Sulfation of opioid drugs by human cytosolic sulfotransferases: Metabolic labeling study and enzymatic analysis

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 40-48

  Kurogi, Katsuhisa ^a   Chepak, Andriy ^a   Hanrahan, Michael T ^a   Liu, Ming Yih ^b   Sakakibara, Yoichi ^c   Suiko, Masahito ^c   Liu, Ming Cheh ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER   (Taiwan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Cytosolic sulfotransferase; Drugs; Opioids; Sulfation; SULT

Indexed keywords

BUPRENORPHINE; BUTORPHANOL; HYDROMORPHONE; LEVORPHANOL; MORPHINE; NALBUPHINE; NALORPHINE; NALOXONE; NALTREXOL; NALTREXONE; OPIATE DERIVATIVE; OXYMORPHONE; PENTAZOCINE; RADIOPHARMACEUTICAL AGENT; SULFATE S 35; SULFOTRANSFERASE; UNCLASSIFIED DRUG; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST; SULFATE; SULFUR;

ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG SULFATION; ENZYMATIC ASSAY; ENZYME ANALYSIS; HEPATOMA CELL; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; KIDNEY; KINETICS; LIVER; LUNG; PRIORITY JOURNAL; SMALL INTESTINE; CYTOSOL; METABOLISM;

ANALGESICS, OPIOID; CYTOSOL; HEP G2 CELLS; HUMANS; INTESTINE, SMALL; KIDNEY; LIVER; LUNG; NARCOTIC ANTAGONISTS; SULFATES; SULFOTRANSFERASES; SULFUR RADIOISOTOPES;

EID: 84901981302     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.003     Document Type: Article

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