메뉴 건너뛰기




Volumn 10, Issue 7, 2013, Pages

Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

Author keywords

[No Author keywords available]

Indexed keywords

DISUFENTON SODIUM;

EID: 84881240391     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001489     Document Type: Article
Times cited : (222)

References (64)
  • 1
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J, (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3: 711-715.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 2
    • 0037447488 scopus 로고    scopus 로고
    • Translation of highly promising basic science research into clinical applications
    • Contopoulos-Ioannidis DG, Ntzani E, Ioannidis JP, (2003) Translation of highly promising basic science research into clinical applications. Am J Med 114: 477-484.
    • (2003) Am J Med , vol.114 , pp. 477-484
    • Contopoulos-Ioannidis, D.G.1    Ntzani, E.2    Ioannidis, J.P.3
  • 3
    • 77952385324 scopus 로고    scopus 로고
    • Research ethics. Beyond access vs. protection in trials of innovative therapies
    • London AJ, Kimmelman J, Emborg ME, (2010) Research ethics. Beyond access vs. protection in trials of innovative therapies. Science 328: 829-830.
    • (2010) Science , vol.328 , pp. 829-830
    • London, A.J.1    Kimmelman, J.2    Emborg, M.E.3
  • 4
    • 84861998609 scopus 로고    scopus 로고
    • Should preclinical studies be registered?
    • Kimmelman J, Anderson JA, (2012) Should preclinical studies be registered? Nat Biotechnol 30: 488-489.
    • (2012) Nat Biotechnol , vol.30 , pp. 488-489
    • Kimmelman, J.1    Anderson, J.A.2
  • 5
    • 84859169880 scopus 로고    scopus 로고
    • Drug development: raise standards for preclinical cancer research
    • Begley CG, Ellis LM, (2012) Drug development: raise standards for preclinical cancer research. Nature 483: 531-533.
    • (2012) Nature , vol.483 , pp. 531-533
    • Begley, C.G.1    Ellis, L.M.2
  • 6
    • 80055088241 scopus 로고    scopus 로고
    • Believe it or not: how much can we rely on published data on potential drug targets?
    • Prinz F, Schlange T, Asadullah K, (2011) Believe it or not: how much can we rely on published data on potential drug targets? Nat Rev Drug Discov 10: 712.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 712
    • Prinz, F.1    Schlange, T.2    Asadullah, K.3
  • 7
    • 77950572352 scopus 로고    scopus 로고
    • Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    • doi 10.1371/journal.pbio.1000344
    • Sena ES, van der Worp HB, Bath PM, Howells DW, Macleod MR, (2010) Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol 8: e1000344 doi:10.1371/journal.pbio.1000344.
    • (2010) PLoS Biol , vol.8
    • Sena, E.S.1    van der Worp, H.B.2    Bath, P.M.3    Howells, D.W.4    Macleod, M.R.5
  • 8
    • 77950679333 scopus 로고    scopus 로고
    • Can animal models of disease reliably inform human studies?
    • doi 10.1371/journal.pmed.1000245
    • van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, et al. (2010) Can animal models of disease reliably inform human studies? PLoS Med 7: e1000245 doi:10.1371/journal.pmed.1000245.
    • (2010) PLoS Med , vol.7
    • van der Worp, H.B.1    Howells, D.W.2    Sena, E.S.3    Porritt, M.J.4    Rewell, S.5
  • 10
    • 66849097996 scopus 로고    scopus 로고
    • Update of the stroke therapy academic industry roundtable preclinical recommendations
    • Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, et al. (2009) Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40: 2244-2250.
    • (2009) Stroke , vol.40 , pp. 2244-2250
    • Fisher, M.1    Feuerstein, G.2    Howells, D.W.3    Hurn, P.D.4    Kent, T.A.5
  • 11
    • 41549162512 scopus 로고    scopus 로고
    • EQUATOR: reporting guidelines for health research
    • Altman DG, Simera I, Hoey J, Moher D, Schulz K, (2008) EQUATOR: reporting guidelines for health research. Lancet 371: 1149-1150.
    • (2008) Lancet , vol.371 , pp. 1149-1150
    • Altman, D.G.1    Simera, I.2    Hoey, J.3    Moher, D.4    Schulz, K.5
  • 12
    • 0344065373 scopus 로고    scopus 로고
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development
    • Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30: 2752-2758.
    • Stroke , vol.30 , pp. 2752-2758
  • 15
    • 85041813459 scopus 로고    scopus 로고
    • Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
    • doi 10.1371/journal.pbio.1000412
    • Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG, (2010) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8: e1000412 doi:10.1371/journal.pbio.1000412.
    • (2010) PLoS Biol , vol.8
    • Kilkenny, C.1    Browne, W.J.2    Cuthill, I.C.3    Emerson, M.4    Altman, D.G.5
  • 16
    • 77958165327 scopus 로고    scopus 로고
    • AGREE II: advancing guideline development, reporting, and evaluation in health care
    • Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, et al. (2010) AGREE II: advancing guideline development, reporting, and evaluation in health care. Prev Med 51: 421-424.
    • (2010) Prev Med , vol.51 , pp. 421-424
    • Brouwers, M.C.1    Kho, M.E.2    Browman, G.P.3    Burgers, J.S.4    Cluzeau, F.5
  • 18
    • 78650304989 scopus 로고    scopus 로고
    • Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis
    • Lamontagne F, Briel M, Duffett M, Fox-Robichaud A, Cook DJ, et al. (2010) Systematic review of reviews including animal studies addressing therapeutic interventions for sepsis. Crit Care Med 38: 2401-2408.
    • (2010) Crit Care Med , vol.38 , pp. 2401-2408
    • Lamontagne, F.1    Briel, M.2    Duffett, M.3    Fox-Robichaud, A.4    Cook, D.J.5
  • 19
    • 33747644452 scopus 로고    scopus 로고
    • A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting
    • Peters JL, Sutton AJ, Jones DR, Rushton L, Abrams KR, (2006) A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting. J Environ Sci Health B 41: 1245-1258.
    • (2006) J Environ Sci Health B , vol.41 , pp. 1245-1258
    • Peters, J.L.1    Sutton, A.J.2    Jones, D.R.3    Rushton, L.4    Abrams, K.R.5
  • 20
    • 84858976293 scopus 로고    scopus 로고
    • Inroads to predict in vivo toxicology-an introduction to the eTOX Project
    • Briggs K, Cases M, Heard DJ, Pastor M, Pognan F, et al. (2012) Inroads to predict in vivo toxicology-an introduction to the eTOX Project. Int J Mol Sci 13: 3820-3846.
    • (2012) Int J Mol Sci , vol.13 , pp. 3820-3846
    • Briggs, K.1    Cases, M.2    Heard, D.J.3    Pastor, M.4    Pognan, F.5
  • 21
    • 45749118607 scopus 로고    scopus 로고
    • Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project
    • Taylor CF, Field D, Sansone SA, Aerts J, Apweiler R, et al. (2008) Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nat Biotechnol 26: 889-896.
    • (2008) Nat Biotechnol , vol.26 , pp. 889-896
    • Taylor, C.F.1    Field, D.2    Sansone, S.A.3    Aerts, J.4    Apweiler, R.5
  • 22
    • 35948989284 scopus 로고    scopus 로고
    • The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration
    • Smith B, Ashburner M, Rosse C, Bard J, Bug W, et al. (2007) The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration. Nat Biotechnol 25: 1251-1255.
    • (2007) Nat Biotechnol , vol.25 , pp. 1251-1255
    • Smith, B.1    Ashburner, M.2    Rosse, C.3    Bard, J.4    Bug, W.5
  • 23
    • 76849104977 scopus 로고    scopus 로고
    • Survey of the quality of experimental design, statistical analysis and reporting of research using animals
    • doi 10.1371/journal.pone.0007824
    • Kilkenny C, Parsons P, Kadyszewski E, Festing MF, Cuthill IC, et al. (2010) Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4: e7824 doi:10.1371/journal.pone.0007824.
    • (2010) PLoS One , vol.4
    • Kilkenny, C.1    Parsons, P.2    Kadyszewski, E.3    Festing, M.F.4    Cuthill, I.C.5
  • 24
    • 34249980646 scopus 로고    scopus 로고
    • Drug administration in animal studies of cardiac arrest does not reflect human clinical experience
    • Reynolds JC, Rittenberger JC, Menegazzi JJ, (2007) Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. Resuscitation 74: 13-26.
    • (2007) Resuscitation , vol.74 , pp. 13-26
    • Reynolds, J.C.1    Rittenberger, J.C.2    Menegazzi, J.J.3
  • 27
    • 0028091401 scopus 로고
    • The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial
    • Noseworthy JH, Ebers GC, Vandervoort MK, Farquhar RE, Yetisir E, et al. (1994) The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology 44: 16-20.
    • (1994) Neurology , vol.44 , pp. 16-20
    • Noseworthy, J.H.1    Ebers, G.C.2    Vandervoort, M.K.3    Farquhar, R.E.4    Yetisir, E.5
  • 28
    • 40949113623 scopus 로고    scopus 로고
    • Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
    • Wood L, Egger M, Gluud LL, Schulz KF, Juni P, et al. (2008) Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 336: 601-605.
    • (2008) BMJ , vol.336 , pp. 601-605
    • Wood, L.1    Egger, M.2    Gluud, L.L.3    Schulz, K.F.4    Juni, P.5
  • 29
    • 41249090758 scopus 로고    scopus 로고
    • Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach
    • Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, et al. (2008) Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 39: 929-934.
    • (2008) Stroke , vol.39 , pp. 929-934
    • Crossley, N.A.1    Sena, E.2    Goehler, J.3    Horn, J.4    van der Worp, B.5
  • 30
    • 79957948408 scopus 로고    scopus 로고
    • Dopamine agonists in animal models of Parkinson's disease: a systematic review and meta-analysis
    • Rooke ED, Vesterinen HM, Sena ES, Egan KJ, Macleod MR, (2011) Dopamine agonists in animal models of Parkinson's disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 17: 313-320.
    • (2011) Parkinsonism Relat Disord , vol.17 , pp. 313-320
    • Rooke, E.D.1    Vesterinen, H.M.2    Sena, E.S.3    Egan, K.J.4    Macleod, M.R.5
  • 31
    • 70350303591 scopus 로고    scopus 로고
    • Effects of NXY-059 in experimental stroke: an individual animal meta-analysis
    • Bath PM, Gray LJ, Bath AJ, Buchan A, Miyata T, et al. (2009) Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol 157: 1157-1171.
    • (2009) Br J Pharmacol , vol.157 , pp. 1157-1171
    • Bath, P.M.1    Gray, L.J.2    Bath, A.J.3    Buchan, A.4    Miyata, T.5
  • 32
    • 33749615999 scopus 로고    scopus 로고
    • Translation of research evidence from animals to humans
    • Hackam DG, Redelmeier DA, (2006) Translation of research evidence from animals to humans. JAMA 296: 1731-1732.
    • (2006) JAMA , vol.296 , pp. 1731-1732
    • Hackam, D.G.1    Redelmeier, D.A.2
  • 34
    • 39649084919 scopus 로고    scopus 로고
    • The FDA critical path initiative and its influence on new drug development
    • Woodcock J, Woosley R, (2008) The FDA critical path initiative and its influence on new drug development. Annu Rev Med 59: 1-12.
    • (2008) Annu Rev Med , vol.59 , pp. 1-12
    • Woodcock, J.1    Woosley, R.2
  • 36
    • 67849135779 scopus 로고    scopus 로고
    • Combination therapies for traumatic brain injury: prospective considerations
    • Margulies S, Hicks R, (2009) Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma 26: 925-939.
    • (2009) J Neurotrauma , vol.26 , pp. 925-939
    • Margulies, S.1    Hicks, R.2
  • 38
    • 53049100118 scopus 로고    scopus 로고
    • Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards
    • Rice AS, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, et al. (2008) Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain 139: 243-247.
    • (2008) Pain , vol.139 , pp. 243-247
    • Rice, A.S.1    Cimino-Brown, D.2    Eisenach, J.C.3    Kontinen, V.K.4    Lacroix-Fralish, M.L.5
  • 39
    • 45049087094 scopus 로고    scopus 로고
    • Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
    • Grounds MD, Radley HG, Lynch GS, Nagaraju K, De Luca A, (2008) Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy. Neurobiol Dis 31: 1-19.
    • (2008) Neurobiol Dis , vol.31 , pp. 1-19
    • Grounds, M.D.1    Radley, H.G.2    Lynch, G.S.3    Nagaraju, K.4    De Luca, A.5
  • 40
    • 84855984716 scopus 로고    scopus 로고
    • Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice
    • Willmann R, Luca AD, Benatar M, Grounds M, Dubach J, et al. (2012) Enhancing translation: guidelines for standard pre-clinical experiments in mdx mice. Neuromuscul Disord 22: 43-49.
    • (2012) Neuromuscul Disord , vol.22 , pp. 43-49
    • Willmann, R.1    Luca, A.D.2    Benatar, M.3    Grounds, M.4    Dubach, J.5
  • 41
    • 0029990054 scopus 로고    scopus 로고
    • North of England evidence based guidelines development project: methods of guideline development
    • Eccles M, Clapp Z, Grimshaw J, Adams PC, Higgins B, et al. (1996) North of England evidence based guidelines development project: methods of guideline development. BMJ 312: 760-762.
    • (1996) BMJ , vol.312 , pp. 760-762
    • Eccles, M.1    Clapp, Z.2    Grimshaw, J.3    Adams, P.C.4    Higgins, B.5
  • 43
    • 84878650332 scopus 로고    scopus 로고
    • Announcement: Reducing our irreproducibility
    • Announcement: Reducing our irreproducibility. Nature 496: 398.
    • Nature , vol.496 , pp. 398
  • 44
    • 65549162019 scopus 로고    scopus 로고
    • Drug-eluting stents in preclinical studies: updated consensus recommendations for preclinical evaluation
    • Schwartz RS, Edelman E, Virmani R, Carter A, Granada JF, et al. (2008) Drug-eluting stents in preclinical studies: updated consensus recommendations for preclinical evaluation. Circ Cardiovasc Interv 1: 143-153.
    • (2008) Circ Cardiovasc Interv , vol.1 , pp. 143-153
    • Schwartz, R.S.1    Edelman, E.2    Virmani, R.3    Carter, A.4    Granada, J.F.5
  • 45
    • 0037401333 scopus 로고    scopus 로고
    • The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo
    • Verhagen H, Aruoma OI, van Delft JH, Dragsted LO, Ferguson LR, et al. (2003) The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo. Food Chem Toxicol 41: 603-610.
    • (2003) Food Chem Toxicol , vol.41 , pp. 603-610
    • Verhagen, H.1    Aruoma, O.I.2    van Delft, J.H.3    Dragsted, L.O.4    Ferguson, L.R.5
  • 48
    • 21044444574 scopus 로고    scopus 로고
    • New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development
    • Kamath AT, Fruth U, Brennan MJ, Dobbelaer R, Hubrechts P, et al. (2005) New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development. Vaccine 23: 3753-3761.
    • (2005) Vaccine , vol.23 , pp. 3753-3761
    • Kamath, A.T.1    Fruth, U.2    Brennan, M.J.3    Dobbelaer, R.4    Hubrechts, P.5
  • 49
    • 10244236377 scopus 로고    scopus 로고
    • Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    • Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, (2004) Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8: R204-R212.
    • (2004) Crit Care , vol.8
    • Bellomo, R.1    Ronco, C.2    Kellum, J.A.3    Mehta, R.L.4    Palevsky, P.5
  • 50
    • 84856604868 scopus 로고    scopus 로고
    • Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis
    • Moreno B, Espejo C, Mestre L, Suardiaz M, Clemente D, et al. (2012) [Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis.]. Rev Neurol 54: 114-124.
    • (2012) Rev Neurol , vol.54 , pp. 114-124
    • Moreno, B.1    Espejo, C.2    Mestre, L.3    Suardiaz, M.4    Clemente, D.5
  • 51
    • 85047679058 scopus 로고
    • The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion
    • Walker MJ, Curtis MJ, Hearse DJ, Campbell RW, Janse MJ, et al. (1988) The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia infarction, and reperfusion. Cardiovasc Res 22: 447-455.
    • (1988) Cardiovasc Res , vol.22 , pp. 447-455
    • Walker, M.J.1    Curtis, M.J.2    Hearse, D.J.3    Campbell, R.W.4    Janse, M.J.5
  • 52
    • 84879409719 scopus 로고    scopus 로고
    • The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias
    • E-pub ahead of print 10.1016/j.pharmthera.2013.04.008
    • Curtis M, Hancox J, Farkas A, Wainwright C, Stables C, et al. (2013) The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacol Ther E-pub ahead of print. doi: 10.1016/j.pharmthera.2013.04.008.
    • (2013) Pharmacol Ther
    • Curtis, M.1    Hancox, J.2    Farkas, A.3    Wainwright, C.4    Stables, C.5
  • 53
    • 0029855862 scopus 로고    scopus 로고
    • Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis
    • Piper RD, Cook DJ, Bone RC, Sibbald WJ, (1996) Introducing critical appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med 24: 2059-2070.
    • (1996) Crit Care Med , vol.24 , pp. 2059-2070
    • Piper, R.D.1    Cook, D.J.2    Bone, R.C.3    Sibbald, W.J.4
  • 55
    • 84867302438 scopus 로고    scopus 로고
    • A call for transparent reporting to optimize the predictive value of preclinical research
    • Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, et al. (2012) A call for transparent reporting to optimize the predictive value of preclinical research. Nature 490: 187-191.
    • (2012) Nature , vol.490 , pp. 187-191
    • Landis, S.C.1    Amara, S.G.2    Asadullah, K.3    Austin, C.P.4    Blumenstein, R.5
  • 56
    • 79952212677 scopus 로고    scopus 로고
    • Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy
    • Bolon B, Stolina M, King C, Middleton S, Gasser J, et al. (2011) Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacy. J Biomed Biotechnol 2011: 569068.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 569068
    • Bolon, B.1    Stolina, M.2    King, C.3    Middleton, S.4    Gasser, J.5
  • 57
    • 62449174377 scopus 로고    scopus 로고
    • Good laboratory practice: preventing introduction of bias at the bench
    • Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, et al. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke 40: e50-e52.
    • (2009) Stroke , vol.40
    • Macleod, M.R.1    Fisher, M.2    O'Collins, V.3    Sena, E.S.4    Dirnagl, U.5
  • 58
    • 84881263546 scopus 로고    scopus 로고
    • US National Institutes of Health National Institute of Neurological Disorders and Stroke Bethesda (Maryland): US National Institutes of Health National Institute of Neurological Disorders and Stroke
    • US National Institutes of Health National Institute of Neurological Disorders and Stroke (2011) Improving the quality of NINDS-supported preclinical and clinical research through rigorous study design and transparent reporting. Bethesda (Maryland): US National Institutes of Health National Institute of Neurological Disorders and Stroke.
    • (2011) Improving the quality of NINDS-supported preclinical and clinical research through rigorous study design and transparent reporting
  • 59
    • 80054682663 scopus 로고    scopus 로고
    • The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies
    • Pullen N, Birch CL, Douglas GJ, Hussain Q, Pruimboom-Brees I, et al. (2011) The translational challenge in the development of new and effective therapies for endometriosis: a review of confidence from published preclinical efficacy studies. Hum Reprod Update 17: 791-802.
    • (2011) Hum Reprod Update , vol.17 , pp. 791-802
    • Pullen, N.1    Birch, C.L.2    Douglas, G.J.3    Hussain, Q.4    Pruimboom-Brees, I.5
  • 60
    • 84862297965 scopus 로고    scopus 로고
    • Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies
    • Shineman DW, Basi GS, Bizon JL, Colton CA, Greenberg BD, et al. (2011) Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies. Alzheimers Res Ther 3: 28.
    • (2011) Alzheimers Res Ther , vol.3 , pp. 28
    • Shineman, D.W.1    Basi, G.S.2    Bizon, J.L.3    Colton, C.A.4    Greenberg, B.D.5
  • 61
    • 3342971030 scopus 로고    scopus 로고
    • Myocardial protection at a crossroads: the need for translation into clinical therapy
    • Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, et al. (2004) Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 95: 125-134.
    • (2004) Circ Res , vol.95 , pp. 125-134
    • Bolli, R.1    Becker, L.2    Gross, G.3    Mentzer Jr., R.4    Balshaw, D.5
  • 62
    • 60549090781 scopus 로고    scopus 로고
    • Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke
    • Stem Cell Therapies as an Emerging Paradigm in Stroke Participants
    • Stem Cell Therapies as an Emerging Paradigm in Stroke Participants (2009) Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 40: 510-515.
    • (2009) Stroke , vol.40 , pp. 510-515
  • 63
    • 79952072156 scopus 로고    scopus 로고
    • Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II
    • Savitz SI, Chopp M, Deans R, Carmichael ST, Phinney D, et al. (2011) Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II. Stroke 42: 825-829.
    • (2011) Stroke , vol.42 , pp. 825-829
    • Savitz, S.I.1    Chopp, M.2    Deans, R.3    Carmichael, S.T.4    Phinney, D.5
  • 64
    • 84870018625 scopus 로고    scopus 로고
    • Preclinical research in Rett syndrome: setting the foundation for translational success
    • Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, et al. (2012) Preclinical research in Rett syndrome: setting the foundation for translational success. Dis Model Mech 5: 733-745.
    • (2012) Dis Model Mech , vol.5 , pp. 733-745
    • Katz, D.M.1    Berger-Sweeney, J.E.2    Eubanks, J.H.3    Justice, M.J.4    Neul, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.