Basophils are not the key antigen-presenting cells in allergic patients

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 67, Issue 5, 2012, Pages 601-608

  Eckl Dorna, Julia ^a   Ellinger, A ^b   Blatt, K ^a   Ghanim, V ^a   Steiner, I ^a   Pavelka, M ^b   Valent, P ^a   Valenta, R ^c   Niederberger, V ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Medical University of Vienna   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Allergen; Allergy; Antigen presenting cells; Basophils; Bet v 1; Th2

Indexed keywords

INTERLEUKIN 3;

ALLERGY; ANTIGEN PRESENTING CELL; ARTICLE; BASOPHIL; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; PATIENT; PRIORITY JOURNAL; T LYMPHOCYTE;

ALLERGENS; ANTIGEN-PRESENTING CELLS; ANTIGENS, PLANT; BASOPHILS; EPITOPES; HUMANS; HYPERSENSITIVITY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 84859772927     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2012.02792.x     Document Type: Article

References (32)

1. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245-252. (Pubitemid 28155090)
2. Paul WE, Zhu J. How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol 2010;10:225-235.
3. Zhu J, Paul WE. Peripheral CD4+ T cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev 2010;238:247-262.
4. von Bubnoff D, Geiger E, Bieber T. Antigen- presenting cells in allergy. J Allergy Clin Immunol 2001;108:329-339.
5. Steinman RM, Banchereau J. Taking dendritic cells into medicine. Nature 2007;449:419-426. (Pubitemid 47509552)
6. Valent P, Bettelheim P. The human basophil. Crit Rev Oncol Hematol 1990;10:327-352.
7. Valent P, Bettelheim P. Cell surface structures on human basophils and mast cells: biochemical and functional characterization. Adv Immunol 1992;52:333-423.
8. Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009;10:713-720.
9. Yoshimoto T, Yasuda K, Tanaka H, Nakahira M, Imai Y, Fujimori Y et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide- MHC class II complexes to CD4+ T cells. Nat Immunol 2009;10:706-712.
10. Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol 2009;10:697-705.
11. Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M et al. Inflammatory dendritic cells-not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 2010;207:2097-2111.
12. Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 2010;33:364-374.
13. Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, Valent P et al. Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci U S A 2004;101(Suppl 2):14677-14682. (Pubitemid 39346742)
14. Buhring HJ, Streble A, Valent P. The basophil- specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol 2004;133:317-329. (Pubitemid 38490210)
15. Dvorak AM. Ultrastructural studies of human basophils and mast cells. J Histochem Cytochem 2005;53:1043-1070. (Pubitemid 41262975)
16. Ferreira F, Hirtenlehner K, Jilek A, Godnik- Cvar J, Breiteneder H, Grimm R et al. Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996;183:599-609. (Pubitemid 26059521)
17. Valent P, Besemer J, Muhm M, Majdic O, Lechner K, Bettelheim P. Interleukin 3 activates human blood basophils via high-affinity binding sites. Proc Natl Acad Sci U S A 1989a;86:5542-5546. (Pubitemid 19185580)
18. Zheng X, Karsan A, Duronio V, Chu F, Walker DC, Bai TR et al. Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-kappaB-dependent and -independent pathways. Immunology 2002;107:306-315. (Pubitemid 35356950)
19. Didichenko SA, Spiegl N, Brunner T, Dahinden CA. IL-3 induces a Pim1-dependent antiapoptotic pathway in primary human basophils. Blood 2008;112:3949-3958.
20. Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E et al. Interleukin-3 is a differentiation factor for human basophils. Blood 1989b;73:1763-1769. (Pubitemid 19145104)
21. Valent P, Dahinden CA. Role of interleukins in the regulation of basophil development and secretion. Curr Opin Hematol 2010;17:60-66.
22. Kim S, Prout M, Ramshaw H, Lopez AF, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol 2010;184:1143-1147.
23. Phythian-Adams AT, Cook PC, Lundie RJ, Jones LH, Smith KA, Barr TA et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med 2010;207:2089-2096.
24. van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, Duez C et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 2005;201:981-991. (Pubitemid 40524467)
25. Lambrecht BN, Salomon B, Klatzmann D, Pauwels RA. Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice. J Immunol 1998;160:4090-4097. (Pubitemid 28176120)
26. Charbonnier AS, Hammad H, Gosset P, Stewart GA, Alkan S, Tonnel AB et al. Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response. J Leukoc Biol 2003;73:91-99. (Pubitemid 36125679)
27. Bellinghausen I, Brand U, Knop J, Saloga J. Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors. J Allergy Clin Immunol 2000;105:988-996. (Pubitemid 30324409)
28. Hammad H, Charbonnier AS, Duez C, Jacquet A, Stewart GA, Tonnel AB et al. Th2 polarization by Der p 1-pulsed monocyte- derived dendritic cells is due to the allergic status of the donors. Blood 2001;98:1135-1141.
29. Lundberg K, Lindstedt M, Larsson K, Dexlin L, Wingren C, Ohlin M et al. Augmented Phl p 5-specific Th2 response after exposure of dendritic cells to allergen in complex with specific IgE compared to IgG1 and IgG4. Clin Immunol 2008;128:358-365.
30. Maurer D, Ebner C, Reininger B, Fiebiger E, Kraft D, Kinet JP et al. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol 1995;154:6285-6290.
31. van der Heijden FL, Joost van Neerven RJ, van Katwijk M, Bos JD, Kapsenberg ML. Serum-IgE-facilitated allergen presentation in atopic disease. J Immunol 1993;150(8 Pt 1):3643-3650. (Pubitemid 23129745)
32. Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K et al. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 2010;11:608-617.