Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils

Journal of Immunology

Volumn 167, Issue 4, 2001, Pages 2282-2291

  Miura, K ^a   Saini, S S ^a   Gauvreau, G ^a   MacGlashan D W , Jr ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CYTOKINE; IMMUNOGLOBULIN E RECEPTOR; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN 3; INTERLEUKIN 5; JANUS KINASE; JANUS KINASE 2; LEUKOTRIENE C4; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NERVE GROWTH FACTOR; PHOSPHOLIPASE A2; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; STAT5 PROTEIN; STAUROSPORINE; UNCLASSIFIED DRUG;

ARTICLE; BASOPHIL; BETA CHAIN; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035881580     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.4.2282     Document Type: Article

References (51)

1. Characteristics of human basophil sulfidopeptide leukotriene release: Releasability defined as the ability of the basophil to respond to dimeric cross-links
2. Differential release of mediators from human basophils: Differences in arachidonic acid metabolism following activation by unrelated stimuli
3. Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils
4. Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists
5. Modulation of human basophil histamine release by hematopoetic growth factors
6. Basophil priming by neurotrophic factors: Activation through the trk receptor
7. Degranulation of human basophils by picomolar concentrations of IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor
8. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
9. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge: Characterization of eosinophil and mast cell mediators
10. Appearance of granulocyte-macrophage colony-stimulating factor activity at allergen-challenged cutaneous latephase reaction sites
11. Production of granulocyte/macrophage colony-stimulating factor in human airways during allergen-induced late-phase reactions in atopic subjects
12. Bronchial mucosal expression of the genes encoding chemokines RANTES and MCP-3 in symptomatic atopic and nonatopic asthmatics: Relationship to the eosinophil-active cytokines interleukin (IL)-5, granulocyte macrophage-colony-stimulating factor, and IL-3
13. Nerve growth factor: A neurotrophin with activity on cells of the immune system
14. Nerve growth factor: An important molecule in allergic inflammation and tissue remodelling
15. Stimulus-dependent leukotriene release from human basophils: A comparative study of C5a and Fmet-Leu-Phe
16. Interleukin-3 alters free arachidonic acid generation in C5a-stimulated human basophils
17. Interleukin 3-dependent mediator release in basophils triggered by C5a
18. Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation
19. Eotaxin potentiates antigen-dependent basophil IL-4 production
20. Secretion of interleukin-4 from human basophils: The relationship between IL-4 mRNA and protein in resting and stimulated hasophils
21. Expression of protein kinase C isozymes in human basophils: Regulation by physiological and non-physiological stimuli
22. Basophil counting with a new staining method using Alcian blue
23. Dual phase priming by interleukin-3 for leukotriene C4 generation in human basophils
24. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production
25. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils
26. 2 is phosphorylated and activated by MAP kinase
27. 2) by interleukin-3 (IL-3) is associated with increased free arachidonic acid and LTC4 release in human basophils
28. Cell cycle-dependent activation of Ras
29. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras
30. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, Stat3, and Stat5b
31. 2+ changes in human lung mast cells: Graded vs. all-or-nothing elevations after IgE-mediated stimulation
32. Measuring leukotrienes of slow-reacting substance of anaphylaxis: Development of a specific radioimmunoassay
33. The gene and cDNA for the human high affinity immunoglobulin E receptor β chain and expression of the complete human receptor
34. Expression and modulation of FcεRIα and FcεRIβ in human blood basophils
35. Hemopoietic growth factors regulate the survival of human basophils in vitro
36. In vitro regulation of FcεRIα expression on human basophils by IgE antibody
37. Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils
38. Mechanism of activation of the GM-CSF, IL-3, AND IL-5 family of receptors
39. Negative regulation of FcεRI signaling by FcγRII costimulation in human blood basophils
40. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein
41. Trks: Signal transduction and intracellular pathways
42. Neurotrophin signal transduction by the Trk receptor
43. p75 and Trk: A two-receptor system
44. Regulation of glucose transport and c-los and egr-1 expression in cells with mutated or endogenous growth hormone receptors
45. Effects of tyrosine kinase inhibitors on tyrosine phosphorylations and the insulin-like effects in response to human growth hormone in isolated rat adipocytes
46. The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak- STAT pathways in eosinophils
47. Pharmacology of IgE-mediated desensitization of human basophils: Effects of protein kinase C and Src-family kinase inhibitors
48. SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
49. Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex
50. Src homology 2 protein tyrosine phosphatase (SHPTP2)/Src homology 2 phosphatase 2 (SHP2) tyrosine phospharase is a positive regulator of the interleukin 5 receptor signal transduction pathways leading to the prolongation of eosinophil survival
51. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells