Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 864, Issue 1-2, 2008, Pages 87-94

  Xie, Jiashu ^a   Ding, Cungang ^a   Ge, Qinghua ^a   Zhou, Zhen ^a   Zhi, Xiaojin ^a  

^a National Pharmaceutical Engineering and Research Center   (China)

Author keywords

Bilobalide; Ginkgolides; LC MS MS; Matrix effect; Pharmacokinetic; Simultaneous analysis

Indexed keywords

EXTRACTION; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC SOLVENTS; PHARMACOKINETICS;

BILOBALIDE; GINKGOLIDES; LIQUID-LIQUID EXTRACTION; MATRIX EFFECT; SIMULTANEOUS ANALYSIS;

ESTERS;

BILOBALIDE; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOPENTANES; FEMALE; FURANS; GINKGO BILOBA; GINKGOLIDES; LACTONES; MALE; PLANT EXTRACTS; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

GINKGO BILOBA; RATTUS;

EID: 40849139243     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.01.045     Document Type: Article

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