Aerosol delivery of spermine-based poly(amino ester)/Akt1 shRNA complexes for lung cancer gene therapy

International Journal of Pharmaceutics

Volumn 420, Issue 2, 2011, Pages 256-265

  Jiang, Hu Lin ^a   Hong, Seong Ho ^a   Kim, You Kyoung ^a   Islam, Mohammad Ariful ^a   Kim, Hye Joon ^a   Choi, Yun Jaie ^a   Nah, Jae Woon ^b   Lee, Kee Ho ^c   Han, Ki Won ^a   Chae, Chanhee ^a   Cho, Chong Su ^a   Cho, Myung Haing ^a,d  

^a Seoul National University   (South Korea)

^b Sunchon National University   (South Korea)

^c Korea Institute of Radiation and Medical Science   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Aerosol delivery; Gene therapy; Lung cancer; Poly(amino ester); Spermine

Indexed keywords

COPOLYMER; DNA; GLYCEROL PROPOXYLATE TRIACRYLATE; POLY(AMINO ESTER); PROTEIN AKT 1; PROTEIN KINASE B; SHORT HAIRPIN RNA; SPERMINE; UNCLASSIFIED DRUG;

AEROSOL DELIVERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENE THERAPY; CARCINOGENESIS; CONTROLLED STUDY; DRUG ANALYSIS; DRUG DELIVERY SYSTEM; FEMALE; GEL CHROMATOGRAPHY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MICHAEL ADDITION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ONCOGENE K RAS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ACRYLATES; ADENOCARCINOMA; AEROSOLS; ANIMALS; CELL LINE, TUMOR; CROSS-LINKING REAGENTS; DNA; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; POLYESTERS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS P21(RAS); RNA, SMALL INTERFERING; SOLUBILITY; SPERMINE; TRANSFECTION; TUMOR BURDEN;

EID: 80054697358     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.08.045     Document Type: Article

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