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Volumn 45, Issue 4, 2015, Pages 958-965

Development of thymic Foxp3+ regulatory T cells: TGF-β matters

Author keywords

Apoptosis; Foxp3; IL 2; TGF ; Thymic Treg cells

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84926960339     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444999     Document Type: Short Survey
Times cited : (97)

References (54)
  • 1
    • 82755198003 scopus 로고    scopus 로고
    • Regulatory T cell lineage commitment in the thymus
    • Klein, L. and Jovanovic, K., Regulatory T cell lineage commitment in the thymus. Semin. Immunol. 2011. 23: 401-409.
    • (2011) Semin. Immunol. , vol.23 , pp. 401-409
    • Klein, L.1    Jovanovic, K.2
  • 2
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    • Klein, L., Kyewski, B., Allen, P. M. and Hogquist, K. A., Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat. Rev. Immunol. 2014. 14: 377-391.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 3
    • 84875498856 scopus 로고    scopus 로고
    • Development and maintenance of regulatory T cells
    • Ohkura, N., Kitagawa, Y. and Sakaguchi, S., Development and maintenance of regulatory T cells. Immunity 2013. 38: 414-423.
    • (2013) Immunity , vol.38 , pp. 414-423
    • Ohkura, N.1    Kitagawa, Y.2    Sakaguchi, S.3
  • 4
    • 33947667310 scopus 로고    scopus 로고
    • Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells
    • Bayer, A. L., Yu, A. and Malek, T. R., Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J. Immunol. 2007. 178: 4062-4071.
    • (2007) J. Immunol. , vol.178 , pp. 4062-4071
    • Bayer, A.L.1    Yu, A.2    Malek, T.R.3
  • 5
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio, C. W. and Hsieh, C. S., A two-step process for thymic regulatory T cell development. Immunity 2008. 28: 100-111.
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 6
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek, T.R., Yu, A., Vincek, V., Scibelli, P. and Kong, L., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002. 17: 167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 7
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai, X., Cowan, M., Feigenbaum, L. and Singer, A., CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat. Immunol. 2005. 6: 152-162.
    • (2005) Nat. Immunol. , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 8
    • 84879601640 scopus 로고    scopus 로고
    • Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
    • Tai, X., Erman, B., Alag, A., Mu, J., Kimura, M., Katz, G., Guinter, T. et al., Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity 2013. 38: 1116-1128.
    • (2013) Immunity , vol.38 , pp. 1116-1128
    • Tai, X.1    Erman, B.2    Alag, A.3    Mu, J.4    Kimura, M.5    Katz, G.6    Guinter, T.7
  • 9
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y., A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 2005. 6: 1142-1151.
    • (2005) Nat. Immunol. , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 10
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • Hsieh, C. S., Lee, H. M. and Lio, C. W., Selection of regulatory T cells in the thymus. Nat. Rev. Immunol. 2012. 12: 157-167.
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 11
    • 84920964462 scopus 로고    scopus 로고
    • Epigenetic control of thymic Treg-cell development
    • Kitagawa, Y., Ohkura, N. and Sakaguchi, S., Epigenetic control of thymic Treg-cell development. Eur. J. Immunol. 2015. 45: 11-16.
    • (2015) Eur. J. Immunol. , vol.45 , pp. 11-16
    • Kitagawa, Y.1    Ohkura, N.2    Sakaguchi, S.3
  • 13
    • 84896036640 scopus 로고    scopus 로고
    • Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation
    • Caton, A.J., Kropf, E., Simons, D. M., Aitken, M., Weissler, K. A. and Jordan, M. S., Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation. Eur. J. Immunol. 2014. 44: 785-793.
    • (2014) Eur. J. Immunol. , vol.44 , pp. 785-793
    • Caton, A.J.1    Kropf, E.2    Simons, D.M.3    Aitken, M.4    Weissler, K.A.5    Jordan, M.S.6
  • 15
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. and vonBoehmer, H., Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 2002. 3: 756-763.
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    von Boehmer, H.4
  • 16
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A.E., Holzapfel, K. L., Xing, Y., Cunningham, N. R., Maltzman, J. S., Punt, J. and Hogquist, K. A., T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 2011. 208: 1279-1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 18
    • 84866524744 scopus 로고    scopus 로고
    • A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self
    • Lee, H.M., Bautista, J. L., Scott-Browne, J., Mohan, J. F. and Hsieh, C. S., A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 2012. 37: 475-486.
    • (2012) Immunity , vol.37 , pp. 475-486
    • Lee, H.M.1    Bautista, J.L.2    Scott-Browne, J.3    Mohan, J.F.4    Hsieh, C.S.5
  • 19
    • 37849008688 scopus 로고    scopus 로고
    • Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
    • Burchill, M.A., Yang, J., Vang, K. B., Moon, J. J., Chu, H. H., Lio, C. W., Vegoe, A. L. et al., Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 2008. 28: 112-121.
    • (2008) Immunity , vol.28 , pp. 112-121
    • Burchill, M.A.1    Yang, J.2    Vang, K.B.3    Moon, J.J.4    Chu, H.H.5    Lio, C.W.6    Vegoe, A.L.7
  • 20
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells
    • Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S. and Chen, W., A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells. Nat. Immunol. 2008. 9: 632-440.
    • (2008) Nat. Immunol. , vol.9 , pp. 440-632
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 21
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot, J. D., Dooley, J. L., Farr, A. G. and Rudensky, A. Y., Developmental regulation of Foxp3 expression during ontogeny. J. Exp. Med. 2005. 202: 901-906.
    • (2005) J. Exp. Med. , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 22
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., Jin, W., Hardegen, N., Lei, K. J., Li, L., Marinos, N., McGrady, G. and Wahl, S. M., Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 2003. 198: 1875-1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 23
    • 33947644716 scopus 로고    scopus 로고
    • Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
    • Davidson, T. S., DiPaolo, R. J., Ersson, J. and Shevach, E. M., Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J. Immunol. 2007. 178: 4022-4026.
    • (2007) J. Immunol. , vol.178 , pp. 4022-4026
    • Davidson, T.S.1    DiPaolo, R.J.2    Ersson, J.3    Shevach, E.M.4
  • 24
    • 44849096534 scopus 로고    scopus 로고
    • Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg
    • Horwitz, D.A., Zheng, S. G., Wang, J. and Gray, J. D., Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg. Eur. J. Immunol. 2008. 38: 912-915.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 912-915
    • Horwitz, D.A.1    Zheng, S.G.2    Wang, J.3    Gray, J.D.4
  • 26
    • 84903754303 scopus 로고    scopus 로고
    • In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response
    • Kasagi, S., Zhang, P., Che, L., Abbatiello, B., Maruyama, T., Nakatsukasa, H., Zanvit, P. et al., In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response. Sci. Transl. Med. 2014. 6: 241ra78.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 241-278
    • Kasagi, S.1    Zhang, P.2    Che, L.3    Abbatiello, B.4    Maruyama, T.5    Nakatsukasa, H.6    Zanvit, P.7
  • 27
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li, M. O., Sanjabi, S. and Flavell, R. A., Transforming growth factor-beta controls development, homeostasis and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006. 25: 455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 28
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie, J. C., Liggitt, D. and Rudensky, A. Y., Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 2006. 25: 441-454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 29
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996. 184: 387-396.
    • (1996) J. Exp. Med. , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 30
    • 77953267301 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    • Ouyang, W., Beckett, O., Ma, Q. and Li, M. O., Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity 2010. 32: 642-653.
    • (2010) Immunity , vol.32 , pp. 642-653
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Li, M.O.4
  • 31
    • 0034022166 scopus 로고    scopus 로고
    • TGF-beta influences the life and death decisions of T lymphocytes
    • Wahl, S. M., Orenstein, J. M. and Chen, W., TGF-beta influences the life and death decisions of T lymphocytes. Cytokine Growth Factor Rev. 2000. 11: 71-79.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 71-79
    • Wahl, S.M.1    Orenstein, J.M.2    Chen, W.3
  • 32
    • 0035920554 scopus 로고    scopus 로고
    • Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    • Chen, W., Jin, W., Tian, H., Sicurello, P., Frank, M., Orenstein, J. M. and Wahl, S. M., Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J. Exp. Med. 2001. 194: 439-453.
    • (2001) J. Exp. Med. , vol.194 , pp. 439-453
    • Chen, W.1    Jin, W.2    Tian, H.3    Sicurello, P.4    Frank, M.5    Orenstein, J.M.6    Wahl, S.M.7
  • 34
    • 67649844269 scopus 로고    scopus 로고
    • Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control
    • Wirnsberger, G., Mair, F. and Klein, L., Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control. Proc. Natl. Acad. Sci. USA 2009. 106: 10278-10283.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10278-10283
    • Wirnsberger, G.1    Mair, F.2    Klein, L.3
  • 36
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3+ regulatory T cells specific for self-antigen expressed and presented by Aire+ medullary thymic epithelial cells
    • Aschenbrenner, K., D'Cruz, L. M., Vollmann, E. H., Hinterberger, M., Emmerich, J., Swee, L. K., Rolink, A. and Klein, L., Selection of Foxp3+ regulatory T cells specific for self-antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat. Immunol. 2007. 8: 351-358.
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6    Rolink, A.7    Klein, L.8
  • 37
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C.D. and Sprent, J., T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994. 372: 100-103.
    • (1994) Nature , vol.372 , pp. 100-103
    • Surh, C.D.1    Sprent, J.2
  • 38
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2 and PAF
    • Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y. and Henson, P. M., Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2 and PAF. J. Clin. Invest. 1998. 101: 890-898.
    • (1998) J. Clin. Invest. , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3    Freed, P.W.4    Westcott, J.Y.5    Henson, P.M.6
  • 39
    • 51549110623 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells
    • Xiao, Y.Q., Freire-de-Lima, C. G., Schiemann, W. P., Bartton, D. L., Vandivier, R. W. and Henson, P. M., Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J. Immunol. 2008. 181: 3575-3585.
    • (2008) J. Immunol. , vol.181 , pp. 3575-3585
    • Xiao, Y.Q.1    Freire-de-Lima, C.G.2    Schiemann, W.P.3    Bartton, D.L.4    Vandivier, R.W.5    Henson, P.M.6
  • 40
    • 0034960320 scopus 로고    scopus 로고
    • TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
    • Chen, W., Frank, M. E., Jin, W. and Wahl, S. M., TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity 2001. 14: 715-725.
    • (2001) Immunity , vol.14 , pp. 715-725
    • Chen, W.1    Frank, M.E.2    Jin, W.3    Wahl, S.M.4
  • 42
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • van Santen, H. M., Benoist, C. and Mathis, D., Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J. Exp. Med. 2004. 200: 1221-1230.
    • (2004) J. Exp. Med. , vol.200 , pp. 1221-1230
    • van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 43
    • 51649112340 scopus 로고    scopus 로고
    • T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    • Pesu, M., Watford, W. T., Wei, L., Xu, L., Fuss, I., Strober, W., Ersson, J. et al., T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 2008. 455: 246-250.
    • (2008) Nature , vol.455 , pp. 246-250
    • Pesu, M.1    Watford, W.T.2    Wei, L.3    Xu, L.4    Fuss, I.5    Strober, W.6    Ersson, J.7
  • 44
    • 84896973126 scopus 로고    scopus 로고
    • TGF-beta activation and function in immunity
    • Travis, M. A. and Sheppard, D., TGF-beta activation and function in immunity. Annu. Rev. Immunol. 2014. 32: 51-82.
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 51-82
    • Travis, M.A.1    Sheppard, D.2
  • 48
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
    • Zhang, Y., Feng, X. H. and Derynck, R., Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 1998. 394: 909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 49
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
    • Ruan, Q., Kameswaran, V., Tone, Y., Li, L., Liou, H. C., Greene, M. I., Tone, M. and Chen, Y. H., Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity 2009. 31: 932-940.
    • (2009) Immunity , vol.31 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3    Li, L.4    Liou, H.C.5    Greene, M.I.6    Tone, M.7    Chen, Y.H.8
  • 50
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R. and Zhang, Y. E., Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003. 425: 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 51
    • 78650309487 scopus 로고    scopus 로고
    • Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
    • Maruyama, T., Li, J., Vaque, J. P., Konkel, J. E., Wang, W., Zhang, B., Zhang, P. et al., Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat. Immunol. 2011. 12: 86-95.
    • (2011) Nat. Immunol. , vol.12 , pp. 86-95
    • Maruyama, T.1    Li, J.2    Vaque, J.P.3    Konkel, J.E.4    Wang, W.5    Zhang, B.6    Zhang, P.7
  • 52
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan, Y. Y., Chi, H., Xie, M., Schneider, M. D. and Flavell, R. A., The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 2006. 7: 851-858.
    • (2006) Nat. Immunol. , vol.7 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 53
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • Schlenner, S. M., Weigmann, B., Ruan, Q., Chen, Y. and vonBoehmer, H., Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J. Exp. Med. 2012. 209: 1529-1535.
    • (2012) J. Exp. Med. , vol.209 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    von Boehmer, H.5
  • 54
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X. P., Forbush, K. and Rudensky, A. Y., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010. 463: 808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.