Structural plasticity in the human cytosolic sulfotransferase dimer and its role in substrate selectivity and catalysis

Drug Metabolism and Pharmacokinetics

Volumn 30, Issue 1, 2015, Pages 3-20

  Tibbs, Zachary E ^a   Rohn Glowacki, Katie Jo ^a   Crittenden, Frank ^a   Guidry, Amber L ^a   Falany, Charles N ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

3 diphosphoadenosine; 3 phosphoadenosine 5 phosphosulfate; Cytosolic sulfotransferase; Metabolism; PAP; PAPS; Structure; Sulfation; SULT

Indexed keywords

ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; CYTOSOLIC SULFOTRANSFERASE; SULFOTRANSFERASE; UNCLASSIFIED DRUG; DRUG; ISOENZYME; PROTEIN BINDING;

CATALYSIS; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; REVIEW; SULFATION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTER ANALYSIS; CYTOSOL; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; CLUSTER ANALYSIS; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

EID: 84925014270     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.1016/j.dmpk.2014.10.004     Document Type: Review

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