Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans

Mitochondrion

Volumn 22, Issue , 2015, Pages 45-59

  McCormack, Shana ^a   Polyak, Erzsebet ^a   Ostrovsky, Julian ^a   Dingley, Stephen D ^a   Rao, Meera ^a   Kwon, Young Joon ^a   Xiao, Rui ^a   Zhang, Zhe ^b   Nakamaru Ogiso, Eiko ^a   Falk, Marni J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Fenofibrate; Mitochondrial disease; Nicotinic acid; Resveratrol; Rosiglitazone; Transcriptome

Indexed keywords

BRANCHED CHAIN AMINO ACID; FENOFIBRATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESVERATROL; ROSIGLITAZONE; SIRTUIN; TRANSCRIPTOME; MUTANT PROTEIN;

ADULTHOOD; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DRUG TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LARVAL STAGE; LONGEVITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; ANIMAL; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY;

ANIMALIA; CAENORHABDITIS ELEGANS;

ANIMALS; CAENORHABDITIS ELEGANS; ELECTRON TRANSPORT COMPLEX I; LONGEVITY; MITOCHONDRIA; MUTANT PROTEINS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; SIGNAL TRANSDUCTION; SIRTUINS;

EID: 84925370954     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2015.02.005     Document Type: Article

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