Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase

Protein Science

Volumn 17, Issue 10, 2008, Pages 1706-1718

  Mochalkin, Igor ^a   Miller, J Richard ^a   Evdokimov, Artem ^a   Lightle, Sandra ^a   Yan, Chunhong ^a,c   Stover, Charles Ken ^a   Waldrop, Grover L ^b  

^a PFIZER INC   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

Biotin; Carboxylases; Crystallography; Enzymes; Mechanism enzymes

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; BACTERIAL ENZYME; BIOTIN; BIOTIN CARBOXYL CARRIER PROTEIN; BIOTIN CARBOXYLASE; CARBOXYLASE; CARBOXYLTRANSFERASE; MAGNESIUM; MALONYL COENZYME A; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBUNIT; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

BINDING SITES; BIOTIN; CARBON-NITROGEN LIGASES; CATALYSIS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; MAGNESIUM; NUCLEOTIDES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS);

EID: 52949102964     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.035584.108     Document Type: Article

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