24-Hydroxycholesterol sulfation by human cytosolic sulfotransferases: Formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver X receptor activation

Drug Metabolism and Disposition

Volumn 37, Issue 10, 2009, Pages 2069-2078

  Cook, Ian T ^a   Duniec Dmuchowski, Zofia ^b   Kocarek, Thomas A ^b   Runge Morris, Melissa ^b   Falany, Charles N ^a  

^a University of Alabama at Birmingham   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24 HYDROXYCHOLESTEROL; APOLIPOPROTEIN E; BILE ACID; CHOLESTEROL DERIVATIVE; CYTOSOLIC SULFOTRANSFERASE; HOMODIMER; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; OXYSTEROL; SULFATASE; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHOLESTEROL METABOLISM; CONCENTRATION (PARAMETERS); CONJUGATION; ENZYME BINDING; FLUORESCENCE RESONANCE ENERGY TRANSFER; HOMEOSTASIS; HUMAN; HYDROLYSIS; IC 50; LIPID TRANSPORT; MOLECULAR DOCKING; PRIORITY JOURNAL; REGULATORY MECHANISM; SIMULATION; SULFATION;

CYTOSOL; ENZYME INHIBITORS; HUMANS; HYDROXYCHOLESTEROLS; LIVER; MODELS, MOLECULAR; ORPHAN NUCLEAR RECEPTORS; SULFATASES; SULFATES; SULFOTRANSFERASES;

TRIFLUORO;

EID: 70349280717     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.025759     Document Type: Article

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