Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis

Microvascular Research

Volumn 77, Issue 2, 2009, Pages 187-191

  Milner, Christopher S ^a   Hansen, Tania M ^a   Singh, Harprit ^a   Brindle, Nicholas P J ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Angiopoietin; Endothelial; Receptor tyrosine kinase; Tie1; Tie2

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; TIE 1 RECEPTOR; TYROSINE KINASE RECEPTOR;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOLYSIS; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANGIOPOIETIN-1; APOPTOSIS; BASE SEQUENCE; CASPASE 3; CASPASE 7; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, TIE-1; RECEPTOR, TIE-2; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING;

EID: 60449109349     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2008.09.003     Document Type: Article

References (35)

1. Cho C.-H., Kammerer R.A., Lee H.J., Yasunaga K., Kim K.-T., Choi H.-H., Kim W., Kim S.H., Park S.K., Lee G.M., and Koh G.Y. Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 5553-5558
2. Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., and Yancopoulos G.D. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87 (1996) 1161-1169
3. Davis S., Papadopoulos N., Aldrich T.H., Maisonpierre P.C., Huang T., Kovac L., Xu A., Leidich R., Radziejewska E., Rafique A., Goldberg J., Jain V., Bailey K., Karow M., Fandl J., Samuelsson S.J., Ioffe E., Rudge J.S., Daly T.J., Radziejewski C., and Yancopoulos G.D. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. Nat. Struct. Biol. 10 (2003) 38-44
4. Dumont D.J., Yamaguchi T.P., Conlon R.A., Rossant J., and Breitman M.L. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene 7 (1992) 71-80
5. Fiedler U., Krissl T., Koidl S., Weiss C., Koblizek T., Deutsch U., Martiny-Baron G., Marme D., and Augustin H.G. Angiopoietin-1 and Angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J. Biol. Chem. 278 (2003) 1721-1727
6. Gamble J.R., Drew J., Trezise L., Underwood A., Parsons M., Kasminkas L., Rudge J., Yancopoulos G., and Vadas M.A. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions. Circ. Res. 87 (2000) 603-607
7. Gavard J., Patel V., and Gutkind J.S. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev. Cell 14 (2008) 25-36
8. Harfouche R., Hassessian H.M., Guo Y., Faivre V., Srikant C.B., Yancopoulos G.D., and Hussain S.N. Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. Microvasc. Res. 64 (2002) 135-147
9. Jho D., Mehta D., Ahmmed G., Gao X.P., Tiruppathi C., Broman M., and Malik A.B. Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Circ. Res. 96 (2005) 1282-1290
10. Jones N., Iljin K., Dumont D.J., and Alitalo K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat. Rev. Mol. Cell Biol. 2 (2001) 257-267
11. Kim I., Kim H.G., So J.S., Kim J.H., Kwak H.J., and Koh G.Y. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Circ. Res. 86 (2000) 24-29
12. Kim K.T., Choi H.H., Steinmetz M.O., Maco B., Kammerer R.A., Ahn S.Y., Kim H.Z., Lee G.M., and Koh G.Y. Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate Tie2. J. Biol. Chem. 280 (2005) 20126-20131
13. Kontos C.D., Cha E.H., York J.D., and Peters K.G. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol. Cell Biol. 22 (2002) 1704-1713
14. Kwak H.J., So J.N., Lee S.J., Kim I., and Koh G.Y. Angiopoietin-1 is an apoptosis survival factor for endothelial cells. FEBS Lett. 448 (1999) 249-253
15. Li X., Hahn C.N., Parsons M., Drew J., Vadas M.A., and Gamble J.R. Role of protein kinase C{zeta} in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood 104 (2004) 1716-1724
16. Li X., Stankovic M., Bonder C.S., Hahn C.N., Parsons M., Pitson S.M., Xia P., Proia R.L., Vadas M.A., and Gamble J.R. Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood 111 (2008) 3489-3497
17. Maisonpierre P.C., Suri C., Jones P.F., Bartunkova S., Wiegand S.J., Radziejewski C., Compton D., McClain J., Aldrich T.H., Papadopoulos N., Daly T.J., Davis S., Sato T.N., and Yancopoulos G.D. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277 (1997) 55-60
18. Marron M.B., Hughes D.P., Edge M.D., Forder C.L., and Brindle N.P.J. Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. J. Biol. Chem. 275 (2000) 39741-39746
19. Marron M.B., Singh H., Tahir T.A., Kavumkal J., Kim H.-Z., Koh G.Y., and Brindle N.P.J. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor tyrosine kinase Tie2. J. Biol. Chem. 282 (2007) 30509-30517
20. Matthews J.A., Batki A., Hynds C., and Kricka L.J. Enhanced chemiluminescent method for the detection of DNA dot-hybridization assays. Anal. Biochem. 151 (1985) 205-209
21. Nambu H., Nambu R., Oshima Y., Hackett S.F., Okoye G., Wiegand S., Yancopoulos G., Zack D.J., and Campochiaro P.A. Angiopoietin 1 inhibits ocular neovascularization and breakdown of the blood-retinal barrier. Gene Ther. 11 (2004) 865-873
22. Papapetropoulos A., García-Cardeña G., Dengler T.J., Maisonpierre P.C., Yancopoulos G.D., and Sessa W.C. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab. Invest. 79 (1999) 213-223
23. Papapetropoulos A., Fulton D., Mahboubi K., Kalb R.G., O'Connor D.S., Li F., Altieri D.C., and Sessa W.C. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/Survivin pathway. J. Biol. Chem. 275 (2000) 9102-9105
24. Partanen J., Armstrong E., Makela T.P., Korhonen J., Sandberg M., Renkonen R., Knuutila S., Huebner K., and Alitalo K. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol. Cell Biol. 12 (1992) 1698-1707
25. Runting A.S., Stacker S.A., and Wilks A.F. Tie2, a putative protein tyrosine kinase from a new class of cell surface receptor. Growth Factors 9 (1993) 99-105
26. Saharinen P., Kerkela K., Ekman N., Marron M., Brindle N., Lee G.M., Augustin H., Koh G.Y., and Alitalo K. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J. Cell Biol. 169 (2005) 239-243
27. Satchell S.C., Anderson K.L., and Mathieson P.W. Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J. Am. Soc. Nephrol. 15 (2004) 566-574
28. Suri C., Jones P.F., Patan S., Bartunkova S., Maisonpierre P.C., Davis S., Sato T.N., and Yancopoulos G.D. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87 (1996) 1171-1180
29. Thurston G., Suri C., Smith K., McClain J., Sato T.N., Yancopoulos G.D., and McDonald D.M. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286 (1999) 2511-2514
30. Thurston G., Rudge J.S., Ioffe E., Zhou H., Ross L., Croll S.D., Glazer N., Holash J., McDonald D.M., and Yancopoulos G.D. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat. Med. 6 (2000) 460-463
31. Valenzuela D.M., Griffiths J.A., Rojas J., Aldrich T.H., Jones P.F., Zhou H., McClain J., Copeland N.G., Gilbert D.J., Jenkins N.A., Huang T., Papadopoulos N., Maisonpierre P.C., Davis S., and Yancopoulos G.D. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 1904-1909
32. Weber C.C., Cai H., Ehrbar M., Kubota H., Martiny-Baron G., Weber W., Djonov V., Weber E., Mallik A.S., Fussenegger M., Frei K., Hubbell J.A., and Zisch A.H. Effects of protein and gene transfer of the Ang1 fibrinogen-like receptor-binding domain for endothelial and vessel organization. J. Biol. Chem. 280 (2005) 22445-22453
33. Yuan H.T., Venkatesha S., Chan B., Deutsch U., Mammoto T., Sukhatme V.P., Woolf A.S., and Karumanchi S.A. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival. FASEB J. 21 (2007) 3171-3183
34. Zhao Y.D., Campbell A.I.M., Robb M., Ng D., and Stewart D.J. Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ. Res. 92 (2003) 984-991
35. Ziegler S., Bird T., Schneringer J., Schooley K., and Baum P. Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. Oncogene 8 (1993) 663-670