Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages 9770-9775

  McCain, Megan L ^a   Sheehy, Sean P ^a   Grosberg, Anna ^a,b   Goss, Josue A ^a   Parker, Kevin Kit ^a  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Contraction; Mechanotransduction; Microarray; Muscular thin films; Organs on chips

Indexed keywords

CALCIUM; MYOSIN HEAVY CHAIN ALPHA; MYOSIN HEAVY CHAIN BETA; SILICONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHIP; CELL SHAPE; CLINICAL OBSERVATION; CYTOARCHITECTURE; GENE EXPRESSION PROFILING; HEART CONTRACTION; HEART FAILURE; HEART FUNCTION; HEART VENTRICLE; IN VITRO STUDY; MICROENVIRONMENT; MUSCLE STRENGTH; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMERE;

CONTRACTION; MECHANOTRANSDUCTION; MICROARRAY; MUSCULAR THIN FILMS; ORGANS ON CHIPS;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELLS, CULTURED; GENE EXPRESSION PROFILING; HEART FAILURE; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS, SPRAGUE-DAWLEY; SARCOMERES; SYSTOLE; TIME FACTORS; VENTRICULAR MYOSINS; VENTRICULAR REMODELING;

ANIMALIA;

EID: 84878958845     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304913110     Document Type: Article

References (60)

1. Lorell BH, Carabello BA (2000) Left ventricular hypertrophy: Pathogenesis, detection, and prognosis. Circulation 102(4):470-479. (Pubitemid 30490688)
2. Gerdes AM (2002) Cardiac myocyte remodeling in hypertrophy and progression to failure. J Card Fail 8(6, suppl):S264-S268.
3. Grossman W, Jones D, McLaurin LP (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56(1):56-64.
4. Ho CY (2009) Hypertrophic cardiomyopathy: Preclinical and early phenotype. J Cardiovasc Transl Res 2(4):462-470.
5. Jane-Lise S, Corda S, Chassagne C, Rappaport L (2000) The extracellular matrix and the cytoskeleton in heart hypertrophy and failure. Heart Fail Rev 5(3):239-250.
6. Gerdes AM, Onodera T, Wang X, McCune SA (1996) Myocyte remodeling during the progression to failure in rats with hypertension. Hypertension 28(4):609-614. (Pubitemid 26327957)
7. Gerdes AM (1992) Remodeling of ventricular myocytes during cardiac hypertrophy and heart failure. J Fla Med Assoc 79(4):253-255.
8. Gupta MP (2007) Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure. J Mol Cell Cardiol 43(4):388-403.
9. Miyata S, Minobe W, Bristow MR, Leinwand LA (2000) Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res 86(4):386-390. (Pubitemid 30141756)
10. Gómez AM, et al. (1997) Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276(5313):800-806. (Pubitemid 27199861)
11. Piacentino V, 3rd, et al. (2003) Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res 92(6):651-658.
12. Wilson JR, et al. (1987) Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects. Circulation 75(4):857-867. (Pubitemid 17052671)
13. Mulieri LA, Hasenfuss G, Leavitt B, Allen PD, Alpert NR (1992) Altered myocardial force-frequency relation in human heart failure. Circulation 85(5):1743-1750.
14. Davies CH, et al. (1995) Reduced contraction and altered frequency response of isolated ventricular myocytes from patients with heart failure. Circulation 92(9):2540-2549.
15. Carll AP, Willis MS, Lust RM, Costa DL, Farraj AK (2011) Merits of non-invasive rat models of left ventricular heart failure. Cardiovasc Toxicol 11(2):91-112.
16. Kelso EJ, et al. (1996) Mechanical effects of ET-1 in cardiomyocytes isolated from normal and heart-failed rabbits. Mol Cell Biochem 157(1-2):149-155. (Pubitemid 26142447)
17. Frank D, et al. (2008) Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension 51(2):309-318. (Pubitemid 351159944)
18. Gopalan SM, et al. (2003) Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng 81(5):578-587. (Pubitemid 36222316)
19. Blaauw E, et al. (2010) Stretch-induced hypertrophy of isolated adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol 299(3):H780-H787.
20. Kensah G, et al. (2011) A novel miniaturized multimodal bioreactor for continuous in situ assessment of bioartificial cardiac tissue during stimulation and maturation. Tissue Eng Part C Methods 17(4):463-473.
21. Rana OR, et al. (2008) A simple device to apply equibiaxial strain to cells cultured on flexible membranes. Am J Physiol Heart Circ Physiol 294(1):H532-H540.
22. Bhadriraju K, Chen CS (2002) Engineering cellular microenvironments to improve cell-based drug testing. Drug Discov Today 7(11):612-620. (Pubitemid 34606016)
23. Balachandran K, et al. (2011) Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci USA 108(50):19943-19948.
24. Grosberg A, Alford PW, McCain ML, Parker KK (2011) Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip 11(24):4165-4173.
25. Alford PW, et al. (2011) Blast-induced phenotypic switching in cerebral vasospasm. Proc Natl Acad Sci USA 108(31):12705-12710.
26. Zhuang J, Yamada KA, Saffitz JE, Kléber AG (2000) Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circ Res 87(4):316-322. (Pubitemid 30655973)
27. Yamada K, Green KG, Samarel AM, Saffitz JE (2005) Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch. Circ Res 97(4):346-353. (Pubitemid 41216139)
28. Greenbaum RA, Ho SY, Gibson DG, Becker AE, Anderson RH (1981) Left ventricular fibre architecture in man. Br Heart J 45(3):248-263. (Pubitemid 11137851)
29. Alford PW, Feinberg AW, Sheehy SP, Parker KK (2010) Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials 31(13):3613-3621.
30. Barry SP, Davidson SM, Townsend PA (2008) Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol 40(10):2023-2039.
31. Eichler GS, Huang S, Ingber DE (2003) Gene Expression Dynamics Inspector (GEDI): For integrative analysis of expression profiles. Bioinformatics 19(17):2321-2322. (Pubitemid 37483992)
32. Sheehy SP, Huang S, Parker KK (2009) Time-warped comparison of gene expression in adaptive and maladaptive cardiac hypertrophy. Circ Cardiovasc Genet 2(2):116-124.
33. Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30(1):207-210. (Pubitemid 34679544)
34. Eder P, Molkentin JD (2011) TRPC channels as effectors of cardiac hypertrophy. Circ Res 108(2):265-272.
35. Martínez ML, Heredia MP, Delgado C (1999) Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts. J Mol Cell Cardiol 31(9):1617-1625. (Pubitemid 29414582)
36. Xing W, et al. (2006) Myocardin induces cardiomyocyte hypertrophy. Circ Res 98(8): 1089-1097.
37. Torrado M, et al. (2003) Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy. J Mol Med (Berl) 81(9):566-577. (Pubitemid 37214995)
38. Cribbs L (2010) T-type calcium channel expression and function in the diseased heart. Channels (Austin) 4(6):447-452.
39. Heling A, et al. (2000) Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium. Circ Res 86(8):846-853. (Pubitemid 30246981)
40. LeGrice IJ, et al. (2012) Progression of myocardial remodeling and mechanical dysfunction in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol 303(11):H1353-H1365.
41. Parker KK, Ingber DE (2007) Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci 362(1484):1267-1279. (Pubitemid 47195021)
42. Terracio L, et al. (1991) Expression of collagen binding integrins during cardiac development and hypertrophy. Circ Res 68(3):734-744.
43. Clemente CF, et al. (2012) Focal adhesion kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways. J Mol Cell Cardiol 52(2):493-501.
44. Lu H, et al. (2006) Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 114(21):2271-2279. (Pubitemid 44789501)
45. Pong T, et al. (2011) Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med (Maywood) 236(3):366-373.
46. Pope AJ, Sands GB, Smaill BH, LeGrice IJ (2008) Three-dimensional transmural organization of perimysial collagen in the heart. Am J Physiol Heart Circ Physiol 295(3):H1243-H1252.
47. Strijkers GJ, et al. (2009) Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse. NMR Biomed 22(2):182-190.
48. Feinberg AW, et al. (2012) Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials 33(23):5732-5741.
49. Bers DM (2008) Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 70:23-49.
50. Simpson DG, Majeski M, Borg TK, Terracio L (1999) Regulation of cardiac myocyte protein turnover and myo fibrillar structure in vitro by specific directions of stretch. Circ Res 85(10):e59-e69.
51. Gaasch WH (1994) Diagnosis and treatment of heart failure based on left ventricular systolic or diastolic dysfunction. JAMA 271(16):1276-1280.
52. Berry MF, et al. (2006) Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 290(6):H2196-H2203. (Pubitemid 43846045)
53. Huh D, et al. (2010) Reconstituting organ-level lung functions on a chip. Science 328 (5986):1662-1668.
54. Huh D, Torisawa YS, Hamilton GA, Kim HJ, Ingber DE (2012) Microengineered physiological biomimicry: Organs-on-chips. Lab Chip 12(12):2156-2164.
55. Hirt MN, et al. (2012) Increased afterload induces pathological cardiac hypertrophy: a new in vitro model. Basic Res Cardiol 107(6):307.
56. Davis RP, van den Berg CW, Casini S, Braam SR, Mummery CL (2011) Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med 17(9):475-484.
57. Bray MA, Sheehy SP, Parker KK (2008) Sarcomere alignment is regulated by myocyte shape. Cell Motil Cytoskeleton 65(8):641-651.
58. Irizarry RA, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31(4):e15.
59. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article3.
60. Howlett SE, Grandy SA, Ferrier GR (2006) Calciumspark properties in ventricularmyocytes are altered in aged mice. Am J Physiol Heart Circ Physiol 290(4):H1566-H1574.