Dimerization is responsible for the structural stability of human sulfotransferase 1a1

Drug Metabolism and Disposition

Volumn 37, Issue 5, 2009, Pages 1083-1088

  Lu, Lu Yi ^a   Chiang, Han Ping ^a   Chen, Wei Ti ^a   Yang, Yuh Shyong ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HOMODIMER; MONOMER; RECOMBINANT PROTEIN; SULFOTRANSFERASE 1A1; UREA;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; DIMERIZATION; DISSOCIATION CONSTANT; ENZYME KINETICS; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; LIQUID CHROMATOGRAPHY; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; THERMOSTABILITY;

ALGORITHMS; ARYLSULFOTRANSFERASE; CATALYSIS; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; CYTOSOL; DIMERIZATION; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; UREA;

EID: 66449124488     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025395     Document Type: Article

References (27)

1. Burkart MD and Wong CH (1999) A continuous assay for the spectrophotometry analysis of sulfotransferases using aryl sulfotransferase IV. Anal Biochem 274:131-137.
2. Cornish-Bowden A (1995) Analysis of Enzyme Kinetic Data, pp 118-122, Oxford University Press, Oxford.
3. Coughtrie MW (2002) Sulfation through the looking glass-recent advances in sulfotransferase research for the curious. Pharmacogenomics J 2:297-308.
4. Gamage NU, Duggleby RG, Barnett AC, Tresillian M, Latham CF, Liyou NE, McManus ME,and Martin JL (2003) Structure of a human carcinogen-converting enzyme, SULT1A1: structural and kinetic implications of substrate inhibition. J Biol Chem 278:7655-7662.
5. Gamage NU, Tsvetanov S, Duggleby RG, McManus ME, and Martin JL (2005) The structure of humanSULT1A1 crystallizedwithestradiol: aninsightintoactivesiteplasticityandsubstrate inhibition with multi-ring substrates. J Biol Chem 280:41482-41486.
6. GillSC andvonHippelPH (1989)Calculation of proteinextinctioncoefficients fromaminoacid sequence data. Anal Biochem 182:319-326.
7. Glatt H (2000) Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact 129:141-170.
8. Hausmann S, Pei Y, and Shuman S (2003) Homodimeric quaternary structure is required for the in vivo function and thermal stability of Saccharomyces cerevisiae and Schizosaccharomyces pombe RNA triphosphatases. J Biol Chem 278:30487-30496.
9. Hempel N, Barnett A, Gamage N, McManus ME, and Negishi M (2005) Human SULT1A sulfotransferases, in Human Cytosolic Sulfotransferases (Pacifici GM and Coughtrie MW eds) pp 181-232, CRC Press, London.
10. Hempel N, Gamage N, Martin JL, and McManus ME (2007) Human cytosolic sulfotransferase SULT1A1. Int J Biochem Cell Biol 39:685-689.
11. Hirata H, Hinoda Y, Okayama N, Suehiro Y, Kawamoto K, Kikuno N, Rabban JT, Chen LM, and Dahiya R (2008) CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. Cancer 112:1964-1973.
12. Kiehlbauch CC, Lam YF, and Ringer DP (1995) Homodimeric and heterodimeric aryl sulfo- transferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene. J Biol Chem 270:18941- 18947.
13. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
14. LehmanK, SchwerB, HoCK, RouzankinaI, andShumanS (1999) Aconserveddomainofyeast RNA triphosphatase flanking the catalytic core regulates self-association and interaction with the guanylyltransferase component of the mRNA capping apparatus. J Biol Chem 274:22668 - 22678.
15. Lin ES and Yang YS (2000) Nucleotide binding and sulfation catalyzed by phenol sulfotrans- ferase. Biochem Biophys Res Commun 271:818-822.
16. Lu LY, Hsieh YC, Liu MY, Lin YH, Chen CJ, and Yang YS (2008) Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepi- androsterone sulfotransferase (SULT2A1). Mol Pharmacol 73:660-668.
17. MacDonald RI and Pozharski EV (2001) Free energies of urea and of thermal unfolding show that two tandem repeats of spectrin are thermodynamically more stable than a single repeat. Biochemistry 40:3974-3984.
18. Mei G, Di Venere A, Rosato N, and Finazzi-Agro A (2005) The importance of being dimeric. FEBS J 272:16-27.
19. 213His), both of which exist in Japanese as well as Caucasians. J Biochem 126:271-277.
20. Pedersen LC, Petrotchenko EV, and Negishi M (2000) Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase. FEBS Lett 475:61-64.
21. 137 in the sulfuryl transfer reaction. J Biol Chem 277:17928-17932.
22. Perez-Iratxeta C and Andrade-Navarro MA (2008) K2D2: estimation of protein secondary structure from circular dichroism spectra. BMC Struct Biol 8:25.
23. Petrotchenko EV, Pedersen LC, Borchers CH, Tomer KB, and Negishi M (2001) The dimer- ization motif of cytosolic sulfotransferases. FEBS Lett 490:39-43.
24. SakakibaraY,TakamiY, NakayamaT, SuikoM,andLiuMC (1998) Localizationandfunctional analysis of the substrate specificity/catalytic domains of human M-form and P-form phenol sulfotransferases. J Biol Chem 273:6242-6247.
25. Shevtsov S, Petrotchenko EV, Pedersen LC, and Negishi M (2003) Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environ Health Perspect 111:884-888.
26. Strott CA (2002) Sulfonation and molecular action. Endocr Rev 23:703-732.
27. Yang YS, Marshall AD, McPhie P, Guo WX, Xie X, Chen X, and Jakoby WB (1996) Two phenol sulfotransferase species from one cDNA: nature of the differences. Protein Expr Purif 8:423-429.