C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

Blood

Volumn 122, Issue 20, 2013, Pages 3473-3481

  Asgari, Elham ^a   Le Friec, Gaelle ^a   Yamamoto, Hidekazu ^a   Perucha, Esperanza ^b   Sacks, Steven S ^a   Köhl, Jörg ^c,d   Cook, H Terence ^e   Kemper, Claudia ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LÜBECK   (Germany)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; CRYOPYRIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 23; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TOLL LIKE RECEPTOR 4; C3 PROTEIN, HUMAN; CARRIER PROTEIN; CD11B ANTIGEN; COMPLEMENT COMPONENT C3; CYTOKINE; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; PURINERGIC P2X7 RECEPTOR; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR;

ARTICLE; CELL INFILTRATION; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTRACELLULAR SIGNALING; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; MACROPHAGE; MESENCHYMAL STEM CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; TH17 CELL; AGONISTS; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; GENETICS; GRAFT REJECTION; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); SIGNAL TRANSDUCTION; DRUG EFFECT; DRUG POTENTIATION;

ADENOSINE TRIPHOSPHATE; CARRIER PROTEINS; CELLS, CULTURED; COMPLEMENT C3; CYTOKINES; DENDRITIC CELLS; ENZYME ACTIVATION; GRAFT REJECTION; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; KIDNEY TRANSPLANTATION; LIPOPOLYSACCHARIDES; MACROPHAGE-1 ANTIGEN; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MONOCYTES; RECEPTORS, PURINERGIC P2X7; RECOMBINANT PROTEINS; TH17 CELLS; TOLL-LIKE RECEPTORS;

EID: 84888240043     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-05-502229     Document Type: Article

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