An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure

Science Translational Medicine

Volumn 4, Issue 159, 2012, Pages

  Thorneloe, Kevin S ^a   Cheung, Mui ^a   Bao, Weike ^a   Alsaid, Hasan ^a   Lenhard, Stephen ^a   Jian, Ming Yuan ^b   Costell, Melissa ^a   Maniscalco Hauk, Kristeen ^a   Krawiec, John A ^a   Olzinski, Alan ^a   Gordon, Earl ^a   Lozinskaya, Irina ^a   Elefante, Lou ^a   Qin, Pu ^a   Matasic, Daniel S ^a   James, Chris ^a   Tunstead, James ^a   Donovan, Brian ^a   Kallal, Lorena ^a   Waszkiewicz, Anna ^a   Vaidya, Kalindi ^a   Davenport, Elizabeth A ^a   Larkin, Jonathan ^a   Burgert, Mark ^a   Casillas, Linda N ^a   Marquis, Robert W ^a   Ye, Guosen ^a   Eidam, Hilary S ^a   Goodman, Krista B ^a   Toomey, John R ^a   Roethke, Theresa J ^a   Jucker, Beat M ^a   Schnackenberg, Christine G ^a   Townsley, Mary I ^b   Lepore, John J ^a   Willette, Robert N ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIURETIC AGENT; FUROSEMIDE; GSK 1016790; GSK 2193874; GSK 2263095; GSK 634775; HYDROCHLOROTHIAZIDE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ANTIBODY LABELING; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD VESSEL PERMEABILITY; CALCIUM TRANSPORT; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; HEART FAILURE; HEART INFARCTION; HUMAN; HUMAN TISSUE; IC 50; IMMUNOREACTIVITY; LUNG CAPILLARY; LUNG EDEMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; VENOUS PRESSURE;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PRESSURE; CALCIUM; DISEASE MODELS, ANIMAL; DIURETICS; ENDOTHELIUM; HEART FAILURE; HEART RATE; HUMANS; ION CHANNEL GATING; LUNG; MEMBRANE TRANSPORT MODULATORS; MICE; MICE, KNOCKOUT; PERMEABILITY; PROTEIN TRANSPORT; PULMONARY EDEMA; RATS; TRPV CATION CHANNELS; WATER-ELECTROLYTE BALANCE;

EID: 84869141720     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3004276     Document Type: Article

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