Methotrexate-loaded SLNs prepared by coacervation technique: In vitro cytotoxicity and in vivo pharmacokinetics and biodistribution

Nanomedicine

Volumn 6, Issue 9, 2011, Pages 1561-1573

  Battaglia, Luigi ^a   Serpe, Loredana ^a   Muntoni, Elisabetta ^a   Zara, GianPaolo ^a   Trotta, Michele ^a   Gallarate, Marina ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

biodistribution; coacervation; methotrexate; pharmacokinetic; SLN

Indexed keywords

CHLORHEXIDINE GLUCONATE; DEQUALINIUM; METHOTREXATE; SOLID LIPID NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG UPTAKE; ENCAPSULATION; FEMALE; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TECHNIQUE; TUMOR MODEL;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG CARRIERS; FEMALE; HUMANS; LIPIDS; MALE; METHOTREXATE; NANOPARTICLES; RATS; RATS, WISTAR;

EID: 80052851292     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.11.52     Document Type: Article

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