Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 1-2, 2006, Pages 86-95

  Lu, Bin ^a   Xiong, Su Bin ^a   Yang, Hong ^a   Yin, Xiao Dong ^a   Chao, Ruo Bing ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Breast cancer; Lymph node metastases; Mitoxantrone; Site specific delivery; Solid lipid nanoparticles

Indexed keywords

MITOXANTRONE; PLACEBO; SOLID LIPID NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; DISPERSION; DRUG ANALYSIS; DRUG RELEASE; DRUG TISSUE LEVEL; HUMAN; HUMAN CELL; LIVER TOXICITY; LUNG TOXICITY; LYMPH NODE METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS; BODY WEIGHT; BREAST NEOPLASMS; CELL LINE, TUMOR; CHLOROFORM; DRUG COMPOUNDING; FEMALE; FREEZE DRYING; HUMANS; INDICATORS AND REAGENTS; INJECTIONS; KINETICS; LETHAL DOSE 50; LEUKEMIA P388; LYMPHATIC METASTASIS; MITOXANTRONE; NANOSTRUCTURES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STERILIZATION; TISSUE DISTRIBUTION;

EID: 33644888826     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.01.001     Document Type: Article

References (18)

1. A. Bargoni, R. Cavalli, O. Caputo, A. Fundarò, M.R. Gasco, and G.P. Zara Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats Pharm. Res. 15 5 1998 745 750
2. V.K. Batra, J.A. Morrison, D.L. Woodward, and A. Yacobi Pharmacokinetics of mitoxantrone in man and laboratory animals Drug Metabol. Rev. 17 1986 311 329
3. T.B. Bevers Breast cancer chemoprevention: current clinical practice and future direction Biomed. Pharmacother. 55 2001 559 564
4. H. Chamras, A. Ardashian, D. Heber, and J.A. Glasy Fattic acid modulation of human MCF-7 breast cancer cell proliferation, apoptosis and differentiation J. Nutr. Biochem. 13 2002 711 716
5. A. Hagiwara, T. Takahashi, and K. Sawai Methotrexate bound to carbon particles used for treating cancers with lymph node metastases in animal experiments and a clinical pilot study Cancer 78 10 1996 2199 2209
6. A.E. Hawley, L. Illum, and S.S. Davis Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake Pharm. Res. 14 5 1997 657 661
7. O.Y.P. Hu Novel assay method for mitoxantrone in plasma and its application in cancer patients J. Chromatogr. 532 1990 337 350
8. S.L. Li Oncology of Mammary Gland 2000 Publishing House of Science and Technology Beijing 1 134
9. B. Lu, and S.B. Xiong Determination of entrapment rate and entrapment yield of mitoxantrone solid lipid nanoparticles Drug Stand. China 5 5 2004 32 36
10. D.C. Montgomery Response surface methodology D.C. Montgomery Design and Analysis of Experiments 2nd ed. 1984 John Wiley & Sons New York 445 474
11. R.H. Müller, W. Mehenert, J.S. Lucks, C. Schwarz, C. Freitas, and D. Ruhl Solid lipid nanoparticles (SLN). An alternative colloidal carrier system for controlled drug delivery Eur. J. Pharm. Biopharm. 41 1995 62 69
12. C. Oussoren, W.M.C. Eling, and D.J.A. Crommelin The influence of the route of administration and liposome composition on the potential of liposomes to protect tissue local toxicity of two antitumor drugs Biochim. Biophys. Acta 1369 1998 159 172
13. W.T. Phillips, R. Klipper, and B. Goins Novel method of greatly enhanced delivery of liposomes to lymph nodes J. Parmacol. Exp. Ther. 295 1 2000 309 313
14. K.M. Rentsch, R.A. Schwendener, and E. Haeseler Determination of mitoxantrone in mouse whole blood and different tissues by high-performance liquid chromatography J. Chromatogr. 679 1996 185 192
15. M. Schaich, T. Illmer, and W. Aulitzky Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine and high dose ara-C for elderly acute myeloid leukaemia patients aged 61-65 years Haematologica 87 8 2002 808 815
16. B. Siekmann, and K. Westensen Melt-homogenized solid lipid nanoparticles stabilized by the nonionic surfactant tyloxapol. I. Preparation and particle size determination Pharm. Pharmacol. Lett. 3 1994 194 197
17. Z.R. Zhang, and G.T. Liao Studies on mitoxantrone nanospheres for hepatic targeting G.T. Liao Targeted Drug Delivery Systems 1997 Publishing House of Science and Technology Sichuan 230 231
18. V.C. Zingler, M. Nabauer, K. Jahn, A. Grobeta, R. Hohlfeld, T. Brandt, and M. Strupp Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis Eur. Neurol. 54 1 2005 28 33