Solid lipid nanoparticles: Promising therapeutic nanocarriers for drug delivery

Current Drug Delivery

Volumn 11, Issue 6, 2014, Pages 771-791

  Thukral, Dipti Kakkar ^a   Dumoga, Shweta ^a   Mishra, Anil K ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Administration routes; Cancer chemotherapy; Characterization; Drug delivery; Solid lipid nanoparticles

Indexed keywords

ADJUVANT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ELECTROLYTE; EMULSIFYING AGENT; NANOCARRIER; PEPTIDES AND PROTEINS; SOLID LIPID NANOPARTICLE; TUBERCULOSTATIC AGENT; VACCINE; DRUG; DRUG CARRIER; LIPID; NANOPARTICLE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BLOOD BRAIN BARRIER; BREAST CANCER; CANCER CHEMOTHERAPY; CHEMICAL COMPOSITION; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ELECTRON MICROSCOPY; ELECTRON SPIN RESONANCE; FREEZE DRYING; GENE TARGETING; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; INTRANASAL DRUG ADMINISTRATION; INTRAOCULAR DRUG ADMINISTRATION; LIGHT EXPOSURE; LIPOPHILICITY; LUNG CANCER; NANOEMULSION; NUCLEAR MAGNETIC RESONANCE; ORAL DRUG ADMINISTRATION; PARENTERAL DRUG ADMINISTRATION; PARTICLE SIZE; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TEMPERATURE SENSITIVITY; TOPICAL DRUG ADMINISTRATION; ZETA POTENTIAL; CHEMICAL PHENOMENA; CHEMISTRY; MEDICINAL CHEMISTRY;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS;

EID: 84926383059     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/156720181106141202122335     Document Type: Article

References (244)

1. Allen, T.M.; Cullis, P.R. Drug delivery systems: entering the mainstream. Science, 2004, 303(5665), 1818-1822.
2. Zhang, X.; Huang, Y.; Li, S. Nanomicellar carriers for targeted delivery of anticancer agents. Ther. Deliv., 2014, 5(1), 53-68.
3. Allen, T.M.; Cullis, P.R. Liposomal drug delivery systems: From concept to clinical applications. Adv. Drug Deliv. Rev., 2013, 65, 36-48.
4. Gregoriadis, G. Homing of Liposomes to Target-Cells. Biochem. Soc. Trans., 1975, 3(5), 613-618.
5. Torchilin, V.P. Liposomes as delivery agents for medical imaging. Mol. Med. Today, 1996, 2(6), 242-249.
6. Ali, M.H.; Moghaddam, B.; Kirby, D.J.; Mohammed, A.R.; Perrie, Y. The role of lipid geometry in designing liposomes for the solubilisation of poorly water soluble drugs. Int. J. Pharm., 2013, 453(1), 225-232.
7. Karewicz, A.; Bielska, D.; Gzyl-Malcher, B.; Kepczynski, M.; Lach, R.; Nowakowska, M. Interaction of curcumin with lipid monolayers and liposomal bilayers. Colloids Surf. B Biointerfaces. 2011, 88(1), 231-239.
8. You, J.; Wan, F.; Cui, F.D.; Sun, Y.; Du, Y.; Hu, F.Q. Preparation and characteristic of vinorelbinebitartrate-loaded solid lipid nanoparticles. Int. J. Pharm., 2007, 343, 270-276.
9. Laouini, A.; Jaafar-Maalej, C.; Limayem-Blouza, I.; Sfar, S.; Charcosset, C.; Fessi, H. Preparation, Characterization and Applications of Liposomes: State of the Art. Colloid Sci. Biotechnol., 2012, 1, 147-168.
10. Batist, G.; Ramakrisshan, G.; Rao, C.S.; Chandrasekharan, A.; Gutheil, J.; Guthrie, T.; Shah, P.; Khojasteh, A.; Nair, M.K.; Hoelzer, K.; Tkaczuk, K.; Park, Y.C.; Lee, L.W. Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamidein a randomized, multicenter trial of metastatic breast cancer. J. Clin. Oncol., 2001, 19(5), 1444-1454.
11. Gabizon, A.; Martin, F. Polyethylene glycol-coated (pegylated) liposomal doxorubicin. Rationale for use in solid tumors. Drugs, 1997, 54, 15-21.
12. Yuan, H.; Chen, C.Y.; Chai, G.H.; Du, Y.Z.; Hu, F.Q. Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles. Mol. Pharm., 2013, 10(5), 1865-1873.
13. Trotta, M.; Debernardi, F.; Caputo, O. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int. J. Pharm., 2003, 257, 153-160.
14. Trotta, M.; Cavalli, R.; Carlotti, M.E.; Battaglia, L.; Debernardi, F. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. Int. J. Pharm., 2005, 288, 281-288.
15. Rupenagunta, A.; Somasundaram, I.; Ravichandiram, V.; Kausalya, J.; Senthilnathan, B. Solid lipid nanoparticles- A versatile carrier system. J. Pharm. Res., 2011, 4(7), 2069-2075.
16. Fahr, A.; Liu, X. Drug delivery strategies for poorly water soluble drugs. Expert Opin. Drug Deliv., 2007, 4(4), 403-416.
17. Martins, S.; Sarmento, B.; Ferreira, D.C.; Souto, E.B. Lipidnanoparticles. Int. J. Nanomed., 2007, 2(4), 595-607.
18. Zang, X.G.; Miao, J.; Dai, Y.Q.; Du, Y.Z.; Yaun, H.; Hu, F.Q. Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cell. Int. J. Pharm., 2008, 361(1-2), 239-244.
19. Wissing, S.A.; Muller, R.H. The influence of solid lipid nanoparticles on skin hydration and viscoelasticity-in vivo. Eur. J. Pharm. Biopharm., 2003, 56(1), 67-72.
20. Li, Y.C.; Dong, L.; Jia, A.; Chang, X.M.; Xue, H. Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization. Nan. Fang. Yi. Ke. Da. Xue. Xue. Bao., 2006, 26(5), 541-544.
21. Fadda, P.; Monduzzi, M.; Caboi, F.; Piras, S.; Lazzari, P. Solid lipid nanoparticle preparation by a warm microemulsion based process: influence of microemulsion microstructure. Int. J. Pharm., 2013, 446(1-2), 166-175.
22. Mojahedian, M.M.; Daneshamouz, S.; Samani, S.M.; Zargaran, A. A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique. Chem. Phys. Lipids, 2013, 174, 32-38.
23. Palei, N. N.; Das, M. K. Preparation and characterization of lornoxicam loaded solid lipid nanoparticles made from different lipids. Int. J. Pharm. Pharm. Sci., 2013, 5, 438-442.
24. Schubert, M.A.; Muller-Goymann, C.C. Characterization of surface- modified solid lipid nanoparticles (SLNs). Influence of lecithin and non-ionic emulsifier. Eur. J. Pharm. Biopharm., 2005, 61(1-2), 77-86.
25. Schubert, M.A.; Harms, N.; Muller-Goymann, C.C. Structural investigation on lipid nanoparticle containing high amount lecithin. Eur. J. Pharm. Sci., 2006, 27(2-3), 226-236.
26. Heurtault, B.; Saulnier, P.; Pech, B.; Proust, J.E.; Benoit, J.P. A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm. Res., 2002, 19(6), 875-880.
27. Gfarcia-Fuentes, M.; Torres, D.; Martin-Pastor, M.; Alonso, M.J. Application of NMR spectroscopy to the characterization of PEGstabilized lipid nanoparticles. Langmuir, 2004, 20(20), 8839-8845.
28. Gfarcia-Fuentes, M.; Alonso, M.J.; Torres, D. Design and characterization of a new drug nanocarrier made from solid-liquid lipid mixtures. J. Colloid. Interface Sci., 2005, 285(2), 590-598.
29. Silva, A.C.; González-Mira, E.; García, M.L.; Egea, M.A.; Fonseca, J.; Silva, R.; Santos, D.; Souto, E.B.; Ferreira, D. Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf. B.Biointerfaces, 2011, 86(1), 158-165.
30. Charcosset, C.; El-Harati, A.; Fessi, H. Preparation of solid lipid nanoparticles using a membrane contractor. J. Control. Release, 2005, 108(1), 112-120.
31. Akbari, Z.; Amanlou, M.; Karimi-Sabet, J.; Golestani, A.; Niassar, M.S. Preparation and characterization of solid lipid nanoparticles through rapid expansion of supercritical solution. Int. Pharm. Sci. Res., 2014, 5(5), 1693-1704.
32. Azarmi, S.; Huang, Y.; Chen, H.; McQuarrie, M.; Abrams, D.; Roa, W.; Finlay, W. H.; Miller, G. G.; Löbenberg, R. Optimization of a two-step desolvation method for preparing gelatin nanoparticles and cell uptake studies in 143B osteosarcoma cancer cells. J. Pharm. Pharm. Sci., 2006, 9(1), 124-132.
33. Martena, V.; Censi, R.; Hoti, E.; Malaj, L.; Martino, P.D. A new nanospray drying method for the preparation of nicergoline pure nanoparticles. J. Nanoparticle Res., 2012, 14, 934.
34. Alayoubi, A.; Ayoub, N.M.; Malaviya, A.; Sylvester, P.W.; Nazzal, S. Entrapment into nanoemulsions potentiates the anticancer activity of tocotrienols against the highly malignant (+SA) mouse mammary epithelial cells. J. Nanosci. Nanotechnol., 2014, 14(5), 4002-4005.
35. Paliwal, R.; Rai, S.; Vaidya, B.; Khatri, K.; Goyal, A. K.; Mishra, N.; Mehta, A.; Vyas, S. P. Effect of lipid core material on characteristics of solid lipid nanoparticles designed for oral lymphatic delivery. Nanomedicine, 2009, 5, 184-191.
36. Bunjes, H.; Koch, M.H.; Westesen, K. Influence of emulsifiers on the crystallization of solid lipid nanoparticles. J. Pharm. Sci., 2003, 92(7), 1509-1520.
37. Rosenblatt, K.M.; Bunjes, H. Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alphamodification. Mol. Pharm., 2009, 6(1), 105-120.
38. Olbrich, C.; Müller, R. H. Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures. Int. J. Pharm., 1999, 180, 31-39.
39. Xie, S. Y.; Wang, S. L. ; Zhao, B. K.; Han, C.; Wang, M.; Zhou, W. Z. Effect of PLGA as a polymeric emulsifier on preparation of hydrophilic protein-loaded solid lipid nanoparticles. Colloids Surf. B Biointerfaces, 2008, 67, 199-204.
40. Pallerla, S.M.; Prabhakar, B. A Review on Solid Lipid Nanoparticles. Int. J. Pharm. Sci. Rev. Res., 2013, 20(2), 196-206.
41. Heurtault, B.; Saulnier, P.; Pech, B.; Proust, J.E.; Benoit, J. P. Physico-chemical stability of colloidal lipid particles. Biomaterials, 2003, 24, 4283-4300.
42. Freitas, C.; Müller, R. H. Effect of light and temperature on zeta potential and physical stability of solid lipid nanoparticle (SLNTM) dispersions. Int. J. Pharm., 1998, 168, 221-229.
43. ZurMühlen, A.; ZurMühlen, E.; Niehus, H.; Mehnert, W. Atomic force microscopy studies of solid lipid nanoparticles. Pharm. Res., 1996, 13(9), 1411-1416.
44. Siekmann, B.; Westesen, K. Submicron sized parental carrier systems based on solid lipids. Pharm. Pharmacol. Lett., 1992, 1, 123-126.
45. Freitas, C.; Lucks, J.S.; Muller, R.H. In: Effect of storage conditions on long term stability of solid lipid nanoparticles (SLN) in aqueous dispersion. In: Proceedings of the 1st world meeting APGI/APV, Budapest, May 9-11, 1995, pp. 493-494.
46. Freitas, C.; Müller, R.H. Correlation between long-term stability of solid lipid nanoparticles (SLN™) and crystallinity of the lipid phase. Eur. J. Pharm. Biopharm., 1999, 47(2), 125-132
47. Choi, K.O.; Aditya, N.P.; Ko, S. Effect of aqueous pH and electrolyte concentration on structure, stability and flow behavior of nonionic surfactant based solid lipid nanoparticles. Food Chem., 2014, 147, 239-244.
48. Mehnert, W.; ZurMuÈhlen, A.; Dingler, A.; Weyhers, H.; Muller, R.H. Solid Lipid Nanoparticles (SLN) -einneuartigerWirkstoff- Carrier fur KosmetikaundPharmazeutika. II. Wirkstoff-Inkorporation, Freisetzung und Sterilizierbarkeit. Pharm. Ind., 1997, 511-514.
49. Westesen, K.; Bunjes, H.; Koch, M.H.J. Physicochemical characterization of lipid nanoparticles and evaluation of their drug loadingcapacity and sustained release potential. J. Control. Release, 1997, 48, 223-236.
50. Westesen, K.; Siekmann, B.; Koch, M.H.J. Investigations on the physical state of lipid nanoparticles by synchrotron radiation X-ray diffraction. Int. J. Pharm., 1993, 93, 189-199.
51. Siekmann, B.; Westesen, K. Thermoanalysis of the recrystallization process of melt-homogenized glyceride nanoparticles. Colloids Surf. B Biointerfaces, 1994, 3(25), 159-175.
52. Mehnert, W.; Mader, K. Solid lipid nanoparticles: Production, characterization and applications. Adv. Drug Del. Rev., 2001, 47, 165-196.
53. ZurMühlen, A.; Schwarz, C.; Mehnert, W. Solid lipid nanoparticles (SLN) for controlled drug delivery-drug release and release mechanism. Eur. J. Pharm. Biopharm., 1998, 45(2), 149-155.
54. Heiati, H.; Tawashi, R.; Phillips, N. C. Solid lipid nanoparticles as drug carriers: II. Plasma stability and biodistribution of solid lipid nanoparticles containing the lipophilic prodrug 3′-azido-3′- deoxythymidine palmitate in mice. Int. J. Pharm., 1998, 174, 71-80.
55. Cohen-Sela, E.; Chorny, M.; Koroukhov, N.; Danenberg, H.D.; Golomb, G. A new double emulsion solvent diffusion technique for encapsulating hydrophilic molecules in PLGA nanoparticles. J. Control. Release, 2009, 133(2), 90-95.
56. Lim, S.J.; Kim, C.K. Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid. Int. J. Pharm., 2002, 243, 135-146.
57. Santos, I.R.D.; Richard, J.; Pech, B.; Thies, C.; Benoit, J.P. Microencapsulation of protein particles within lipids using a novel supercritical fluid process. Int. J. Pharm., 2002, 242, 69-78.
58. Hatziantoniou, S.; Deli, G. ; Nikas, Y.; Demetzos, C.; Papaioannou, G.T. Scanning electron microscopy study on nanoemulsions and solid lipid nanoparticles containing high amounts of ceramides. Micron, 2007, 38, 819-823.
59. Hu, F.Q.; Yuan, H.; Zhang, H.H.; Fang, M. Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization. Int. J. Pharm., 2002, 239, 121-128.
60. Das, S.; Ng, W.K.; Tan, R.B. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs): development, characterizations and comparative evaluations of clotrimazoleloaded SLNs and NLCs. Eur. J. Pharm. Sci., 2012, 47(1), 139-151.
61. Manjunath, K.; Venkateswarlu, V. Pharmacokinetics tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J. Control. Release, 2005, 107(2), 215-228.
62. Schwarz, W.; Mehnert, J.S.; Lucks, R.H.; Müller Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J. Control. Release, 1994, 30(1), 83-96.
63. Tiyaboonchai, W.; Tungpradit, W.; Plianbangchang, P. Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. Int. J. Pharm., 2007, 337, 299-306.
64. Zhang, Q.; Yie, G.; Li, Y.; Yang, Q.; Nagai, T. Studies on the cyclosporine A loaded stearic acid nanoparticles. Int. J. Pharm., 2000, 200(2), 153-159.
65. Ugazio, E.; Cavalli, R.; Gasco, M. R. Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int. J. Pharm., 2002, 241(2), 341-344.
66. Abdelbary, G.; Fahmy, R.H. Diazepam-loaded solid lipid nanoparticles: design and characterization. AAPS Pharm. Sci. Tech., 2009, 10(1), 211-219.
67. Schwarz, C.; Mehnert, W. Solid lipid nanoparticles (SLN) for controlled drug delivery. II. Drug incorporation and physicochemical characterization. J. Microencapsul., 1999, 16(2), 205-13.
68. Motwani, S.K., Chopra, S.; Talegaonkar, S.; Kohli, K.; Ahmad, F.J.; Khar, R.K. Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: formulation, optimization and in vitro characterisation. Eur. J. Pharm. Biopharm., 2008, 68(3), 513-25.
69. Hu, F.Q.; Hong, Y.; Yuan, H. Preparation and characterization of solid lipid nanoparticles containing peptide. Int. J. Pharm., 2004, 273, 29-35.
70. Hippalgaonkar, K; Adelli, GR; Hippalgaonkar, K; Repka, MA; Majumdar, S. Indomethacin-loaded solid lipid nanoparticles for ocular delivery: development, characterization, and in vitro evaluation. J. Ocul. Pharmacol. Ther., 2013, 29(2), 216-228.
71. Chattopadhyay, P.; Shekunov, B.Y.; Yim, D.; Cipolla, D.; Boyd, B.; Farr, S. Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system. Adv. Drug Deliv. Rev., 2007, 59, 444-453.
72. Kheradmandnia, S.; Vasheghani-Farahani, E.; Nosrati, M.; Atyabi, F. Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomedicine, 2010, 6(6), 753-759.
73. Zhang, N.; Ping, Q.; Huang, G.; Xu, W.; Cheng, Y.; Han, X. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm., 2006, 327(1-2), 153-159.
74. Garcıa-Fuentes, M.; Torres, D.; Alonso, M. J. Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules. Colloids Surf. B Biointerfaces, 2002, 27, 159-168.
75. Liu, J.; Gong, T.; Wang, C.; Zhong, Z.; Zhang, Z. Solid lipid nanoparticles loaded with insulin by sodium cholatephosphatidylcholine- based mixed micelles: preparation and characterization. Int. J. Pharm., 2007, 340(1-2), 153-162.
76. Hou, D.; Xie, C.; Huang, K.; Zhu, C. The production and characteristics of solid lipid nanoparticles (SLNs). Biomaterials, 2003, 24(10), 1781-1785.
77. Kumar, V.V.; Chandrasekar, D.; Ramakrishna, S.; Kishan, V.; Rao, Y.M.; Diwan, P.V. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. Int. J. Pharm., 2007, 335(1-2), 167-175.
78. Vivek, K.; Reddy, H.; Murthy, R.S. Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles. AAPS Pharm. Sci. Tech., 2007, 8(4), E83.
79. Zhang, D.; Tan, T.; Gao, L. Preparation of oridonin-loaded solid lipid nanoparticles and studies on them in vitro and in vivo. Nanotechnol., 2006, 17, 5821-5828.
80. Wissing, S. A.; Müller, R. H. Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration. J. Control. Release, 2002, 81(3), 225-233.
81. Xie, F.M.; Zeng, K.; Li, G. F.; Lin, Z.F.; Sun, L. D. Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin. Di Yi Jun Yi Da Xue Xue Bao, 2005, 25(1), 99-101.
82. zurMühlen, A.; zurMühlen, E.; Niehus, H.; Mehnert, W. Atomic force microscopy studies of solid lipid nanoparticles. Pharm. Res. 1996, 13(9), 1411-1416.
83. Maia, C.S., Mehnertb, W., Schäfer-Kortinga, M. Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int. J. Pharm., 2000, 196(2), 165-167.
84. Olbrich, C.; Kayser, O.; Müller, R. H. Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)-effect of surfactants, storage time and crystallinity. Int. J. Pharm., 2002, 237(1-2), 119-128.
85. Jenning, V.; Thünemann, A.F.; Gohla, S.H. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int. J. Pharm., 2000, 199(2), 167-177.
86. Pandey, R.; Sharma, S.; Khuller, G. K. Oral solid lipid nanoparticle- based antitubercular chemotherapy. Tuberculosis (Edinb)., 2005, 85(5-6), 415-120.
87. Nair, R.; Kumar, K. S. A.; Vishnupriya, K.; Badivaddin, T. Md.; Sevukarajan, M. Preparation and Characterization of Rizatriptan Loaded Solid Lipid Nanoparticles (SLNs). J. Biomed. Sci. Res., 2011, 3(2), 392-396.
88. Li, Y.; Huang, C.; Cen, Y.; Xu, S.; Xu, S. Preparation of tea polyphenols sustained-release microcapsule. Zhong Yao Cai., 2000, 23(5), 281-284.
89. Schwarz, C.; Mehnert, W. Freeze-drying of drug-free and drugloaded solid lipid nanoparticles (SLN). Int. J. Pharm., 1997, 157(2), 171-179.
90. Kim, B. D.; Na, K.; Choi, H. K. Preparation and characterization of solid lipid nanoparticles (SLN) made of cacao butter and curdlan. Eur. J. Pharm. Sci., 2005, 24(2-3), 199-205.
91. Luo, Y; Chen, D; Ren, L; Zhao, X; Qin, J. Solid lipid nanoparticles for enhancing vinpocetine's oral bioavailability. J. Control. Release, 2006, 114(1), 53-59.
92. Jenning, V.; Gysler, A.; Schäfer-Korting, M.; Gohla, S.H. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur. J. Pharm. Biopharm., 2000, 49(3), 211-218.
93. Fariss, M.W.; Zhang, J. Vitamin E therapy in Parkinson’s disease. Toxicology, 2003, 189(1-2), 129-146.
94. Umadevi, S.K.; Kumar, K.J.; Narendranath, B.; Chandrakala, M.; Kumar, E.S.; Hanumesh, M.S.; Suresh, S.; Thiruganesh, M.R.; Gunasekaran, V.; Shanmugam, V. Suitability of vitamin E solid lipid nanoparticles (SLN) enriched carbopol gels for cosmetic application. In proceeding of: 1st international symposium on frontiers in pharmaceutical research and nanotechnology, India, 2011, Vol. 1.
95. Müller, R.H.; Runge, S.A.; Ravelli, V.; Thünemann, A.F.; Mehnert, W.; Souto, E.B. Cyclosporine-loaded solid lipid nanoparticles (SLN®): Drug–lipid physicochemical interactions and characterization of drug incorporation. Eur. J. Pharm. Biopharm., 2008, 68(3), 535-544.
96. Gokce, E.H.; Sandri, G.; Bonferoni, M.C.; Rossi, S.; Ferrari, F.; Güneri, T.; Caramella, C. Cyclosporine A loaded SLNs: evaluation of cellular uptake and corneal cytotoxicity. Int. J. Pharm., 2008, 364(1), 76-86.
97. Lukowski, G.; Pflegel, P. Electron diffraction of solid lipid nanoparticles loaded with acyclovir. Pharmazie, 1997, 52, 642-643.
98. Seyfoddin, A.; Al-Kassas, R. Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir. Drug Dev. Ind. Pharm., 2013, 39(4), 508-19.
99. Bunjes, H. EinflußnahmeunterschiedlicherFaktorenaufStruktur und Eigenschaften von NanopartikelnausfestenTriglyceriden. Ph.D. Thesis, Friedrich-Schiller-Universitat Jena, 1998.
100. Venkateswarlu, V.; Manjunath, K. Preparation, characterization and in-vitro release kinetics of clozapine solid lipid nanoparticles. J. Control. Release, 2004, 95, 627-638.
101. Muller, R.H.; Schwarz, C.; Zur Muhlen, A. Incorporation of lipophilic drugs and drug release profiles of solid lipid nanoparticles (SLN). Proc. Int. Symp. Control. Rel. Bioact. Mater., 1994, 21, 146-147.
102. ZurMuÈhlen, A.; Mehnert, W. Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles. Pharmazie, 1998, 53, 552.
103. Lombardi, B.S.; Regehly, M.; Sivaramakrishnan, R.; Mehnert, W.; Korting, H.C.; Danker, K.; Röder, B.; Kramer, K.D.; Schäfer-Korting, M. Lipid nanoparticles for skin penetration enhancementcorrelation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J. Control. Release, 2005, 110(1), 151-63.
104. Shah, R.M; Malherbe, F; Eldrige, D; Palombo, E.A; Harding I.H. Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J. Colloid interface sci. 2014, 428, 268-294.
105. Muller, R.H.; Mehnert, W.; Lucks, J.S. Solid lipid nanoparticles(SLN) - An alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm., 1995, 41, 62-69.
106. Muller, R.H.; Mäder, K.; Gohla, S.H. Solid Lipid Nanoparticles for controlled drug delivery- A Review of the State of the art. Eur. J. Pharm. Bio. Pharm., 2000, 50(1), 161-177.
107. Isaacson, C.W.; Bouchard, D. Asymmetric flow field flow fractionation of aqueous C60 nanoparticles withsize determination by dynamic light scattering and quantification by liquid chromatography atmospheric pressure photo-ionization mass spectrometry. J. Chromatogr. A., 2010, 26, 1217(9), 1506-12.
108. Kato, H.; Suzuki, M.; Fujita, K.; Horie, M.; Endoh, S.; Yoshida, Y.; Iwahashi, H.; Takahashi, K.; Nakamura, A.; Kinugasa, S.Reliable size determination of nanoparticles using dynamic light scatteringmethod for in vitro toxicology assessment. Toxicol. In Vitro., 2009, 23(5), 927-34.
109. Yadav, N.; Khatak, S.; Sara, U.V.S. Solid lipid nanoparticles- a review. Int. J. Appl. Pharm., 2013, 5(2), 8-18.
110. Paranjpe, M.; Finke, J.H.; Richter, C.; Gothsch, T.; Kwade, A.; Büttgenbach, S.; Müller-Goyman, C.C. Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application. Int. J. Pharm., 2014, 476(1-2), 41-49.
111. Drake, B.; Prater, C.B.; Weisenhorn, A.L.; Gould, S.A.C.; Albrecht, T.R.; Quate, C.F. Imaging crystals polymers and process in water with the AFM. Science, 1989, 243, 1586-1589.
112. Zimmermann, E; Souto, EB; Müller, RH. Physicochemical investigations on the structure of drug-free and drug-loaded solid lipid nanoparticles (SLN) by means of DSC and 1H NMR. Pharmazie, 2005, 60(7), 508-513.
113. Meyer, E.; Heinzelmann, H. In: Scanning force microscopy In: Wiesendanger R, Guntherodt H.J., editors. Scanning tunneling microscopy II, Surface Science. Springer Verlag: New York, 1992, pp. 99-149.
114. Mukherjee, S.; Ray, S.; Thakur, R.S. Solid lipid nanoparticles (SLN): A Modern Formulation Approach in Drug Delivery System. Ind. J. Pharm. Sci., 2009, 71(4), 349-358.
115. Jenning, V. Feste Lipid Nanopartikelals Trager system furdiedermale Applikation von Retinol. Ph.D. Thesis, Free University of Berlin, 1999.
116. Jores, K.; Mehnert, W.; Mäder, K. Physicochemical investigations on solid lipid nanoparticles and on oil-loaded solid lipid nanoparticles: a nuclear magnetic resonance and electron spin resonance study. Pharm. Res., 2003, 20(8), 1274-1283.
117. Victorov, A.V.; Medvedeva, N.V; Gladkaya, E.M.; Morozkin, A.D.; Podrez, E.A.; Kosykh, V.A.; Yurkiv, V.A. Composition and structure of lipopolysaccharide-human plasma low density lipoprotein complex. Analytical ultracentrifugation, 31P-NMR, ESR and fluorescence spectroscopy studies. Biochim. Biophys. Acta., 1989, 984(1), 119-127.
118. Torchilin, V.P. Nanoparticulates as drug carriers. Imperial College Press, London, 2006.
119. Wissing, S.A.; Muller, R.H. Cosmetic applications for solid lipid nanoparticles (SLN). Int. J. Pharm., 2003, 254, 65-68.
120. Smith, A.; Hunneyball, I. M. Evaluation of poly (lactic acid) as a biodegradable drug delivery system for parenteral administration. Int. J. Pharm., 1986, 30, 215-220.
121. Fundaro, A.; Cavalli, R.; Bargoni, A.; Vighetto, D.; Zara, G.P.; Gasco, M.R. Non-stealth and stealth solid lipid nanospheres carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. Pharm. Res., 2000, 42(4), 337-343.
122. Yang, S.; Zhu, J.; Lu, Y.; Ling, B.; Yang, C. Body distribution of camptothecin solid lipid nanoparticles after oral administration. Pharm Res., 1999, 16, 751-757.
123. Martins, S.M.; Sarmento, B.; Nunes, C.; Lúcio, M.; Reis, S.; Ferreira, D.C. Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration. Eur. J. Pharm. Biopharm. 2013, 85, 488-502.
124. Jain, J.; Fernandes, C.; Patravale, V. Formulation development of parenteral phospholipid-based microemulsion of etoposide. AAPS Pharm. Sci. Tech., 2010, 11(2), 826-831.
125. Lu, B.; Xiong, S.B.; Yang, H.; Yin X.D.; Chao, R.B. Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases. Eur. J. Pharm. Sci., 2006, 28(1- 2), 86-95.
126. Reddy L.H.; Vivek, K.; Bakshi, N.; Murthy, R.S. Tamoxifen citrate loaded solid lipid nanoparticles (SLN): preparation, characterization, in vitro drug release, and pharmacokinetic evaluation. Pharm. Dev. Technol., 2006, 11(2), 167-77.
127. Koziara, J. M.; Lockman, P. R.; Allen, D. D.; Mumper, R. J. Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Control. Release, 2004, 99, 259-269.
128. Chen, D.B.; Yang, T.Z.; Lu, W.L.; Zhang, Q. In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. Chem. Pharm. Bull. 2001, 49(11), 1444-7.
129. Beri, A.; Boydell, J. Clozapine in borderline personality disorder: A review of the evidence. Ann. Clin. Psychiatry, 2014, 26(2), 139-44.
130. Suresh, G.; Manjunath, K.; Venkateswarlu, V.; Satyanarayana, V. Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles. AAPS Pharm. Sci. Tech., 2007, 8(1), 24.
131. Esposito, E.; Fantin, M.; Marti, M.; Drechsler, M.; Paccamiccio, L.; Mariani, P.; Sivieri, E.; Lain, F.; Menegatti Morari, M.; Cortesi, R. Solid lipid nanoparticles as delivery systems for bromocriptine. Pharm. Res., 2008, 25(7), 1521-30.
132. Huang, G.; Zhang, N.; Bi, X.; Dou, M. Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicity. Int. J. Pharm., 2008, 355(1-2), 314-320.
133. Ye, J.; Wang, Q.; Zhou, X.; Zhang, N. Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis. Int. J. Pharm., 2008, 352(1-2), 273-279.
134. Xiang, Q.Y.; Wang, M. T.; Chen, F.; Gong, T.; Jian, Y. L.; Zhang, Z. R.; Huang, Y. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch. Pharm. Res., 2007, 30(4), 519-525.
135. Colman, I.; Friedman, B. W.; Brown, M. D.; Innes, G. D.; Grafstein, E.; Roberts, T. E.; Rowe, B. H. Parenteral dexamethasone for acute severe migraine headache: meta-analysis of randomised controlled trials for preventing recurrence. BMJ., 2008, 336(7657), 1359-1361.
136. Muller, R. H.; Keck, C. M. Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles. J. Biotech., 2004, 113, 151-170.
137. Prego, C.; Garcia, M.; Torres, D. Transmucosal macromolecular drug delivery. J. Control. Release, 2005, 101, 151-162.
138. Vila, A.; Gill, H.; McCallion, O.; Alonso, M. J. Transport of PLAPEG particles across the nasal mucosa: effect of particle size and PEG coating density. J. Control. Release, 2004, 98, 231-244.
139. Tobio, M.; Gref, R.; Sanchez, A. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm. Res., 1998, 15, 270-276.
140. Agu, R.U.; Ugwoke, M.I.; Armand, M. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir. Res., 2001, 2, 198-209.
141. Banga, A. K. Delivery of protein therapeutics. Business Briefing: Pharmatech., 2003, 198-201.
142. Videira, M.A.; Botelho, M.F.; Santos, A.C. Lymphatic uptake of pulmonary delivered solid lipid nanoparticles. J. Drug Target, 2002, 10, 607-613.
143. Pandey, R.; Khuller, G. K. Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis. Tuberculosis, 2005, 85, 227-234.
144. De Campos, A.; Sanchez, A.; Alonso, M. J. Chitosan nanoparticles: a new vehicle for the improvement of the ocular retention of drugs. Application to cyclosporin A. Int. J. Pharm., 2001, 224, 159-168.
145. Barbault-Foucher, S.; Gref, R.; Russo, P. Design of poly-ε- caprolactone nanospheres coated with bioadhesive hyaluronic acid for ocular delivery. J. Control. Release, 2002, 83, 365-375.
146. Ludwig, A. The use of mucoadhesive polymers in ocular drug delivery. Adv. Drug Del. Rev., 2005, 57, 1595-1639.
147. Friedrich, I.; Reichl, S.; Muller-Goymann, C. C. Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS). Int. J. Pharm., 2005, 305, 167-175.
148. Seyfoddin, A.; Shaw, J.; Al-Kassas, R. Solid lipid nanoparticles for ocular drug delivery. Drug Deliv., 2010, 17(7), 467-489.
149. Cavalli, R.; Gasco, M. R.; Chetoni, P.; Burqalassi, S.; Saettone, M. F. Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin. Int. J. Pharm., 2002, 238(1-2), 241-245.
150. Sznitowska, M.; Gajewska, M.; Janicki, S.; Radwanska, A.; Lukowski, G. Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits. Eur. J. Pharm. Biopharm., 2001, 52(2), 159-163.
151. Haarde, H.; Das, M.; Jain, S. Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert Opin. Drug Deliv., 2011, 8(11), 1401-1424.
152. Tobio, M.; Sanchez, A.; Vila, A. The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloid. Surf. B Biointerfaces, 2000, 18, 315-323.
153. Olbrich, C.; Bakowski, U.; Lehr, C. M. Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA. J. Contr. Rel., 2001, 77, 345-55.
154. Yang, S. C.; Lu, L. F.; Cai, Y. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release, 1999, 9, 299-307.
155. Demirel, M.; Yazan, Y.; Muller, R. H.; Kilic, F.; Bozan, B. Formulation and in vitro-in vivo evaluation of piribedil solid lipid particles. J. Microencapsul., 2001, 18(3), 359-71.
156. Li, H.; Zhao, X.; Ma, Y.; Zhai, G.; Li, L.; Lou, H. Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J. Control. Release, 2009, 133(3), 238-244.
157. Khalil, R. M.; El-Bary, A. A.; Kassem, M. A.; Ghorab, M. M.; Ahmed, M. B. In: Solid lipid nanoparticles for topical delivery of Meloxicam: Development and in-vitro characterization. In: Proceeding of the 1st Annual international interdisciplinary conference, A Zores, Portugal, April 24-26, 2013.
158. Küchler, S.; Herrmann, W.; Panek-Minkin, G.; Blaschke, T.; Zoschke, C.; Kramer, K. D.; Bittl, R.; Schäfer-Korting, M. SLN for topical application in skin diseases-characterization of drug-carrier and carrier-target interactions. Int. J. Pharm., 2010, 390(2), 225-233.
159. Korting, M. S.; Mehnert, W.; Korting, H. C. Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv. Drug Del. Rev., 2007, 59, 427-443.
160. Moddaresi, M.; Brown, M.B.; Zhao, Y.; Tamburic, S.; Jones, S.A. The role of vehicle-nanoparticle interactions in topical drug delivery. Int. J. Pharm., 2010, 400(1-2), 176-182.
161. Wissing, S. A.; Muller, R. H. A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles. Int. J. Cosm. Sci., 2001, 23, 233-243.
162. Castro, G.A.; Oliveira, C.A.; Mahecha, G.A.; Ferreira, L.A. Comedolytic effect and reduced skin irritation of a new formulation of all-trans retinoic acid-loaded solid lipid nanoparticles for topical treatment of acne. Arch. Dermatol. Res., 2011, 303(7), 513-520.
163. Uner, M.; Wissing, S.A.; Yener, G. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate. Pharmazie, 2005, 60, 577-582.
164. Uner, M.; Wissing, S.A.; Yener, G. Investigation of skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel. Pharmazie, 2005, 60, 751-755.
165. Souto, E. B.; Wissing, S. A.; Barbosa, C. M. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int. J. Pharm., 2004, 278, 71-77.
166. Mei, Z.; Chen, H.; Weng, T. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur. J. Pharm. Biopharm., 2003, 56, 189-196.
167. Chen, H.; Chang, X.; Du, D. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J. Control. Release, 2006, 110, 296-306.
168. Munster, U.; Nakamura, C.; Haberland, A. RU 58841-myristate - prodrug development for topical treatment of acne and androgenic alopecia. Pharmazie, 2005, 60, 8-12.
169. Mei, Z.; Wu, Q. Triptolide loaded solid lipid nanoparticle hydrogel for topical application. Drug Devel. Ind. Pharm., 2005, 31, 161-168.
170. Souto, E. B.; Muller, R. H. The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents. Pharmazie, 2006, 61, 431-437.
171. Bragagni, M.; Mennini, N.; Maestrelli, F.; Cirri, M.; Mura, P. Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib. Drug Deliv., 2012, 19(7), 54-61.
172. Jenning, V.; Schafer-Korting, M.; Gohla, S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J. Control. Release, 2000, 66, 115-126.
173. Liu, J.; Hu, W.; Chen, H.; Ni, Q.; Xu, H.; Yang, X. Isotretinoinloaded solid lipid nanoparticles with skin targeting for topical delivery. Int. J. Pharm., 2007, 328, 191-195.
174. Venishetty, V.K.; Komuravelli, R.; Kuncha, M.; Sistla, R.; Diwan, P.V. Increased brain uptake of docetaxel and ketoconazole loaded folate-graftedsolid lipid nanoparticles. Nanomedicine, 2013, 9(1), 111-21.
175. Choi, M. J.; Kim, J. H.; Maibach, H. I. Topical DNA vaccination with DNA/Lipid based complex.Curr. Drug Deliv., 2006, 3, 7-45.
176. Jain, S. K.; Chourasia, M. K.; Masuriha, R. Solid lipid nanoparticles bearing flurbiprofen for transdermal delivery. Drug Deliv., 2005, 12, 207-215.
177. Schlupp, P.; Blaschke, T.; Kramer, K.D.; Höltje, H.D.; Mehnert, W.; Schäfer-Korting, M. Drug release and skin penetration from solid lipid nanoparticles and a base cream: a systematic approach from a comparison of three glucocorticoids. Skin Pharmacol. Physiol., 2011, 24(4), 199-209.
178. Kuchler, S.; Wolf, N.B.; Heilmann, S.; Weindl, G.; Helfmann, J.; Yahya, M. M.; Stein, C.; Schäfer-Korting, M. 3D-wound healing model: influence of morphine and solid lipid nanoparticles. J. Biotechnol., 2010, 148(1), 24-30.
179. Golmohammadzadeh, S.; Mokhtari, M.; Jaafari, M. R. Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles. Braz. J. Pharm. Sci., 2012, 48, 683-690.
180. Mulla, J. S.; Khazi, I. M. Influence of process variables on particle size of solid lipid nanoparticles. Ind. J. Novel Drug Deliv., 2009, 1(1), 47-49.
181. Schwarz, C.; Freitas, C.; Mehnert, W.; Muller, R. H. Sterilization and physical stability of drug-free and etomidate-loadedsolid lipid nanoparticles. Proc. Int. Symp. Control. Rel. Bioct. Mater., 1995, 22, 766-767.
182. Pandita, D.; Ahuja, A.; Velpandian, T.; Lather, V.; Dutta, T.; Khar, R.K. Characterization and in vitro assessment of paclitaxel loaded lipid nanoparticles formulated using modified solvent injection technique. Pharmazie, 2009, 64(5), 301-10.
183. Schwarz, C.; Mehnert, W. In: Sterilization of drug-free and tetracaine- loaded solid lipid nanoparticles (SLN). In: Proc. 1st World Meeting APGI/APV, Budapest, 1995, 485-486.
184. Heiati, H.; Tawashi, R.; Phillips, N.C. Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilisation. J. Microencapsul., 1998, 15, 173-184.
185. Soares, S.; Fonte, P.; Costa, A.; Andrade, J.; Seabra, V.; Ferreira, D.; Reis, S.; Sarmento, B. Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin- loaded solid lipid nanoparticles. Int. J. Pharm., 2013, 456(2), 370-381.
186. Li, R. H.; Soo, S.Y.; Eun, J.S.; Lee, M.K. Preparation and evaluation of freeze-dried solid lipid nanoparticles with various cryoprotectants. J. Kor. Pharm. Sci., 2010, 40(1), 39-43.
187. Duncan, R. The dawning era of polymer therapeutics. Nat. Rev. Drug Disc., 2003, 2, 347-360.
188. Chimmiri, P.; Rajalakshmi, R.; Mahitha, B.; Ramesh, G.; Noor, A.V.H. Solid lipid nanoparticles: a novel carrier for cancer therapy. Int. J. Biol. Pharm. Res., 2012, 3(3), 405-413.
189. Kamble, V. A.; Jagdale, D. M.; Kadam, J. Solid lipid nanoparticles as drug delivery system. Int. J. Pharm. Bio. Sci., 2010, 1(3), 1-9.
190. Yassin, A.E.; Anwer, M.K.; Mowafy, H.A.; El-Bagory, I.M.; Bayomi, M.A.; Alsarra, I.A. Optimization of 5-flurouracil solidlipid nanoparticles: a preliminary study to treat colon cancer. Int. J. Med. Sci., 2010, 7(6), 398-408.
191. Battaglia, L.; Serpe, L.; Muntoni, E.; Zara, G.; Trotta, M.; Gallarate, M. Methotrexate-loaded SLNs prepared by coacervation technique: in vitro cytotoxicity and in vivo pharmacokinetics and biodistribution. Nanomedicine (Lond), 2011, 6(9), 1561-1573.
192. Miglietta, A.; Cavalli, R.; Bocca, C.; Gabriel, L.; Gasco, M. R. Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel. Int. J. Pharm., 2000, 210, 61-7.
193. Zhuang, Y.G.; Xu, B.; Huang, F.; Wu, J.J.; Chen, S. Solid lipid nanoparticles of anticancer drugs against MCF-7 cell line and a murine breast cancer model. Pharmazie, 2012, 67(11), 925-929.
194. Raza, K; Singh B, Singal P, Wadhwa S, Katare OP. Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids Surf. B Biointerfaces, 2013, 105, 67-74.
195. Cavalli, R., Caputo, O., Gasco, M. R. Preparation and characterization of solid lipid nanospheres containing paclitaxel. Eur. J. Pharm. Sci., 2000, 10(4), 305-309.
196. Wan, F.; You, J.; Sun, Y.; Zhang, X.G.; Cui, F.D.; Du, Y.Z.; Yuan, H.; Hu, F.Q. Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro. Int. J. Pharm., 2008, 359(1-2), 104-10.
197. Mei, Z.; Li, X.; Wu, Q.; Hu, S.; Yang, X. The research on the antiinflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. Pharm. Res., 2005, 51, 345-351.
198. Shuhendler, A.J.; Cheung, R.Y.; Manias, J.; Connor, A.; Rauth, A.M.; Wu, X.Y. A novel Doxorubicin -mitomycin C coencapsulated nanoparticle formulation exhibits anticancer syngery in multidrug resistant human breast cancer cells. Breast Cancer Res. Treat., 2010, 119(2), 255-269.
199. Aboutaleb, E.; Atyabi, F.; Khoshayand, M. R.; Vatanara, A. R.; Ostad, S. N.; Kobarfard, F.; Dinarvand, R. Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles: Optimization and in vivo evaluation. J. Biomed. Mater. Res. A., 2014, 102(7), 2125-2136.
200. Cho, H.J.; Park, J.W.; Yoon, I.S.; Kim, D.D. Surface-modified solid lipid nanoparticles for oral delivery of docetaxel: enhanced intestinal absorption and lymphatic uptake. Int. J. Nanomed., 2014, 9, 495-504.
201. Murthy, R.S.R. Solid lipid nanoparticles as carriers for anti-cancer drugs to solid tumours. Drug Deliv., 2005, 12, 385-392.
202. Ruckmani, K.; Sivakumar, M.; Ganeshkumar, P.A. Methotrexate loaded solid lipid nanoparticles (SLN) for effective treatment of carcinoma. J. Nanosci. Nanotechnol. 2006, 6(9-10), 2991-2995.
203. Mulik, R.S.; Mönkkönen, J.; Juvonen, R.O.; Mahadik, K.R.; Paradkar, A.R. Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in vitro anticancer activity by induction of apoptosis. Int. J. Pharm., 2010, 398(1-2), 190-203.
204. Kang, K.W.; Chun M.K., Kim, O., Subedi, R.K., Ahn, S.G.; Yoon, J.H.; Choi, H.K. Doxorubicin-loaded solid lipid nanoparticles to overcome multidrug resistance in cancer therapy. Nanomedicine, 2010, 6(2), 210-3.
205. Videira, M.A.; Botelho, M.F.; Santos, A.C., Gouveia, L.F., de Lima J.J., Almeida, A.J. Lymphatic uptake of pulmonary delivered solid lipid nanoparticles. J. Drug Target, 2002, 10, 607-613.
206. Bhandari, R.; Kaur, I.P. Pharmacokinetics, tissue distribution and relative bioavailability of isoniazid-solid lipid nanoparticles. Int. J. Pharm., 2013, 441(1-2), 202-212.
207. Kaur, I.P.; Singh, H. Nanostructured drug delivery for better management of tuberculosis. J. Control. Release. 2014, 184, 36-50.
208. Vyas, S.P.; Khar, R. K. Controlled Drug Delivery - Concepts and Advances, First Edition, Vallabh Prakashan, 2002, pp. 38-50.
209. Jain, A.; Jain, A.; Gulbake, A.; Shilpi, S.; Hurkat, P.; Jain, S.K. Peptide and protein delivery using new drug delivery systems. Crit. Rev. Ther. Drug Carrier Syst., 2013, 30(4), 293-329.
210. Almeida, A.J.; Souto, E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Del. Rev., 2007, 59, 478-490.
211. Borgia, S. L.; Regehly, M.; Sivaramakrishnan, R.; Mehnert, W.; Korting, H.C.; Danker, K.; Röder, B.; Kramer, K.D.; Schäfer-Korting, M. Lipid nanoparticles for skin penetration enhancement– correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J. Control. Release, 2005, 110, 151-163.
212. Cevc, G. Lipid vesicles and other colloids as drug carriers on the skin, Adv. Drug Deliv. Rev., 2004, 56, 675-711.
213. Otberg, N.; Richter, H.; Schaefer, H.; Blume-Peytavi, U.; Sterry, W.; Lademann, J. Variations of hair follicle size and distribution in different body sites. J. Invest. Dermatol., 2004, 122, 14-19.
214. Grams, Y.Y.; Bouwstra, J.A. Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle, J. Control. Release, 2002, 83253-83262.
215. Santos Maia, C.; Mehnert, W.; Schaller, M.; Korting, H.; Gysler, A.; Haberland, A.; Schäfer-Korting, M. Drug targeting by solid lipid nanoparticles for dermal use. J. Drug Target, 2002, 10, 489-495.
216. Castro, G.A.; Coelho, A.L.; Oliveira, C.A.; Mahecha, G.A.; Oréfice, R.L.; Ferreira, L.A. Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles. Int. J. Pharm., 2009, 381(1), 77-83.
217. Santos, M. C.; Mehnert, W.; Schaller, M.; Korting, H.C.; Gysler, A.; Haberland, A.; Schäfer-Korting, M. Drug targeting by solid lipid nanoparticles for dermal use. J. Drug Target, 2002, 10(6), 489-495.
218. Kalariya, M.; Padhi, B.K.; Chougule, M.; Misra, A. Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: formulation and clinical implications. Ind. J. Exp. Biol., 2005, 43, 233-240.
219. Lawrence, R.N. William Pardridge discusses the lack of BBB research. Drug Discov. Today, 2002, 7, 223-226.
220. Begley, D.J. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol. Ther., 2004, 104, 29-45.
221. Yang, S.C.; Zhu, J.B.; Lu, Y.; Liang, B.W.; Yang, C.Z. Body distribution of camptothecin solid lipid nanoparticles after oral administration, Pharm. Res., 1999, 16, 751-757.
222. Zara, G.P.; Cavalli, R.; Fundarò, A.; Bargoni, A.; Caputo, O.; Gasco, M.R. Pharmacokinetics of doxorubicin incorporated in solid lipid nanospheres (SLN). Pharmacol. Res., 1999, 40, 281-286.
223. Minagawa, T.; Sakanaka, K.; Inaba, S.I.; Sai, Y.; Tamai, I.; Suwa, T.; Tsuji, A. Blood-brain-barrier transport of lipid microspheres containing clinprost, a prostaglandin I2 analogue. J. Pharm. Pharmacol., 1996, 48, 1016-1022.
224. Podio, V.; Zara, G.P.; Carazzone, M.; Cavalli, R.; Gasco, M.R. Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats. J. Pharm. Pharmacol., 2000, 52, 1057-1063.
225. Yang, S.C.; Lu, L.F.; Cai, Y.; Zhu, J.B.; Liang, B.W.; Yang, C.Z. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J. Control. Release, 1999, 59, 299-307.
226. Fundarò, A.; Cavalli, R.; Bargoni, A.; Vighetto, D.; Zara, G.P.; Gasco, M.R. Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats. Pharmacol. Res., 2000, 42, 337-343.
227. Salama, H.A.; Mahmoud, A.A.; Kamel, A.O.; Abdel, H.M.; Awad, G.A. Brain delivery of olanzapine by intranasal administration of transfersomal vesicles. J. Liposome Res., 2012, 22(4), 336-45.
228. Gasco, M.R. Method for producing solid lipid microspheres having a narrow size distribution, US Patent, 1993, 5, 250 236.
229. Manjunath, K.; Venkateswarlu, V. Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J. Control. Release, 2005, 107, 215-228.
230. Reddy, L. H.; Sharma, R.K.; Chuttani, K.; Mishra, A.K.; Murthy, R.S.R. Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J. Control. Release, 2005, 105, 185-198.
231. Wang, J.X.; Sun, X.; Zhang, Z.R. Enhanced brain targeting by synthesis of 3', 5'-dioctanoyl-5-fluoro-2'-deoxyuridine and incorporation into solid lipid nanoparticles. Eur. J. Pharm. Biopharm., 2002, 54, 285-290.
232. Wang, W.; Zhao, X.; Hu, H.; Chen, D.; Gu, J.; Deng, Y.; Sun, J. Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability. Drug Deliv., 2010, 7(3), 114-22.
233. Berkman, M.S., Yazan, Y. Solid lipid nanoparticles: a possible vehicle for zinc oxide and octocrylene. Pharmazie, 2012, 67(3), 202-8.
234. Niculae, G.; Badea, N.; Meghea, A.; Oprea, O.; Lacatusu, I. Coencapsulation of butyl-methoxydibenzoylmethane and octocrylene into lipid nanocarriers: UV performance, photostability and in vitro release. Photochem. Photobiol., 2013, 89(5), 1085-94.
235. Shidhaye, S.S., Vaidya, R., Sutar, S., Patwardhan A, Kadam VJ. Solid lipid nanoparticles and nanostructured lipid carriers-- innovative generations of solid lipid carriers. Curr. Drug Deliv., 2008, 5(4), 324-31.
236. Pardeike, J.; Hommoss, A.; Müller, R. H. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int. J. Pharm., 2009, 366, 170-184.
237. Yu, W.; Liu, C.; Ye, J.; Zou, W.; Zhang, N.; Xu, W. Novel cationic SLN containing a synthesized single-tailed lipid as a modifier for gene delivery. Nanotechnology, 2009, 20(21), 215-102.
238. Tabatt, K.; Sameti, M.; Olbrich, C. Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur. J. Pharm. Biopharm., 2004, 57, 155-162.
239. Pedersen, N.; Hansen, S.; Heydenreich, A.V. Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands. Eur. J.Pharm. Biopharm., 2006, 62, 155-162.
240. Vighi, E.; Ruozi, B., Montanari, M.; Battini, R.; Leo, E. pDNA condensation capacity and in vitro gene delivery properties of cationic solid lipid nanoparticles. Int. J. Pharm., 2010, 389 (1-2), 254-61.
241. Yu, W.; Liu, C.; Liu, Y.; Zhang, N.; Xu, W. Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages. Pharm. Res., 2010, 27(8), 1584-96.
242. Csaba, N.; Garcia-Fuentes, M.; Alonso, M. J. Nanoparticles for nasal vaccination, Adv. Drug Del. Rev., 2009, 61, 140-157.
243. Lai, F.; Wissing, S.A.; Müller, R.H.; Fadda, A.M. Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: preparation and characterization. AAPS Pharm. Sci. Tech., 2006, 7(1), E10-E18.
244. Ghadiri M.; Fatemi S.; Vatanara A.; Doroud D.; Najafabadi A.R.; Darabi M.; Rahimi A.A. Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size. Int. J. Pharm., 2012, 424 (1-2), 128-37.