Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles

International Journal of Pharmaceutics

Volumn 381, Issue 1, 2009, Pages 77-83

  Castro, Gisele A ^a   Coelho, Anna Luíza L R ^a   Oliveira, Cleida A ^a   Mahecha, Germán A B ^a   Oréfice, Rodrigo L ^a   Ferreira, Lucas A M ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Acne; Ion pairing; Retinoic acid; Skin irritation; Solid lipid nanoparticles; Topical treatment

Indexed keywords

OCTADECYLAMINE; PLACEBO; RETINOIC ACID; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; VITANOL A;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG STABILITY; ENCAPSULATION; FEMALE; MOUSE; NANOPHARMACEUTICS; NANOTECHNOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SKIN IRRITATION; TOXICITY TESTING; X RAY CRYSTALLOGRAPHY;

ACNE VULGARIS; ADMINISTRATION, CUTANEOUS; AMINES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ELECTROCHEMICAL TECHNIQUES; EMULSIONS; EXANTHEMA; EXCIPIENTS; FEMALE; MICE; MICE, HAIRLESS; NANOPARTICLES; PARTICLE SIZE; PHASE TRANSITION; SCATTERING, SMALL ANGLE; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TRETINOIN; X-RAY DIFFRACTION;

EID: 70349202036     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.07.025     Document Type: Article

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