Basophils: Historical reflections and perspectives

Chemical Immunology and Allergy

Volumn 100, Issue , 2014, Pages 172-192

  Marone, Gianni ^a   Borriello, Francesco ^a   Varricchi, Gilda ^a   Genovese, Arturo ^a   Granata, Francescopaolo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HISTAMINE; HISTAMINE H2 RECEPTOR; HISTAMINE RELEASING FACTOR; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 3 RECEPTOR; LEPTIN RECEPTOR; MELANOCORTIN RECEPTOR; NEUROTROPHIN RECEPTOR; TOLL LIKE RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; VASCULOTROPIN A;

ADAPTIVE IMMUNITY; ALLERGY; ANGIOGENESIS; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; BACTERIAL CELL INTERACTION; BASOPHIL; CELL INTERACTION; CYTOLOGY; DISEASES; HISTORY OF MEDICINE; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOPATHOLOGY; INFECTION; INNATE IMMUNITY; MEDIATOR; NEOPLASM; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; VIRUS INFECTION; ANIMAL; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; PATHOLOGY;

ADAPTIVE IMMUNITY; ANIMALS; AUTOIMMUNE DISEASES; BASOPHILS; HUMANS; HYPERSENSITIVITY; IMMUNITY, INNATE; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; RECEPTORS, IGE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84927173076     PISSN: 16602242     EISSN: 16622898     Source Type: Book Series    
DOI: 10.1159/000358734     Document Type: Article

References (209)

1. Ehrlich P: Beiträge zur Kenntniss der granulirten Bindegewebszellen und der eosinophilen Leukocythen. Arch Anat Physiol (Leipzig) 1879; 3: 166.
2. Canfield PJ: Comparative cell morphology in the peripheral blood film from exotic and native animals. Aust Vet J 1998; 76: 793.
3. Marone G, Triggiani M, Genovese A, De Paulis A: Role of human mast cells and basophils in bronchial asthma. Adv Immunol 2005; 88: 97.
4. Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T: Nonredundant roles of basophils in immunity. Annu Rev Immunol 2011; 29: 45.
5. Crivellato E, Nico B, Ribatti D: The history of the controversial relationship between mast cells and basophils. Immunol Lett 2011; 141: 10.
6. Gurish MF, Austen KF: Developmental origin and functional specialization of mast cell subsets. Immunity 2012; 37: 25.
7. Schroeder JT: Basophils: emerging roles in the pathogenesis of allergic disease. Immunol Rev 2011; 242: 144.
8. Plager DA, Weiss EA, Kephart GM, Mocharla RM, Matsumoto R, Checkel JL, Schwartz LB, Gleich GJ, Leiferman KM: Identification of basophils by a mAb directed against pro-major basic protein 1. J Allergy Clin Immunol 2006; 117: 626.
9. Kepley CL, Craig SS, Schwartz LB: Identification and partial characterization of a unique marker for human basophils. J Immunol 1995; 154: 6548.
10. McEuen AR, Buckley MG, Compton SJ, Walls AF: Development and characterization of a monoclonal antibody specific for human basophils and the identification of a unique secretory product of basophil activation. Lab Invest 1999; 79: 27.
11. Ishizaka T, Ishizaka K, Johansson SG, Bennich H: Histamine release from human leukocytes by anti-E antibodies. J Immunol 1969; 102: 884.
12. Ishizaka K, Tomioka H, Ishizaka T: Mechanisms of passive sensitization. 1. Presence of IgE and IgG molecules on human leukocytes. J Immunol 1970; 105: 1459.
13. Ishizaka T, De Bernardo R, Tomioka H, Lichtenstein LM, Ishizaka K: Identification of basophil granulocytes as a site of allergic histamine release. J Immunol 1972; 108: 1000.
14. Lichtenstein LM, Osler AG: Studies on the mechanisms of hypersensitivity phenomena. 9. Histamine release from human leukocytes by ragweed pollen antigen. J Exp Med 1964; 120: 507.
15. Marone G, Spadaro G, Patella V, Genovese A: The clinical relevance of basophil releasability. J Allergy Clin Immunol 1994; 94: 1293.
16. Seder RA, Paul WE, Dvorak AM, Sharkis SJ, Kagey-Sobotka A, Niv Y, Finkelman FD, Barbieri SA, Galli SJ, Plaut M: Mouse splenic and bone marrow cell populations that express high-affinity Fc receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci USA 1991; 88: 2835.
17. Brunner T, Heusser CH, Dahinden CA: Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. J Exp Med 1993; 177: 605.
18. Schroeder JT, MacGlashan DW Jr, Kagey-Sobotka A, White JM, Lichtenstein LM: IgE-dependent IL-4 secretion by human basophils. The relationship between cytokine production and histamine release in mixed leukocyte cultures. J Immunol 1994; 153: 1808.
19. MacGlashan D Jr, White JM, Huang SK, Ono SJ, Schroeder JT, Lichtenstein LM: Secretion of IL-4 from human basophils: the relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 1994; 152: 3006.
20. Gibbs BF, Haas H, Falcone FH, Albrecht C, Vollrath IB, Noll T, Wolff HH, Amon U: Purified human peripheral blood basophils release interleukin-13 and preformed interleukin-
21. following immunological activation. Eur J Immunol 1996; 26: 2493.
22. Li H, Sim TC, Alam R: IL-13 released by and localized in human basophils. J Immunol 1996; 156: 4833.
23. Ochensberger B, Daepp GC, Rihs S, Dahinden CA: Human blood basophils produce interleukin-13 in response to IgE-receptordependent and-independent activation. Blood 1996; 88: 3028.
24. Redrup AC, Howard BP, MacGlashan DW Jr, Kagey-Sobotka A, Lichtenstein LM, Schroeder JT: Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. J Immunol 1998; 160: 1957.
25. Schroeder JT, Chichester KL, Bieneman AP: Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease. J Immunol 2009; 182: 2432.
26. Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 2007; 110: 913.
27. Sokol CL, Barton GM, Farr AG, Medzhitov R: A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008; 9: 310.
28. Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D: Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 2010; 33: 364.
29. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM: Genetic analysis of basophil function in vivo. Nat Immunol 2011; 12: 527.
30. Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, Obata K, Ishikawa R, Yoshikawa S, Mukai K, Kawano Y, Minegishi Y, Yokozeki H, Watanabe N, Karasuyama H: Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest 2010; 120: 2867.
31. Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M: Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness. J Immunol 2012; 188: 1809.
32. Malveaux FJ, Conroy MC, Adkinson NF Jr, Lichtenstein LM: IgE receptors on human basophils: relationship to serum IgE concentration. J Clin Invest 1978; 62: 176.
33. MacGlashan D Jr, McKenzie-White J, Chichester K, Bochner BS, Davis FM, Schroeder JT, Lichtenstein LM: In vitro regulation of FcRI expression on human basophils by IgE antibody. Blood 1998; 91: 1633.
34. Lantz CS, Yamaguchi M, Oettgen HC, Katona IM, Miyajima I, Kinet JP, Galli SJ: IgE regulates mouse basophil Fc epsilon RI expression in vivo. J Immunol 1997; 158: 2517.
35. Florio G, Petraroli A, Patella V, Triggiani M, Marone G: The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. AIDS 2000; 14: 931.
36. Genovese A, Borgia G, Bjorck L, Petraroli A, de Paulis A, Piazza M, Marone G: Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human FcRI + cells through interaction with the light chains of IgE. J Immunol 2003; 170: 1854.
37. Conroy MC, Adkinson NF Jr, Lichtenstein LM: Measurement of IgE on human basophils: relation to serum IgE and anti-IgEinduced histamine release. J Immunol 1977; 118: 1317.
38. MacGlashan DW Jr: Relationship between spleen tyrosine kinase and phosphatidylinositol? phosphatase expression and secretion from human basophils in the general population. J Allergy Clin Immunol 2007; 119: 626.
39. Dvorak AM, Monahan-Earley RA, Estrella P, Kissell S, Donahue RE: Ultrastructure of monkey peripheral blood basophils stimulated to develop in vivo by recombinant human interleukin 3. Lab Invest 1989; 61: 677.
40. Dvorak AM, Saito H, Estrella P, Kissell S, Arai N, Ishizaka T: Ultrastructure of eosinophils and basophils stimulated to develop in human cord blood mononuclear cell cultures containing recombinant human interleukin-
41. or interleukin-3. Lab Invest 1989; 61: 116.
42. Lantz CS, Boesiger J, Song CH, Mach N, Kobayashi T, Mulligan RC, Nawa Y, Dranoff G, Galli SJ: Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998; 392: 90.
43. Hirai K, Morita Y, Misaki Y, Ohta K, Takaishi T, Suzuki S, Motoyoshi K, Miyamoto T: Modulation of human basophil histamine release by hemopoietic growth factors. J Immunol 1988; 141: 3958.
44. Kurimoto Y, de Weck AL, Dahinden CA: Interleukin 3-dependent mediator release in basophils triggered by C5a. J Exp Med 1989; 170: 467.
45. Miura K, Saini SS, Gauvreau G, MacGlashan DW Jr: Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. J Immunol 2001; 167: 2282.
46. Yamaguchi M, Hirai K, Shoji S, Takaishi T, Ohta K, Morita Y, Suzuki S, Ito K: Haemopoietic growth factors induce human basophil migration in vitro. Clin Exp Allergy 1992; 22: 379.
47. Bochner BS, McKelvey AA, Sterbinsky SA, Hildreth JE, Derse CP, Klunk DA, Lichtenstein LM, Schleimer RP: IL-3 augments adhesiveness for endothelium and CD11b expression in human basophils but not neutrophils. J Immunol 1990; 145: 1832.
48. Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D: MHC class II-dependent basophil-CD4 + T cell interactions promote TH2 cytokine-dependent immunity. Nat Immunol 2009; 10: 697.
49. Giacomin PR, Siracusa MC, Walsh KP, Grencis RK, Kubo M, Comeau MR, Artis D: Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol 2012; 189: 4371.
50. Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, Artis D: TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature 2011; 477: 229.
51. Siracusa MC, Wojno ED, Artis D: Functional heterogeneity in the basophil cell lineage. Adv Immunol 2012; 115: 141.
52. Voehringer D: Basophil modulation by cytokine instruction. Eur J Immunol 2012; 42: 2544.
53. Pecaric-Petkovic T, Didichenko SA, Kaempfer S, Spiegl N, Dahinden CA: Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 2009; 113: 1526.
54. Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M: An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J Immunol 2008; 181: 5981.
55. Ali H: Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a. Immunol Lett 2010; 128: 36.
56. Bischoff SC, de Weck AL, Dahinden CA: Interleukin
57. and granulocyte/macrophagecolony-stimulating factor render human basophils responsive to low concentrations of complement component C3a. Proc Natl Acad Sci USA 1990; 87: 6813.
58. Procaccini C, Jirillo E, Matarese G: Leptin as an immunomodulator. Mol Aspects Med 2012; 33: 35.
59. Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K: Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils. J Immunol 2011; 186: 5254.
60. Shore SA: Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 2010; 108: 735.
61. Levi-Montalcini R: The nerve growth factor
62. years later. Science 1987; 237: 1154.
63. Skaper SD: The neurotrophin family of neurotrophic factors: An overview. Methods Mol Biol 2012; 846: 1.
64. Bischoff SC, Dahinden CA: Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils. Blood 1992; 79: 2662.
65. Burgi B, Otten UH, Ochensberger B, Rihs S, Heese K, Ehrhard PB, Ibanez CF, Dahinden CA: Basophil priming by neurotrophic factors: Activation through the trk receptor. J Immunol 1996; 157: 5582.
66. Sin AZ, Roche EM, Togias A, Lichtenstein LM, Schroeder JT: Nerve growth factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects. J Allergy Clin Immunol 2001; 108: 387.
67. Gibbs BF, Zillikens D, Grabbe J: Nerve growth factor influences IgE-mediated human basophil activation: functional properties and intracellular mechanisms compared with IL-3. Int Immunopharmacol 2005; 5: 735.
68. Sloane DE, Tedla N, Awoniyi M, Macglashan DW Jr, Borges L, Austen KF, Arm JP: Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 2004; 104: 2832.
69. Bieneman AP, Chichester KL, Chen YH, Schroeder JT: Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol 2005; 115: 295.
70. Komiya A, Nagase H, Okugawa S, Ota Y, Suzukawa M, Kawakami A, Sekiya T, Matsushima K, Ohta K, Hirai K, Yamamoto K, Yamaguchi M: Expression and function of Toll-like receptors in human basophils. Int Arch Allergy Immunol 2006; 140(suppl 1):23.
71. de Paulis A, Montuori N, Prevete N, Fiorentino I, Rossi FW, Visconte V, Rossi G, Marone G, Ragno P: Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and-like 2. J Immunol 2004; 173: 5739.
72. Yamaguchi M, Koketsu R, Suzukawa M, Kawakami A, Iikura M: Human basophils and cytokines/chemokines. Allergol Int 2009; 58: 1.
73. Iikura M, Miyamasu M, Yamaguchi M, Kawasaki H, Matsushima K, Kitaura M, Morita Y, Yoshie O, Yamamoto K, Hirai K: Chemokine receptors in human basophils: inducible expression of functional CXCR4. J Leukoc Biol 2001; 70: 113.
74. Blasi F, Carmeliet P: uPAR: A versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3: 932.
75. Carmeliet P: Angiogenesis in life, disease and medicine. Nature 2005; 438: 932.
76. Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 2003; 9: 669.
77. de Paulis A, Prevete N, Fiorentino I, Rossi FW, Staibano S, Montuori N, Ragno P, Longobardi A, Liccardo B, Genovese A, Ribatti D, Walls AF, Marone G: Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 2006; 177: 7322.
78. Hartnell A, Heinemann A, Conroy DM, Wait R, Sturm GJ, Caversaccio M, Jose PJ, Williams TJ: Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2. J Immunol 2004; 173: 6448.
79. Hirai K, Miyamasu M, Yamaguchi M, Nakajima K, Ohtoshi T, Koshino T, Takaishi T, Morita Y, Ito K: Modulation of human basophil histamine release by insulin-like growth factors. J Immunol 1993; 150: 1503.
80. Boie Y, Sawyer N, Slipetz DM, Metters KM, Abramovitz M: Molecular cloning and characterization of the human prostanoid DP receptor. J Biol Chem 1995; 270: 18910.
81. Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, Nakamura M, Takano S: CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999; 459: 195.
82. Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, Takano S: Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 1999; 162: 1278.
83. Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, Takamori Y, Ichimasa M, Sugamura K, Nakamura M, Takano S, Nagata K: Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001; 193: 255.
84. Yoshimura-Uchiyama C, Iikura M, Yamaguchi M, Nagase H, Ishii A, Matsushima K, Yamamoto K, Shichijo M, Bacon KB, Hirai K: Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptorhomologous molecule expressed on Th2 cells/DP2. Clin Exp Allergy 2004; 34: 1283.
85. Gauvreau GM, Plitt JR, Baatjes A, Mac-Glashan DW: Expression of functional cysteinyl leukotriene receptors by human basophils. J Allergy Clin Immunol 2005; 116: 80.
86. Iikura M, Suzukawa M, Yamaguchi M, Sekiya T, Komiya A, Yoshimura-Uchiyama C, Nagase H, Matsushima K, Yamamoto K, Hirai K: 5-Lipoxygenase products regulate basophil functions: 5-Oxo-ETE elicits migration, and leukotriene B 4 induces degranulation. J Allergy Clin Immunol 2005; 116: 578.
87. Grant GE, Rokach J, Powell WS: 5-Oxo-ETE and the OXE receptor. Prostaglandins Other Lipid Mediat 2009; 89: 98.
88. Sturm GJ, Schuligoi R, Sturm EM, Royer JF, Lang-Loidolt D, Stammberger H, Amann R, Peskar BA, Heinemann A: 5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent chemoattractant for human basophils. J Allergy Clin Immunol 2005; 116: 1014.
89. Suzukawa M, Komiya A, Iikura M, Nagase H, Yoshimura-Uchiyama C, Yamada H, Kawasaki H, Ohta K, Matsushima K, Hirai K, Yamamoto K, Yamaguchi M: Trans-basement membrane migration of human basophils: role of matrix metalloproteinase-9. Int Immunol 2006; 18: 1575.
90. Meknache N, Jonsson F, Laurent J, Guinnepain MT, Daeron M: Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcRIIIB (CD16B). J Immunol 2009; 182: 2542.
91. Okayama Y, Kirshenbaum AS, Metcalfe DD: Expression of a functional high-affinity IgG receptor, FcRI, on human mast cells: up-regulation by IFN-. J Immunol 2000; 164: 4332.
92. Anselmino LM, Perussia B, Thomas LL: Human basophils selectively express the FcRII (CDw32) subtype of IgG receptor. J Allergy Clin Immunol 1989; 84: 907.
93. Zhu D, Kepley CL, Zhang K, Terada T, Yamada T, Saxon A: A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med 2005; 11: 446.
94. Gibbs BF, Sabato V, Bridts CH, Ebo DG, Ben-Zimra M, Levi-Schaffer F: Expressions and inhibitory functions of CD300a receptors on purified human basophils. Exp Dermatol 2012; 21: 884.
95. Sabato V, Verweij MM, Bridts CH, Levi-Schaffer F, Gibbs BF, De Clerck LS, Schiavino D, Ebo DG: CD300a is expressed on human basophils and seems to inhibit IgE/ FcRI-dependent anaphylactic degranulation. Cytometry B Clin Cytom 2012; 82: 132.
96. Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T, Arase H: Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J Immunol 2005; 175: 4441.
97. MacGlashan D Jr: Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy 2010; 40: 1365.
98. Bohm M, Apel M, Sugawara K, Brehler R, Jurk K, Luger TA, Haas H, Paus R, Eiz-Vesper B, Walls AF, Ponimaskin E, Gehring M, Kapp A, Raap U: Modulation of basophil activity: A novel function of the neuropeptide -melanocyte-stimulating hormone. J Allergy Clin Immunol 2012; 129: 1085.
99. Novak N, Mete N, Bussmann C, Maintz L, Bieber T, Akdis M, Zumkehr J, Jutel M, Akdis C: Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2. J Allergy Clin Immunol 2012; 130: 1153.
100. Lichtenstein LM, Gillespie E: Inhibition of histamine release by histamine controlled by H2 receptor. Nature 1973; 244: 287.
101. MacGlashan DW Jr, Peters SP, Warner J, Lichtenstein LM: Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links. J Immunol 1986; 136: 2231.
102. Austen KF: The cysteinyl leukotrienes: where do they come from? What are they? Where are they going? Nat Immunol 2008; 9: 113.
103. Triggiani M, Schleimer RP, Warner JA, Chilton FH: Differential synthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine and platelet-activating factor by human inflammatory cells. J Immunol 1991; 147: 660.
104. Schroeder JT, Lichtenstein LM, MacDonald SM: An immunoglobulin E-dependent recombinant histamine-releasing factor induces interleukin-4 secretion from human basophils. J Exp Med 1996; 183: 1265.
105. Gauchat JF, Henchoz S, Mazzei G, Aubry JP, Brunner T, Blasey H, Life P, Talabot D, Flores-Romo L, Thompson J, et al: Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993; 365: 340.
106. Yanagihara Y, Kajiwara K, Basaki Y, Ikizawa K, Ebisawa M, Ra C, Tachimoto H, Saito H: Cultured basophils but not cultured mast cells induce human IgE synthesis in B cells after immunologic stimulation. Clin Exp Immunol 1998; 111: 136.
107. Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, Hippe A, Corrigan CJ, Dong C, Homey B, Yao Z, Ying S, Huston DP, Liu YJ: IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007; 204: 1837.
108. Qi Y, Operario DJ, Oberholzer CM, Kobie JJ, Looney RJ, Georas SN, Mosmann TR: Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol 2010; 126: 1260.
109. Li H, Sim TC, Grant JA, Alam R: The production of macrophage inflammatory protein-1 alpha by human basophils. J Immunol 1996; 157: 1207.
110. Oliver JM, Tarleton CA, Gilmartin L, Archibeque T, Qualls CR, Diehl L, Wilson BS, Schuyler M: Reduced FcRI-mediated release of asthma-promoting cytokines and chemokines from human basophils during omalizumab therapy. Int Arch Allergy Immunol 2010; 151: 275.
111. Chen K, Xu W, Wilson M, He B, Miller NW, Bengten E, Edholm ES, Santini PA, Rath P, Chiu A, Cattalini M, Litzman J, Bussel JB, Huang B, Meini A, Riesbeck K, Cunningham-Rundles C, Plebani A, Cerutti A: Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nat Immunol 2009; 10: 889.
112. Thueson DO, Speck LS, Lett-Brown MA, Grant JA: Histamine-releasing activity (HRA). 1. Production by mitogen-or antigen-stimulated human mononuclear cells. J Immunol 1979; 123: 626.
113. MacDonald SM: Histamine-releasing factors. Curr Opin Immunol 1996; 8: 778.
114. MacDonald SM, Rafnar T, Langdon J, Lichtenstein LM: Molecular identification of an IgE-dependent histamine-releasing factor. Science 1995; 269: 688.
115. Schroeder JT, Lichtenstein LM, MacDonald SM: Recombinant histamine-releasing factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils. J Immunol 1997; 159: 447.
116. MacDonald SM: Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy. J Asthma Allergy 2012; 5: 51.
117. Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T: Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest 2012; 122: 218.
118. Falcone FH, Zillikens D, Gibbs BF: The 21st century renaissance of the basophil? Current insights into its role in allergic responses and innate immunity. Exp Dermatol 2006; 15: 855.
119. Oh K, Shen T, Le Gros G, Min B: Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils. Blood 2007; 109: 2921.
120. Falcone FH, Dahinden CA, Gibbs BF, Noll T, Amon U, Hebestreit H, Abrahamsen O, Klaucke J, Schlaak M, Haas H: Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur J Immunol 1996; 26: 1147.
121. Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R: Basophils function as antigen-presenting cells for an allergeninduced T helper type 2 response. Nat Immunol 2009; 10: 713.
122. Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y, Nakanishi K: Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 2009; 10: 706.
123. Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B: The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 2010; 11: 608.
124. Phythian-Adams AT, Cook PC, Lundie RJ, Jones LH, Smith KA, Barr TA, Hochweller K, Anderton SM, Hammerling GJ, Maizels RM, MacDonald AS: CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med 2010; 207: 2089.
125. Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M, Muskens F, Lambrecht BN: Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 2010; 207: 2097.
126. Kitzmuller C, Nagl B, Deifl S, Walterskirchen C, Jahn-Schmid B, Zlabinger GJ, Bohle B: Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Allergy 2012; 67: 593.
127. Eckl-Dorna J, Ellinger A, Blatt K, Ghanim V, Steiner I, Pavelka M, Valent P, Valenta R, Niederberger V: Basophils are not the key antigen-presenting cells in allergic patients. Allergy 2012; 67: 601.
128. Sharma M, Hegde P, Aimanianda V, Beau R, Senechal H, Poncet P, Latge JP, Kaveri SV, Bayry J: Circulating human basophils lack the features of professional antigen presenting cells. Sci Rep 2013; 3: 1188.
129. Karpanen T, Alitalo K: Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 2008; 3: 367.
130. Granata F, Frattini A, Loffredo S, Staiano RI, Petraroli A, Ribatti D, Oslund R, Gelb MH, Lambeau G, Marone G, Triggiani M: Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2. J Immunol 2010; 184: 5232.
131. Detoraki A, Staiano RI, Granata F, Giannattasio G, Prevete N, de Paulis A, Ribatti D, Genovese A, Triggiani M, Marone G: Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 2009; 123: 1142.
132. Melillo RM, Guarino V, Avilla E, Galdiero MR, Liotti F, Prevete N, Rossi FW, Basolo F, Ugolini C, de Paulis A, Santoro M, Marone G: Mast cells have a protumorigenic role in human thyroid cancer. Oncogene 2010; 29: 6203.
133. Corrigan CJ, Wang W, Meng Q, Fang C, Wu H, Reay V, Lv Z, Fan Y, An Y, Wang YH, Liu YJ, Lee TH, Ying S: T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma. Proc Natl Acad Sci USA 2011; 108: 1579.
134. Thomas M, Augustin HG: The role of the Angiopoietins in vascular morphogenesis. Angiogenesis 2009; 12: 125.
135. Thurston G, Suri C, Smith K, McClain J, Sato TN, Yancopoulos GD, McDonald DM: Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 1999; 286: 2511.
136. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55.
137. Milner CS, Hansen TM, Singh H, Brindle NP: Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. Microvasc Res 2009; 77: 187.
138. Huang H, Bhat A, Woodnutt G, Lappe R: Targeting the ANGPT-TIE2 pathway in malignancy. Nat Rev Cancer 2010; 10: 575.
139. Kanazawa H, Tochino Y, Asai K: Angiopoietin- as a contributing factor of exercise-induced bronchoconstriction in asthmatic patients receiving inhaled corticosteroid therapy. J Allergy Clin Immunol 2008; 121: 390.
140. Kumpers P, David S, Haubitz M, Hellpap J, Horn R, Brocker V, Schiffer M, Haller H, Witte T: The Tie2 receptor antagonist angiopoietin facilitates vascular inflammation in systemic lupus erythematosus. Ann Rheum Dis 2009; 68: 1638.
141. Prevete N, Staiano RI, Granata F, Detoraki A, Necchi V, Ricci V, Triggiani M, De Paulis A, Marone G, Genovese A: Expression and function of Angiopoietins and their tie receptors in human basophils and mast cells. J Biol Regul Homeost Agents 2013;27:827-839.
142. de la Fuente J, Estrada-Pena A, Venzal JM, Kocan KM, Sonenshine DE: Overview: ticks as vectors of pathogens that cause disease in humans and animals. Front Biosci 2008; 13: 6938.
143. Voehringer D: The role of basophils in helminth infection. Trends Parasitol 2009; 25: 551.
144. Falcone FH, Pritchard DI, Gibbs BF: Do basophils play a role in immunity against parasites? Trends Parasitol 2001; 17: 126.
145. Mitre E, Nutman TB: Basophils, basophilia and helminth infections. Chem Immunol Allergy 2006; 90: 141.
146. Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, Urban JF Jr, Dvorak AM, Finkelman FD, LeGros G, Paul WE: Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 2004; 200: 507.
147. Mitre E, Taylor RT, Kubofcik J, Nutman TB: Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections. J Immunol 2004; 172: 2439.
148. van Panhuys N, Prout M, Forbes E, Min B, Paul WE, Le Gros G: Basophils are the major producers of IL-4 during primary helminth infection. J Immunol 2011; 186: 2719.
149. White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P: The V-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 1989; 56: 27.
150. Bouvet JP, Pires R, Lunel-Fabiani F, Crescenzo-Chaigne B, Maillard P, Valla D, Opolon P, Pillot J: Protein F: A novel F(ab)-binding factor, present in normal liver, and largely released in the digestive tract during hepatitis. J Immunol 1990; 145: 1176.
151. Kotzin BL, Leung DY, Kappler J, Marrack P: Superantigens and their potential role in human disease. Adv Immunol 1993; 54: 99.
152. Marone G, Rossi FW, Detoraki A, Granata F, Genovese A, Spadaro G: Role of superallergens in allergic disorders. Chem Immunol Allergy 2007; 93: 195.
153. Marrack P, Kappler J: The staphylococcal enterotoxins and their relatives. Science 1990; 248: 705.
154. Bachert C, Gevaert P, Zhang N, van Zele T, Perez-Novo C: Role of staphylococcal superantigens in airway disease. Chem Immunol Allergy 2007; 93: 214.
155. Goodyear CS, Silverman GJ: B cell superantigens: A microbe's answer to innatelike B cells and natural antibodies. Springer Semin Immunopathol 2005; 26: 463.
156. Pastacaldi C, Lewis P, Howarth P: Staphylococci and staphylococcal superantigens in asthma and rhinitis: A systematic review and meta-analysis. Allergy 2011; 66: 549.
157. Viau M, Zouali M: B-lymphocytes, innate immunity, and autoimmunity. Clin Immunol 2005; 114: 17.
158. Pascual V, Capra JD: B-cell superantigens? Curr Biol 1991; 1: 315.
159. Silverman GJ, Goodyear CS: A model Bcell superantigen and the immunobiology of B lymphocytes. Clin Immunol 2002; 102: 117.
160. Zouali M: B-cell superantigens: implications for selection of the human antibody repertoire. Immunol Today 1995; 16: 399.
161. Silverman GJ, Roben P, Bouvet JP, Sasano M: Superantigen properties of a human sialoprotein involved in gut-associated immunity. J Clin Invest 1995; 96: 417.
162. Patella V, Bouvet JP, Marone G: Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. J Immunol 1993; 151: 5685.
163. Patella V, Giuliano A, Bouvet JP, Marone G: Endogenous superallergen protein Fv induces IL-4 secretion from human FcRI + cells through interaction with the VH3 region of IgE. J Immunol 1998; 161: 5647.
164. Marone G, Tamburini M, Giudizi MG, Biagiotti R, Almerigogna F, Romagnani S: Mechanism of activation of human basophils by Staphylococcus aureus Cowan 1. Infect Immun 1987; 55: 803.
165. Patella V, Florio G, Petraroli A, Marone G: HIV-1 gp120 induces IL-4 and IL-13 release from human FcRI + cells through interaction with the VH3 region of IgE. J Immunol 2000; 164: 589.
166. Patella V, Casolaro V, Bjorck L, Marone G: Protein L: A bacterial Ig-binding protein that activates human basophils and mast cells. J Immunol 1990; 145: 3054.
167. Genovese A, Bouvet JP, Florio G, Lamparter-Schummert B, Bjorck L, Marone G: Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. Infect Immun 2000; 68: 5517.
168. de Paulis A, Prevete N, Fiorentino I, Walls AF, Curto M, Petraroli A, Castaldo V, Ceppa P, Fiocca R, Marone G: Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20). J Immunol 2004; 172: 7734.
169. Polk DB, Peek RM Jr: Helicobacter pylori : gastric cancer and beyond. Nat Rev Cancer 2010; 10: 403.
170. de Paulis A, Prevete N, Rossi FW, Rivellese F, Salerno F, Delfino G, Liccardo B, Avilla E, Montuori N, Mascolo M, Staibano S, Melillo RM, D'Argenio G, Ricci V, Romano M, Marone G: Helicobacter pylori Hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo. J Immunol 2009; 183: 3761.
171. Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, Larosa DF, Renner ED, Orange JS, Bushman FD, Artis D: Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nat Med 2012; 18: 538.
172. Hill DA, Artis D: The influence of commensal bacteria-derived signals on basophil-associated allergic inflammation. Gut Microbes 2013; 4: 76.
173. Ida S, Hooks JJ, Siraganian RP, Notkins AL: Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med 1977; 145: 892.
174. Busse WW, Swenson CA, Borden EC, Treuhaft MW, Dick EC: Effect of influenza A virus on leukocyte histamine release. J Allergy Clin Immunol 1983; 71: 382.
175. Lett-Brown MA, Aelvoet M, Hooks JJ, Georgiades JA, Thueson DO, Grant JA: Enhancement of basophil chemotaxis in vitro by virus-induced interferon. J Clin Invest 1981; 67: 547.
176. Chen YH, Bieneman AP, Creticos PS, Chichester KL, Schroeder JT: IFN- inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. J Allergy Clin Immunol 2003; 112: 944.
177. Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS Jr: STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol 2009; 183: 2016.
178. Clerici M, Shearer GM: A TH1 TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993; 14: 107.
179. Vigano A, Principi N, Crupi L, Onorato J, Vincenzo ZG, Salvaggio A: Elevation of IgE in HIV-infected children and its correlation with the progression of disease. J Allergy Clin Immunol 1995; 95: 627.
180. de Paulis A, De Palma R, Di Gioia L, Carfora M, Prevete N, Tosi G, Accolla RS, Marone G: Tat protein is an HIV-1-encoded -chemokine homolog that promotes migration and up-regulates CCR3 expression on human FcRI + cells. J Immunol 2000; 165: 7171.
181. de Paulis A, Florio G, Prevete N, Triggiani M, Fiorentino I, Genovese A, Marone G: HIV-1 envelope gp41 peptides promote migration of human FcRI + cells and inhibit IL-13 synthesis through interaction with formyl peptide receptors. J Immunol 2002; 169: 4559.
182. Li Y, Li L, Wadley R, Reddel SW, Qi JC, Archis C, Collins A, Clark E, Cooley M, Kouts S, Naif HM, Alali M, Cunningham A, Wong GW, Stevens RL, Krilis SA: Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood 2001; 97: 3484.
183. Charles N, Hardwick D, Daugas E, Illei GG, Rivera J: Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med 2010; 16: 701.
184. Charles N, Rivera J: Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus. Curr Allergy Asthma Rep 2011; 11: 378.
185. Dijkstra D, Hennig C, Witte T, Hansen G: Basophils from humans with systemic lupus erythematosus do not express MHCII. Nat Med 2012; 18: 488.
186. Schuerwegh AJ, Ioan-Facsinay A, Dorjee AL, Roos J, Bajema IM, van der Voort EI, Huizinga TW, Toes RE: Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc Natl Acad Sci USA 2010; 107: 2586.
187. Athreya BH, Moser G, Raghavan TE: Increased circulating basophils in juvenile rheumatoid arthritis: A preliminary report. Am J Dis Child 1975; 129: 935.
188. Nouri-Aria KT, Irani AM, Jacobson MR, O'Brien F, Varga EM, Till SJ, Durham SR, Schwartz LB: Basophil recruitment and IL-4 production during human allergeninduced late asthma. J Allergy Clin Immunol 2001; 108: 205.
189. Kepley CL, McFeeley PJ, Oliver JM, Lipscomb MF: Immunohistochemical detection of human basophils in postmortem cases of fatal asthma. Am J Respir Crit Care Med 2001; 164: 1053.
190. Guo CB, Liu MC, Galli SJ, Bochner BS, Kagey-Sobotka A, Lichtenstein LM: Identification of IgE-bearing cells in the latephase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol 1994; 10: 384.
191. Bascom R, Pipkorn U, Lichtenstein LM, Naclerio RM: The influx of inflammatory cells into nasal washings during the late response to antigen challenge: effect of systemic steroid pretreatment. Am Rev Respir Dis 1988; 138: 406.
192. Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H: Basophil recruitment and activation in inflammatory skin diseases. Allergy 2011; 66: 1107.
193. Xia HZ, Zweiman B, Schwartz LB: Levels of tryptase, chymase, and FcRI? messenger RNA in human skin are unchanged after IgE-dependent stimulation of cutaneous mast cells in vivo. J Allergy Clin Immunol 1997; 99: 224.
194. Ying S, Robinson DS, Meng Q, Barata LT, McEuen AR, Buckley MG, Walls AF, Askenase PW, Kay AB: C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: Association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 1999; 163: 3976.
195. Lichtenstein LM, Norman PS, Winkenwerder WL: Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever. Am J Med 1968; 44: 514.
196. Ebo DG, Bridts CH, Hagendorens MM, Aerts NE, De Clerck LS, Stevens WJ: Basophil activation test by flow cytometry: present and future applications in allergology. Cytometry B Clin Cytom 2008; 74: 201.
197. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Nadeau KC: Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol 2011; 154: 318.
198. Ono E, Taniguchi M, Higashi N, Mita H, Kajiwara K, Yamaguchi H, Tatsuno S, Fukutomi Y, Tanimoto H, Sekiya K, Oshikata C, Tsuburai T, Tsurikisawa N, Otomo M, Maeda Y, Hasegawa M, Miyazaki E, Kumamoto T, Akiyama K: CD203c expression on human basophils is associated with asthma exacerbation. J Allergy Clin Immunol 2010; 125: 483.
199. Casolaro V, Spadaro G, Marone G: Human basophil releasability. 6. Changes in basophil releasability in patients with allergic rhinitis or bronchial asthma. Am Rev Respir Dis 1990; 142: 1108.
200. Detoraki A, Granata F, Staibano S, Rossi FW, Marone G, Genovese A: Angiogenesis and lymphangiogenesis in bronchial asthma. Allergy 2010; 65: 946.
201. Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Panizzolo C, Zanin ME, Zuin R, Maestrelli P, Fabbri LM, Saetta M: Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006; 174: 975.
202. Chetta A, Zanini A, Foresi A, D'Ippolito R, Tipa A, Castagnaro A, Baraldo S, Neri M, Saetta M, Olivieri D: Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 2005; 35: 1437.
203. Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, Hirokawa K, Etori M, Yamashita M, Kubota T, Minegishi Y, Yonekawa H, Karasuyama H: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 2005; 23: 191.
204. Schafer T, Heinrich J, Wjst M, Adam H, Ring J, Wichmann HE: Association between severity of atopic eczema and degree of sensitization to aeroallergens in school children. J Allergy Clin Immunol 1999; 104: 1280.
205. Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H: Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 2008; 28: 581.
206. Vadas P, Gold M, Perelman B, Liss GM, Lack G, Blyth T, Simons FE, Simons KJ, Cass D, Yeung J: Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med 2008; 358: 28.
207. Mukai K, BenBarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, Galli SJ: Critical role of P1-Runx1 in mouse basophil development. Blood 2012; 120: 76.
208. Anthony RM, Kobayashi T, Wermeling F, Ravetch JV: Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway. Nature 2011; 475: 110.
209. Ugajin T, Kojima T, Mukai K, Obata K, Kawano Y, Minegishi Y, Eishi Y, Yokozeki H, Karasuyama H: Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol 2009; 86: 1417.