Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20012-20025

  Hong, Jin ^a   Kim, Bong Woo ^b   Choo, Hyo Jung ^a   Park, Jung Jin ^a   Yi, Jae Sung ^a   Yu, Dong Min ^a   Lee, Hyun ^a   Yoon, Gye Soon ^c   Lee, Jae Seon ^d   Ko, Young Gyu ^a  

^a Korea University   (South Korea)

^b Seowon University   (South Korea)

^c Ajou University   (South Korea)

^d Inha University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; MITOCHONDRIA; PHOSPHATASES; PROTEINS;

INSULIN RECEPTOR SUBSTRATE-1; INSULIN RECEPTORS; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL COMPLEX; NADH DEHYDROGENASE; OXIDATIVE PHOSPHORYLATION; PROTEIN-TYROSINE PHOSPHATASE 1B; SKELETAL MYOGENESIS;

INSULIN;

ENZYME ACTIVATOR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) FLAVOPROTEIN 1; PROTEIN TYROSINE PHOSPHATASE 1B; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESVERATROL; SIRTUIN 1; SRT 1720; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX I DEFICIENCY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INACTIVATION; GENE SILENCING; MITOCHONDRIAL RESPIRATION; MOLECULAR INTERACTION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION;

INSULIN RESISTANCE; MITOCHONDRIAL DISEASE; MITOCHONDRIAL METABOLISM; MYOGENESIS; SIRTUIN 1 (SIRT1);

ANIMALS; CELL LINE; ELECTRON TRANSPORT COMPLEX I; GENE KNOCKDOWN TECHNIQUES; INSULIN; INSULIN RESISTANCE; MICE; MITOCHONDRIAL DISEASES; MODELS, BIOLOGICAL; MUSCLE DEVELOPMENT; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; NAD; OXIDATIVE PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84904479727     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.560078     Document Type: Article

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