Invivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models

Biomaterials

Volumn 34, Issue 31, 2013, Pages 7744-7753

  Conde, João ^a,b   Tian, Furong ^c   Hernández, Yulán ^a   Bao, Chenchen ^c,d   Cui, Daxiang ^d   Janssen, Klaus Peter ^e   Ibarra, M Ricardo ^a   Baptista, Pedro V ^b   Stoeger, Tobias ^c   de la Fuente, Jesús M ^a  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Gene silencing; Inflammatory response; Lung cancer therapy; Mice tumor targeting; RGD siRNA nanoparticles

Indexed keywords

FUNCTIONALIZED GOLD NANOPARTICLES; GENE SILENCING; GOLD NANOPARTICLES; INFLAMMATORY RESPONSE; INTRATRACHEAL INSTILLATION; LUNG CANCER THERAPY; THERAPEUTIC EFFECTS; TUMOR TARGETING;

BIOLOGICAL ORGANS; CELL PROLIFERATION; DISEASES; ENZYME ACTIVITY; GENE EXPRESSION; GOLD; GOLD COMPOUNDS; MAMMALS; METAL NANOPARTICLES;

TUMORS;

GOLD NANOPARTICLE; SMALL INTERFERING RNA; GOLD; METAL NANOPARTICLE; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE SILENCING; IMMUNE RESPONSE; INFLAMMATION; LUNG CANCER; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RNA INTERFERENCE; TUMOR CELL; TUMOR VOLUME; ANIMAL; C57BL MOUSE; CHEMISTRY; FLOW CYTOMETRY; GENETICS; IN VITRO STUDY; LUNG CANCER THERAPY; LUNG TUMOR; METABOLISM; MICE TUMOR TARGETING; PHYSIOLOGY; RGD/SIRNA NANOPARTICLES; TUMOR CELL LINE;

MURINAE; MUS;

GENE SILENCING; INFLAMMATORY RESPONSE; LUNG CANCER THERAPY; MICE TUMOR TARGETING; RGD/SIRNA NANOPARTICLES;

ANIMALS; CELL LINE, TUMOR; FEMALE; FLOW CYTOMETRY; GENE SILENCING; GOLD; INTEGRIN ALPHAVBETA3; LUNG NEOPLASMS; METAL NANOPARTICLES; MICE, INBRED C57BL; RNA, SMALL INTERFERING; IN VITRO TECHNIQUES;

EID: 84880951110     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.06.041     Document Type: Article

References (34)

1. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature 1998, 39:806-811.
2. Wall N.R., Shi Y. Small RNA: can RNA interference be exploited for therapy?. The Lancet 2003, 362:1401-1403.
3. Lee S.H., Mok H., Jo S., Am Hong C., Park T.G. Dual gene targeted multimeric siRNA for combinatorial gene silencing. Biomaterials 2011, 32:2359-2368.
4. Li X., Xie Q.R., Zhang J., Xia W., Gu H. The packaging of siRNA within the mesoporous structure of silica nanoparticles. Biomaterials 2011, 32:9546-9556.
5. Shrestha R., Elsabahy M., Florez-Malaver S., Samarajeewa S., Wooley K.L. Endosomal escape and siRNA delivery with cationic shell crosslinked knedel-like nanoparticles with tunable buffering capacities. Biomaterials 2012, 33:8557-8568.
6. Gil P.R., Parak W.J. Composite nanoparticles take aim at cancer. ACS Nano 2008, 2:2200-2205.
7. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
8. Lammers T., Aime S., Hennink W.E., Storm G., Kiessling F. Theranostic nanomedicines. Acc Chem Res 2011, 44:1029-1038.
9. Ghosh P., Han G., De M., Kim C.K., Rotello V.M. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 2008, 60:1307-1315.
10. Conde J., Doria G., Baptista P. Noble metal nanoparticles applications in cancer. JDrug Deliv 2012, 2012:751075.
11. Lee S.K., Han M.S., Asokan S., Tung C.H. Effective gene silencing by multilayered siRNA-coated gold nanoparticles. Small 2011, 7:364-370.
12. Kim S.T., Chompoosor A., Yeh Y.C., Agasti S.S., Solfiell D.J., Rotello V.M. Dendronized gold nanoparticles for siRNA delivery. Small 2012, 8:3253-3256.
13. Giljohann D.A., Seferos D.S., Prigodich A.E., Patel P.C., Mirkin C.A. Gene regulation with polyvalent siRNA-nanoparticle conjugates. JAm Chem Soc 2009, 131:2072-2073.
14. Lee Y., Lee S.H., Kim J.S., Maruyama A., Chen X., Park T.G. Controlled synthesis of PEI-coated gold nanoparticles using reductive catechol chemistry for siRNA delivery. JControl Release 2011, 155:3-10.
15. Song W.J., Du J.Z., Sun T.M., Zhang P.Z., Wang J. Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery. Small 2010, 6:239-246.
16. Lee J.S., Green J.J., Love K.T., Sunshine J., Langer R., Anderson D.G. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett 2009, 9:2402-2406.
17. Lee S.H., Bae K.H., Kim S.H., Lee K.R., Park T.G. Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers. Int J Pharm 2008, 364:94-101.
18. Guo S., Huang Y., Jiang Q., Sun Y., Deng L., Liang Z., et al. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano 2010, 4:5505-5511.
19. Conde J., Ambrosone A., Sanz V., Hernandez Y., Marchesano V., Tian F., et al. Design of multifunctional gold nanoparticles for invitro and invivo gene silencing. ACS Nano 2012, 6:8316-8324.
20. Li B., Chen J., Wang J.H. RGD peptide-conjugated poly(dimethylsiloxane) promotes adhesion, proliferation, and collagen secretion of human fibroblasts. JBiomed Mater Res A 2006, 79:989-998.
21. Cai W., Sam Gambhir S., Chen X. Multimodality tumor imaging targeting integrin alphavbeta3. Biotechniques 2005, 39:14-25.
22. Götz A.A., Rozman J., Rödel H.G., Fuchs H., Gailus-Durner V., Hrabě de Angelis M., et al. Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets. Part Fibre Toxicol 2011, 8:1-13.
23. Schiller H.B., Szekeres A., Binder B.R., Stockinger H., Leksa V. Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor. Mol Biol Cell 2009, 20:745-756.
24. Steele J.G., Rowlatt C., Sandall J.K., Franks L.M. Cell surface properties of high- and low-metastatic cell lines selected from a spontaneous mouse lung carcinoma. Int J Cancer 1983, 32:769-779.
25. Dobrovolskaia M.A., Aggarwal P., Hall J.B., McNeil S.E. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 2008, 5:487-495.
26. Lewinski N., Colvin V., Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26-49.
27. Brooks P.C., Clark R.A.F., Cheresh D.A. Requirement of vascular integrin αvβ3 for angiogenesis. Science 1994, 264:569-571.
28. Erbacher P., Remy J.S., Behr J.P. Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther 1999, 6:138-145.
29. Siegel R., Naishadham D., Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012, 62:10-29.
30. Soucek L., Whitfield J., Martins C.P., Finch A.J., Murphy D.J., Sodir N.M., et al. Modelling Myc inhibition as a cancer therapy. Nature 2008, 455:679-683.
31. Dhar S., Daniel W.L., Giljohann D.A., Mirkin C.A., Lippard S.J. Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads. JAm Chem Soc 2009, 131:14652-14653.
32. Brown S.D., Nativo P., Smith J.A., Stirling D., Edwards P.R., Venugopal B., et al. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. JAm Chem Soc 2010, 132:4678-4684.
33. Chen Y.H., Tsai C.Y., Huang P.Y., Chang M.Y., Cheng P.C., Chou C.H., et al. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharmaceutics 2007, 4:713-722.
34. Li H., Sorenson A.L., Poczobutt J., Amin J., Joyal T., Sullivan T., et al. Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis. PLoS One 2011, 6:e28133.