-
1
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov, R. (2008) Origin and physiological roles of inflammation. Nature 454, 428-435
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
2
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen, J. (2002) The immunopathogenesis of sepsis. Nature 420, 885-891
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
3
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., and Tschopp, J. (2008) Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320, 674-677
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
Pétrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
4
-
-
77950362382
-
The inflammasomes
-
Schroder, K., and Tschopp, J. (2010) The inflammasomes. Cell 140, 821-832
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
5
-
-
84875738389
-
SnapShot: Inflammasomes
-
Atianand, M. K., Rathinam, V. A., and Fitzgerald, K. A. (2013) SnapShot: Inflammasomes. Cell 153, 272-272.e1
-
(2013)
Cell
, vol.153
-
-
Atianand, M.K.1
Rathinam, V.A.2
Fitzgerald, K.A.3
-
6
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira, K., Haspel, J. A., Rathinam, V. A., Lee, S. J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., Fitzgerald, K. A., Ryter, S. W., and Choi, A. M. (2011) Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
Haspel, J.A.2
Rathinam, V.A.3
Lee, S.J.4
Dolinay, T.5
Lam, H.C.6
Englert, J.A.7
Rabinovitch, M.8
Cernadas, M.9
Kim, H.P.10
Fitzgerald, K.A.11
Ryter, S.W.12
Choi, A.M.13
-
7
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
-
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B. G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T., and Akira, S. (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456, 264-268
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
Tanaka, K.11
Kawai, T.12
Tsujimura, T.13
Takeuchi, O.14
Yoshimori, T.15
Akira, S.16
-
8
-
-
79954421862
-
Mitochondrial ROS fuel the inflammasome
-
Sorbara, M. T., and Girardin, S. E. (2011) Mitochondrial ROS fuel the inflammasome. Cell Res. 21, 558-560
-
(2011)
Cell Res.
, vol.21
, pp. 558-560
-
-
Sorbara, M.T.1
Girardin, S.E.2
-
9
-
-
50249175120
-
Chemical and biological approaches synergize to ameliorate protein-folding diseases
-
Mu, T. W., Ong, D. S., Wang, Y. J., Balch, W. E., Yates, J. R., 3rd, Segatori, L., and Kelly, J. W. (2008) Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 134, 769-781
-
(2008)
Cell
, vol.134
, pp. 769-781
-
-
Mu, T.W.1
Ong, D.S.2
Wang, Y.J.3
Balch, W.E.4
Yates III, J.R.5
Segatori, L.6
Kelly, J.W.7
-
10
-
-
84861743338
-
Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress
-
Liu, X. D., Ko, S., Xu, Y., Fattah, E. A., Xiang, Q., Jagannath, C., Ishii, T., Komatsu, M., and Eissa, N. T. (2012) Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J. Biol. Chem. 287, 19687-19698
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 19687-19698
-
-
Liu, X.D.1
Ko, S.2
Xu, Y.3
Fattah, E.A.4
Xiang, Q.5
Jagannath, C.6
Ishii, T.7
Komatsu, M.8
Eissa, N.T.9
-
11
-
-
84856857478
-
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway
-
Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K., and Tschopp, J. (2012) ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis. 3, e261
-
(2012)
Cell Death Dis.
, vol.3
-
-
Menu, P.1
Mayor, A.2
Zhou, R.3
Tardivel, A.4
Ichijo, H.5
Mori, K.6
Tschopp, J.7
-
12
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., and Dixit, V. M. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232
-
(2006)
Nature
, vol.440
, pp. 228-232
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
McBride, J.4
O'Rourke, K.5
Roose-Girma, M.6
Lee, W.P.7
Weinrauch, Y.8
Monack, D.M.9
Dixit, V.M.10
-
13
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A. S., Menu, P., and Tschopp, J. (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
14
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B., and Kroemer, G. (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
15
-
-
77956410115
-
Selective autophagy: Ubiquitin-mediated recognition and beyond
-
Kraft, C., Peter, M., and Hofmann, K. (2010) Selective autophagy: ubiquitin-mediated recognition and beyond. Nat. Cell Biol. 12, 836-841
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 836-841
-
-
Kraft, C.1
Peter, M.2
Hofmann, K.3
-
16
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Overvatn, A., Stenmark, H., and Johansen, T. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 171, 603-614
-
(2005)
J. Cell Biol.
, vol.171
, pp. 603-614
-
-
Bjørkøy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
17
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil, G. S. (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140, 900-917
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
18
-
-
0036270698
-
Retro-translocation of proteins from the endoplasmic reticulum into the cytosol
-
Tsai, B., Ye, Y., and Rapoport, T. A. (2002) Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell Biol. 3, 246-255
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 246-255
-
-
Tsai, B.1
Ye, Y.2
Rapoport, T.A.3
-
19
-
-
34247118826
-
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
-
Kanneganti, T. D., Lamkanfi, M., Kim, Y. G., Chen, G., Park, J. H., Franchi, L., Vandenabeele, P., and Núñez, G. (2007) Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26, 433-443
-
(2007)
Immunity
, vol.26
, pp. 433-443
-
-
Kanneganti, T.D.1
Lamkanfi, M.2
Kim, Y.G.3
Chen, G.4
Park, J.H.5
Franchi, L.6
Vandenabeele, P.7
Núñez, G.8
-
20
-
-
34548027736
-
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
-
Pétrilli, V., Papin, S., Dostert, C., Mayor, A., Martinon, F., and Tschopp, J. (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14, 1583-1589
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1583-1589
-
-
Pétrilli, V.1
Papin, S.2
Dostert, C.3
Mayor, A.4
Martinon, F.5
Tschopp, J.6
-
21
-
-
4444220680
-
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
-
Seibenhener, M. L., Babu, J. R., Geetha, T., Wong, H. C., Krishna, N. R., and Wooten, M. W. (2004) Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol. Cell. Biol. 24, 8055-8068
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8055-8068
-
-
Seibenhener, M.L.1
Babu, J.R.2
Geetha, T.3
Wong, H.C.4
Krishna, N.R.5
Wooten, M.W.6
-
22
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., Espevik, T., Lien, E., Fitzgerald, K. A., Rock, K. L., Moore, K. J., Wright, S. D., Hornung, V., and Latz, E. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
Bauernfeind, F.G.6
Abela, G.S.7
Franchi, L.8
Nuñez, G.9
Schnurr, M.10
Espevik, T.11
Lien, E.12
Fitzgerald, K.A.13
Rock, K.L.14
Moore, K.J.15
Wright, S.D.16
Hornung, V.17
Latz, E.18
-
23
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., and Latz, E. (2008) Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-856
-
-
Hornung, V.1
Bauernfeind, F.2
Halle, A.3
Samstad, E.O.4
Kono, H.5
Rock, K.L.6
Fitzgerald, K.A.7
Latz, E.8
-
24
-
-
0020674618
-
Endocytosis and the recycling of plasma membrane
-
Steinman, R. M., Mellman, I. S., Muller, W. A., and Cohn, Z. A. (1983) Endocytosis and the recycling of plasma membrane. J. Cell Biol. 96, 1-27
-
(1983)
J. Cell Biol.
, vol.96
, pp. 1-27
-
-
Steinman, R.M.1
Mellman, I.S.2
Muller, W.A.3
Cohn, Z.A.4
-
25
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
Shintani, T., and Klionsky, D. J. (2004) Autophagy in health and disease: a double-edged sword. Science 306, 990-995
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
26
-
-
79956014819
-
Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells
-
Yoon, Y. H., Cho, K. S., Hwang, J. J., Lee, S. J., Choi, J. A., and Koh, J. Y. (2010) Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells. Invest. Ophthalmol. Vis. Sci. 51, 6030-6037
-
(2010)
Invest. Ophthalmol. Vis. Sci.
, vol.51
, pp. 6030-6037
-
-
Yoon, Y.H.1
Cho, K.S.2
Hwang, J.J.3
Lee, S.J.4
Choi, J.A.5
Koh, J.Y.6
-
27
-
-
77955352128
-
Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy
-
Fan, W., Tang, Z., Chen, D., Moughon, D., Ding, X., Chen, S., Zhu, M., and Zhong, Q. (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6, 614-621
-
(2010)
Autophagy
, vol.6
, pp. 614-621
-
-
Fan, W.1
Tang, Z.2
Chen, D.3
Moughon, D.4
Ding, X.5
Chen, S.6
Zhu, M.7
Zhong, Q.8
-
28
-
-
0037223288
-
Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor --induced cell death
-
Ono, K., Kim, S. O., and Han, J. (2003) Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor --induced cell death. Mol. Cell. Biol. 23, 665-676
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 665-676
-
-
Ono, K.1
Kim, S.O.2
Han, J.3
-
29
-
-
54949137644
-
Lysosomal membrane permeabilization in cell death
-
Boya, P., and Kroemer, G. (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27, 6434-6451
-
(2008)
Oncogene
, vol.27
, pp. 6434-6451
-
-
Boya, P.1
Kroemer, G.2
-
30
-
-
77951666702
-
Regulation of apoptosis-associated lysosomal membrane permeabilization
-
Johansson, A. C., Appelqvist, H., Nilsson, C., Kågedal, K., Roberg, K., and Ollinger, K. (2010) Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 15, 527-540
-
(2010)
Apoptosis
, vol.15
, pp. 527-540
-
-
Johansson, A.C.1
Appelqvist, H.2
Nilsson, C.3
Kågedal, K.4
Roberg, K.5
Ollinger, K.6
-
31
-
-
79960542894
-
Cutting edge: Reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome
-
Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., and Hornung, V. (2011) Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J. Immunol. 187, 613-617
-
(2011)
J. Immunol.
, vol.187
, pp. 613-617
-
-
Bauernfeind, F.1
Bartok, E.2
Rieger, A.3
Franchi, L.4
Núñez, G.5
Hornung, V.6
-
32
-
-
77649260429
-
Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease
-
van de Veerdonk, F. L., Smeekens, S. P., Joosten, L. A., Kullberg, B. J., Dinarello, C. A., van der Meer, J. W., and Netea, M. G. (2010) Reactive oxygen species-independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease. Proc. Natl. Acad. Sci. U.S.A. 107, 3030-3033
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 3030-3033
-
-
Van De Veerdonk, F.L.1
Smeekens, S.P.2
Joosten, L.A.3
Kullberg, B.J.4
Dinarello, C.A.5
Van Der Meer, J.W.6
Netea, M.G.7
-
33
-
-
57449092891
-
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
-
Malhotra, J. D., Miao, H., Zhang, K., Wolfson, A., Pennathur, S., Pipe, S. W., and Kaufman, R. J. (2008) Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc. Natl. Acad. Sci. U.S.A. 105, 18525-18530
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 18525-18530
-
-
Malhotra, J.D.1
Miao, H.2
Zhang, K.3
Wolfson, A.4
Pennathur, S.5
Pipe, S.W.6
Kaufman, R.J.7
|