Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI-IT-TOF/MS: Shengmai injection as an example

Journal of Mass Spectrometry

Volumn 44, Issue 2, 2009, Pages 230-244

  Zheng, Chaonan ^a   Hao, Haiping ^a   Wang, Xuan ^a   Wu, Xiaolan ^a   Wang, Guangji ^a   Sang, Guowei ^b   Liang, Yan ^a   Xie, Lin ^a   Xia, Chunhua ^a   Yao, Xilin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

Author keywords

Diagnostic fragment ion based extension strategy (dfibes); LC IT TOF MS; Serial components; Shengmai injection; Structure characterization; Traditional chinese medicine prescription (tcmp)

Indexed keywords

CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CHROMATOGRAPHY; IONIZATION OF LIQUIDS; IONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; STANDARDIZATION;

DIAGNOSTIC FRAGMENT-ION-BASED EXTENSION STRATEGY (DFIBES); LC-IT-TOF/MS; SERIAL COMPONENTS; SHENGMAI INJECTION; STRUCTURE CHARACTERIZATION; TRADITIONAL CHINESE MEDICINE PRESCRIPTION (TCMP);

MEDICINE;

GINSENG EXTRACT; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 2; GOMISIN; LIGNAN DERIVATIVE; OPHIOPOGON ROOT; SCHISANDRA CHINENSIS EXTRACT; SCHIZANDRIN; SCHIZANDRIN B; SCHIZANDROL A;

ANALYSIS; ARTICLE; CHINESE MEDICINE; DIAGNOSTIC FRAGMENT ION BASED EXTENSION STRATEGY; DIAGNOSTIC PROCEDURE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FRAGMENTATION REACTION; GINSENG; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRESCRIPTION; PRIORITY JOURNAL; SCHISANDRACEAE; SCREENING; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; GINSENOSIDES; LIGNANS; MASS SPECTROMETRY; MEDICINE, CHINESE TRADITIONAL; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

PANAX GINSENG; SCHISANDRA CHINENSIS;

EID: 59949083512     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1502     Document Type: Article

References (45)

1. Y. Liu, J. Yang, Z. Cai. Chemical investigation on Sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2006, 41, 1642.
2. X. G. He, L. Z. Lian, L. Z. Lin. Analysis of lignan constituents from Schisandra chinensis by liquid chromatography-electrospray mass spectrometry. Journal of Chromatography A 1997, 757, 81.
3. L. Z. Lin, X. G. He, L. Z. Lian, W. King, J. Elliott. Liquid chromatographic-electrospray mass spectrometric study of the phthalides of Angelica sinensis and chemical changes of Z-ligustilide. Journal of Chromatography A 1998, 810, 71.
4. H. Zhang, P. Shen, Y. Cheng. Identification and determination of the major constituents in traditional chinese medicine Si-Wu-Tang by HPLC coupled with DAD and ESI-MS. Journal of Pharmaceutical and Biomedical Analysis 2004, 34, 705.
5. N. Fuzzati, B. Gabetta, K. Jayakar, R. Pace, F. Peterlongo. Liquid chromatography-electrospray mass spectrometric identification of ginsenosides in Panax ginseng roots. Journal of Chromatography A 1999, 854, 69.
6. Q. Tian, S. J. Schwartz. Mass spectrometry and tandem mass spectrometry of citrus limonoids. Analytical Chemistry 2003, 75, 5451.
7. H. J. Zhang, Y. J. Wu, Y. Y. Cheng. Analysis of 'SHENMAI' injection by HPLC/MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2003, 31, 175.
8. I. Parejo, O. Jauregui, F. Viladomat, J. Bastida, C. Codina. Characterization of acylated flavonoid-O-glycosides and methoxylated flavonoids from Tagetes maxima by liquid chromatography coupled to electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2004, 18, 2801.
9. Y. Sun, W. Li, J. F. Fitzloff, R. B. van Breemen. Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba. Journal of Mass Spectrometry 2005, 40, 373.
10. D. C. van Setten, G. J. ten Hove, E. J. Wiertz, J. P. Kamerling, G. van de Werken. Multiple-stage tandem mass spectrometry for structural characterization of saponins. Analytical Chemistry 1998, 70, 4401.
11. X. Huang, F. Song, Z. Liu, S. Liu. Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. Journal of Mass Spectrometry 2007, 42, 1148.
12. A. H. Liu, H. Guo, M. Ye, Y. H. Lin, J. H. Sun, M. Xu, D. A. Guo. Detection, characterization and identification of phenolic acids in Danshen using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry. Journal of Chromatography A 2007, 1161, 170.
13. J. Liu, X. Yang, J. He, M. Xia, L. Xu, S. Yang. Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry. Journal of Mass Spectrometry 2007, 42, 861.
14. F. Sun, Q. He, P. Shi, P. Xiao, Y. Cheng. Characterization and identification of triterpenoid saponins in crude extracts from Clematis spp. by high-performance liquid chromatography/electrospray ionization with multi-stage tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007, 21, 3743.
15. P. C. Eklund, M. J. Backman, L. A. Kronberg, A. I. Smeds, R. E. Sjoholm. Identification of lignans by liquid chromatography-electrospray ionization ion-trap mass spectrometry. Journal of Mass Spectrometry 2008, 43, 97.
16. B. Li, Z. Abliz, G. Fu, M. Tang, S. Yu. Characteristic fragmentation behavior of some glucuronide-type triterpenoid saponins using electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2005, 19, 381.
17. B. Li, Z. Abliz, M. Tang, G. Fu, S. Yu. Rapid structural characterization of triterpenoid saponins in crude extract from Symplocos chinensis using liquid chromatography combined with electrospray ionization tandem mass spectrometry. Journal of Chromatography A 2006, 1101, 53.
18. A. Tolonen, J. Uusitalo. Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching. Rapid Communications in Mass Spectrometry 2004, 18, 3113.
19. E. C. Chan, S. L. Yap, A. J. Lau, P. C. Leow, D. F. Toh, H. L. Koh. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Communications in Mass Spectrometry 2007, 21, 519.
20. Z. Zhu, H. Zhang, L. Zhao, X. Dong, X. Li, Y. Chai, G. Zhang. Rapid separation and identification of phenolic and diterpenoid constituents from Radix Salvia miltiorrhizae by high-performance liquid chromatography diode-array detection, electrospray ionization time-of-flight mass spectrometry and electrospray ionization quadrupole ion trap mass spectrometry. Rapid Communications in Mass Spectrometry 2007, 21, 1855.
21. L. Zhao, Z. Y. Lou, Z. Y. Zhu, G. Q. Zhang, Y. F. Chai. Characterization of constituents in Stellera chamaejasme L. by rapid-resolution liquid chromatography-diode array detection and electrospray ionization time-of-flight mass spectrometry. Biomedical Chromatography 2008, 22, 64.
22. R. Li, Y. Zhou, Z. Wu, L. Ding. ESI-QqTOF-MS/MS and APCI-IT-MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica. Journal of Mass Spectrometry 2006, 41, 1.
23. C. M. Li, X. L. Zhang, X. Y. Xue, F. F. Zhang, Q. Xu, X. M. Liang. Structural characterization of iridoid glucosides by ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2008, 22, 1941.
24. Y. Wang, X. Lu, G. Xu. Development of a comprehensive two-dimensional hydrophilic interaction chromatography/quadrupole time-of-flight mass spectrometry system and its application in separation and identification of saponins from Quillaja saponaria. Journal of Chromatography A 2008, 1181, 51.
25. J. Qu, Q. Liang, G. Luo, Y. Wang. Screening and identification of glycosides in biological samples using energy-gradient neutral loss scan and liquid chromatography tandem mass spectrometry. Analytical Chemistry 2004, 76, 2239.
26. J. S. You, H. F. Huang, Y. L. Chang, Y. S. Lee. Sheng-mai-san reduces adriamycin-induced cardiomyopathy in rats. The American Journal of Chinese Medicine 2006, 34, 295.
27. K. Yu, Y. Ma, Q. Shao, H. Qu, Y. Cheng. Simultaneously determination of five ginsenosides in rabbit plasma using solid-phase extraction and HPLC/MS technique after intravenous administration of 'SHENMAI' injection. Journal of Pharmaceutical and Biomedical Analysis 2007, 44, 532.
28. N. Fuzzati. Analysis methods of ginsenosides. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2004, 812, 119.
29. H. F. Dai, W. L. Mei. Ophiopojaponin D, a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl. Archives of Pharmacal Research 2005, 28, 1236.
30. Z. H. Cheng, T. Wu, B. Y. Yu. Steroidal glycosides from tubers of Ophiopogon japonicus. Journal of Asian Natural Products Research 2006, 8, 555.
31. J. M. Chang, C. C. Shen, Y. L.Huang, M. Y.Chien, J. C. Ou, B. J. Shieh, C. C. Chen. Five new homoisoflavonoids from the tuber of Ophiopogon japonicus. Journal of Natural Products 2002, 65, 1731.
32. M. Ye, D. Guo, G. Ye, C. Huang. Analysis of homoisoflavonoids in Ophiopogon japonicus by HPLC-DAD-ESI-MSn. Journal of the American Society for Mass Spectrometry 2005, 16, 234.
33. L. Opletal, H. Sovova, M. Bartlova. Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2004, 812, 357.
34. J. Sultan, W. Gabryelski. Structural identification of highly polar nontarget contaminants in drinking water by ESI-FAIMS-Q-TOF-MS. Analytical Chemistry 2006, 78, 2905.
35. E. B. Kujawinski, M. D. Behn. Automated analysis of electrospray ionization fourier transform ion cyclotron resonance mass spectra of natural organic matter. Analytical Chemistry 2006 78, 4363.
36. X. S. Miao, C. D. Metcalfe, C. Hao, R. E. March. Electrospray ionization mass spectrometry of ginsenosides. Journal of Mass Spectrometry 2002, 37, 495.
37. S. Liu, M. Cui, Z. Liu, F. Song, W. Mo. Structural analysis of saponins from medicinal herbs using electrospray ionization tandem mass spectrometry. Journal of the American Society for Mass Spectrometry 2004, 15, 133.
38. B. Domon, C. E. Costello. A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates. Glycoconjugate Journal 1988, 5, 397.
39. K. Zou, S. Zhu, C. Tohda, S. Cai, K. Komatsu. Dammarane-type triterpene saponins from Panax japonicus. Journal of Natural Products 2002, 65, 346.
40. X. Huang, F. Song, Z. Liu, S. Liu. Structural characterization and identification of dibenzocyclooctadiene lignans in Fructus Schisandrae using electrospray ionization ion trap multiple-stage tandem mass spectrometry and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry. Analytica Chimica Acta 2008, 615, 124.
41. H. B. Zhai, P. Z. Cong. Mass spectrometric studies on dibenocyclooctadiene lignan compounds from schisandraceae plants. Acta Pharmacologica Sinica 1990, 25, 110.
42. M. Ye, Y. Yan, D. A. Guo. Characterization of phenolic compounds in the Chinese herbal drug Tu-Si-Zi by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2005, 19, 1469.
43. F. Song, M. Cui, Z. Liu, B. Yu, S. Liu. Multiple-stage tandem mass spectrometry for differentiation of isomeric saponins. Rapid Communications in Mass Spectrometry 2004, 18, 2241.
44. T. W. Chan, P. P. But, S. W. Cheng, I. M. Kwok, F. W. Lau, H. X. Xu. Differentiation and authentication of Panax ginseng, Panax quinquefolius, and ginseng products by using HPLC/MS. Analytical Chemistry 2000, 72, 1281.
45. Y. Bao, C. Li, H. Shen, F. Nan. Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the chinese multiherb remedy xiaochaihu-tang using liquid chromatographic tandem mass spectrometry. Analytical Chemistry 2004, 76, 4208.