Solid lipid nanoparticles (SLN) for controlled drug delivery. II. Drug incorporation and physicochemical characterization

Journal of Microencapsulation

Volumn 16, Issue 2, 1999, Pages 205-213

  Schwarz, C ^a   Mehnert, W ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Drug incorporation; Etomidate; Long term stability; Solid lipid nanoparticles (SLN); Tetracaine

Indexed keywords

ETOMIDATE; LIPID; NANOPARTICLE; TETRACAINE;

ARTICLE; COLLOID; CONTROLLED RELEASE FORMULATION; DISPERSION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STABILITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; SOLID; ZETA POTENTIAL;

EID: 0032982005     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/026520499289185     Document Type: Article

References (15)

1. DOMB, A. J., 1993, Liposphere parenteral delivery system. Proceedings of an International Symposium on Controlled Release and Bioactive Materials, 20, 121-122.
2. FREITAS, C., LUCKS, J. S., and MÜLLER, R. H., 1995, Effect of storage conditions on long-term stability of 'Solid Lipid Nanoparticles' (SLN) in aqueous dispersion. Proceedings of the 1st World Meeting APGI/APV, Budapest, 9/11 May, 493-494.
3. GASCO, M. R., MOREL, S., and CARPIGNANO, R., 1992, Optimization of the incorporation of deoxycorticosterone acetate in lipospheres. European Journal of Pharmaceutics and Biopharmaceutics, 38, 7-10.
4. MÜLLER, R. H., 1991, Colloidal Carriers for Controlled Drug Delivery and Targeting (Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH, and Boca Raton, Ann Arbor, Boston: CRC Press).
5. MÜLLER, R. H., 1996, Zetapotential und Partikelladung in der Laborpraxis (Stuttgart: Wissenschaftliche Verlagsgesellschaft mbH).
6. MÜLLER, R. H., and HEINEMANN, S., 1992, Fat emulsions for parenteral nutrition. I: Evaluation of microscopic and laser light scattering methods for the determination of the physical stability. Clinical Nutrition, 11, 223-236.
7. MÜLLER, R. H., and HEINEMANN, S., 1993, Fat emulsions for parenteral nutrition. II: Characterization and physical long-term stability of Lipofundin MCT/LCT. Clinical Nutrition, 12, 298-309.
8. MÜLLER, R. H., and HEINEMANN, S., 1994, Fat emulsions for parenteral nutrition. III: Lipofundin MCT regimens for TPN with low and medium electrolyte load. International Journal of Pharmaceutics, 101, 175-189.
9. MÜLLER, R. H., MEHNERT, W., LUCKS, J. S., SCHWARZ, C., ZUR MÜHLEN, A., WEYHERS, H., FREITAS, C., and RÜHL, D., 1995, Solid lipid nanoparticles (SLN) - an alternative colloidal carrier system for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 41, 62-69.
10. NEY, P., 1973, Zetapotentiale und Flotierbarkeit von Mineralien (Wien, New York: Springer-Verlag).
11. SCHWARZ, C., 1995, Feste Lipidnanopartikrel: Herstellung, Charakterisierung, Arzneistoffinkorporation und -freisetzung, Sterilisation und Lyophilisation, PhD thesis, Freie Universität Berlin.
12. SCHWARZ, C., MEHNERT, W., LUCKS, J. S., and MÜLLER, R. H., 1994, Solid lipid nanoparticles (SLN) for controlled drug delivery. I: Production, characterization and sterilization. Journal of Controlled Release, 30, 83-96.
13. SIEKMANN, B., and WESTESEN, K., 1992, Submicron-sized parenteral carrier systems based on solid lipids. Pharmaceutical and Pharmacological Letters, 1, 123-126.
14. WESTESEN, K., SIEKMANN, B., and KOCH, M., 1993, Investigations on the physical state of lipid nanoparticles by synchroton radiation X-ray diffraction. International Journal of Pharmaceutics, 93, 189-199.
15. ZUR MÜHLEN, A., and MEHNERT, W., 1995, Drug incorporation and delivery of prednisolone loaded solid lipid nanoparticles Proceedings of the 1st World Meeting APGI/APV, Budapest, 9/11 May, 455-456.