Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Bonar, Sheri L ^a   Brydges, Susannah D ^b   Mueller, James L ^b   McGeough, Matthew D ^b   Pena, Carla ^b   Chen, Debbie ^b   Grimston, Susan K ^a   Hickman Brecks, Cynthia L ^a   Ravindran, Soumya ^a   McAlinden, Audrey ^a   Novack, Deborah V ^a   Kastner, Daniel L ^c   Civitelli, Roberto ^a   Hoffman, Hal M ^b   Mbalaviele, Gabriel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 6; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; COLLAGEN TYPE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; BONE MARROW DISEASE; BONE MASS; CARTILAGE CELL; CAUSAL ATTRIBUTION; CELL DIFFERENTIATION; CELL LINEAGE; CELL LOSS; CINCA SYNDROME; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EPIPHYSIS DISEASE; GROWTH RETARDATION; HISTOPATHOLOGY; IN VITRO STUDY; LONG BONE; MOUSE; MUTATIONAL ANALYSIS; NEUTROPHILIA; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPENIA; PERINATAL PERIOD; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SKELETON MALFORMATION; ANIMAL; BONE; BONE DEVELOPMENT; BONE MARROW; CELL FRACTIONATION; CELL PROLIFERATION; CONGENITAL MALFORMATION; GROWTH PLATE; INFLAMMATION; JOINT; LEUKOCYTOSIS; METABOLISM; ORGAN SIZE; PATHOLOGY; STAINING; SURVIVAL;

MUS;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; BONE MARROW; BONE RESORPTION; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL LINEAGE; CELL PROLIFERATION; COLLAGEN TYPE II; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; GROWTH PLATE; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; JOINTS; LEUKOCYTOSIS; MICE; ORGAN SIZE; OSTEOBLASTS; OSTEOCLASTS; STAINING AND LABELING; SURVIVAL ANALYSIS;

EID: 84860475314     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035979     Document Type: Article

References (32)

1. Doherty TA, Brydges SD, Hoffman HM, (2011) Autoinflammation: translating mechanism to therapy. J Leukoc Biol 90: 37-47.
2. Schroder K, Tschopp J, (2010) The Inflammasomes. Cell 140: 821-832.
3. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, et al. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464: 1357-1361.
4. Mariathasan S, Weiss DS, Newton K, McBride J, O'Rourke K, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440: 228-232.
5. Rajamäki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, et al. (2010) Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation. PLoS ONE 5: e11765.
6. Schroder K, Zhou R, Tschopp J, (2010) The NLRP3 Inflammasome: A Sensor for Metabolic Danger? Science 327: 296-300.
7. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J, (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241.
8. Hoffman HM, Brydges SD, (2011) Genetic and Molecular Basis of Inflammasome-mediated Disease. J Biol Chem 286: 10889-10896.
9. Aksentijevich I, Putnam DC, Remmers EF, Mueller JL, Le J, et al. (2007) The clinical continuum of cryopyrinopathies: Novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum 56: 1273-1285.
10. Aksentijevich I, Nowak M, Mallah M, Chae JJ, Watford WT, et al. (2002) De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum 46: 3340-3348.
11. Feldmann J, Prieur A-M, Quartier P, Berquin P, Certain S, et al. (2002) Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes. Am J Hum Genet 71: 198-203.
12. Hill S, Namde M, Dwyer A, Poznanski A, Canna S, et al. (2007) Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol 37: 145-152.
13. Kronenberg HM, (2003) Developmental regulation of the growth plate. Nature 423: 332-336.
14. Raisz LG, (2005) Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest 115: 3318-3325.
15. Walsh NC, Gravallese EM, (2010) Bone remodeling in rheumatic disease: a question of balance. Immunol Rev 233: 301-312.
16. Pacifici R, Rifas L, McCracken R, Vered I, McMurtry C, et al. (1989) Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc Natl Acad Sci USA 86: 2398-2402.
17. Ding J, Ghali O, Lencel P, Broux O, Chauveau C, et al. (2009) TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells. Life Sci 84: 499-504.
18. Novack DV, Teitelbaum SL, (2008) The Osteoclast: Friend or Foe? Annu Rev Pathol: Mechanisms of Disease 3: 457-484.
19. Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, et al. (2000) TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 106: 1481-1488.
20. Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, et al. (2009) Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity. Immunity 30: 875-887.
21. Meng G, Zhang F, Fuss I, Kitani A, Strober W, (2009) A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses. Immunity 30: 860-874.
22. Muto A, Mizoguchi T, Udagawa N, Ito S, Kawahara I, et al. (2011) Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res 26: 2978-2990.
23. Sibley CH, Plass N, Snow J, Wiggs E, Brewer C, et al. (2012) Sustained response and prevention of damage progression in patients with neonatal-onset multisystem inflammatory disease (NOMID) treated with anakinra. Arthritis Rheum 2012. Epub ahead of print.
24. Zwerina J, Redlich K, Polzer K, Joosten L, Krönke G, et al. (2007) TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci USA 104: 11742-11747.
25. Ford-Hutchinson AF, Ali Z, Lines SE, Hallgrímsson B, Boyd SK, et al. (2007) Inactivation of Pten in Osteo-Chondroprogenitor Cells Leads to Epiphyseal Growth Plate Abnormalities and Skeletal Overgrowth. J Bone Miner Res 22: 1245-1259.
26. Di Benedetto A, Watkins M, Grimston S, Salazar V, Donsante C, et al. (2010) N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. J Cell Sci 123: 2640-2648.
27. Vaira S, Alhawagri M, Anwisye I, Kitaura H, Faccio R, et al. (2008) RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest 118: 2088-2097.
28. Cremer M, Kang AH, (1988) Collagen-induced arthritis in rodents: a review of immunity to type II collagen with emphasis on the importance of molecular conformation and structure. J Int Rev Immunol 4: 65-81.
29. Hjorten R, Hansen U, Underwood RA, Telfer HE, Fernandes RJ, et al. (2007) Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone 41: 535-542.
30. Vaira S, Johnson T, Hirbe AC, Alhawagri M, Anwisye I, et al. (2008) RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci USA 105: 3897-3902.
31. Watkins M, Grimston SK, Norris JY, Guillotin B, Shaw A, et al. (2011) Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling. Mol Biol Cell 22: 1240-1251.
32. Mbalaviele G, Anderson G, Jones A, De Ciechi P, Settle S, et al. (2006) Inhibition of p38 Mitogen-Activated Protein Kinase Prevents Inflammatory Bone Destruction. J Pharmacol Exp Ther 317: 1044-1053.