Basophils: Emerging roles in the pathogenesis of allergic disease

Immunological Reviews

Volumn 242, Issue 1, 2011, Pages 144-160

  Schroeder, John T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allergy; Asthma; Basophil; Cytokine; Fc receptors; Inflammation

Indexed keywords

ANTIGEN; CD203C ANTIGEN; CD63 ANTIGEN; CD69 ANTIGEN; CHEMOKINE; CYCLOSPORIN A; CYTOKINE RECEPTOR; FC RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; HISTAMINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN LIKE RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 5 RECEPTOR; LYMPHOCYTE RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; NERVE GROWTH FACTOR RECEPTOR; OMALIZUMAB; RANTES; TACROLIMUS; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

ALLERGIC DISEASE; ARTICLE; BASOPHIL; CELL INFILTRATION; CELL MATURATION; CELL MIGRATION; CELLULAR IMMUNITY; CHEMOTAXIS; CYTOKINE RELEASE; HISTAMINE RELEASE; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; MAST CELL; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ADULT; ANIMALS; ANTIGEN-PRESENTING CELLS; BASOPHILS; CELL MOVEMENT; CHILD; HISTAMINE; HUMANS; HYPERSENSITIVITY; IMMUNITY, INNATE; IMMUNOGLOBULIN E; INFLAMMATION; INTERLEUKIN-13; INTERLEUKIN-4; MAST CELLS; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 79959339642     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01023.x     Document Type: Article

References (127)

1. Ishizaka T, De Bernardo R, Tomioka H, Lichtenstein LM, Ishizaka K. Identification of basophil granulocytes as a site of allergic histamine release. J Immunol 1972;108:1000-1008.
2. Arinobu Y, Iwasaki H, Akashi K. Origin of basophils and mast cells. Allergol Int 2009;58:21-28.
3. Dvorak AM, Monahan-Earley RA, Estrella P, Kissell S, Donahue RE. Ultrastructure of monkey peripheral blood basophils stimulated to develop in vivo by recombinant human interleukin 3. Lab Invest 1989;61:677-690.
4. Langdon JM, Schroeder JT, Vonakis BM, Bieneman AP, Chichester K, Macdonald SM. Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. J Leukoc Biol 2008;84:1151-1158.
5. Lantz CS, et al. Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature 1998;392:90-93.
6. Perrigoue JG, et al. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol 2009;10:697-705.
7. Lantz CS, Min B, Tsai M, Chatterjea D, Dranoff G, Galli SJ. IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro. Lab Invest 2008;88:1134-1142.
8. Jogie-Brahim S, Min HK, Fukuoka Y, Xia HZ, Schwartz LB. Expression of alpha-tryptase and beta-tryptase by human basophils. J Allergy Clin Immunol 2004;113:1086-1092.
9. Foster B, Schwartz LB, Devouassoux G, Metcalfe DD, Prussin C. Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils. J Allergy Clin Immunol 2002;109:287-293.
10. Meier HL, Heck LW, Schulman ES, MacGlashan DW Jr. Purified human mast cells and basophils release human elastase and cathepsin G by an IgE-mediated mechanism. Int Arch Allergy Appl Immunol 1985;77:179-183.
11. Burster T, Macmillan H, Hou T, Boehm BO, Mellins ED. Cathepsin G: roles in antigen presentation and beyond. Mol Immunol 2010;47:658-665.
12. Tschopp CM, et al. Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood 2006;108:2290-2299.
13. McEuen AR, et al. Mass, charge, and subcellular localization of a unique secretory product identified by the basophil-specific antibody BB1. J Allergy Clin Immunol 2001;107:842-848.
14. Mochizuki A, McEuen AR, Buckley MG, Walls AF. The release of basogranulin in response to IgE-dependent and IgE-independent stimuli: validity of basogranulin measurement as an indicator of basophil activation. J Allergy Clin Immunol 2003;112:102-108.
15. Ali FR, Kay AB, Larche M. Airway hyperresponsiveness and bronchial mucosal inflammation in T cell peptide-induced asthmatic reactions in atopic subjects. Thorax 2007;62:750-757.
16. von Bubnoff D, Novak N, Kraft S, Bieber T. The central role of FcepsilonRI in allergy. Clin Exp Dermatol 2003;28:184-187.
17. Zaidi AK, Saini SS, Macglashan DW Jr. Regulation of Syk kinase and FcRbeta expression in human basophils during treatment with omalizumab. J Allergy Clin Immunol 2010;125:902-908.e907.
18. Eckman JA, et al. Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge. J Allergy Clin Immunol 2010;125:889-895.e887.
19. Schroeder JT, et al. Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol 2010;125:896-901.e896.
20. Macglashan D Jr. IgE and Fc{epsilon}RI regulation. Ann N Y Acad Sci 2005;1050:73-88.
21. MacGlashan DW Jr. Relationship between spleen tyrosine kinase and phosphatidylinositol 5' phosphatase expression and secretion from human basophils in the general population. J Allergy Clin Immunol 2007;119:626-633.
22. Kepley CL, et al. Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol 2000;106:337-348.
23. Kepley CL, et al. Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes. J Biol Chem 2004;279:35139-35149.
24. Zhu D, Kepley CL, Zhang K, Terada T, Yamada T, Saxon A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med 2005;11:446-449.
25. Saxon A, Zhu D, Zhang K, Chan LA, Kepley CL. Recent advances in the use of genetically engineered negative signaling molecules to treat allergic diseases. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M 2006;223-231; discussion 231-233.
26. Van Scott MR, et al. Systemic administration of an Fcgamma-Fc(epsilon)-fusion protein in house dust mite sensitive nonhuman primates. Clin Immunol 2008;128:340-348.
27. Zhao W, Kepley CL, Morel PA, Okumoto LM, Fukuoka Y, Schwartz LB. Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells. J Immunol 2006;177:694-701.
28. Meknache N, Jonsson F, Laurent J, Guinnepain MT, Daeron M. Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B). J Immunol 2009;182:2542-2550.
29. Tsujimura Y, et al. Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity 2008;28:581-589.
30. Vadas P, et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med 2008;358:28-35.
31. Lie WJ, et al. Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. Clin Exp Allergy 2003;33:1125-1134.
32. Bonini S, et al. Nerve growth factor and asthma. Allergy 2002;57(Suppl. 72):13-15.
33. Abram M, et al. Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation. J Immunol 2009;182:4705-4712.
34. Burgi B, et al. Basophil priming by neurotrophic factors. Activation through the trk receptor. J Immunol 1996;157:5582-5588.
35. Miura K, Saini SS, Gauvreau G, MacGlashan DW Jr. Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. J Immunol 2001;167:2282-2291.
36. Smithgall MD, Comeau MR, Yoon BR, Kaufman D, Armitage R, Smith DE. IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells. Int Immunol 2008;20:1019-1030.
37. Suzukawa M, et al. An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor. J Immunol 2008;181:5981-5989.
38. Pecaric-Petkovic T, Didichenko SA, Kaempfer S, Spiegl N, Dahinden CA. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 2009;113:1526-1534.
39. Schroeder JT, MacGlashan DW Jr, Lichtenstein LM. Human basophils: mediator release and cytokine production. Adv Immunol 2001;77:93-122.
40. Vonakis BM, Macglashan DW Jr, Vilarino N, Langdon JM, Scott RS, MacDonald SM. Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced priming and activation of human basophils. Blood 2008;111:1789-1796.
41. Schroeder JT, Lichtenstein LM, MacDonald SM. Recombinant histamine-releasing factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils. J Immunol 1997;159:447-452.
42. Chen YH, Bieneman AP, Creticos PS, Chichester KL, Schroeder JT. IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. J Allergy Clin Immunol 2003;112:944-950.
43. Akdis CA, Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009;123:735-746; quiz 747-748.
44. Ryan JJ, et al. Mast cell homeostasis: a fundamental aspect of allergic disease. Crit Rev Immunol 2007;27:15-32.
45. Gillespie SR, et al. IL-10 inhibits Fc epsilon RI expression in mouse mast cells. J Immunol 2004;172:3181-3188.
46. Le T, et al. Interferons modulate Fc epsilon RI-dependent production of autoregulatory IL-10 by circulating human monocytoid dendritic cells. J Allergy Clin Immunol 2009;123:217-223.
47. Nagata K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999;459:195-199.
48. Yoshimura-Uchiyama C, et al. Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2. Clin Exp Allergy 2004;34:1283-1290.
49. Schuligoi R, et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. Pharmacology 2010;85:372-382.
50. Kleine-Tebbe J, Erdmann S, Knol EF, MacGlashan DW Jr, Poulsen LK, Gibbs BF. Diagnostic tests based on human basophils: potentials, pitfalls and perspectives. Int Arch Allergy Immunol 2006;141:79-90.
51. MacGlashan D Jr. Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes. Clin Exp Allergy 2010;40:1365-1377.
52. Yoshimura C, et al. Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3. J Allergy Clin Immunol 2002;109:817-823.
53. Sabroe I, Jones EC, Usher LR, Whyte MK, Dower SK. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses. J Immunol 2002;168:4701-4710.
54. Bieneman AP, Chichester KL, Chen YH, Schroeder JT. Toll-like receptor 2 ligands activate human basophils for both IgE-dependent and IgE-independent secretion. J Allergy Clin Immunol 2005;115:295-301.
55. Komiya A, et al. Expression and function of toll-like receptors in human basophils. Int Arch Allergy Immunol 2006;140(Suppl):23-27.
56. Sloane DE, et al. Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood 2004;104:2832-2839.
57. Schroeder JT, MacGlashan DW Jr, Kagey-Sobotka A, White JM, Lichtenstein LM. IgE-dependent IL-4 secretion by human basophils. The relationship between cytokine production and histamine release in mixed leukocyte cultures. J Immunol 1994;153:1808-1817.
58. MacGlashan D Jr, White JM, Huang SK, Ono SJ, Schroeder JT, Lichtenstein LM. Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophils. J Immunol 1994;152:3006-3016.
59. Schroeder JT, MacGlashan DW Jr, Kagey-Sobotka A, White JM, Lichtenstein LM. Cytokine generation by human basophils. J Allergy Clin Immunol 1994;94:1189-1195.
60. Kepley CL, Youssef L, Andrews RP, Wilson BS, Oliver JM. Syk deficiency in nonreleaser basophils. J Allergy Clin Immunol 1999;104:279-284.
61. Lavens-Phillips SE, MacGlashan DW Jr. The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils. Am J Respir Cell Mol Biol 2000;23:566-571.
62. Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008;9:310-318.
63. Ochensberger B, Daepp GC, Rihs S, Dahinden CA. Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation. Blood 1996;88:3028-3037.
64. Redrup AC, Howard BP, MacGlashan DW Jr, Kagey-Sobotka A, Lichtenstein LM, Schroeder JT. Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. J Immunol 1998;160:1957-1964.
65. Sin AZ, Roche EM, Togias A, Lichtenstein LM, Schroeder JT. Nerve growth factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects. J Allergy Clin Immunol 2001;108:387-393.
66. Li H, Sim TC, Alam R. IL-13 released by and localized in human basophils. J Immunol 1996;156:4833-4838.
67. Schroeder JT, Chichester KL, Bieneman AP. Human basophils secrete IL-3: evidence of autocrine priming for phenotypic and functional responses in allergic disease. J Immunol 2009;182:2432-2438.
68. Macglashan D Jr, Honigberg L, Smith A, Buggy J, Schroeder JT. Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor. Int Immunopharmacol 2011;11:475-479.
69. Hock MB, Brown MA. Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness. J Biol Chem 2003;278:26695-26703.
70. Schroeder JT, Miura K, Kim HH, Sin A, Cianferoni A, Casolaro V. Selective expression of nuclear factor of activated T cells 2/c1 in human basophils: evidence for involvement in IgE-mediated IL-4 generation. J Allergy Clin Immunol 2002;109:507-513.
71. Charles N, et al. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity 2009;30:533-543.
72. Zon LI, et al. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood 1993;81:3234-3241.
73. Schroeder JT, Howard BP, Jenkens MK, Kagey-Sobotka A, Lichtenstein LM, MacGlashan DW Jr. IL-4 secretion and histamine release by human basophils are differentially regulated by protein kinase C activation. J Leukoc Biol 1998;63:692-698.
74. Vasagar K, Vonakis BM, Gober LM, Viksman A, Gibbons SP Jr, Saini SS. Evidence of in vivo basophil activation in chronic idiopathic urticaria. Clin Exp Allergy 2006;36:770-776.
75. Gober LM, et al. Expression of activation markers on basophils in a controlled model of anaphylaxis. J Allergy Clin Immunol 2007;119:1181-1188.
76. de Paulis A, et al. Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J Immunol 2006;177:7322-7331.
77. Qi Y, et al. Human basophils express amphiregulin in response to T cell-derived IL-3. J Allergy Clin Immunol 2010;126:1260-1266.
78. Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, Paul WE. Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature 1989;339:64-67.
79. Wang YH, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007;204:1837-1847.
80. Kawaguchi M, et al. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol 2001;167:4430-4435.
81. Schroeder JT, Kagey-Sobotka A, Lichtenstein LM. The role of the basophil in allergic inflammation. Allergy 1995;50:463-472.
82. Mitre E, Nutman TB. Basophils, basophilia and helminth infections. Chem Immunol Allergy 2006;90:141-156.
83. Dvorak HF. Cutaneous basophil hypersensitivity. J Allergy Clin Immunol 1976;58:229-240.
84. Min B, Paul WE. Basophils and type 2 immunity. Curr Opin Hematol 2008;15:59-63.
85. Sokol CL, Medzhitov R. Role of basophils in the initiation of Th2 responses. Curr Opin Immunol 2010;22:73-77.
86. Sullivan BM, Locksley RM. Basophils: a nonredundant contributor to host immunity. Immunity 2009;30:12-20.
87. Siracusa MC, Comeau MR, Artis D. New insights into basophil biology: initiators, regulators, and effectors of type 2 inflammation. Ann N Y Acad Sci 2011;1217:166-177.
88. Kepley CL, Craig SS, Schwartz LB. Identification and partial characterization of a unique marker for human basophils. J Immunol 1995;154:6548-6555.
89. Plager DA, et al. Identification of basophils by a mAb directed against pro-major basic protein 1. J Allergy Clin Immunol 2006;117:626-634.
90. Buhring HJ, et al. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. Blood 2001;97:3303-3305.
91. Guo CB, Liu MC, Galli SJ, Bochner BS, Kagey-Sobotka A, Lichtenstein LM. Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol 1994;10:384-390.
92. Kepley CL, McFeeley PJ, Oliver JM, Lipscomb MF. Immunohistochemical detection of human basophils in postmortem cases of fatal asthma. Am J Respir Crit Care Med 2001;164:1053-1058.
93. Jeffery PK, Haahtela T. Allergic rhinitis and asthma: inflammation in a one-airway condition. BMC Pulm Med 2006;6(Suppl):S5.
94. Ying S, Kikuchi Y, Meng Q, Kay AB, Kaplan AP. TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. J Allergy Clin Immunol 2002;109:694-700.
95. Gauvreau GM, Evans MY. Allergen inhalation challenge: a human model of asthma exacerbation. Contrib Microbiol 2007;14:21-32.
96. Lichtenstein LM, Bochner BS. The role of basophils in asthma. Ann N Y Acad Sci 1991;629:48-61.
97. Macfarlane AJ, et al. Basophils, eosinophils, and mast cells in atopic and nonatopic asthma and in late-phase allergic reactions in the lung and skin. J Allergy Clin Immunol 2000;105:99-107.
98. Irani AM, et al. Immunohistochemical detection of human basophils in late-phase skin reactions. J Allergy Clin Immunol 1998;101:354-362.
99. Schroeder JT, Lichtenstein LM, Roche EM, Xiao H, Liu MC. IL-4 production by human basophils found in the lung following segmental allergen challenge. J Allergy Clin Immunol 2001;107:265-271.
100. Nouri-Aria KT, et al. Basophil recruitment and IL-4 production during human allergen-induced late asthma. J Allergy Clin Immunol 2001;108:205-211.
101. Schroeder JT, Bieneman AP, Chichester KL, Breslin L, Xiao H, Liu MC. Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon-alpha from plasmacytoid dendritic cells. Clin Exp Allergy 2010;40:745-754.
102. Lichtenstein LM, Norman PS, Winkenwerder WL. Clinical and in vitro studies on the role of immunotherapy in ragweed hay fever. Am J Med 1968;44:514-524.
103. May CD. High spontaneous release of histamine in vitro from leukocytes of persons hypersensitive to food. J Allergy Clin Immunol 1976;58:432-437.
104. May CD, Remigio L. Observations on high spontaneous release of histamine from leucocytes in vitro. Clin Allergy 1982;12:229-241.
105. Sampson HA, Broadbent KR, Bernhisel-Broadbent J. Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N Engl J Med 1989;321:228-232.
106. Frischmeyer-Guerrerio PA, et al. Basophil responses in children undergoing immunotherapy for milk allergy. J Allergy Clin Immunol 2011;127:AB26 #86 (abstract).
107. Paganelli R, Cavagni G, Pallone F. The role of antigenic absorption and circulating immune complexes in food allergy. Ann Allergy 1986;57:330-336.
108. Gernez Y, et al. Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol 2011;154:318-327.
109. Ono E, et al. CD203c expression on human basophils is associated with asthma exacerbation. J Allergy Clin Immunol 2010;125:483-489.
110. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol 2006;6:226-233.
111. Saini S, Bloom DC, Bieneman A, Vasagar K, Togias A, Schroeder J. Systemic effects of allergen exposure on blood basophil IL-13 secretion and FcepsilonRIbeta. J Allergy Clin Immunol 2004;114:768-774.
112. Schroeder JT, et al. TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression. J Immunol 2005;175:5724-5731.
113. Gill MA, et al. Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol 2010;184:5999-6006.
114. Tversky JR, Le TV, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT. Human blood dendritic cells from allergic subjects have impaired capacity to produce interferon-alpha via Toll-like receptor 9. Clin Exp Allergy 2008;38:781-788.
115. Gehlhar K, Bilitewski C, Reinitz-Rademacher K, Rohde G, Bufe A. Impaired virus-induced interferon-alpha2 release in adult asthmatic patients. Clin Exp Allergy 2006;36:331-337.
116. Tversky JR, Bieneman AP, Chichester KL, Hamilton RG, Schroeder JT. Subcutaneous allergen immunotherapy restores human dendritic cell innate immune function. Clin Exp Allergy 2010;40:94-102.
117. Mohrs M, Shinkai K, Mohrs K, Locksley RM. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 2001;15:303-311.
118. Voehringer D, Shinkai K, Locksley RM. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 2004;20:267-277.
119. Min B, et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 2004;200:507-517.
120. Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009;10:713-720.
121. Yoshimoto T, et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 2009;10:706-712.
122. Hammad H, Lambrecht BN. Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses. Allergy 2011;66:579-587.
123. Grayson MH, et al. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 2007;204:2759-2769.
124. Reimer JM, Magnusson S, Juremalm M, Nilsson G, Hellman L, Wernersson S. Isolation of transcriptionally active umbilical cord blood-derived basophils expressing Fc epsilon RI, HLA-DR and CD203c. Allergy 2006;61:1063-1070.
125. Mazzoni A, Young HA, Spitzer JH, Visintin A, Segal DM. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J Clin Invest 2001;108:1865-1873.
126. Mazzoni A, Leifer CA, Mullen GE, Kennedy MN, Klinman DM, Segal DM. Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells. J Immunol 2003;170:2269-2273.
127. Schroeder JT, Chichester KL, Bieneman AP. Toll-like receptor 9 suppression in plasmacytoid dendritic cells after IgE-dependent activation is mediated by autocrine TNF-alpha. J Allergy Clin Immunol 2008;121:486-491.