SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens

Food and Chemical Toxicology

Volumn 46, Issue 4, 2008, Pages 1249-1256

  Meinl, Walter ^a   Donath, Claudia ^a   Schneider, Heiko ^a   Sommer, Yasmin ^a   Glatt, Hansruedi ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

Benzylic alcohols; Mutagenicity; Safrole; Salmonella typhimurium; Sulphotransferases

Indexed keywords

1 NAPHTHOL; 4 NITROPHENOL; 5 HYDROXYMETHYLFURFURAL; ALCOHOL; COMPLEMENTARY DNA; CORTICOSTERONE; PARACETAMOL; PROMUTAGEN; SULFOTRANSFERASE; SULFOTRANSFERASE1C3; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENE SEQUENCE; GENETIC CODE; GENOME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; MASS SPECTROMETRY; MUTAGENESIS; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM;

ANIMALS; BACTERIA; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOSOL; GENOME, HUMAN; HUMANS; MUTAGENICITY TESTS; MUTAGENS; RATS; SAFROLE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; SULFOTRANSFERASES;

BACTERIA (MICROORGANISMS); SALMONELLA TYPHIMURIUM;

EID: 39149086046     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.08.040     Document Type: Article

References (32)

1. Arlt V.M., Glatt H.R., Gamboa da Costa G., Reynisson J., Takamura-Enya T., and Phillips D.H. Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone. Toxicol. Sci. 98 (2007) 445-457
2. Dooley T.P., Haldeman-Cahill R., Joiner J., and Wilborn T.W. Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells. Biochem. Biophys. Res. Commun. 277 (2000) 236-245
3. Engst W., Landsiedel R., Hermersdörfer H., Doehmer J., and Glatt H.R. Benzylic hydroxylation of 1-methylpyrene and 1-ethylpyrene by human and rat cytochromes P450 individually expressed in V79 Chinese hamster cells. Carcinogenesis 20 (1999) 1777-1785
4. Engst W., Pabel U., and Glatt H.R. Conjugation of 4-nitrophenol and 4-hydroxylonazolac in V79-derived cells expressing individual forms of human sulphotransferases. Environ. Toxicol. Appl. Pharmacol. 11 (2002) 243-250
5. Falany C.N. Sulfation and sulfotransferases: 3. Enzymology of human cytosolic sulfotransferases. FASEB J. 11 (1997) 206-216
6. Foldes A., and Meek J.L. Rat brain phenolsulfotransferase: partial purification and some properties. Biochim. Biophys. Acta 327 (1973) 365-374
7. Freimuth R.R., Wiepert M., Chute C.G., Wieben E.D., and Weinshilboum R.M. Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes. Pharmacogenomics J. 4 (2004) 54-65
8. Fuda H., Lee Y.C., Shimizu C., Javitt N.B., and Strott C.A. Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase. J. Biol. Chem. 277 (2002) 36161-36166
9. Glatt H.R. Sulphotransferases. In: Ioannides C. (Ed). Handbook of Enzyme Systems that Metabolise Drugs and Other Xenobiotics (2002), John Wiley & Sons, Sussex 353-439
10. Glatt H.R. Activation and inactivation of carcinogens by human sulfotransferases. In: Pacifici G.M., and Coughtrie M.W.H. (Eds). Human Cytosolic Sulfotransferases (2005), Taylor & Francis, London 281-306
11. Glatt H.R., and Meinl W. Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity. Carcinogenesis 25 (2004) 779-786
12. Glatt H.R., and Meinl W. Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects. Meth. Enzymol. 400 (2005) 230-249
13. Glatt H.R., and Sommer Y. Health risks by 5-hydroxymethylfurfural (HMF) and related compounds. In: Skog K., and Alexander J. (Eds). Acrylamide and Other Health Hazardous Compounds in Heat-treated Foods (2006), Woodhead Publishing, Cambridge 328-357
14. Glatt H.R., Boeing H., Engelke C.E.H., Kuhlow L.M.A., Pabel U., Pomplun D., Teubner W., and Meinl W. Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. Mutation Res. 482 (2001) 27-40
15. Glatt H.R., Pabel U., Meinl W., Frederiksen H., Frandsen H., and Muckel E. Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes. Carcinogenesis 25 (2004) 801-807
16. Glatt H.R., Teubner W., and Meinl W. Sulfotransferases expressed in the human gastro-intestinal tract and their ability to activate promutagens/carcinogens. In: Oesch F. (Ed). 15th International Symposium on Microsomes and Drug Oxidations (2005), Medimond/Monduzzi, Bologna 9-15
17. Hagen M., Pabel U., Landsiedel R., Bartsch I., Falany C.N., and Glatt H.R. Expression of human estrogen sulfotransferase in Salmonella typhimurium: differences between hHST and hEST in the enantioselective activation of 1-hydroxyethylpyrene to a mutagen. Chem.-Biol. Interact. 109 (1998) 249-253
18. Her C., Wood T.C., Eichler E.E., Mohrenweiser H.W., Ramagli L.S., Siciliano M.J., and Weinshilboum R.M. Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene. Genomics 53 (1998) 284-295
19. Hildebrandt M.A., Salavaggione O.E., Martin Y.N., Flynn H.C., Jalal S., Wieben E.D., and Weinshilboum R.M. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. Biochem. Biophys. Res. Commun. 321 (2004) 870-878
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
21. Landsiedel R., Pabel U., Engst W., Ploschke J., Seidel A., and Glatt H.R. Chiral inversion of 1-hydroxyethylpyrene enantiomers mediated by enantioselective sulfotransferases. Biochem. Biophys. Res. Commun. 247 (1998) 181-185
22. Landsiedel R., Andrae U., Kuhlow A., Scholtyssek M., Engst W., and Glatt H.R. Enantioselective metabolic activation of safrole. In: Eisenbrand G., Dayan A.D., Elias P.S., Grunow W., and Schlatter J. (Eds). Carcinogenic/Anticarcinogenic Factors in Food (2000), Wiley-VCH Verlag, Weinheim (Germany) 464-467
23. Maron D.M., and Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113 (1983) 173-215
24. Meinl W., Meerman J.H., and Glatt H.R. Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium. Pharmacogenetics 12 (2002) 677-689
25. Meinl W., Pabel U., Osterloh-Quiroz M., Hengstler J.G., and Glatt H.R. Human sulfotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. Int. J. Cancer 118 (2006) 1090-1097
26. Miller J.A. The metabolism of xenobiotics to reactive electrophiles in chemical carcinogenesis and mutagenesis: a collaboration with Elizabeth Cavert Miller and our associates. Drug Metab. Rev. 30 (1998) 645-674
27. Muckel E., Frandsen H., and Glatt H.R. Heterologous expression of human N-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines. Food Chem. Toxicol. 40 (2002) 1063-1068
28. Nagata K., Yoshinari K., Ozawa S., and Yamazoe Y. Arylamine activating sulfotransferase in liver. Mutat. Res. 376 (1997) 267-272
29. Sakakibara Y., Yanagisawa K., Katafuchi J., Ringer D.P., Takami Y., Nakayama T., Suiko M., and Liu M.C. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. J. Biol. Chem. 273 (1998) 33929-33935
30. Schneider H., and Glatt H.R. Sulpho-conjugation of ethanol in humans in vivo and by individual sulphotransferase forms in vitro. Biochem. J. 383 (2004) 543-549
31. Stanley E.L., Hume R., and Coughtrie M.W. Expression profiling of human fetal cytosolic sulfotransferases involved in steroid and thyroid hormone metabolism and in detoxification. Mol. Cell Endocrinol. 240 (2005) 32-42
32. Teubner W., Meinl W., Florian S., Kretzschmar M., and Glatt H.R. Identification and localization of soluble sulfotransferases in the human gastrointestinal tract. Biochem. J. 404 (2007) 207-215