Atomic force microscopy studies of Solid Lipid Nanoparticles

Pharmaceutical Research

Volumn 13, Issue 9, 1996, Pages 1411-1416

  Zur Muhlen A ^a   Zur Muhlen E ^b   Niehus, H ^b   Mehnert, W ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

atomic force microscopy; controlled drug delivery; prednisolone; solid lipid nanoparticles

Indexed keywords

LIPID; NANOPARTICLE; PREDNISOLONE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; MICROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION;

EID: 0029857983     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016042504830     Document Type: Article

References (20)

1. R. H. Müller, J. S. Lucks. Arzneistoffträger aus festen Lipidteilchen-Feste Lipid Nanosphären (SLN). German Patent Application P 41 31 562.6 (1991). European Patent Application PCT/ EP 92/02132 (1992).
2. C. Schwarz, W. Mehnert, J. S. Lucks, R. H. Müller. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J. Control. Rel. 30:83-96 (1994).
3. R. H. Müller, C. Schwarz, A. zur Mühlen, W. Mehnert. Incorporation of lipophilic drugs and drug release profiles of solid lipid nanoparticles (SLN)., Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 21:146-147 (1994).
4. A. zur Mühlen, W. Mehnert. Drug Incorporation and Delivery of prednisolone loaded Solid Lipid Nanoparticles. Proc. 1st World Meeting APGI/APV, Budapest 9/11 May, 455-456 (1995).
5. E. Meyer, H. Heinzelmann. Scanning force microscopy. In R. Wiesendanger, H. J. Güntherodt. (eds.), Scanning Tunneling Microscopy II, Surface Sciences 28., Springer Verlag, Berlin, New York, 1992 pp. 99-149.
6. B. Drake, C. B. Prater, A. L. Weisenhorn, S. A. C. Gould, T. R. Albrecht, C. F. Quate, D. S. Cannell, H. G. Hansma, P. K. Hansma. Imaging crystals polymers and processes in water whith the AFM. Science 243:1586-1589 (1989).
7. W. Häberle, J. K. H. Hörber, F. Ohnesorge, D. P. E. Smith, G. Binnig. In situ investigations of single living cells infected by viruses. Ultramicroscopy 1161:42-44 (1992).
8. K. M. Shakesheff, M. C. Davies, A. Domb, T. O. Glasbey, D. E. Jackson, J. Heller, C. J. Roberts, A. G. Shard, S. J. B. Tendler, P. M. Williams. Visualizing the degredation of polymer surfaces with an Atomic Force Microscope. Proceed. Intern. Symp. Control. Rel. Bioact. Mat. 21:1343-1344 (1994).
9. R. Gref, Y. Minamitake, M. T. Peracchia, V. Trubetskoy, V. Torchilin, R. Langer. Biodegradable Long-Circulating Polymeric Nanospheres. Science 263:1600-1603 (1994).
10. A. R. Kirby, A. P. Gunning, V. J. Morris. Imaging xanthan gum by atomic force microscopy. Carbohydr. Res. 267:161-166 (1995).
11. R. H. Müller, W. Mehnert, J. S. Lucks, C. Schwarz, A. zur Mühlen, H. Weyhers, C. Freitas, D. Rühl. Solid lipid nanoparticles (SLN) - an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. 41:62-69 (1995).
12. P. H. Vallotton, M. M. Denn, B. A. Wood, M. B. Salmeron. Comparison of medical-grade ultrahigh molecular weight polyethylene microstructure by atomic force microscopy and transmission electron microscopy. J. Biomatter. Sci. Polymer 6:609-622 (1994).
13. J. W. Hagemann, J. A. Rothfus. Polymorphism and transformation Energetic of saturated Monoacid Triglycerides from DSC and theoretical modeling. J. Am. Oil. Chem. Soc. 60:1123-1131 (1983).
14. H. Mori, Solidification problems in prepapation of fats. In: N. Garti, K. Sato. Crystallisation and Polymorphism of Fats and Fatty Acids. Marcel Dekker Inc., New York, Basel, 1988. 422-442.
15. K. Thoma, P. Serno. Instabilitäten des Schmelzverhaltens von Hartfett-Suppositorien und deren Nachweis. Pharm. Ztg. 127:980-986 (1982).
16. B. W. Müller. Suppositorien, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1986.
17. B. Siekmann, K. Westesen. Thermoanalysis of the recrystallisation process of melt-homogenized glyceride nanoparticles. Coll. Surf. B 3:159-175 (1994).
18. K. Westesen, B. Siekmann, M. Koch. Investigations on the physical state of lipid nanoparticles by synchroton radiation X-ray diffraction. Int. J. Pharm. 93:189-199 (1993).
19. T. Eldem, P. Speiser, H. Altorfer. Polymorphic behaviour of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy. Pharm. Res. 8:178-184 (1991).
20. B. Siekmann, K. Westesen. Submicron-sized parenteral carrier systems based on solid lipids. Pharm. Pharmacol. Lett. 1:123-126 (1992).