메뉴 건너뛰기




Volumn 2, Issue 1, 2006, Pages 35-43

Mechanisms of disease: Is osteoporosis the obesity of bone?

Author keywords

Adipocyte; Bone; Fat; Obesity; Osteoporosis

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYTOKINE; FATTY ACID DERIVATIVE; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN; OSTEOCLAST DIFFERENTIATION FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; ROSIGLITAZONE;

EID: 31544457103     PISSN: 17458382     EISSN: 17458390     Source Type: Journal    
DOI: 10.1038/ncprheum0070     Document Type: Review
Times cited : (823)

References (57)
  • 1
    • 11844251380 scopus 로고    scopus 로고
    • US Department of Health and Human Services Rockville: US Department of Health and Human Services
    • US Department of Health and Human Services (2004) Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville: US Department of Health and Human Services
    • (2004) Bone Health and Osteoporosis: A Report of the Surgeon General
  • 2
    • 0035188787 scopus 로고    scopus 로고
    • Defining the genetics of osteoporosis: Using the mouse to understand man
    • Rosen CJ et al. (2001) Defining the genetics of osteoporosis: Using the mouse to understand man. Osteoporos Int 12: 803-810
    • (2001) Osteoporos Int , vol.12 , pp. 803-810
    • Rosen, C.J.1
  • 3
    • 0027141298 scopus 로고
    • Peak bone mineral density in young women
    • Recker RR and Heaney RP (1993) Peak bone mineral density in young women. JAMA 270: 2926-2927
    • (1993) JAMA , vol.270 , pp. 2926-2927
    • Recker, R.R.1    Heaney, R.P.2
  • 4
    • 0034781590 scopus 로고    scopus 로고
    • Bone mineral density and body composition in boys with distal forearm fractures: A dual-energy X-ray absorptiometry study
    • Goulding A et al. (2001) Bone mineral density and body composition in boys with distal forearm fractures: A dual-energy X-ray absorptiometry study. J Pediatr 139: 509-515
    • (2001) J Pediatr , vol.139 , pp. 509-515
    • Goulding, A.1
  • 6
    • 0033731670 scopus 로고    scopus 로고
    • Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions
    • Kveiborg M et al. (2000) Changes in the insulin-like growth factor-system may contribute to in vitro age-related impaired osteoblast functions. Exp Gerontol 35: 1061-1074
    • (2000) Exp Gerontol , vol.35 , pp. 1061-1074
    • Kveiborg, M.1
  • 7
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas SC (2000) Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21: 115-137
    • (2000) Endocr Rev , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 9
    • 0029961204 scopus 로고    scopus 로고
    • The function of adipocytes in the bone marrow stroma: An update
    • Gimble JM et al. (1996) The function of adipocytes in the bone marrow stroma: An update. Bone 19: 421-428
    • (1996) Bone , vol.19 , pp. 421-428
    • Gimble, J.M.1
  • 10
    • 0034954807 scopus 로고    scopus 로고
    • Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection
    • Cohen PG (2001) Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypotheses 56: 702-708
    • (2001) Med Hypotheses , vol.56 , pp. 702-708
    • Cohen, P.G.1
  • 11
    • 0032416022 scopus 로고    scopus 로고
    • Bone stem cells
    • Aubin JE (1998) Bone stem cells. J Cell Biochem Suppl 30-31: 73-82
    • (1998) J Cell Biochem , vol.30-31 , Issue.SUPPL. , pp. 73-82
    • Aubin, J.E.1
  • 12
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    • Ducy P et al. (2000) Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass. Cell 100: 197-207
    • (2000) Cell , vol.100 , pp. 197-207
    • Ducy, P.1
  • 13
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda S et al. (2002) Leptin regulates bone formation via the sympathetic nervous system. Cell 111: 305-317
    • (2002) Cell , vol.111 , pp. 305-317
    • Takeda, S.1
  • 14
    • 15844384047 scopus 로고    scopus 로고
    • Leptin regulation of bone resorption by the sympathetic nervous system and CART
    • Elefteriou F et al. (2005) Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434: 514-520
    • (2005) Nature , vol.434 , pp. 514-520
    • Elefteriou, F.1
  • 15
    • 0034714050 scopus 로고    scopus 로고
    • Leptin is a potent stimulator of bone growth in ob/ob mice
    • Steppan CM et al. (2000) Leptin is a potent stimulator of bone growth in ob/ob mice. Regul Pept 92: 73-78
    • (2000) Regul Pept , vol.92 , pp. 73-78
    • Steppan, C.M.1
  • 16
    • 18744376564 scopus 로고    scopus 로고
    • Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo
    • Cornish J et al. (2002) Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 175: 405-415
    • (2002) J Endocrinol , vol.175 , pp. 405-415
    • Cornish, J.1
  • 17
    • 0034914287 scopus 로고    scopus 로고
    • Leptin reduces ovariectomy-induced bone loss in rats
    • Burguera B. et al. (2001) Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology 142: 3546-3553
    • (2001) Endocrinology , vol.142 , pp. 3546-3553
    • Burguera, B.1
  • 18
    • 1542376122 scopus 로고    scopus 로고
    • Leptin deficiency - Lessons in regional differences in the regulation of bone mass
    • Reid IR (2004) Leptin deficiency - lessons in regional differences in the regulation of bone mass. Bone 34: 369-371
    • (2004) Bone , vol.34 , pp. 369-371
    • Reid, I.R.1
  • 19
    • 1542316258 scopus 로고    scopus 로고
    • Leptin deficiency produces contrasting phenotypes in bones of the limb and spine
    • Hamrick MW et al. (2004) Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 34: 376-383
    • (2004) Bone , vol.34 , pp. 376-383
    • Hamrick, M.W.1
  • 20
    • 24344469903 scopus 로고    scopus 로고
    • β-adrenergic receptor KO mice have increased bone mass and strength but are not protected from ovariectomy-induced bone loss
    • [abstract]
    • Dhillon H et al. (2004) β-adrenergic receptor KO mice have increased bone mass and strength but are not protected from ovariectomy-induced bone loss [abstract]. J Bone Miner Res 19 (Suppl): S32
    • (2004) J Bone Miner Res , vol.19 , Issue.SUPPL.
    • Dhillon, H.1
  • 21
    • 24344436180 scopus 로고    scopus 로고
    • β1β2 adrenergic receptor KO mice have decreased total body and cortical bone mass despite increased trabecular number
    • [abstract]
    • Pierroz DD et al. (2004) β1β2 adrenergic receptor KO mice have decreased total body and cortical bone mass despite increased trabecular number [abstract]. J Bone Miner Res 19 (Suppl): S32
    • (2004) J Bone Miner Res , vol.19 , Issue.SUPPL.
    • Pierroz, D.D.1
  • 22
    • 2142652189 scopus 로고    scopus 로고
    • PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T et al. (2004) PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 113: 846-855
    • (2004) J Clin Invest , vol.113 , pp. 846-855
    • Akune, T.1
  • 23
    • 0347719481 scopus 로고    scopus 로고
    • Bone is a target for the antidiabetic compound rosiglitazone
    • Rzonca SO et al. (2004) Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology 145: 401-406
    • (2004) Endocrinology , vol.145 , pp. 401-406
    • Rzonca, S.O.1
  • 24
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways
    • Moerman EJ et al. (2004) Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways. Aging Cell 3: 379-389
    • (2004) Aging Cell , vol.3 , pp. 379-389
    • Moerman, E.J.1
  • 25
    • 0001127727 scopus 로고
    • Adipose conversion is accelerated in bone marrow cells of congenitally osteoporotic SAMP6 mice
    • [abstract]
    • Uchiyama Y et al. (1994) Adipose conversion is accelerated in bone marrow cells of congenitally osteoporotic SAMP6 mice [abstract]. J Bone Miner Res 9 (Suppl 1): S321
    • (1994) J Bone Miner Res , vol.9 , Issue.SUPPL. 1
    • Uchiyama, Y.1
  • 26
    • 23044440774 scopus 로고    scopus 로고
    • Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice
    • Botolin S. et al. (2005) Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice. Endocrinology 146: 3622-3631
    • (2005) Endocrinology , vol.146 , pp. 3622-3631
    • Botolin, S.1
  • 27
    • 8444237400 scopus 로고    scopus 로고
    • Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    • Rosen CJ et al. (2004) Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone 35: 1046-1058
    • (2004) Bone , vol.35 , pp. 1046-1058
    • Rosen, C.J.1
  • 28
    • 14644415937 scopus 로고    scopus 로고
    • Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    • Rosen CJ et al. (2005) Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol 20: 255-260
    • (2005) Pediatr Nephrol , vol.20 , pp. 255-260
    • Rosen, C.J.1
  • 29
    • 0036861322 scopus 로고    scopus 로고
    • Relationships among body mass, its components, and bone
    • Reid IR (2002) Relationships among body mass, its components, and bone. Bone 31: 547-555
    • (2002) Bone , vol.31 , pp. 547-555
    • Reid, I.R.1
  • 30
    • 24944533001 scopus 로고    scopus 로고
    • The relative contributions of lean tissue mass and fat mass to bone density in young women
    • Wang MC et al. (2005) The relative contributions of lean tissue mass and fat mass to bone density in young women. Bone 37: 474-481
    • (2005) Bone , vol.37 , pp. 474-481
    • Wang, M.C.1
  • 31
    • 3042572544 scopus 로고    scopus 로고
    • Changes in bone mineral content after surgical treatment of morbid obesity
    • von Mach MA et al. (2004) Changes in bone mineral content after surgical treatment of morbid obesity. Metabolism 53: 918-921
    • (2004) Metabolism , vol.53 , pp. 918-921
    • von Mach, M.A.1
  • 32
    • 0028963682 scopus 로고
    • Risk factors for hip fracture in white women
    • Study of Osteoporotic Fractures Research Group
    • Cummings SR et al. (1995) Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 332: 767-773
    • (1995) N Engl J Med , vol.332 , pp. 767-773
    • Cummings, S.R.1
  • 33
    • 31544460512 scopus 로고    scopus 로고
    • Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
    • (online 23 February) (accessed 4 October 2005)
    • Nguyen ND et al. (online 23 February 2005) Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study. [http://www.biomedcentral.com/1471-2474/6/11] (accessed 4 October 2005)
    • (2005)
    • Nguyen, N.D.1
  • 34
    • 0343517092 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study
    • Garnero P et al. (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: The OFELY study. J Bone Miner Res 15: 1526-1536
    • (2000) J Bone Miner Res , vol.15 , pp. 1526-1536
    • Garnero, P.1
  • 36
    • 31544453727 scopus 로고    scopus 로고
    • Major determinants of bone mineral density (BMD) at multiple skeletal sites in Chinese
    • [abstract]
    • Hsu Y et al. (2004) Major determinants of bone mineral density (BMD) at multiple skeletal sites in Chinese [abstract]. J Bone Miner Res 19 (Suppl): S421
    • (2004) J Bone Miner Res , vol.19 , Issue.SUPPL.
    • Hsu, Y.1
  • 37
    • 0033735617 scopus 로고    scopus 로고
    • Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry
    • Wehrli FW et al. (2000) Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology 217: 527-538
    • (2000) Radiology , vol.217 , pp. 527-538
    • Wehrli, F.W.1
  • 38
    • 0015137446 scopus 로고
    • Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies
    • Meunier P et al. (1971) Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 80: 147-154
    • (1971) Clin Orthop Relat Res , vol.80 , pp. 147-154
    • Meunier, P.1
  • 39
    • 0024496975 scopus 로고
    • Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: A stereological study
    • Rozman C et al. (1989) Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: A stereological study. Exp Hematol 17: 34-37
    • (1989) Exp Hematol , vol.17 , pp. 34-37
    • Rozman, C.1
  • 40
    • 0034842784 scopus 로고    scopus 로고
    • Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis
    • Justesen J. et al. (2001) Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology 2: 165-171
    • (2001) Biogerontology , vol.2 , pp. 165-171
    • Justesen, J.1
  • 41
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • Verma S et al. (2002) Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55: 693-698
    • (2002) J Clin Pathol , vol.55 , pp. 693-698
    • Verma, S.1
  • 42
    • 0034820239 scopus 로고    scopus 로고
    • Potential value of vertebral proton MR spectroscopy in determining bone weakness
    • Schellinger D et al. (2001) Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol 22: 1620-1627
    • (2001) AJNR Am J Neuroradiol , vol.22 , pp. 1620-1627
    • Schellinger, D.1
  • 43
    • 22944489618 scopus 로고    scopus 로고
    • Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study
    • Yeung DK et al. (2005) Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study. J Magn Reson Imaging 22: 279-285
    • (2005) J Magn Reson Imaging , vol.22 , pp. 279-285
    • Yeung, D.K.1
  • 44
    • 0032977597 scopus 로고    scopus 로고
    • Bone mineral density in patients with type 1 and type 2 diabetes
    • Tuominen JT et al. (1999) Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22: 1196-1200
    • (1999) Diabetes Care , vol.22 , pp. 1196-1200
    • Tuominen, J.T.1
  • 45
    • 13244255379 scopus 로고    scopus 로고
    • Steroid effects on osteogenesis through mesenchymal cell gene expression
    • Li X et al. (2005) Steroid effects on osteogenesis through mesenchymal cell gene expression. Osteoporos Int 16: 101-108
    • (2005) Osteoporos Int , vol.16 , pp. 101-108
    • Li, X.1
  • 46
    • 0034057844 scopus 로고    scopus 로고
    • Pluripotential marrow cells produce adipocytes when transplanted into steroid-treated mice
    • Cui Q et al. (2000) Pluripotential marrow cells produce adipocytes when transplanted into steroid-treated mice. Connect Tissue Res 41: 45-56
    • (2000) Connect Tissue Res , vol.41 , pp. 45-56
    • Cui, Q.1
  • 47
    • 0036820983 scopus 로고    scopus 로고
    • The epidemiology of corticosteroid-induced osteoporosis: A meta-analysis
    • van Staa TP et al. (2002) The epidemiology of corticosteroid-induced osteoporosis: A meta-analysis. Osteoporos Int 13: 777-787
    • (2002) Osteoporos Int , vol.13 , pp. 777-787
    • van Staa, T.P.1
  • 48
    • 0036128727 scopus 로고    scopus 로고
    • Transforming growth factor β2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma
    • Ahdjoudj S et al. (2002) Transforming growth factor β2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. J Bone Miner Res 17: 668-677
    • (2002) J Bone Miner Res , vol.17 , pp. 668-677
    • Ahdjoudj, S.1
  • 49
    • 1442277150 scopus 로고    scopus 로고
    • Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women
    • Papakitsou EF et al. (2004) Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women. Maturitas 47: 185-193
    • (2004) Maturitas , vol.47 , pp. 185-193
    • Papakitsou, E.F.1
  • 50
    • 1642526587 scopus 로고    scopus 로고
    • Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs)
    • Sekiya I et al. (2004) Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs). J Bone Miner Res 19: 256-264
    • (2004) J Bone Miner Res , vol.19 , pp. 256-264
    • Sekiya, I.1
  • 51
    • 0033785920 scopus 로고    scopus 로고
    • Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation
    • Rodriguez JP et al. (2000) Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem 79: 557-565
    • (2000) J Cell Biochem , vol.79 , pp. 557-565
    • Rodriguez, J.P.1
  • 52
    • 0348230958 scopus 로고    scopus 로고
    • Obesity is associated with macrophage accumulation in adipose tissue
    • Weisberg SP et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808
    • (2003) J Clin Invest , vol.112 , pp. 1796-1808
    • Weisberg, S.P.1
  • 53
    • 0025854709 scopus 로고
    • Relationships between marrow fat and bone turnover in ovariectomized and intact rats
    • Martin RB and Zissimos SL (1991) Relationships between marrow fat and bone turnover in ovariectomized and intact rats. Bone 12: 123-131
    • (1991) Bone , vol.12 , pp. 123-131
    • Martin, R.B.1    Zissimos, S.L.2
  • 54
    • 2342613539 scopus 로고    scopus 로고
    • Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications
    • Nuttall ME and Gimble JM (2004) Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4: 290-294
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 290-294
    • Nuttall, M.E.1    Gimble, J.M.2
  • 55
    • 0033197899 scopus 로고    scopus 로고
    • Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2
    • Lecka-Czernik B et al. (1999) Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARγ2. J Cell Biochem 74: 357-371
    • (1999) J Cell Biochem , vol.74 , pp. 357-371
    • Lecka-Czernik, B.1
  • 56
    • 0027399714 scopus 로고
    • Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells
    • Dorheim MA et al. (1993) Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells. J Cell Physiol 154: 317-328
    • (1993) J Cell Physiol , vol.154 , pp. 317-328
    • Dorheim, M.A.1
  • 57
    • 0026718865 scopus 로고
    • Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures
    • Beresford JN et al. (1992) Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 102: 341-351
    • (1992) J Cell Sci , vol.102 , pp. 341-351
    • Beresford, J.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.