Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 51, 2011, Pages 20808-20813

  Romanino, Klaas ^a   Mazelin, Laetitia ^b   Albert, Verena ^a   Conjard Duplany, Agnès ^c   Lin, Shuo ^a   Bentzinger, C Florian ^a,f   Handschin, Christoph ^a   Puigserver, Pere ^d   Zorzato, Francesco ^e   Schaeffer, Laurent ^b   Gangloff, Yann Gaël ^b   Rüegg, Markus A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITÉ DE LYON   (France)

^c Lyon 1 University   (France)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY HOSPITAL BASEL   (Switzerland)

^f OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BEZAFIBRATE; CARNITINE PALMITOYLTRANSFERASE I; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE I; CYTOCHROME C OXIDASE IV; DYSTROPHIN; GENOMIC DNA; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MEDIUM CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTENSOR DIGITORUM LONGUS MUSCLE; GENE OVEREXPRESSION; KNOCKOUT MOUSE; KYPHOSIS; MALE; MITOCHONDRION; MOUSE; MUSCLE FORCE; MUSCLE MASS; MYOPATHY; NONHUMAN; PRIORITY JOURNAL; SOLEUS MUSCLE; TIBIALIS ANTERIOR MUSCLE; TRANSGENIC MOUSE;

ANIMALS; BEZAFIBRATE; GENE EXPRESSION REGULATION; GLYCOGEN; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIA, MUSCLE; MODELS, GENETIC; MUSCLE, SKELETAL; MUSCULAR DISEASES; PROTEINS; TRANS-ACTIVATORS;

MAMMALIA; MUS;

EID: 84862965401     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111448109     Document Type: Article

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