Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

EMBO Molecular Medicine

Volumn 3, Issue 7, 2011, Pages 410-427

  Falk, Marni J ^a   Polyak, Erzsebet ^a   Zhang, Zhe ^a   Peng, Min ^b   King, Rhonda ^b   Maltzman, Jonathan S ^b   Okwuego, Ezinne ^a   Horyn, Oksana ^a   Nakamaru Ogiso, Eiko ^b   Ostrovsky, Julian ^a   Xie, Letian X ^c   Chen, Jia Yan ^c   Marbois, Beth ^c   Nissim, Itzhak ^a,b   Clarke, Catherine F ^c   Gasser, David L ^b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Coenzyme Q; Kidney; Mitochondria; Mouse; Probucol

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; LIQSORB; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHOLIPID; PROBUCOL; UBIQUINONE; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ENERGY METABOLISM; ENZYME DEFICIENCY; FEMALE; GLOMERULOPATHY; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; METABOLIC PARAMETERS; MISSENSE MUTATION; MITOCHONDRIAL RESPIRATION; MOUSE; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PRIMARY COENZYME Q DEFICIENCY; PRIORITY JOURNAL; PROTEIN METABOLISM; TRANSCRIPTION REGULATION; TREATMENT DURATION; VITAMIN METABOLISM; WEANING;

ALBUMINURIA; ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; ENERGY METABOLISM; FEMALE; HYPERGLYCEMIA; KIDNEY; KIDNEY DISEASES; MALE; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; OXIDATIVE STRESS; PROBUCOL; SIGNAL TRANSDUCTION; UBIQUINONE;

EID: 79960083220     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201100149     Document Type: Article

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