Lipid-lowering fibrates extend C. Elegans lifespan in a NHR-49/PPARalpha-dependent manner

Aging

Volumn 5, Issue 4, 2013, Pages 270-275

  Brandstädt, Sven ^a   Schmeisser, Kathrin ^a   Zarse, Kim ^a,b   Ristow, Michael ^a,b,c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b ETH ZURICH   (Switzerland)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

Ageing; Beta oxidation; C. elegans; Healthspan; Lifespan; Nematodes; Nuclear receptors; Peroxisome proliferator activated receptor alpha; Peroxisomes; Pharmacology; PPARalpha

Indexed keywords

EID: 84877667893     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100548     Document Type: Article

References (37)

1. Friedman DB, Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988; 118:75-86.
2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R: A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366:461-464.
3. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997; 277:942-946.
4. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001; 292:104-106.
5. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS A mutant Drosophila insulin receptor homolog that extends lifespan and impairs neuroendocrine function. Science. 2001; 292:107-110.
6. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A Dwarf mice and the ageing process. Nature. 1996; 384:33.
7. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 2003; 421:182-187.
8. Blüher M, Kahn BB, Kahn CR Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003; 299572-574.
9. Weindruch R, Walford RL The retardation of aging and disease by dietary restriction. Springfield, Illinois: Charles C Thomas Pub Ltd.; 1988.
10. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009; 325:201-204.
11. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F Genetics: influence of TOR kinase on lifespan in C. elegans. Nature. 2003; 426:620.
12. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009; 460:392-395.
13. Kaeberlein M: Resveratrol and rapamycin are they antiaging drugs? Bioessays 2010; 32:96-99
14. Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012; 15:713-724.
15. Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011; 66:191-201.
16. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL et al Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003; 425:191-196.
17. Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 2004; 430:686-689.
18. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006; 444:337-342.
19. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E et al Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metab. 2008; 8:157-168.
20. Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 2007; 6:280-293.
21. Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M Low-dose lithium uptake promotes longevity in humans and metazoans. Eur J Nutr. 2011; 50:387-389.
22. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008; 283:350-357.
23. Zarse K, Bossecker A, Muller-Kuhrt L, Siems K, Hernandez MA, Berendsohn WG, Birringer M, Ristow M The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans. Horm Metab Res. 2011; 43:241-243.
24. Schmeisser S, Zarse K, Ristow M Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. Horm Metab Res. 2011; 43:687-692.
25. Schmeisser S, Priebe S, Groth M, Monajembashi S, Hemmerich P, Guthke R, Platzer M, Ristow M Neuronal ROS Signaling Rather Than AMPK/Sirtuin-Mediated Energy Sensing Links Dietary Restriction to Lifespan Extension. Molecular Metabolism. 2013; in press
26. Staels B, Dallongeville J, Auwerx J, Schoonjans K, Leitersdorf E, Fruchart JC Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 1998; 98:2088-2093.
27. Berger J, Moller DE The mechanisms of action of PPARs. Annu Rev Med. 2002; 53:409-435.
28. Schoonjans K, Staels B, Auwerx J The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta. 1996; 1302:93-109.
29. Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, Teissier E, Minnich A, Jaye M, Duverger N et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med. 2001; 7:53-58.
30. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999; 103:1489-1498.
31. Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 2005; 3:e53.
32. Kniazeva M, Crawford QT, Seiber M, Wang CY, Han M Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol. 2004; 2:E257.
33. Murphy MP How mitochondria produce reactive oxygen species. Biochem. J 2009; 417:1-13.
34. Tapia PC Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: 'Mitohormesis' for health and vitality. Med Hypotheses. 2006; 66:832-843.
35. Ristow M, Schmeisser S Extending life span by increasing oxidative stress. Free Radic Biol Med. 2011; 51:327-336.
36. Inoue I, Goto S, Matsunaga T, Nakajima T, Awata T, Hokari S, Komoda T, Katayama S The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001; 50:3-11.
37. Gruber J, Ng LF, Poovathingal SK, Halliwell B Deceptively simple but simply deceptive -Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects. FEBS Lett. 2009; 583:3377-3387