메뉴 건너뛰기




Volumn 16, Issue 3, 2015, Pages 5254-5270

Development of small RNA delivery systems for lung cancer therapy

Author keywords

Drug delivery system; Lung cancer; MiRNA; RNAi; SiRNA

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; EPHRIN RECEPTOR A2; NANOPARTICLE; PROTEIN KINASE C; PROTEIN KINASE N; RAS PROTEIN; RIBONUCLEOTIDE REDUCTASE;

EID: 84925881823     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16035254     Document Type: Review
Times cited : (52)

References (86)
  • 1
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore, P.D.; Tuschl, T.; Sharp, P.A.; Bartel, D.P. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 2000, 101, 25–33.
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 2
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A.; Xu, S.; Montgomery, M.K.; Kostas, S.A.; Driver, S.E.; Mello, C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391, 806–811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 3
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411, 494–498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 4
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E.; Caudy, A.A.; Hammond, S.M.; Hannon, G.J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001, 409, 363–366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 5
    • 34248682403 scopus 로고    scopus 로고
    • RNAi therapeutics: Principles, prospects and challenges
    • Aagaard, L.; Rossi, J.J. RNAi therapeutics: Principles, prospects and challenges. Adv. Drug Deliv. Rev. 2007, 59, 75–86.
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 75-86
    • Aagaard, L.1    Rossi, J.J.2
  • 8
    • 38749136602 scopus 로고    scopus 로고
    • Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
    • DeVincenzo, J.; Cehelsky, J.E.; Alvarez, R.; Elbashir, S.; Harborth, J.; Toudjarska, I.; Nechev, L.; Murugaiah, V.; van Vliet, A.; Vaishnaw, A.K, et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antivir. Res. 2008, 77, 225–231.
    • (2008) Antivir. Res. , vol.77 , pp. 225-231
    • Devincenzo, J.1    Cehelsky, J.E.2    Alvarez, R.3    Elbashir, S.4    Harborth, J.5    Toudjarska, I.6    Nechev, L.7    Murugaiah, V.8    Van Vliet, A.9    Vaishnaw, A.K.10
  • 9
    • 58149232358 scopus 로고    scopus 로고
    • Artificial microRNAs as siRNA shuttles: Improved safety as compared to shRNAs in vitro and in vivo
    • Boudreau, R.L.; Martins, I.; Davidson, B.L. Artificial microRNAs as siRNA shuttles: Improved safety as compared to shRNAs in vitro and in vivo. Mol. Ther. 2009, 17, 169–175.
    • (2009) Mol. Ther , vol.17 , pp. 169-175
    • Boudreau, R.L.1    Martins, I.2    Davidson, B.L.3
  • 11
  • 12
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: MicroRNA biogenesis pathways and their regulation
    • Winter, J.; Jung, S.; Keller, S.; Gregory, R.I.; Diederichs, S. Many roads to maturity: MicroRNA biogenesis pathways and their regulation. Nat. Cell Biol. 2009, 11, 228–234.
    • (2009) Nat. Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 13
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce, C.M, Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 2009, 10, 704–714.
    • (2009) Nat. Rev. Genet , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 14
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs—MicroRNAs with a role in cancer
    • Esquela-Kerscher, A.; Slack, F.J. Oncomirs—MicroRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6, 259–269.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 16
    • 79955006086 scopus 로고    scopus 로고
    • Lung cancer: New biological insights and recent therapeutic advances
    • Ramalingam, S.S.; Owonikoko, T.K.; Khuri, F.R. Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J. Clin. 2011, 61, 91–112.
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 91-112
    • Ramalingam, S.S.1    Owonikoko, T.K.2    Khuri, F.R.3
  • 17
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao, W.; Girard, N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011, 12, 175–180.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 18
    • 0036166921 scopus 로고    scopus 로고
    • The treatment of limited small cell lung cancer: A report of the progress made and future prospects
    • Turrisi, A.T.; Sherman, C.A. The treatment of limited small cell lung cancer: A report of the progress made and future prospects. Eur. J. Cancer 2002, 38, 279–291.
    • (2002) Eur. J. Cancer , vol.38 , pp. 279-291
    • Turrisi, A.T.1    Sherman, C.A.2
  • 20
    • 84888610334 scopus 로고    scopus 로고
    • A novel platform to enable inhaled naked RNAi medicine for lung cancer
    • Fujita, Y.; Takeshita, F.; Mizutani, T.; Ohgi, T.; Kuwano, K.; Ochiya, T. A novel platform to enable inhaled naked RNAi medicine for lung cancer. Sci. Rep. 2013, 3, doi:10.1038/srep03325.
    • (2013) Sci. Rep , pp. 3
    • Fujita, Y.1    Takeshita, F.2    Mizutani, T.3    Ohgi, T.4    Kuwano, K.5    Ochiya, T.6
  • 21
    • 79954580272 scopus 로고    scopus 로고
    • Jr. Current prospects for RNA interference-based therapies
    • Davidson, B.L.; McCray, P.B., Jr. Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 2011, 12, 329–340.
    • (2011) Nat. Rev. Genet , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 23
    • 84878234504 scopus 로고    scopus 로고
    • Companies in footrace to deliver RNAi
    • Bouchie, A. Companies in footrace to deliver RNAi. Nat. Biotechnol. 2012, 30, 1154–1157.
    • (2012) Nat. Biotechnol , vol.30 , pp. 1154-1157
    • Bouchie, A.1
  • 28
    • 84878559366 scopus 로고    scopus 로고
    • Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes
    • Shim, G.; Choi, H.W.; Lee, S.; Choi, J.; Yu, Y.H.; Park, D.E.; Choi, Y.; Kim, C.W.; Oh, Y.K. Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes. Mol. Ther. 2013, 21, 816–824.
    • (2013) Mol. Ther , vol.21 , pp. 816-824
    • Shim, G.1    Choi, H.W.2    Lee, S.3    Choi, J.4    Yu, Y.H.5    Park, D.E.6    Choi, Y.7    Kim, C.W.8    Oh, Y.K.9
  • 30
    • 34247167175 scopus 로고    scopus 로고
    • Down-regulation of IGF-IR using small, interfering, hairpin RNA (SiRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice
    • Dong, A.Q.; Kong, M.J.; Ma, Z.Y.; Qian, J.F.; Xu, X.H. Down-regulation of IGF-IR using small, interfering, hairpin RNA (siRNA) inhibits growth of human lung cancer cell line A549 in vitro and in nude mice. Cell Biol. Int. 2007, 31, 500–507.
    • (2007) Cell Biol. Int , vol.31 , pp. 500-507
    • Dong, A.Q.1    Kong, M.J.2    Ma, Z.Y.3    Qian, J.F.4    Xu, X.H.5
  • 31
    • 84865130582 scopus 로고    scopus 로고
    • Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin
    • Tian, H.; Liu, S.; Zhang, J.; Zhang, S.; Cheng, L.; Li, C.; Zhang, X.; Dail, L.; Fan, P.; Dai, L, et al. Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin. J. Biomed. Nanotechnol. 2012, 8, 633–641.
    • (2012) J. Biomed. Nanotechnol. , vol.8 , pp. 633-641
    • Tian, H.1    Liu, S.2    Zhang, J.3    Zhang, S.4    Cheng, L.5    Li, C.6    Zhang, X.7    Dail, L.8    Fan, P.9    Dai, L.10
  • 34
    • 84886092551 scopus 로고    scopus 로고
    • Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice
    • Mainelis, G.; Seshadri, S.; Garbuzenko, O.B.; Han, T.; Wang, Z.; Minko, T. Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice. J. Aerosol Med. Pulm. Drug Deliv. 2013, 26, 345–354.
    • (2013) J. Aerosol Med. Pulm. Drug Deliv , vol.26 , pp. 345-354
    • Mainelis, G.1    Seshadri, S.2    Garbuzenko, O.B.3    Han, T.4    Wang, Z.5    Minko, T.6
  • 35
    • 81255143432 scopus 로고    scopus 로고
    • Innovative strategy for treatment of lung cancer: Targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA
    • Taratula, O.; Garbuzenko, O.B.; Chen, A.M.; Minko, T. Innovative strategy for treatment of lung cancer: Targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA. J. Drug Targets 2011, 19, 900–914.
    • (2011) J. Drug Targets , vol.19 , pp. 900-914
    • Taratula, O.1    Garbuzenko, O.B.2    Chen, A.M.3    Minko, T.4
  • 36
    • 84880446740 scopus 로고    scopus 로고
    • Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique
    • Okuda, T.; Kito, D.; Oiwa, A.; Fukushima, M.; Hira, D.; Okamoto, H. Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique. Biol. Pharm. Bull. 2013, 36, 1183–1191.
    • (2013) Biol. Pharm. Bull , vol.36 , pp. 1183-1191
    • Okuda, T.1    Kito, D.2    Oiwa, A.3    Fukushima, M.4    Hira, D.5    Okamoto, H.6
  • 37
    • 84857911904 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor
    • Li, J.; Yang, Y.; Huang, L. Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor. J. Control. Release 2012, 158, 108–114.
    • (2012) J. Control. Release , vol.158 , pp. 108-114
    • Li, J.1    Yang, Y.2    Huang, L.3
  • 38
    • 84893515418 scopus 로고    scopus 로고
    • Cationic bovine serum albumin based self-assembled nanoparticles as siRNA delivery vector for treating lung metastatic cancer
    • Han, J.; Wang, Q.; Zhang, Z.; Gong, T.; Sun, X. Cationic bovine serum albumin based self-assembled nanoparticles as siRNA delivery vector for treating lung metastatic cancer. Small 2014, 10, 524–535.
    • (2014) Small , vol.10 , pp. 524-535
    • Han, J.1    Wang, Q.2    Zhang, Z.3    Gong, T.4    Sun, X.5
  • 42
    • 84873082565 scopus 로고    scopus 로고
    • Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles
    • Yu, H.; Zou, Y.; Jiang, L.; Yin, Q.; He, X.; Chen, L.; Zhang, Z.; Gu, W.; Li, Y. Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles. Biomaterials 2013, 34, 2738–2747.
    • (2013) Biomaterials , vol.34 , pp. 2738-2747
    • Yu, H.1    Zou, Y.2    Jiang, L.3    Yin, Q.4    He, X.5    Chen, L.6    Zhang, Z.7    Gu, W.8    Li, Y.9
  • 43
    • 84857795022 scopus 로고    scopus 로고
    • Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis
    • Yang, Y.; Li, J.; Liu, F.; Huang, L. Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol. Ther. 2012, 20, 609–615.
    • (2012) Mol. Ther , vol.20 , pp. 609-615
    • Yang, Y.1    Li, J.2    Liu, F.3    Huang, L.4
  • 44
    • 84893660789 scopus 로고    scopus 로고
    • Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting STAT3 in lung cancer, in vitro and in vivo
    • Das, J.; Das, S.; Paul, A.; Samadder, A.; Bhattacharyya, S.S.; Khuda-Bukhsh, A.R. Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting STAT3 in lung cancer, in vitro and in vivo. Toxicol. Lett. 2014, 225, 454–466.
    • (2014) Toxicol. Lett , vol.225 , pp. 454-466
    • Das, J.1    Das, S.2    Paul, A.3    Samadder, A.4    Bhattacharyya, S.S.5    Khuda-Bukhsh, A.R.6
  • 46
    • 84881311470 scopus 로고    scopus 로고
    • Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC
    • Zhang, Y.; Schwerbrock, N.M.; Rogers, A.B.; Kim, W.Y.; Huang, L. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol. Ther. 2013, 21, 1559–1569.
    • (2013) Mol. Ther , vol.21 , pp. 1559-1569
    • Zhang, Y.1    Schwerbrock, N.M.2    Rogers, A.B.3    Kim, W.Y.4    Huang, L.5
  • 47
    • 73249126217 scopus 로고    scopus 로고
    • Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery
    • Dehousse, V.; Garbacki, N.; Colige, A.; Evrard, B. Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery. Biomaterials 2010, 31, 1839–1849.
    • (2010) Biomaterials , vol.31 , pp. 1839-1849
    • Dehousse, V.1    Garbacki, N.2    Colige, A.3    Evrard, B.4
  • 48
    • 70350148705 scopus 로고    scopus 로고
    • Engineered nanoscaled polyplex gene delivery systems. Mol
    • Fernandez, C.A.; Rice, K.G. Engineered nanoscaled polyplex gene delivery systems. Mol. Pharm. 2009, 6, 1277–1289.
    • (2009) Pharm , vol.6 , pp. 1277-1289
    • Fernandez, C.A.1    Rice, K.G.2
  • 49
    • 79961043075 scopus 로고    scopus 로고
    • MicroRNA delivery by cationic lipoplexes for lung cancer therapy
    • Wu, Y.; Crawford, M.; Yu, B.; Mao, Y.; Nana-Sinkam, S.P.; Lee, L.J. MicroRNA delivery by cationic lipoplexes for lung cancer therapy. Mol. Pharm. 2011, 8, 1381–1389.
    • (2011) Mol. Pharm , vol.8 , pp. 1381-1389
    • Wu, Y.1    Crawford, M.2    Yu, B.3    Mao, Y.4    Nana-Sinkam, S.P.5    Lee, L.J.6
  • 50
    • 84874634568 scopus 로고    scopus 로고
    • Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancer
    • Xia, L.; Guan, W.; Wang, D.; Zhang, Y.S.; Zeng, L.L.; Li, Z.P.; Wang, G.; Yang, Z.Z. Killing effect of Ad5/F35-APE1 siRNA recombinant adenovirus in combination with hematoporphrphyrin derivative-mediated photodynamic therapy on human nonsmall cell lung cancer. BioMed Res. Int. 2013, 2013, doi:org/10.1155/2013/957913.
    • (2013) Biomed Res. Int , pp. 2013
    • Xia, L.1    Guan, W.2    Wang, D.3    Zhang, Y.S.4    Zeng, L.L.5    Li, Z.P.6    Wang, G.7    Yang, Z.Z.8
  • 51
    • 84878420112 scopus 로고    scopus 로고
    • Human apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells
    • Gu, X.; Cun, Y.; Li, M.; Qing, Y.; Jin, F.; Zhong, Z.; Dai, N.; Qian, C.; Sui, J.; Wang, D. Human apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells. Int. J. Med. Sci. 2013, 10, 870–882.
    • (2013) Int. J. Med. Sci , vol.10 , pp. 870-882
    • Gu, X.1    Cun, Y.2    Li, M.3    Qing, Y.4    Jin, F.5    Zhong, Z.6    Dai, N.7    Qian, C.8    Sui, J.9    Wang, D.10
  • 52
    • 84871679186 scopus 로고    scopus 로고
    • Silencing of the COPS3 gene by siRNA reduces proliferation of lung cancer cells most likely via induction of cell cycle arrest and apoptosis
    • Wang, X.M.; Cui, J.W.; Li, W.; Cai, L.; Song, W.; Wang, G.J. Silencing of the COPS3 gene by siRNA reduces proliferation of lung cancer cells most likely via induction of cell cycle arrest and apoptosis. Asian Pac. J. Cancer Prev. 2012, 13, 1043–1048.
    • (2012) Asian Pac. J. Cancer Prev , vol.13 , pp. 1043-1048
    • Wang, X.M.1    Cui, J.W.2    Li, W.3    Cai, L.4    Song, W.5    Wang, G.J.6
  • 53
    • 84868208073 scopus 로고    scopus 로고
    • Effect of protein-tyrosine phosphatase 4A3 by small interfering RNA on the proliferation of lung cancer
    • Lian, Y.X.; Chen, R.; Xu, Y.H.; Peng, C.L.; Hu, H.C. Effect of protein-tyrosine phosphatase 4A3 by small interfering RNA on the proliferation of lung cancer. Gene 2012, 511, 169–176.
    • (2012) Gene , vol.511 , pp. 169-176
    • Lian, Y.X.1    Chen, R.2    Xu, Y.H.3    Peng, C.L.4    Hu, H.C.5
  • 54
    • 84864361751 scopus 로고    scopus 로고
    • Lentivirus-delivered ZEB-1 small interfering RNA inhibits lung adenocarcinoma cell growth in vitro and in vivo
    • Liu, Y.; Yan, X.; Liu, N.; Zhou, J.; Liu, J.; Pang, H.; Cao, J.; Liu, Y.; Wang, Y.; Liu, L, et al. Lentivirus-delivered ZEB-1 small interfering RNA inhibits lung adenocarcinoma cell growth in vitro and in vivo. J. Cancer Res. Clin. Oncol. 2012, 138, 1329–1338.
    • (2012) J. Cancer Res. Clin. Oncol. , vol.138 , pp. 1329-1338
    • Liu, Y.1    Yan, X.2    Liu, N.3    Zhou, J.4    Liu, J.5    Pang, H.6    Cao, J.7    Liu, Y.8    Wang, Y.9    Liu, L.10
  • 55
    • 84861379628 scopus 로고    scopus 로고
    • Proteins kinase Cvarepsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes
    • Caino, M.C.; Lopez-Haber, C.; Kim, J.; Mochly-Rosen, D.; Kazanietz, M.G. Proteins kinase Cvarepsilon is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene 2012, 31, 2593–2600.
    • (2012) Oncogene , vol.31 , pp. 2593-2600
    • Caino, M.C.1    Lopez-Haber, C.2    Kim, J.3    Mochly-Rosen, D.4    Kazanietz, M.G.5
  • 56
    • 79960054148 scopus 로고    scopus 로고
    • Tumor-targeting magnetic lipoplex delivery of short hairpin RNA suppresses IGF-1R overexpression of lung adenocarcinoma A549 cells in vitro and in vivo
    • Wang, C.; Ding, C.; Kong, M.; Dong, A.; Qian, J.; Jiang, D.; Shen, Z. Tumor-targeting magnetic lipoplex delivery of short hairpin RNA suppresses IGF-1R overexpression of lung adenocarcinoma A549 cells in vitro and in vivo. Biochem. Biophys. Res. Commun. 2011, 410, 537–542.
    • (2011) Biochem. Biophys. Res. Commun , vol.410 , pp. 537-542
    • Wang, C.1    Ding, C.2    Kong, M.3    Dong, A.4    Qian, J.5    Jiang, D.6    Shen, Z.7
  • 57
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: MicroRNAs can up-regulate translation
    • Vasudevan, S.; Tong, Y.; Steitz, J.A. Switching from repression to activation: MicroRNAs can up-regulate translation. Science 2007, 318, 1931–1934.
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 61
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • Trang, P.; Wiggins, J.F.; Daige, C.L.; Cho, C.; Omotola, M.; Brown, D.; Weidhaas, J.B.; Bader, A.G.; Slack, F.J. Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol. Ther. 2011, 19, 1116–1122.
    • (2011) Mol. Ther , vol.19 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3    Cho, C.4    Omotola, M.5    Brown, D.6    Weidhaas, J.B.7    Bader, A.G.8    Slack, F.J.9
  • 66
    • 77953232823 scopus 로고    scopus 로고
    • The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice
    • He, X.Y.; Chen, J.X.; Zhang, Z.; Li, C.L.; Peng, Q.L.; Peng, H.M. The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice. J. Cancer Res. Clin. Oncol. 2010, 136, 1023–1028.
    • (2010) J. Cancer Res. Clin. Oncol , vol.136 , pp. 1023-1028
    • He, X.Y.1    Chen, J.X.2    Zhang, Z.3    Li, C.L.4    Peng, Q.L.5    Peng, H.M.6
  • 69
    • 80052698948 scopus 로고    scopus 로고
    • Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells
    • Rai, K.; Takigawa, N.; Ito, S.; Kashihara, H.; Ichihara, E.; Yasuda, T.; Shimizu, K.; Tanimoto, M.; Kiura, K. Liposomal delivery of microRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells. Mol. Cancer Ther. 2011, 10, 1720–1727.
    • (2011) Mol. Cancer Ther , vol.10 , pp. 1720-1727
    • Rai, K.1    Takigawa, N.2    Ito, S.3    Kashihara, H.4    Ichihara, E.5    Yasuda, T.6    Shimizu, K.7    Tanimoto, M.8    Kiura, K.9
  • 72
    • 84862808036 scopus 로고    scopus 로고
    • Cationic polyurethanes-short branch PEI-mediated delivery of mirR145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    • Chiou, G.Y.; Cherng, J.Y.; Hsu, H.S.; Wang, M.L.; Tsai, C.M.; Lu, K.H.; Chien, Y.; Hung, S.C.; Chen, Y.W.; Wong, C.I, et al. Cationic polyurethanes-short branch PEI-mediated delivery of mirR145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J. Control. Release 2012, 159, 240–250.
    • (2012) J. Control. Release , vol.159 , pp. 240-250
    • Chiou, G.Y.1    Cherng, J.Y.2    Hsu, H.S.3    Wang, M.L.4    Tsai, C.M.5    Lu, K.H.6    Chien, Y.7    Hung, S.C.8    Chen, Y.W.9    Wong, C.I.10
  • 76
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: Current progress and future prospects
    • Burnett, J.C.; Rossi, J.J. RNA-based therapeutics: Current progress and future prospects. Chem. Biol. 2012, 19, 60–71.
    • (2012) Chem. Biol , vol.19 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2
  • 79
    • 0038419800 scopus 로고    scopus 로고
    • Induction of an interferon response by RNAi vectors in mammalian cells
    • Bridge, A.J.; Pebernard, S.; Ducraux, A.; Nicoulaz, A.L.; Iggo, R. Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet. 2003, 34, 263–264.
    • (2003) Nat. Genet , vol.34 , pp. 263-264
    • Bridge, A.J.1    Pebernard, S.2    Ducraux, A.3    Nicoulaz, A.L.4    Iggo, R.5
  • 81
    • 3042623020 scopus 로고    scopus 로고
    • Synthesis of biodegradable multi-block copolymers of poly(L-lysine) and poly(ethylene glycol) as a non-viral gene carrier
    • Ahn, C.H.; Chae, S.Y.; Bae, Y.H.; Kim, S.W. Synthesis of biodegradable multi-block copolymers of poly(L-lysine) and poly(ethylene glycol) as a non-viral gene carrier. J. Control. Release 2004, 97, 567–574.
    • (2004) J. Control. Release , vol.97 , pp. 567-574
    • Ahn, C.H.1    Chae, S.Y.2    Bae, Y.H.3    Kim, S.W.4
  • 82
    • 0034127664 scopus 로고    scopus 로고
    • Activation of host antitumoral responses by cationic lipid/DNA complexes
    • Bramson, J.L.; Bodner, C.A.; Graham, R.W. Activation of host antitumoral responses by cationic lipid/DNA complexes. Cancer Gene Ther. 2000, 7, 353–359.
    • (2000) Cancer Gene Ther , vol.7 , pp. 353-359
    • Bramson, J.L.1    Bodner, C.A.2    Graham, R.W.3
  • 83
    • 0032732516 scopus 로고    scopus 로고
    • LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
    • Whitmore, M.; Li, S.; Huang, L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther. 1999, 6, 1867–1875.
    • (1999) Gene Ther , vol.6 , pp. 1867-1875
    • Whitmore, M.1    Li, S.2    Huang, L.3
  • 86
    • 84923284331 scopus 로고    scopus 로고
    • Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer
    • Fujita, Y.; Yagishita, S.; Takeshita, F.; Yamamoto, Y.; Kuwano, K.; Ochiya, T. Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer. Oncotarget 2015, 6, 3335–3345.
    • (2015) Oncotarget , vol.6 , pp. 3335-3345
    • Fujita, Y.1    Yagishita, S.2    Takeshita, F.3    Yamamoto, Y.4    Kuwano, K.5    Ochiya, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.