A model B-cell superantigen and the immunobiology of B lymphocytes

Clinical Immunology

Volumn 102, Issue 2, 2002, Pages 117-134

  Silverman, Gregg J ^a   Goodyear, Carl S ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Fab binding; Ig binding protein; Immunotherapy; Protein A; Repertoire; Superantigen; Tolerance; VH region; Virulence factor

Indexed keywords

B LYMPHOCYTE ANTIGEN; BACTERIAL PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN A; STAPHYLOCOCCUS TOXIN; SUPERANTIGEN; VIRULENCE FACTOR;

ANTIGEN BINDING; B LYMPHOCYTE; CELL INTERACTION; CRYSTALLOGRAPHY; HUMAN; IMMUNOBIOLOGY; IN VIVO STUDY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; T LYMPHOCYTE;

EID: 0036176505     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2001.5143     Document Type: Review

References (86)

1. Antibody-antigen interactions
2. Human antibody responses to bacterial antigens: Studies of a model conventional antigen and a proposed model B cell superantigen
3. B-cell superantigens
4. The dual phases of the response to neonatal exposure to a VH family-restricted staphylococcal B-cell superantigen
5. Characterization of superantigen-induced clonal deletion with a novel clan III-restricted avian monoclonal antibody: Exploiting evolutionary distance to create antibodies specific for a conserved VH region surface
6. A B cell superantigen-induced persistent "hole" in the B-1 repertoire
7. Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity
8. Adoptive transfer of a superantigen-induced "hole" in the repertoire of natural IgM-secreting cells
9. Gene for staphylococcal protein A
10. Complete sequence of the staphylococcal gene encoding protein A: A gene evolved through multiple duplications
11. Staphylococcal protein A consists of five IgG-binding domains
12. Structural studies on the four repetitive Fc-binding regions in protein A from Staphylococcus aureus
13. Polymorphism and evolution of Igh-V gene families
14. Regulation of exoprotein gene expression in Staphylococcus aureus by agar
15. Protein A of Staphylococcus aureus and related immunoglobulin receptors produced by streptococci and pneumonococci
16. Staphylococcus aureus protein A recognizes platelet gC1qR/p33: A novel mechanism for staphylococcal interactions with platelets
17. Surface-associated proteins of Staphylococcus aureus: Their possible roles in virulence
18. Virulence of Staphylococcus aureus in a mouse mastitis model: Studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloning
19. Binding of microbial pathogens to connective tissue fibronectin: An early step in localized invasive infections
20. Virulence of protein A-deficient and alpha-toxin-deficient mutants of Staphylococcus aureus isolated by allele replacement
21. Further characterization of the alternative protein-A interaction of immunoglobulins: Demonstration of an Fc-binding fragment of protein A expressing the alternative reactivity
22. Non-immune F(ab′)2- and Fc-mediated interactions of mammalian immunoglobulins with S. aureus and group C and G streptococci
23. Age-associated changes in binding of human B lymphocytes to a VH3-restricted unconventional bacterial antigen
24. H3 antibodies bind domain D of staphylococcal protein A
25. HIII subgroup
26. HIII H chains
27. H3 encoded immunoglobulins
28. Three-dimensional solution structure of the B domain of staphylococcal protein A: Comparisons of the solution and crystal structures
29. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-resolution
30. Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a
31. V beta 17 gene polymorphism in wild-derived mouse strains: Two amino acid substitutions in the V beta 17 region greatly alter T cell receptor specificity
32. Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta
33. + T cell receptors are consistent with an immunoglobulin-like structure for the receptor
34. The third IgG-binding domain from streptococcal protein G: An analysis by X-ray crystallography of the structure alone and in a complex with Fab
35. Crystal structure of a streptococcal protein G domain bound to an Fab fragment
36. Three-dimensional solution structure of an immunoglobulin light chain-binding domain of protein L: Comparison with the IgG-binding domains of protein G
37. Mapping of the immunoglobulin light chain-binding site of protein L
38. Complex between Peptostreptococcus magnus protein L and a human antibody reveals structural convergence in the interaction modes of Fab binding proteins
39. Molecular selection of human antibodies with an unconventional bacterial B cell antigen
40. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
41. Phylogenetic emergence and molecular evolution of the immunoglobulin family
42. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding
43. Antibody structure and the evolution of immunoglobulin V gene segments
44. Evolution of immunoglobulin heavy chain variable region genes: A VH family can last for 150-200 million years or longer
45. Heavy-chain variable regions in carcharhine sharks: Development of a comprehensive model for the evolution of VH domains among the gnathanstomes
46. Conservation of an immunoglobulin variable-region gene family indicates a specific, noncoding function
47. Structure and evolution of mammalian VH families
48. Chicken monoclonal antibody isolated by a phage display system
49. Selection of specific phage-display antibodies using libraries derived from chicken immunoglobulin genes
50. The antigen-binding characteristics of mAbs derived from in vivo priming of avian B cells
51. Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region
52. The chicken B cell compartment
53. Immunoglobulin gene diversification by gene conversion
54. Mouse Ig coded by VH families S107 or J606 bind to protein A
55. The murine clan V(H) III related 7183, J606 and S107 and DNA4 families commonly encode for binding to a bacterial B cell superantigen
56. Transitional B cells are the target of negative selection in the B cell compartment
57. Chance encounters and organized rendezvous
58. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen
59. Antiphosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae
60. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae
61. Phosphorylcholine: Friend or foe of the immune system
62. B1 cells: Similarities and differences with other B cell subsets
63. B-cell lineages exist in the mouse
64. The CD5 B cell
65. B-cell subsets defined by the Fc epsilon R
66. The peritoneal Ly-1 (CD5) B cell repertoire is unique among murine B cell repertoires
67. An unbiased analysis of VH-D-JH sequences from B-1a, B-1b, and conventional B cells
68. The Ly-1 B cell lineage
69. Development and physiology of Ly-1 B and its human homolog, Leu-1 B
70. + B lymphocytes, polyreactive antibodies and the human B-cell repertoire
71. Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM autoantibodies
72. - B cells
73. - B cell subsets activated through their antigen receptors or CD40 antigens
74. In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone
75. T cell-dependent antibody production by Ly-1 B cells
76. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
77. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus
78. Clonal dominance: Loss and restoration in adoptive transfer
79. Change in the idiotypic pattern of an immune response following syngeneic hemopoetic reconstitution of lethally irradiated mice
80. Alterations of idiotypic profiles: The cellular basis of T15 dominance in BALB/c mice
81. Endotoxin shock in antibody-deficient mice: Unraveling the role of natural antibody and complement in the clearance of lipopolysaccharide
82. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection
83. Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent
84. Enhancement of mucosal antibody responses to Salmonella typhimurium and the microbial hapten phosphorylcholine in mice with X-linked immunodeficiency by B-cell precursors from the peritoneal cavity
85. An experimental vaccine that targets staphylococcal virulence
86. Disquisitions on original antigenic sin. I. Evidence in man