Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery

Biomaterials

Volumn 31, Issue 7, 2010, Pages 1839-1849

  Dehousse, V ^a   Garbacki, N ^a   Colige, A ^a   Evrard, B ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Chitin chitosan; Drug delivery; Gene therapy; RNA interference

Indexed keywords

ATTRACTIVE STRATEGIES; CHITIN/CHITOSAN; DIFFERENT DISTRIBUTIONS; ENDOSOMAL COMPARTMENTS; IN-VITRO; INTRACELLULAR DELIVERY; METHACRYLIC ACIDS; MRNA EXPRESSION; NANOCARRIERS; PH SENSITIVE; PH-RESPONSIVE; RATE-LIMITING STEPS; RNA INTERFERENCE; SIRNA DELIVERY; SWELLING BEHAVIOUR; TRANSFECTION EFFICIENCY;

ACIDS; COMPLEXATION; CONFOCAL MICROSCOPY; COPOLYMERIZATION; DRUG DELIVERY; EXPERIMENTS; GENE THERAPY; GENETIC ENGINEERING; NUCLEIC ACIDS; POTENTIOMETRIC SENSORS; SWELLING;

RNA;

CHITOSAN; MESSENGER RNA; NANOCARRIER; NANOPARTICLE; POLYMETHACRYLIC ACID; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL STRAIN L 929; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG FORMULATION; ENDOSOME; FLUORESCENCE ACTIVATED CELL SORTING; GENE INTERACTION; GENETIC TRANSFECTION; IN VITRO STUDY; MORPHOLOGY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SURFACE CHARGE; ZETA POTENTIAL;

ANIMALS; ANIONS; CELL DEATH; CELL LINE; CHITOSAN; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HYDROGEN-ION CONCENTRATION; METHACRYLATES; MICE; MICROSCOPY, CONFOCAL; NANOPARTICLES; PARTICLE SIZE; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 73249126217     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.11.028     Document Type: Article

References (60)

1. White P.J. Barriers to successful delivery of short interfering RNA after systemic administration. Clin Exp Pharmacol Physiol 35 11 (2008) 1371-1376
2. Akinc A., Zumbuehl A., Goldberg M., Leshchiner E.S., Busini V., Hossain N., et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 26 5 (2008) 561-569
3. Howard K.A. Delivery of RNA interference therapeutics using polycation-based nanoparticles. Adv Drug Deliv Rev 61 9 (2009) 710-720
4. De Smedt S.C., Demeester J., and Hennink W.E. Cationic polymer based gene delivery systems. Pharm Res 17 2 (2000) 113-126
5. Behlke M.A. Progress towards in vivo use of siRNAs. Mol Ther 13 4 (2006) 644-670
6. Engelhardt J.F., Simon R.H., Yang Y., Zepeda M., Weber-Pendleton S., Doranz B., et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum Gene Ther 4 6 (1993) 759-769
7. Lehrman S. Virus treatment questioned after gene therapy death. Nature 401 6753 (1999) 517-518
8. Tseng Y.C., Mozumdar S., and Huang L. Lipid-based systemic delivery of siRNA. Adv Drug Deliv Rev 61 9 (2009) 721-731
9. Zimmermann T.S., Lee A.C., Akinc A., Bramlage B., Bumcrot D., Fedoruk M.N., et al. RNAi-mediated gene silencing in non-human primates. Nature 441 7089 (2006) 111-114
10. Fattal E., and Barratt G. Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br J Pharmacol 157 2 (2009) 179-194
11. Kim W.J., and Kim S.W. Efficient siRNA delivery with non-viral polymeric vehicles. Pharm Res 26 3 (2009) 657-666
12. Akhtar S., Hughes M.D., Khan A., Bibby M., Hussain M., Nawaz Q., et al. The delivery of antisense therapeutics. Adv Drug Deliv Rev 44 1 (2000) 3-21
13. Richardson S.C.W., Kolbe H.J.V., and Duncan R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm 178 2 (1999) 231-243
14. Aiba S. Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans. Int J Biol Macromol 14 4 (1992) 225-228
15. Lai W.F., and Lin M.C. Nucleic acid delivery with chitosan and its derivatives. J Control Release 134 3 (2009) 158-168
16. Weecharangsan W., Opanasopit P., Ngawhirunpat T., Apirakaramwong A., Rojanarata T., Ruktanonchai U., et al. Evaluation of chitosan salts as non-viral gene vectors in CHO-K1 cells. Int J Pharm 348 1-2 (2008) 161-168
17. Mansouri S., Lavigne P., Corsi K., Benderdour M., Beaumont E., and Fernandes J.C. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur J Pharm Biopharm 57 1 (2004) 1-8
18. Mao H.Q., Roy K., Troung-Le V.L., Janes K.A., Lin K.Y., Wang Y., et al. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 70 3 (2001) 399-421
19. Bowman K., and Leong K.W. Chitosan nanoparticles for oral drug and gene delivery. Int J Nanomed 1 2 (2006) 117-128
20. Romoren K., Pedersen S., Smistad G., Evensen O., and Thu B.J. The influence of formulation variables on in vitro transfection efficiency and physicochemical properties of chitosan-based polyplexes. Int J Pharm 261 1-2 (2003) 115-127
21. Pille J.Y., Li H., Blot E., Bertrand J.R., Pritchard L.L., Opolon P., et al. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Hum Gene Ther 17 10 (2006) 1019-1026
22. Rojanarata T., Opanasopit P., Techaarpornkul S., Ngawhirunpat T., and Ruktanonchai U. Chitosan-thiamine pyrophosphate as a novel carrier for siRNA delivery. Pharm Res 25 12 (2008) 2807-2814
23. Alvarez F., Taleb A., Gentili J., Nebois P., Terreux R., Domard M., et al. A Diels-Alder strategy for the building of imidazo[4,5-g]quinoline-4,9-dione derivatives. Eur J Org Chem 9 (2005) 1903-1908
24. Katas H., and Alpar H.O. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release 115 2 (2006 Oct 10) 216-225
25. Mourya V.K., and Inamdar N.N. Trimethyl chitosan and its applications in drug delivery. J Mater Sci Mater Med 20 5 (2009 May) 1057-1079
26. Mao Z., Ma L., Jiang Y., Yan M., Gao C., and Shen J.N. N, N-Trimethylchitosan chloride as a gene vector: synthesis and application. Macromol Biosci 7 6 (2007) 855-863
27. Verheul R.J., Amidi M., van Steenbergen M.J., van Riet E., Jiskoot W., and Hennink W.E. Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans. Biomaterials 30 18 (2009) 3129-3135
28. Kean T., Roth S., and Thanou M. Trimethylated chitosans as non-viral gene delivery vectors: cytotoxicity and transfection efficiency. J Control Release 103 3 (2005) 643-653
29. Prego C., Torres D., Fernandez-Megia E., Novoa-Carballal R., Quinoa E., and Alonso M.J. Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree. J Control Release 111 3 (2006) 299-308
30. Zhang Y., Chen J., Pan Y., Zhao J., Ren L., Liao M., et al. A novel PEGylation of chitosan nanoparticles for gene delivery. Biotechnol Appl Biochem 46 4 (2007) 197-204
31. Kotze A.F., Luessen H.L., de Leeuw B.J., de Boer A.G., Verhoef J.C., and Junginger H.E. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release 51 1 (1998) 35-46
32. Jintapattanakit A., Mao S., Kissel T., and Junyaprasert V.B. Physicochemical properties and biocompatibility of N-trimethyl chitosan: effect of quaternization and dimethylation. Eur J Pharm Biopharm 70 2 (2008) 563-571
33. Thanou M., Florea B.I., Geldof M., Junginger H.E., and Borchard G. Quaternized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials 23 1 (2002) 153-159
34. Ganta S., Devalapally H., Shahiwala A., and Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release 126 3 (2008) 187-204
35. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 92 16 (1995) 7297-7301
36. Kim T.H., Kim S.I., Akaike T., and Cho C.S. Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. J Control Release 105 3 (2005) 354-366
37. Shenoy D., Little S., Langer R., and Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol Pharm 2 5 (2005) 357-366
38. Na K., Lee E.S., and Bae Y.H. Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. J Control Release 87 1-3 (2003) 3-13
39. Bulmus V., Woodward M., Lin L., Murthy N., Stayton P., and Hoffman A. A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J Control Release 93 2 (2003) 105-120
40. Deroanne C.F., Hamelryckx D., Ho T.T.G., Lambert C.A., Catroux P., Lapiere C.M., et al. Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. J Cell Sci 118 6 (2005) 1173-1183
41. Liu X., Howard K.A., Dong M., Andersen M.O., Rahbek U.L., Johnsen M.G., et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials 28 6 (2007) 1280-1288
42. Berger J., Reist M., Mayer J.M., Felt O., and Gurny R. Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm 57 1 (2004) 35-52
43. Gan Q., Wang T., Cochrane C., and McCarron P. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids Surf B-Biointerf 44 2-3 (2005) 65-73
44. Illum L., Jabbal-Gill I., Hinchcliffe M., Fisher A.N., and Davis S.S. Chitosan as a novel nasal delivery system for vaccines. Adv Drug Deliv Rev 51 1-3 (2001) 81-96
45. Erbacher P., Zou S., Bettinger T., Steffan A.M., and Remy J.S. Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability. Pharm Res 15 9 (1998) 1332-1339
46. Nguyen D.A., and Fogler H.S. Facilitated diffusion in the dissolution of carboxylic polymers. AIChE J 51 2 (2005) 415-425
47. Panyam J., and Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55 3 (2003) 329-347
48. Douglas K.L., and Tabrizian M. Effect of experimental parameters on the formation of alginate-chitosan nanoparticles and evaluation of their potential application as DNA carrier. J Biomater Sci Polym Ed 16 1 (2005) 43-56
49. Vinogradov S.V., Bronich T.K., and Kabanov A.V. Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev 54 1 (2002) 135-147
50. Andrade J. In: Peppas N.A. (Ed). Hydrogels in medicine and pharmacy. Fundamentals vol. I (1987), CRC Press, Boca Raton, FL 192 pages. J Controlled Release 1989;10(2):225-225
51. Pouton C.W., Lucas P., Thomas B.J., Uduehi A.N., Milroy D.A., and Moss S.H. Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J Control Release 53 1-3 (1998) 289-299
52. MacLaughlin F.C., Mumper R.J., Wang J., Tagliaferri J.M., Gill I., Hinchcliffe M., et al. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 56 1-3 (1998) 259-272
53. Lackey C.A., Murthy N., Press O.W., Tirrell D.A., Hoffman A.S., and Stayton P.S. Hemolytic activity of pH-responsive polymer-streptavidin bioconjugates. Bioconjug Chem 10 3 (1999 May) 401-405
54. Behr J.P. Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjug Chem 5 5 (1994 Sep) 382-389
55. Moreira C., Oliveira H., Pires L.R., Simoes S., Barbosa M.A., and Pego A.P. Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backbone. Acta Biomater (2009)
56. Ishii T., Okahata Y., and Sato T. Mechanism of cell transfection with plasmid/chitosan complexes. Biochim Biophys Acta 1514 1 (2001) 51-64
57. Hamidi M., Azadi A., and Rafiei P. Hydrogel nanoparticles in drug delivery. Adv Drug Deliv Rev 60 15 (2008) 1638-1649
58. Yessine M.A., Meier C., Petereit H.U., and Leroux J.C. On the role of methacrylic acid copolymers in the intracellular delivery of antisense oligonucleotides. Eur J Pharm Biopharm 63 1 (2006) 1-10
59. Seki K., and Tirrell D.A. pH-Dependent complexation of poly(acrylic acid) derivatives with phospholipid vesicle membranes. Macromolecules 17 9 (2002) 1692-1698
60. Convertine A.J., Benoit D.S., Duvall C.L., Hoffman A.S., and Stayton P.S. Development of a novel endosomolytic diblock copolymer for siRNA delivery. J Control Release 133 3 (2009) 221-229