The cysteinyl leukotrienes: Where do they come from? What are they? Where are they going?

Nature Immunology

Volumn 9, Issue 2, 2008, Pages 113-115

  Austen, K Frank ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; ARACHIDONIC ACID; HISTAMINE; IMMUNOGLOBULIN E; LEUKOTRIENE C4; PEPTIDOLEUKOTRIENE;

ALLERGIC RHINITIS; ANAPHYLAXIS; ARTICLE; ASTHMA; BONE MARROW; CHRONIC INFLAMMATION; CONJUNCTIVITIS; HUMAN; INFLAMMATORY CELL; LUNG FIBROSIS; MAST CELL; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE; URTICARIA;

ANAPHYLAXIS; ANIMALS; ASTHMA; BONE MARROW; CYSTEINE; ENGLAND; GUINEA PIGS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; IMMUNOLOGIC FACTORS; LEUKOTRIENES; MUSCLE, SMOOTH; RATS; RECEPTORS, LEUKOTRIENE; UNITED STATES;

EID: 38349088970     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni0208-113     Document Type: Article

References (24)

1. Austen, K.F. & Brocklehurst, W.E. Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors. J. Exp. Med. 113, 521-539 (1961).
2. Austen, K.F. & Brocklehurst, W.E. Anaphylaxis in chopped guinea pig lung. II. Enhancement of the anaphylactic release of histamine and slow reacting substance by certain dibasic aliphatic acids and inhibition by monobasic fatty acids. J. Exp. Med. 113, 541-557 (1961).
3. Austen, K.F. & Brocklehurst, W.E. Anaphylaxis in chopped guinea pig lung. III. Effect of carbon monoxide, cyanide, salicylaldoxine, and ionic strength. J. Exp. Med. 114, 29-42 (1961).
4. Stechschulte, D.J., Austen, K.F. & Bloch, K.J. Antibodies involved in antigen-induced release of slow reacting substance of anaphylaxis (SRS-A) in the guinea pig and rat. J. Exp. Med. 125., 127-147 (1967).
5. Ishizaka, T., Ishizaka, K., Orange, R.P. & Austen, K.F. The capacity of human immunoglobulin E to mediate the release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung. J. Immunol. 104, 335-343 (1970).
6. Orange, R.P., Murphy, R.C., Kamovsky, M.L. & Austen, K.F. The physicochemical characteristics and purification of slow reacting substance of anaphylaxis. J. Immunol. 110, 760-770 (1973).
7. Murphy, R.C., Hammarstrom, S. & Samuelsson, B. Leukotriene C: A slow-reacting substance from murine mastocytoma cells. Proc. Natl. Acad. Sci. USA 76, 4275-4279 (1979).
8. Marfat, A. & Corey, E.J. Synthesis and structure elucidation of leukotrienes. in Advances in Prostaglandin, Thromboxane, and Leukotriene Research Vol. 14 (eds. Pike, J.E. & Morton, D.R. Jr.) 155-228 (Raven Press, New York, 1985).
9. Lewis, R.A. et al. Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SIRS-A). Importance of the 11-cis-geometry for biological activity. Biochem. Biophys. Res. Commun. 96, 271-277 (1980).
10. 4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc. Natl. Acad. Sci. USA 81, 4922-4925 (1984).
11. Lynch, K.R. et al. Characterization of the human oysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999).
12. 4) in human skin. J, Invest. Dermatol. 80, 115-119 (1983).
13. Weiss, J.W. et al. Bronchoconstrictor effects of leukotriene C in humans. Science 216, 196-198 (1982).
14. Drazen. J.M., Israel, E. & O'Byrne, P. Treatment of asthma with drugs modifying the leukotriene pathway. N. Engl. J. Med. 340, 197-206 (1999).
15. Bisgaard, H. Leukotriane modifiers in pediatric asthma management. Pediatrics 107, 381-390 (2001).
16. 4 synthase of guinea pig lung. J. Clin. Invest. 81, 866-871 (1988).
17. 4. Proc. Natl. Acad. Sci. USA 91, 7663-7667 (1994).
18. 4 synthase: Organization, nucleotide sequence, and chromosomal localization to 5q35. J. Biol. Chem. 271, 11356-11361 (1996).
19. 4 synthase expression by interleukin 4. J. Exp. Med. 193, 123-133 (2001).
20. 4 synthase at 4.5 A resolution in projection. Structure 12, 2009-2014 (2004).
21. 4 synthase, the membrane protein for cysteinyl leukotriene biosynthesis. Nature 448, 609-612 (2007).
22. 4 synthase. J. Biol. Chem. 276, 22608-22613 (2001).
23. Maekawa, A., Austen, K.F. & Kanaoka, Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J. Biol. Chem. 277, 20820-20824 (2002).
24. Beller, T.C. et al. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J. Biol. Chem. 219, 46129-46134 (2004).