Physicochemical characterization of sildenafil-loaded solid lipid nanoparticle dispersions (SLN) for pulmonary application

International Journal of Pharmaceutics

Volumn 476, Issue 1, 2014, Pages 41-49

  Paranjpe, M ^a   Finke, J H ^a   Richter, C ^a   Gothsch, T ^a   Kwade, A ^a   Buttgenbach S ^a   Muller Goymann C C ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Microchannel homogenization; Next generation impactor (NGI); Physicochemical characterization; Pulmonary administration; Sildenafil; Solid lipid nanoparticles (SLN)

Indexed keywords

BERACTANT; LUNG SURFACTANT; PHOSPHOLIPID; SILDENAFIL; SOLID LIPID NANOPARTICLE; TRIACYLGLYCEROL; DRUG CARRIER; LIPID; NANOPARTICLE; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONAMIDE;

ARTICLE; BETA MODIFICATION; BRONCHIOLE; CHEMICAL MODIFICATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STABILITY; GENERAL MEDICAL DEVICE; HOME CARE; LUNG FLUID; MICELLE; MICROCHANNEL HOMOGENIZATION METHOD; NEBULIZATION; NEBULIZER; NEGATIVE STAINING TECHNIQUE; NEXT GENERATION IMPACTOR; PARTICLE SIZE; PHYSICAL CHEMISTRY; POLYMORPHIC MODIFICATION; PULMONARY HYPERTENSION; SHELF LIFE; SIMULATED LUNG FLUID; STAINING; SURFACE PROPERTY; SURFACE TENSION; TRANSMISSION ELECTRON MICROSCOPY; WIDE ANGLE X RAY DIFFRACTION; X RAY DIFFRACTION; CHEMISTRY; DRUG STORAGE; LUNG; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SOLUBILITY;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; LIPIDS; LUNG; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; PHOSPHODIESTERASE 5 INHIBITORS; PHOSPHOLIPIDS; PIPERAZINES; PURINES; SOLUBILITY; SULFONAMIDES; TRIGLYCERIDES; X-RAY DIFFRACTION;

EID: 84907849031     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.09.031     Document Type: Article

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