase. BiochemBiophysResCommun 401: 207-212.
    • (2010) BiochemBiophysResCommun , vol.401 , pp. 207-212
    • Wang, L.1    Mehta, S.2    Gillis, C.3    Law, C.4    Taneja, R.5
  • 37
    • 0034810765 scopus 로고    scopus 로고
    • Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (iNOS) activity in murine endotoxemia
    • DOI 10.1006/bbrc.2001.4842
    • Wang LF, Mehta S, Weicker S, Scott JA, Joseph M, et al. (2001) Relative contribution of hemopoietic and pulmonary parenchymal cells to lung inducible nitric oxide synthase (iNOS) activity in murine endotoxemia. Biochemical & Biophysical Research Communications 283: 694-699. (Pubitemid 32917946)
    • (2001) Biochemical and Biophysical Research Communications , vol.283 , Issue.3 , pp. 694-699
    • Wang, L.F.1    Mehta, S.2    Weicker, S.3    Scott, J.A.4    Joseph, M.5    Razavi, H.M.6    McCormack, D.G.7
  • 41
    • 67349170024 scopus 로고    scopus 로고
    • Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions
    • Hu H, Li X, Li Y, Wang L, Mehta S, et al. (2009) Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions. Microvascular Research 78: 33-39.
    • (2009) Microvascular Research , vol.78 , pp. 33-39
    • Hu, H.1    Li, X.2    Li, Y.3    Wang, L.4    Mehta, S.5
  • 43
    • 0036356846 scopus 로고    scopus 로고
    • Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse
    • Yang S, Chung CS, Ayala A, Chaudry IH, Wang P (2002) Differential alterations in cardiovascular responses during the progression of polymicrobial sepsis in the mouse. Shock 17: 55-60.
    • (2002) Shock , vol.17 , pp. 55-60
    • Yang, S.1    Chung, C.S.2    Ayala, A.3    Chaudry, I.H.4    Wang, P.5
  • 44
    • 0030464170 scopus 로고    scopus 로고
    • Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct
    • Driessens MH, van Hulten P, Zuurbier A, La Riviere G, Roos E (1996) Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. J Leukoc Biol 60: 758-765. (Pubitemid 27041665)
    • (1996) Journal of Leukocyte Biology , vol.60 , Issue.6 , pp. 758-765
    • Driessens, M.H.E.1    Van Hulten, P.2    Zuurbier, A.3    La, R.G.4    Roos, E.5
  • 45
    • 0027294675 scopus 로고
    • Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta-chain of the leukocyte adhesion molecule (CD18)
    • Zahalka MA, Okon E, Naor D (1993) Blocking lymphoma invasiveness with a monoclonal antibody directed against the beta-chain of the leukocyte adhesion molecule (CD18). Journal of Immunology 150: 4466-4477. (Pubitemid 23133723)
    • (1993) Journal of Immunology , vol.150 , Issue.10 , pp. 4466-4477
    • Zahalka, M.A.1    Okon, E.2    Naor, D.3
  • 46
    • 0033838924 scopus 로고    scopus 로고
    • Pulmonary microvascular changes during sepsis: Evaluation using intravital videomicroscopy
    • DOI 10.1006/mvre.2000.2261
    • McCormack DG, Mehta S, Tyml K, Scott JA, Potter R, et al. (2000) Pulmonary microvascular changes during sepsis: evaluation using intravital videomicroscopy. Microvascular research 60: 131-140. (Pubitemid 30667054)
    • (2000) Microvascular Research , vol.60 , Issue.2 , pp. 131-140
    • McCormack, D.G.1    Mehta, S.2    Tyml, K.3    Scott, J.A.4    Potter, R.5    Rohan, M.6
  • 47
    • 70350029795 scopus 로고    scopus 로고
    • Opening the flood-gates: How neutrophil-endothelial interactions regulate permeability
    • DiStasi MR, Ley K (2009) Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability. Trends Immunol 30: 547-556.
    • (2009) Trends Immunol , vol.30 , pp. 547-556
    • DiStasi, M.R.1    Ley, K.2
  • 48
    • 80054718853 scopus 로고    scopus 로고
    • On, around, and through: Neutrophil-endothelial interactions in innate immunity
    • Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP (2011) On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology 26: 334-347.
    • (2011) Physiology , vol.26 , pp. 334-347
    • Schmidt, E.P.1    Lee, W.L.2    Zemans, R.L.3    Yamashita, C.4    Downey, G.P.5
  • 51
    • 34548432210 scopus 로고    scopus 로고
    • Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock
    • DOI 10.1016/j.cardiores.2007.05.024, PII S0008636307002568
    • Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, et al. (2007) Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res 76: 132-140. (Pubitemid 47362040)
    • (2007) Cardiovascular Research , vol.76 , Issue.1 , pp. 132-140
    • Matsuda, N.1    Takano, Y.2    Kageyama, S.-i.3    Hatakeyama, N.4    Shakunaga, K.5    Kitajima, I.6    Yamazaki, M.7    Hattori, Y.8
  • 52
    • 3242664327 scopus 로고    scopus 로고
    • Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
    • DOI 10.1097/01.sla.0000133253.45591.5b
    • Zhou M, Simms HH, Wang P (2004) Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Annals of Surgery 240: 321-330. (Pubitemid 38963025)
    • (2004) Annals of Surgery , vol.240 , Issue.2 , pp. 321-330
    • Zhou, M.1    Simms, H.H.2    Wang, P.3
  • 55
    • 38949147872 scopus 로고    scopus 로고
    • Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species
    • DOI 10.1160/TH07-07-0474
    • Kuckleburg CJ, Tiwari R, Czuprynski CJ (2008) Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb Haemost 99: 363-372. (Pubitemid 351230968)
    • (2008) Thrombosis and Haemostasis , vol.99 , Issue.2 , pp. 363-372
    • Kuckleburg, C.J.1    Tiwari, R.2    Czuprynski, C.J.3
  • 58
    • 0000165143 scopus 로고    scopus 로고
    • Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase
    • Yang JJ, Kettritz R, Falk RJ, Jennette JC, Gaido ML (1996) Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. The American journal of pathology 149: 1617-1626. (Pubitemid 26363968)
    • (1996) American Journal of Pathology , vol.149 , Issue.5 , pp. 1617-1626
    • Yang, J.J.1    Kettritz, R.2    Falk, R.J.3    Jennette, J.C.4    Gaido, M.L.5
  • 59
    • 0035135617 scopus 로고    scopus 로고
    • Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants
    • Yang JJ, Preston GA, Pendergraft WF, Segelmark M, Heeringa P, et al. (2001) Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. The American journal of pathology 158: 581-592. (Pubitemid 32158619)
    • (2001) American Journal of Pathology , vol.158 , Issue.2 , pp. 581-592
    • Yang, J.J.1    Preston, G.A.2    Pendergraft, W.F.3    Segelmark, M.4    Heeringa, P.5    Hogan, S.L.6    Jennette, J.C.7    Falk, R.J.8
  • 60
    • 77951156788 scopus 로고    scopus 로고
    • Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
    • Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I (2010) Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. J Biol Chem 285: 4826-4836.
    • (2010) J Biol Chem , vol.285 , pp. 4826-4836
    • Andersen, J.T.1    Daba, M.B.2    Berntzen, G.3    Michaelsen, T.E.4    Sandlie, I.5
  • 61
    • 0035210960 scopus 로고    scopus 로고
    • Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
    • Ober RJ, Radu CG, Ghetie V, Ward ES (2001) Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. International Immunology 13: 1551-1559. (Pubitemid 33133882)
    • (2001) International Immunology , vol.13 , Issue.12 , pp. 1551-1559
    • Ober, R.J.1    Radu, C.G.2    Ghetie, V.3    Ward, E.S.4
  • 62
    • 0029018663 scopus 로고
    • The role of nitric oxide in lipoxin A4-induced polymorphonuclear neutrophil-dependent cytotoxicity to human vascular endothelium in vitro
    • Bratt J, Gyllenhammar H (1995) The role of nitric oxide in lipoxin A4-induced polymorphonuclear neutrophil-dependent cytotoxicity to human vascular endothelium in vitro. Arthritis Rheum 38: 768-776.
    • (1995) Arthritis Rheum , vol.38 , pp. 768-776
    • Bratt, J.1    Gyllenhammar, H.2
  • 64
    • 0032698316 scopus 로고    scopus 로고
    • Cytokine-mediated apoptosis in cardiac myocytes: The role of inducible nitric oxide synthase induction and peroxynitrite generation
    • Arstall MA, Sawyer DB, Fukazawa R, Kelly RA (1999) Cytokine-mediated apoptosis in cardiac myocytes: the role of inducible nitric oxide synthase induction and peroxynitrite generation. Circulation research 85: 829-840. (Pubitemid 29504158)
    • (1999) Circulation Research , vol.85 , Issue.9 , pp. 829-840
    • Arstall, M.A.1    Sawyer, D.B.2    Fukazawa, R.3    Kelly, R.A.4
  • 65
    • 0034727873 scopus 로고    scopus 로고
    • Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury
    • DOI 10.1016/S0169-328X(00)00253-9, PII S0169328X00002539
    • Satake K, Matsuyama Y, Kamiya M, Kawakami H, Iwata H, et al. (2000) Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury. Brain research Molecular brain research 85: 114-122. (Pubitemid 32056242)
    • (2000) Molecular Brain Research , vol.85 , Issue.1-2 , pp. 114-122
    • Satake, K.1    Matsuyama, Y.2    Kamiya, M.3    Kawakami, H.4    Iwata, H.5    Adachi, K.6    Kiuchi, K.7
  • 66
    • 0035063260 scopus 로고    scopus 로고
    • Sodium salicylate increases CPY2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes
    • Wu D, Cederbaum AI (2001) Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes. Molecular pharmacology 59: 795-805. (Pubitemid 32274008)
    • (2001) Molecular Pharmacology , vol.59 , Issue.4 , pp. 795-805
    • Wu, D.1    Cederbaum, A.I.2


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