Applications of HPLC/MS in the analysis of traditional Chinese medicines

Journal of Pharmaceutical Analysis

Volumn 1, Issue 2, 2011, Pages 81-91

  Li, Miao ^a   Hou, Xiao Fang ^a   Zhang, Jie ^a   Wang, Si Cen ^a   Fu, Qiang ^a   He, Lang Chong ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Component analysis; HPLC MS; Metabolites analysis; Pharmacokinetics; Traditional chinese medicines (TCMs)

Indexed keywords

ACONITINE; ALBIFLORIN; ALKALOID; BAICALIN; BERBERINE; CEPHARANTHINE; DAURICINE; EMODIN; EOTAXIN; FLAVONOID; GLYCOSIDE; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; ISOLIQUIRITIGENIN; JATRORRHIZINE; LIQUIRITIGENIN; LIQUIRITIN; MATERIA MEDICA; OXYMATRINE; PALMATINE; POLYGONUM CUSPIDATUM EXTRACT; SANGUINARINE; SAPONIN; SCOPARONE; SIBUTRAMINE; SILDENAFIL; STEROID; SUGAR; UNINDEXED DRUG; VINCRISTINE;

ANALYTIC METHOD; CELL MEMBRANE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHINESE MEDICINE; DIET SUPPLEMENTATION; DRUG DETERMINATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG SCREENING; DYSLIPIDEMIA; ELECTROSPRAY; ENZYME INHIBITION; FORENSIC SCIENCE; FRITILLARIA; FRUIT; GLYCYRRHIZA URALENSIS; HEMOSTASIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MITRAGYNA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OLEACEAE; PHARMACOKINETICS; PRESCRIPTION; QUALITY CONTROL; REVIEW; SEXUAL FUNCTION; TRADITIONAL MEDICINE; WEIGHT REDUCTION;

EID: 84925835465     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2095-1779(11)70015-6     Document Type: Review

References (90)

1. Yang M, Sun JH, Lu ZQ, et al. Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry. J Chromatogr A, 2009, 1216(11):2045-2062.
2. Gray MJ, Chang D, Zhang Y, et al. Development of liquid chromatography/mass spectrometry methods for the quantitative analysis of herbal medicine in biological fluids: a review. Biomed Chromatogr, 2010, 24(1): 91-103.
3. Li YG, Song L, Liu M, et al. Advancement in analysis of Salviae miltiorrhizae Radix et Rhizoma (Danshen). J Chromatogr A, 2009, 1216(11): 1941-1953.
4. Zhang QY, Ye M. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). J Chromatogr A, 2009, 1216(11):1954-1969.
5. Zhang AH, Sun H, Wang ZG, et al. Metabolomics: Towards understanding traditional Chinese medicine. Planta Medica, 2010, 76(17):2026-2035.
6. Jayaprakasam B, Doddaga S, Wang R, et al. Licorice Flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro. J Agric Food Chem, 2009, 57(3):820-825.
7. Zhao L, Tian X, Fan PC, et al. Separation, determination and identification of the diastereoisomers of podophyllotoxin and its esters by high-performance liquid chromatography/tandem mass spectrometry. J Chromatogr A, 2008, 1210(2):168-177.
8. Wang J, Van Der Heijden R, Spijksma G, et al. Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry. J Chromatogr A, 2009, 1216(11):2169-2178.
9. n and ESI-MS studies on the Aconitum alkaloids in three Chinese medicinal herbs. J Sep Sci, 2010, 33(17-18):2898-2906.
10. n. Talanta, 2009, 77(5):1800-1807.
11. Wang L, Ren J, Sun M, et al. A combined cell membrane chromatography and online HPLC/MS method for screening compounds from Radix Caulophylli acting on the human alpha (1A)-adrenoceptor. J Pharm Biomed Anal, 2010, 51(5):1032-1036.
12. De Jong CF, Derks RJE, Bruyneel B, et al. High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. J Chromatogr A, 2006, 1112(1-2):303-310.
13. Yuan JF, Zhang ZQ, Kang XQ, et al. LC-MS analysis for the components captured by ECV304 cell from extract of Aconitum szechenyianum Gay. Biomed Chromatogr, 2009, 23(4):406-411.
14. Zhou JL, Xin GZ, Shi ZQ, et al. Characterization and identification of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J Chromatogr A, 2010, 1217(45):7109-7122.
15. Alali FQ, Tahboub YR, Al-Daraysih IS, et al. LC-MS and LC-PDA vs. phytochemical analysis of Colchicum brachyphyllum. Pharmazie, 2008, 63 (12):860-865.
16. Zhou Y, Zou X, Liu X, et al. Multistage electrospray ionization mass spectrometric analyses of sulfur-containing iridoid glucosides in Paederia scandens. Rapid Commun Mass Spectrom, 2007, 21(8):1375-1385. (Pubitemid 46663674)
17. Lee KC, Cheuk MW, Chan W, et al. Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometry. Anal Bioanal Chem, 2006, 386 (7-8):2225-2232.
18. Kite GC, Veitch NC, Boalch ME, et al. Flavonol tetraglycosides from fruits of Styphnolobium japonicum (Leguminosae) and the authentication of Fructus Sophorae and Flos Sophorae. Phytochemistry, 2009, 70(6): 785-794.
19. Zhang T, Liu H, Liu XT, et al. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. J Pharm Biomed Anal, 2010, 51(1): 114-124.
20. Dong HJ, Liu ZQ, Song FR, et al. Structural analysis of monoterpene glycosides extracted from Paeonia lactiflora Pall. using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom, 2007, 21(19):3193-3199.
21. Qi LW, Gu XJ, Li P, et al. Structural characterization of pregnane glycosides from Cynanchum auriculatum by liquid chromatography on a hybrid ion trap time-of-flight mass spectrometer. Rapid Commun Mass Spectrom, 2009, 23(14):2151-2160.
22. Xie GX, Plumb R, Su MM, et al. Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. J Sep Sci, 2008, 31 (6-7):1015-1026. (Pubitemid 351649827)
23. Han J, Ye M, Qiao X, et al. Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry. J Pharm Biomed Anal, 2008, 47(3):516-525.
24. Liu AH, Guo H, Ye M, et al. Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. J Chromatogr A, 2007, 1161(1-2):170-182. (Pubitemid 47088514)
25. Lee S, Khoo C, Halstead CW, et al. Liquid chromatographic determination of honokiol and magnolol in Hou Po (Magnolia officinalis) as the raw herb and dried aqueous extract. J AOAC Int, 2007, 90(5):1210-1218. (Pubitemid 47583178)
26. Hu FL, Deng CH, Liu Y, et al. Quantitative determination of chlorogenic acid in Honeysuckle using microwave-assisted extraction followed by nano-LC-ESI mass spectrometry. Talanta, 2009, 77(4):1299-1303.
27. Wang C, Pan YJ, Fan GR, et al. Application of an efficient strategy based on MAE, HPLC-DAD-MS/MS and HSCCC for the rapid extraction, identification, separation and purification of flavonoids from Fructus Aurantii Immaturus. Biomed Chromatogr, 2010, 24(3):235-244.
28. Han QB, Zhou Y, Feng C, et al. Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2009, 877(4):401-407.
29. Zhao YY, Guo ZM, Zhang XL, et al. Off-line 2-D RPLC/RPLC method for separation of components in Dalbergia odorifera T. Chen. J Sep Sci, 2010, 33(9):1224-1230.
30. Yang NY, Duan JA, Shang EX, et al. Analysis of Sesquiterpene Lactones in Eupatorium lindleyanum by HPLC-PDA-ESI-MS/MS. Phytochem Anal, 2010, 21(2):144-149.
31. Liu X, Li SL, Zhou Y, et al. Characterization of protostane triterpenoids in Alisma orientalis by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom, 2010, 24(11):1514-1522.
32. Inbaraj BS, Lu H, Hung CF, et al. Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC-DAD-APCI-MS. J Pharm Biomed Anal, 2008, 47(4-5):812-818.
33. Huang SC, Hung CF, Wu WB, et al. Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry. J Pharm Biomed Anal, 2008, 48(1):105-112.
34. Ahn MJ, Lee MK, Kim YC, et al. The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry. J Pharm Biomed Anal, 2008, 46(2):258-266.
35. Xie Y, Zhao WQ, Zhou TT, et al. An efficient strategy based on MAE, HPLC-DAD-ESI-MS/MS and 2D-prep-HPLC-DAD for the rapid extraction, separation, identification and purification of five active coumarin components from Radix Angelicae Dahuricae. Phytochem Anal, 2010, 21 (5):473-482.
36. Huang LY, Zhong TH, Chen TW, et al. Identification of beta-sitosterol, stigmasterol and ergosterin in A-roxburghii using supercritical fluid extraction followed by liquid chromatography/atmospheric pressure chemical ioneization ion trap mass spectrometry. Rapid Commun Mass Spectrom, 2007, 21(18):3024-3032.
37. Liu YF, Xiao YS, Xue XY, et al. Systematic screening and characterization of novel bufadienolides from toad skin using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom, 2010, 24(5):667-678.
38. Don MJ, Ko HC, Yang CW, et al. Detection of polyphenols and tanshinones in commercial Danshen by liquid chromatography with UV and mass spectrometry. J Food Drug Anal, 2006, 14(3):254-259.
39. Huang WY, Sheu SJ. Separation and identification of the fifteen constituents in forsythiae fructus. J Food Drug Anal, 2007, 15(1):33-39.
40. Kao TH, Huang SC, Inbaraj BS, et al. Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry. Anal Chim Acta, 2008, 626(2):200-211.
41. Liu L, Li YFCheng YY. A method for the production and characterization of fractionated libraries from Chinese herbal formulas. J Chromatography B Analyt Technol Biomed Life Sci, 2008, 862(1-2):196-204.
42. Wen XD, Qi LW, Chen J, et al. Analysis of interaction property of bioactive components in Danggui Buxue Decoction with protein by microdialysis coupled with HPLC-DAD-MS. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 852(1-2):598-604. (Pubitemid 46830165)
43. Wang Y, Yang L, He YQ, et al. Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection. Rapid Commun Mass Spectrom, 2008, 22(12):1767-1778.
44. Yan GL, Sun H, Sun WJ, et al. Rapid and global detection and characterization of aconitum alkaloids in' Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass spectrometry and automated data analysis. J Pharm Biomed Anal, 2010, 53(3):421-431.
45. Zheng CN, Hao HP, Wang X, et al. Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LGESI-IT-TOF/MS:Shengmai injection as an example. J Mass Spectrom, 2009, 44(2):230-244.
46. Zhang HY, Hu P, Luo GA, et al. Screening and identification of multicomponent in Qingkailing injection using combination of liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry. Anal Chim Acta, 2006, 577(2):190-200.
47. Han Z, Liu XS, Ren YP, et al. A rapid method with ultra-high-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of five type B trichothecenes in traditional Chinese medicines. J Sep Sci, 2010, 33(13):1923-1932.
48. 2 in traditional Chinese medicines. Anal Chim Acta, 2010, 664(2):165-171.
49. Liau BC, Jong TT, Lee MR, et al. Supercritical fluid extraction and quantification of aflatoxins in Zizyphi Fructus by liquid chromatography/ atmospheric pressure chemical ionization tandem mass spectrometry. Rapid Commun Mass Spectrom, 2007, 21(5):667-673.
50. Psotova J, Klejdus B, Vecera R, et al. A liquid chromatographic-mass spectrometric evidence of dihydrosanguinarine as a first metabolite of sanguinarine transformation in rat. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 830(1):165-172.
51. Lu SJ, Tran BN, Nelsen JL, et al. Quantitative analysis of mitragynine in human urine by high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2009, 877 (24):2499-2505.
52. Beyer J, Peters FT, Kraemer T, et al. Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization. J Mass Spectrom, 2007, 42(2):150-160.
53. Li W, Liu Y, He YQ, et al. Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes. Xenobiotica, 2008, 38(12):1551-1565.
54. Strzelecki A, Pichon N, Gaulier JM, et al. Acute toxic herbal intake in a suicide attempt and fatal refractory ventricular arrhythmia. Basic Clin Pharmacol Toxicol, 2010, 107(2):698-699.
55. Kaneko R, Hattori S, Furuta S, et al. Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS. J Mass Spectrom, 2006, 41(6): 810-814.
56. Kontrimaviciute V, Breton H, Mathieu O, et al. Liquid chromatography-electro spray mass spectrometry determination of ibogaine and noribogaine in human plasma and whole blood - Application to a poisoning involving Tabemanthe iboga root. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 843(2):131-141.
57. Wang DG, Xu YR, Liu WY. Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Phytomedicine, 2008, 15(10):859-866.
58. Ma CH, Fan MS, Tang YH, et al. Identification of major alkaloids and steroidal saponins in rat serum by HPLC-diode array detection-MS/MS following oral administration of Huangbai-Zhimu herb-pair Extract. Biomed Chromatogr, 2008, 22(8):835-850.
59. Ni SM, Qian DW, Duan JA, et al. UPLC-QTOF/MS-based screening and identification of the constituents and their metabolites in rat plasma and urine after oral administration of Glechoma longituba extract. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878(28):2741-2750.
60. Li FM, Lu XM, Liu HP, et al. A pharmaco-metabonomic study on the therapeutic basis and metabolic effects of Epimedium brevicornum Maxim, on hydrocortisone-induced rat using UPLC-MS. Biomed Chromatogr, 2007, 21(4):397-405.
61. Guo JM, Shang EX, Duan JA, et al. Fast and automated characterization of major constituents in rat biofluid after oral administration of Abelmoschus manihot extract using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and MetaboLynx. Rapid Commun Mass Spectrom, 2010, 24(4):443-453.
62. Li L, Liang SP, Du FF, et al. Simultaneous quantification of multiple licorice flavonoids in rat plasma. J Am Soc Mass Spectrom, 2007, 18(4):778-782.
63. Zhao XJ, Zhang Y, Meng XL, et al. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 873(2): 151-158.
64. (64] Lü HT, Sun H, Wang XJ, et al. Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. J Sep Sci, 2008, 31(4):659-666. (Pubitemid 351419570)
65. Zhang W, Saif MW, Dutschman GE, et al. Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS). J Chromatogr A, 2010, 1217(37):5785-5793.
66. Xiong ZL, Fu YH, Li JJ, et al. A UPLC-MS-MS method for quantification of harpagoside and cinnamic acid in rat plasma and its application to a pharmacokinetic study after oral administration of Yanyan Tablets. Chromatographic, 2010, 72(1-2):163-169.
67. Guilhaumou R, Solas C, Rome A, et al. Validation of an electrospray ionization LC/MS/MS method for quantitative analysis of vincristine in human plasma samples. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878(3-4):423-427.
68. Hao GT, Liang HX, Li YY, et al. Simple, sensitive and rapid HPLC-MS/MS method for the determination of cepharanthine in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878(28):2923-2927.
69. Xin GZ, Zhou JL, Qi LW, et al. Turbulent-flow chromatography coupled on-line to fast high-performance liquid chromatography and mass spectrometry for simultaneous determination of verticine, verticinone and isoverticine in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878(3-4):435-441.
70. 1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chinese medicine. Biomed Chromatogr, 2007, 21(7):735-746.
71. Kim YH, Jeong DW, Paek IB, et al. Liquid chromatography with tandem mass spectrometry for the simultaneous determination of baicalein, baicalin, oroxylin A and wogonin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 844(2):261-267. (Pubitemid 44803009)
72. Suryawanshia S, Asthana RK, Gupta RC. Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation. J Chromatogr B Analyt Technol Biomed Life Sci, 2007, 858(1-2):211-219. (Pubitemid 47513615)
73. Xie JS, Ding CG, Ge QH, et al. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 864(1-2):87-94.
74. Xie Y, Zhou H, Wong YF, et al. Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC-DAD-MS method. J Pharm Biomed Anal, 2008, 46(4):748-756.
75. Feng J, Xu W, Tao X, et al. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple. J Pharm Biomed Anal, 2010, 53(3):591-598.
76. Wang BL, Hu JP, Tan W, et al. Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2008, 865(1-2):114-120.
77. Zhu ZY, Zhao LA, Liu XF, et al. Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix Scutellariae extract to rats. J Chromatogr B Analyt Technol Biomed Life Sci, 2010, 878(24): 2184-2190.
78. Ye M, Guo H, Guo HZ, et al. Simultaneous determination of cytotoxic bufadienolides in the Chinese medicine ChanSu by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detections. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 838(2): 86-95. (Pubitemid 43946741)
79. Liu WL, Song FR, Liu ZQ, et al. Chemical study on combination Taboo of Radix aconiti with Rhizoma pinelliae, Fructus trichosanthis, Bulbus fritillariae thunbergli, Radix ampelopsis and Rhizoma bletillae. Acta Chim Sin, 2010, 68(9):889-896.
80. Zhao YY, Cheng XL, Zhang YM, et al. Simultaneous determination of eight major steroids from Polyporus umbellatus by high-performance liquid chromatography coupled with mass spectrometry detections. Biomed Chromatogr, 2010, 24(2):222-230.
81. 3 in traditional Chinese medicines by ultra-high-performance liquid chromatography-tandem mass spectrometry. J Sep Sci, 2010, 33(17-18):2723-2733.
82. n. J Pharm Biomed Anal, 2007, 44(2):430-438. (Pubitemid 46880096)
83. Wang ZJ, Wo SK, Wang L, et al. Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. J Pharm Biomed Anal, 2009, 50(2):232-244.
84. Jung J, Hermanns-Clausen M, Weinmann W. Anorectic sibutramine detected in a Chinese herbal drug for weight loss. Forensic Sci Inte, 2006, 161(2-3):221-222. (Pubitemid 44142912)
85. Vidal C, Quandte S. Identification of a sibutramine-metabolite in patient urine after intake of a "pure herbal" Chinese slimming product. Ther Drug Monit, 2006, 28(5):690-692.
86. Reepmeyer JC, Woodruff JT. Use of liquid chromatography-mass spectrometry and a hydrolytic technique for the detection and structure elucidation of a novel synthetic vardenafil designer drug added illegally to a "natural" herbal dietary supplement. J Chromatogr A, 2006, 1125(1):67-75.
87. Reepmeyer JC, Woodruff JT. Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. J Pharm Biomed Anal, 2007, 44(4):887-893. (Pubitemid 47103246)
88. Ma C, Bi KS, Su D, et al. Serum and kidney metabolic changes of rat nephrotoxicity induced by Morning Glory Seed. Food Chem Toxicol, 2010, 48(10):2988-2993.
89. Wang P, Sun H, Lv H, et al. Thyroxine and reserpine-induced changes in metabolic profiles of rat urine and the therapeutic effect of Liu Wei Di Huang Wan detected by UPLC-HDMS. J Pharm and Biomed Anal, 2010, 53(3):631-645.
90. Gu Y, Zhang YF, Shi XZ, et al. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta, 2010, 81(3):766-772.