High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts

Journal of Chromatography A

Volumn 1112, Issue 1-2, 2006, Pages 303-310

  de Jong, Camiel F ^a   Derks, Rico J E ^a   Bruyneel, Ben ^a   Niessen, Wilfried ^a   Irth, Hubertus ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Acetylcholinesterase; Continuous flow assay; Label free screening; MS; Narcissus; Natural products

Indexed keywords

AMMONIUM COMPOUNDS; BIOCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; SCREENING;

ACETYLCHOLINESTERASE; CONTINUOUS-FLOW ASSAY; LABEL FREE SCREENING; NARCISSUS; NATURAL PRODUCTS;

ORGANIC COMPOUNDS;

ACETYLCHOLINE; AMINOACRIDINE; AMMONIA; BUFFER; CHOLINESTERASE INHIBITOR; GALANTAMINE; GALLAMINE; HUPERZINE A; PLANT EXTRACT; THIOFLAVINE;

ARTICLE; DRUG DETERMINATION; DRUG SCREENING; ELUTION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MASS SPECTROMETRY; MONITORING; NARCISSUS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; MASS SPECTROMETRY; NARCISSUS; PLANT EXTRACTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

NARCISSUS;

EID: 33645802978     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2006.01.059     Document Type: Article

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