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Volumn 11, Issue 6, 2014, Pages 666-686

Paclitaxel formulations: Challenges and novel delivery options

Author keywords

Cancer; Drug delivery systems; Liposomes; Nanoparticles; Paclitaxel

Indexed keywords

BETA TUBULIN; CARBOPLATIN; CREMOPHOR; CYCLODEXTRIN; CYCLOPHOSPHAMIDE; DENDRIMER; DRUG SOLVENT; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; LIPOSOME; MULTIDRUG RESISTANCE PROTEIN; NANOCARRIER; NANOPARTICLE; PACLITAXEL; SARGRAMOSTIM; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; TRASTUZUMAB; ANTINEOPLASTIC AGENT; NANOMATERIAL;

EID: 84924989806     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/1567201811666140609154949     Document Type: Article
Times cited : (116)

References (208)
  • 1
    • 84867366635 scopus 로고    scopus 로고
    • Liposomal paclitaxel formulations
    • Koudelka, S.; Turanek, J. Liposomal paclitaxel formulations. J. Control. Release, 2012, 163, 322-334.
    • (2012) J. Control. Release , vol.163 , pp. 322-334
    • Koudelka, S.1    Turanek, J.2
  • 2
    • 33847284541 scopus 로고    scopus 로고
    • Pharmacogenetics of paclitaxel metabolism
    • Spratlin, J.; Sawyer, M.B. Pharmacogenetics of paclitaxel metabolism. Crit. Rev. Oncol. Hematol., 2007, 61, 222-229.
    • (2007) Crit. Rev , vol.61 , pp. 222-229
    • Spratlin, J.1    Sawyer, M.B.2
  • 4
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani, M.C.; Taylor, H.L.; Wall, M.E.; Coggon, P.; McPhail, A. T. Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc., 1971, 93, 2325-2327.
    • (1971) J. Am. Chem. Soc , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4    McPhail, A.T.5
  • 5
    • 0027968083 scopus 로고
    • Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer
    • Spencer, C. M.; Faulds, D. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs, 1994, 48(5), 794-847.
    • (1994) Drugs , vol.48 , Issue.5 , pp. 794-847
    • Spencer, C.M.1    Faulds, D.2
  • 7
    • 0020419247 scopus 로고
    • Taxol binds to cellular microtubules
    • Manfredi, J.J.; Parness, J.; Horwitz, S.B. Taxol binds to cellular microtubules. J. Cell Biol., 1982, 94, (3), 688-696.
    • (1982) J. Cell Biol , vol.94 , Issue.3 , pp. 688-696
    • Manfredi, J.J.1    Parness, J.2    Horwitz, S.B.3
  • 8
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff, P.B.; Horwitz, S.B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. U.S.A., 1980, 77, 1561-1565.
    • (1980) Proc. Natl. Acad. Sci. U.S.A , vol.77 , pp. 1561-1565
    • Schiff, P.B.1    Horwitz, S.B.2
  • 9
    • 0036708577 scopus 로고    scopus 로고
    • Characterization of nuclear βII-tubulin in tumor cells: A possible novel target for taxol
    • Xu, K.; Ludueña, R. F. Characterization of nuclear βII-tubulin in tumor cells: A possible novel target for taxol. Cell. Motil. Cytoskeleton, 2002, 53, 39-52.
    • (2002) Cell. Motil. Cytoskeleton , vol.53 , pp. 39-52
    • Xu, K.1    Ludueña, R.F.2
  • 10
    • 0029964257 scopus 로고    scopus 로고
    • Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
    • Haldar, S.; Chintapalli, J.; Croce, C.M. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res., 1996, 56, 1253-1255.
    • (1996) Cancer Res , vol.56 , pp. 1253-1255
    • Haldar, S.1    Chintapalli, J.2    Croce, C.M.3
  • 12
    • 0025827992 scopus 로고
    • Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2'configurations
    • Swindell, C.S.; Krauss, N.E.; Horwitz, S.B.; Ringel, I. Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2'configurations. J. Med. Chem., 1991, 34, 1176-1184.
    • (1991) J. Med. Chem , vol.34 , pp. 1176-1184
    • Swindell, C.S.1    Krauss, N.E.2    Horwitz, S.B.3    Ringel, I.4
  • 13
    • 0032531883 scopus 로고    scopus 로고
    • Pharmaceutical aspects of paclitaxel
    • Panchagnula, R. Pharmaceutical aspects of paclitaxel. Int. J. Pharm., 1998, 172, 1-15.
    • (1998) Int. J. Pharm , vol.172 , pp. 1-15
    • Panchagnula, R.1
  • 15
    • 0028452906 scopus 로고
    • Taxol: The chemistry and structure-activity relationships of a novel anticancer agent
    • Kingston, D. G. I. Taxol: the chemistry and structure-activity relationships of a novel anticancer agent. Trends Biotechnol., 1994, 12, 222-227.
    • (1994) Trends Biotechnol , vol.12 , pp. 222-227
    • Kingston, D.1
  • 17
    • 0028090220 scopus 로고
    • Clinical pharmacokinetics of paclitaxel
    • Sonnichsen, D.; Relling, M. Clinical pharmacokinetics of paclitaxel. Clin. Pharmacokinet., 1994, 27, 256-269.
    • (1994) Clin. Pharmacokinet , vol.27 , pp. 256-269
    • Sonnichsen, D.1    Relling, M.2
  • 19
    • 0027954464 scopus 로고
    • Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation
    • Cresteil, T.; Monsarrat, B.; Alvinerie, P.; Treluyer, J. M.; Vieira, I.; Wright, M. Taxol metabolism by human liver microsomes: Identification of cytochrome P450 isozymes involved in its biotransformation. Cancer Res., 1994, 54, (2), 386-392.
    • (1994) Cancer Res , vol.54 , Issue.2 , pp. 386-392
    • Cresteil, T.1    Monsarrat, B.2    Alvinerie, P.3    Treluyer, J.M.4    Vieira, I.5    Wright, M.6
  • 22
    • 2542559832 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
    • Kim, T.-Y.; Kim, D.W.; Chung, J.Y.; Shin, S.G.; Kim, S.C.; Heo, D.S.; Kim, N.K.; Bang, Y.J. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies. Clin. Cancer Res., 2004, 10, 3708-3716.
    • (2004) Clin. Cancer Res , vol.10 , pp. 3708-3716
    • Kim, T.-Y.1    Kim, D.W.2    Chung, J.Y.3    Shin, S.G.4    Kim, S.C.5    Heo, D.S.6    Kim, N.K.7    Bang, Y.J.8
  • 23
    • 0035848417 scopus 로고    scopus 로고
    • Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers
    • Feng, S.S.; Huang, G. Effects of emulsifiers on the controlled release of paclitaxel (Taxol®) from nanospheres of biodegradable polymers. J. Control. Release, 2001, 71, 53-69.
    • (2001) J. Control. Release , vol.71 , pp. 53-69
    • Feng, S.S.1    Huang, G.2
  • 25
    • 29244491101 scopus 로고    scopus 로고
    • Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel
    • Xie, J.; Wang, C. H. Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. Pharm. Res., 2005, 22, 2079-2090.
    • (2005) Pharm. Res , vol.22 , pp. 2079-2090
    • Xie, J.1    Wang, C.H.2
  • 26
    • 70350244685 scopus 로고    scopus 로고
    • PLGA nanoparticles stabilized with cationic surfactant: Safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat
    • Bhardwaj, V.; Ankola, D.; Gupta, S.; Schneider, M.; Lehr, C.M.; Kumar, M. N. R. PLGA nanoparticles stabilized with cationic surfactant: safety studies and application in oral delivery of paclitaxel to treat chemical-induced breast cancer in rat. Pharm. Res., 2009, 26, 2495-2503.
    • (2009) Pharm. Res , vol.26 , pp. 2495-2503
    • Bhardwaj, V.1    Ankola, D.2    Gupta, S.3    Schneider, M.4    Lehr, C.M.5    Kumar, M.6
  • 29
    • 0027420977 scopus 로고
    • Is Cremophor EL, solvent for paclitaxel, cytotoxic?
    • Fjällskog, M. L.; Frii, L.; Bergh, J. Is Cremophor EL, solvent for paclitaxel, cytotoxic? Lancet, 1993, 342, 873.
    • (1993) Lancet , vol.342 , pp. 873
    • Fjällskog, M.L.1    Frii, L.2    Bergh, J.3
  • 30
    • 0035003021 scopus 로고    scopus 로고
    • Role of formulation vehicles in taxane pharmacology
    • Van Zuylen, L.; Verweij, J.; Sparreboom, A., Role of formulation vehicles in taxane pharmacology. Invest. New Drugs, 2001, 19(2), 125-141.
    • (2001) Invest. New Drugs , vol.19 , Issue.2 , pp. 125-141
    • Van Zuylen, L.1    Verweij, J.2    Sparreboom, A.3
  • 32
    • 0032542499 scopus 로고    scopus 로고
    • Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: An in vitro study
    • Szebeni, J.; Alving, C. R.; Muggia, F. M. Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: An in vitro study. J. Natl. Cancer Inst., 1998, 90, 300-306.
    • (1998) J. Natl. Cancer Inst , vol.90 , pp. 300-306
    • Szebeni, J.1    Alving, C.R.2    Muggia, F.M.3
  • 33
    • 84856245990 scopus 로고    scopus 로고
    • Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20
    • Weiszhar, Z.; Czucz, J.; Revesz, C.; Rosivall, L.; Szebeni, J.; Rozsnyay, Z. Complement activation by polyethoxylated pharmaceutical surfactants: Cremophor-EL, Tween-80 and Tween-20. Eur. J. Pharm. Sci., 2012, 45 (4), 492-498.
    • (2012) Eur. J. Pharm. Sci , vol.45 , Issue.4 , pp. 492-498
    • Weiszhar, Z.1    Czucz, J.2    Revesz, C.3    Rosivall, L.4    Szebeni, J.5    Rozsnyay, Z.6
  • 34
    • 0037413394 scopus 로고    scopus 로고
    • An alternative paclitaxel microemulsion formulation: Hypersensitivity evaluation and pharmacokinetic profile
    • He, L.; Wang, G. L.; Zhang, Q. An alternative paclitaxel microemulsion formulation: hypersensitivity evaluation and pharmacokinetic profile. Int. J. Pharm., 2003, 250 (1), 45-50.
    • (2003) Int. J. Pharm , vol.250 , Issue.1 , pp. 45-50
    • He, L.1    Wang, G.L.2    Zhang, Q.3
  • 35
    • 0030724736 scopus 로고    scopus 로고
    • Methods for preventing reactions secondary to Cremophor EL
    • Michaud, L. Methods for preventing reactions secondary to Cremophor EL. Ann. Pharmacother., 1997, 31, 1402-1404.
    • (1997) Ann. Pharmacother , vol.31 , pp. 1402-1404
    • Michaud, L.1
  • 37
    • 84855801433 scopus 로고    scopus 로고
    • Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: In vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor
    • Sheihet, L.; Garbuzenko, O. B.; Bushman, J.; Gounder, M. K.; Minko, T.; Kohn, J. Paclitaxel in tyrosine-derived nanospheres as a potential anti-cancer agent: in vivo evaluation of toxicity and efficacy in comparison with paclitaxel in Cremophor. Eur. J. Pharm. Sci., 2012, 45 (3), 320-329.
    • (2012) Eur. J. Pharm. Sci , vol.45 , Issue.3 , pp. 320-329
    • Sheihet, L.1    Garbuzenko, O.B.2    Bushman, J.3    Gounder, M.K.4    Minko, T.5    Kohn, J.6
  • 38
    • 0034880214 scopus 로고    scopus 로고
    • Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation
    • Gelderblom, H.; Verweij, J.; Nooter, K.; Sparreboom, A. Cremophor EL: The drawbacks and advantages of vehicle selection for drug formulation. Eur. J. Cancer, 2001, 37(13), 1590-1598.
    • (2001) Eur. J. Cancer , vol.37 , Issue.13 , pp. 1590-1598
    • Gelderblom, H.1    Verweij, J.2    Nooter, K.3    Sparreboom, A.4
  • 39
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles : Implications for cancer chemotherapy
    • Ten Tije, A. J.; Verweij, J.; Loos, W. J.; Sparreboom, A. Pharmacological effects of formulation vehicles : Implications for cancer chemotherapy. Clin. Pharmacokinet., 2003, 42(7), 665-685.
    • (2003) Clin. Pharmacokinet , vol.42 , Issue.7 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3    Sparreboom, A.4
  • 40
    • 0023203448 scopus 로고
    • Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL
    • Besarab, A.; Jarrell, B. E.; Hirsch, S.; Carabasi, R. A.; Cressman, M. D.; Green, P. Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, cremophor EL. Transplantation, 1987, 44(2), 195-201.
    • (1987) Transplantation , vol.44 , Issue.2 , pp. 195-201
    • Besarab, A.1    Jarrell, B.E.2    Hirsch, S.3    Carabasi, R.A.4    Cressman, M.D.5    Green, P.6
  • 41
    • 0000172679 scopus 로고
    • Dialyzer associated neurotoxicity due to a change in fatty acid structure. Trans
    • Podratz, J.L.; Windebank, A.J. Dialyzer associated neurotoxicity due to a change in fatty acid structure. Trans. Am. Soc. Neurochem., 1993, 24, 229.
    • (1993) Am. Soc. Neurochem , vol.24 , pp. 229
    • Podratz, J.L.1    Windebank, A.J.2
  • 42
    • 29144478503 scopus 로고    scopus 로고
    • Peripheral neuropathy: A persisting challenge in paclitaxel-based regimes
    • Mielke, S.; Sparreboom, A.; Mross, K. Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes. Eur. J. Cancer, 2006, 42, 24-30.
    • (2006) Eur. J. Cancer , vol.42 , pp. 24-30
    • Mielke, S.1    Sparreboom, A.2    Mross, K.3
  • 45
    • 0033970658 scopus 로고    scopus 로고
    • Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro
    • Theiss, C.; Meller, K. Taxol impairs anterograde axonal transport of microinjected horseradish peroxidase in dorsal root ganglia neurons in vitro. Cell Tissue Res., 2000, 299, 213-224.
    • (2000) Cell Tissue Res , vol.299 , pp. 213-224
    • Theiss, C.1    Meller, K.2
  • 47
    • 84886583599 scopus 로고    scopus 로고
    • The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions
    • Gornstein, E.; Schwarz, T. L. The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology, 2014, 76, 175-183.
    • (2014) Neuropharmacology , vol.76 , pp. 175-183
    • Gornstein, E.1    Schwarz, T.L.2
  • 50
    • 77949916769 scopus 로고    scopus 로고
    • Acute Taxol nephrotoxicity: Histological and ultrastructural studies of mice kidney parenchyma
    • Rabah, S. O., Acute Taxol nephrotoxicity: Histological and ultrastructural studies of mice kidney parenchyma. Saudi. J. Biol. Sci. 2010, 17(2), 105-114.
    • (2010) Saudi. J. Biol. Sci , vol.17 , Issue.2 , pp. 105-114
    • Rabah, S.O.1
  • 52
    • 0034905407 scopus 로고    scopus 로고
    • Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium
    • Minotti, G.; Saponiero, A.; Licata, S.; Menna, P.; Calafiore, A. M.; Teodori, G.; Gianni, L., Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium. Clin. Cancer Res., 2001, 7, 1511-1515.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1511-1515
    • Minotti, G.1    Saponiero, A.2    Licata, S.3    Menna, P.4    Calafiore, A.M.5    Teodori, G.6    Gianni, L.7
  • 60
  • 61
    • 84890736388 scopus 로고    scopus 로고
    • Advances in P-glycoprotein-based approaches for delivering anticancer drugs: Pharmacokinetic perspective and clinical relevance
    • Saneja, A.; Khare, V.; Alam, N.; Dubey, R. D.; Gupta, P. N. Advances in P-glycoprotein-based approaches for delivering anticancer drugs: Pharmacokinetic perspective and clinical relevance. Expert Opin. Drug Deliv., 2014, 11(1), 121-38.
    • (2014) Expert Opin. Drug Deliv , vol.11 , Issue.1 , pp. 121-138
    • Saneja, A.1    Khare, V.2    Alam, N.3    Dubey, R.D.4    Gupta, P.N.5
  • 62
    • 1842587393 scopus 로고    scopus 로고
    • Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes
    • Shono, Y.; Nishihara, H.; Matsuda, Y.; Furukawa, S.; Okada, N.; Fujita, T.; Yamamoto, A. Modulation of intestinal P-glycoprotein function by cremophor EL and other surfactants by an in vitro diffusion chamber method using the isolated rat intestinal membranes. J. Pharm. Sci., 2004, 93 (4), 877-85.
    • (2004) J. Pharm. Sci , vol.93 , Issue.4 , pp. 877-885
    • Shono, Y.1    Nishihara, H.2    Matsuda, Y.3    Furukawa, S.4    Okada, N.5    Fujita, T.6    Yamamoto, A.7
  • 63
    • 84888197706 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review
    • Sosnik, A. Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review. Adv. Drug Deliv. Rev., 2013, 65 (13-14), 1828-51.
    • (2013) Adv. Drug Deliv. Rev , vol.65 , Issue.13-14 , pp. 1828-1851
    • Sosnik, A.1
  • 65
    • 0025806342 scopus 로고
    • Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers
    • Waugh, W.N.; Trissel, L.A.; Stella, V.J. Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers. Am. J. Hosp. Pharm., 1991, 48, 1520-1524.
    • (1991) Am. J. Hosp. Pharm , vol.48 , pp. 1520-1524
    • Waugh, W.N.1    Trissel, L.A.2    Stella, V.J.3
  • 67
    • 33846236474 scopus 로고    scopus 로고
    • Physical and chemical stability of paclitaxel infusions in different container types
    • Donyai, P.; Sewell, G. J. Physical and chemical stability of paclitaxel infusions in different container types. J. Oncol. Pharm. Pract., 2006, 12, 211-222.
    • (2006) J. Oncol. Pharm. Pract , vol.12 , pp. 211-222
    • Donyai, P.1    Sewell, G.J.2
  • 69
    • 0021203216 scopus 로고
    • Development of an intravenous formulation for the unstable investigational cytotoxic nucleosides 5-azacytosine arabinoside (NSC 281272) and 5-azacytidine (NSC 102816)
    • Mojaverian, P.; Repta, A. Development of an intravenous formulation for the unstable investigational cytotoxic nucleosides 5-azacytosine arabinoside (NSC 281272) and 5-azacytidine (NSC 102816). J. Pharm. Pharmacol., 1984, 36, 728-733.
    • (1984) J. Pharm. Pharmacol , vol.36 , pp. 728-733
    • Mojaverian, P.1    Repta, A.2
  • 71
    • 0021688221 scopus 로고
    • Solubility concepts and their applications to the formulation of pharmaceutical systems. Part I. Theoretical foundations
    • Flynn, G. L. Solubility concepts and their applications to the formulation of pharmaceutical systems. Part I. Theoretical foundations. J. Parenter. Sci. Technol., 1984, 38, 202-209.
    • (1984) J. Parenter. Sci. Technol , vol.38 , pp. 202-209
    • Flynn, G.L.1
  • 72
    • 0026425674 scopus 로고
    • Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue
    • Bissery, M. C.; Guénard, D.; Guéritte-Voegelein, F.; Lavelle, F. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res., 1991, 51, 4845-4852.
    • (1991) Cancer Res , vol.51 , pp. 4845-4852
    • Bissery, M.C.1    Guénard, D.2    Guéritte-Voegelein, F.3    Lavelle, F.4
  • 73
    • 0023097015 scopus 로고
    • New parenteral vehicle for the administration of some poorly water soluble anti-cancer drugs
    • Tarr, B. D.; Yalkowsky, S. H. A new parenteral vehicle for the administration of some poorly water soluble anti-cancer drugs. J. Parenter. Sci. Technol., 1987, 41, 31-33.
    • (1987) J. Parenter. Sci. Technol , vol.41 , pp. 31-33
    • Tarr, B.D.1    Yalkowsky, S.2
  • 75
    • 1242337284 scopus 로고    scopus 로고
    • Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors
    • Yang, S.; Gursoy, R. N.; Lambert, G.; Benita, S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm. Res., 2004, 21, 261-270.
    • (2004) Pharm. Res , vol.21 , pp. 261-270
    • Yang, S.1    Gursoy, R.N.2    Lambert, G.3    Benita, S.4
  • 77
    • 79952416736 scopus 로고    scopus 로고
    • Formulation, characterization and hypersensitivity evaluation of an intravenous emulsion loaded with a paclitaxelcholesterol complex
    • Xia, X.-J.; Guo, R.-F.; Liu, Y.-L.; Zhang, P.-X.; Zhou, C.-P.; Jin, D.- J.; Wang, R.-Y., Formulation, characterization and hypersensitivity evaluation of an intravenous emulsion loaded with a paclitaxelcholesterol complex. Chem. Pharm. Bull., 2011, 5(3), 321-326.
    • (2011) Chem. Pharm. Bull , vol.5 , Issue.3 , pp. 321-326
    • Xia, X.-J.1    Guo, R.-F.2    Liu, Y.-L.3    Zhang, P.-X.4    Zhou, C.-P.5    Jin, D.-J.6    Wang, R.-Y.7
  • 79
    • 0025343062 scopus 로고
    • Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycinconjugated poly (Ethylene glycol)-poly (aspartic acid) block copolymer
    • Yokoyama, M.; Miyauchi, M.; Yamada, N.; Okano, T.; Sakurai, Y.; Kataoka, K.; Inoue, S. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycinconjugated poly (ethylene glycol)-poly (aspartic acid) block copolymer. Cancer Res., 1990, 50, 1693-1700.
    • (1990) Cancer Res , vol.50 , pp. 1693-1700
    • Yokoyama, M.1    Miyauchi, M.2    Yamada, N.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6    Inoue, S.7
  • 80
    • 84896707834 scopus 로고    scopus 로고
    • (PEG-PE)/Vitamin E Micelles for Co-Delivery of Paclitaxel and Curcumin to Overcome Multi-Drug Resistance in Ovarian Cancer
    • Abouzeid, A. H.; Patel, N. R.; Torchilin, V. P., Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)/Vitamin E Micelles for Co-Delivery of Paclitaxel and Curcumin to Overcome Multi-Drug Resistance in Ovarian Cancer. Int. J. Pharm., 2014, 464, 178-184.
    • (2014) Int. J. Pharm , vol.464 , pp. 178-184
    • Abouzeid, A.H.1    Patel, N.R.2    Torchilin, V.P.3    Glycol-Phosphatidylethanolamine, P.4
  • 81
    • 84885334230 scopus 로고    scopus 로고
    • Encapsulation of paclitaxel into lauric acid carboxymethyl chitosan-transferrin micelles for hydrophobic drug delivery and site-specific targeted delivery
    • Nam, J.-P.; Park, S.-C.; Kim, T.-H.; Jang, J.-Y.; Choi, C.; Jang, M.-K.; Nah, J.-W., Encapsulation of paclitaxel into lauric acid carboxymethyl chitosan-transferrin micelles for hydrophobic drug delivery and site-specific targeted delivery. Int. J. Pharm., 2013, 457, (1), 124-135.
    • (2013) Int. J. Pharm , vol.457 , Issue.1 , pp. 124-135
    • Nam, J.-P.1    Park, S.-C.2    Kim, T.-H.3    Jang, J.-Y.4    Choi, C.5    Jang, M.-K.6    Nah, J.-W.7
  • 82
    • 79951769859 scopus 로고    scopus 로고
    • The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery
    • Yao, H.J.; Ju, R.J.; Wang, X.X.; Zhang, Y.; Li, R.J.; Yu, Y.; Zhang, L.; Lu, W.L. The antitumor efficacy of functional paclitaxel nanomicelles in treating resistant breast cancers by oral delivery. Biomaterials, 2011, 32, 3285-3302.
    • (2011) Biomaterials , vol.32 , pp. 3285-3302
    • Yao, H.J.1    Ju, R.J.2    Wang, X.X.3    Zhang, Y.4    Li, R.J.5    Yu, Y.6    Zhang, L.7    Lu, W.L.8
  • 84
    • 38749120897 scopus 로고    scopus 로고
    • New hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel
    • Huh, K. M.; Min, H. S.; Lee, S. C.; Lee, H. J.; Kim, S.; Park, K. A new hydrotropic block copolymer micelle system for aqueous solubilization of paclitaxel. J. Control. Release, 2008, 126, 122-129.
    • (2008) J. Control. Release , vol.126 , pp. 122-129
    • Huh, K.M.1    Min, H.S.2    Lee, S.C.3    Lee, H.J.4    Kim, S.5    Park, K.A.6
  • 85
    • 0032828963 scopus 로고    scopus 로고
    • Development of copolymers of poly (D, L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
    • Burt, H. M.; Zhang, X.; Toleikis, P.; Embree, L.; Hunter, W. L. Development of copolymers of poly (D, L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloids Surf. B. Biointerfaces, 1999, 16, 161-171.
    • (1999) Colloids Surf. B. Biointerfaces , vol.16 , pp. 161-171
    • Burt, H.M.1    Zhang, X.2    Toleikis, P.3    Embree, L.4    Hunter, W.L.5
  • 86
    • 2442640615 scopus 로고    scopus 로고
    • Corecross- linked polymeric micelles as paclitaxel carriers
    • Shuai, X.; Merdan, T.; Schaper, A. K.; Xi, F.; Kissel, T. Corecross- linked polymeric micelles as paclitaxel carriers. Bioconjug. Chem., 2004, 15, 441-448.
    • (2004) Bioconjug. Chem , vol.15 , pp. 441-448
    • Shuai, X.1    Merdan, T.2    Schaper, A.K.3    Xi, F.4    Kissel, T.5
  • 87
    • 20044370444 scopus 로고    scopus 로고
    • Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly (ethylene glycol)-lipid conjugate and positively charged lipids
    • Wang, J.; Mongayt, D.; Torchilin, V. P. Polymeric micelles for delivery of poorly soluble drugs: preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly (ethylene glycol)-lipid conjugate and positively charged lipids. J. Drug Target, 2005, 13, 73-80.
    • (2005) J. Drug Target , vol.13 , pp. 73-80
    • Wang, J.1    Mongayt, D.2    Torchilin, V.P.3
  • 88
    • 0035858296 scopus 로고    scopus 로고
    • In vivo evaluation of polymeric micellar paclitaxel formulation: Toxicity and efficacy
    • Kim, S. C.; Kim, D. W.; Shim, Y. H.; Bang, J. S.; Oh, H. S.; Wan Kim, S.; Seo, M. H. In vivo evaluation of polymeric micellar paclitaxel formulation: Toxicity and efficacy. J. Control. Release, 2001, 72, 191-202.
    • (2001) J. Control. Release , vol.72 , pp. 191-202
    • Kim, S.C.1    Kim, D.W.2    Shim, Y.H.3    Bang, J.S.4    Oh, H.S.5    Wan Kim, S.6    Seo, M.H.7
  • 89
    • 2942613193 scopus 로고    scopus 로고
    • Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles
    • Cho, Y. W.; Lee, J.; Lee, S. C.; Huh, K. M.; Park, K. Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles. J. Control. Release, 2004, 97, 249-257.
    • (2004) J. Control. Release , vol.97 , pp. 249-257
    • Cho, Y.W.1    Lee, J.2    Lee, S.C.3    Huh, K.M.4    Park, K.5
  • 90
    • 70449711530 scopus 로고    scopus 로고
    • Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs
    • Shin, H. C.; Alani, A. W.; Rao, D. A.; Rockich, N. C.; Kwon, G. S. Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. J. Control. Release, 2009, 140, 294-300.
    • (2009) J. Control. Release , vol.140 , pp. 294-300
    • Shin, H.C.1    Alani, A.W.2    Rao, D.A.3    Rockich, N.C.4    Kwon, G.S.5
  • 91
    • 67349137876 scopus 로고    scopus 로고
    • Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: Formulation, optimization and in vitro characterization
    • Wei, Z.; Hao, J.; Yuan, S.; Li, Y.; Juan, W.; Sha, X.; Fang, X. Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization. Int. J. Pharm., 2009, 376, 176-185.
    • (2009) Int. J. Pharm , vol.376 , pp. 176-185
    • Wei, Z.1    Hao, J.2    Yuan, S.3    Li, Y.4    Juan, W.5    Sha, X.6    Fang, X.7
  • 92
    • 33646367645 scopus 로고    scopus 로고
    • Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: Some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux
    • Dabholkar, R. D.; Sawant, R. M.; Mongayt, D. A.; Devarajan, P. V.; Torchilin, V. P. Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int. J. Pharm., 2006, 315, 148-157.
    • (2006) Int. J. Pharm , vol.315 , pp. 148-157
    • Dabholkar, R.D.1    Sawant, R.M.2    Mongayt, D.A.3    Devarajan, P.V.4    Torchilin, V.P.5
  • 93
    • 34848839868 scopus 로고    scopus 로고
    • Micelles of different morphologies—advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery
    • Cai, S.; Vijayan, K.; Cheng, D.; Lima, E. M.; Discher, D. E. Micelles of different morphologies—advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm. Res., 2007, 24, 2099-2109.
    • (2007) Pharm. Res , vol.24 , pp. 2099-2109
    • Cai, S.1    Vijayan, K.2    Cheng, D.3    Lima, E.M.4    Discher, D.E.5
  • 94
    • 64649091716 scopus 로고    scopus 로고
    • PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: Synergistic anticancer effect
    • Musacchio, T.; Laquintana, V.; Latrofa, A.; Trapani, G.; Torchilin, V. P. PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: Synergistic anticancer effect. Mol. Pharm. 2008, 6, 468-479.
    • (2008) Mol. Pharm , vol.6 , pp. 468-479
    • Musacchio, T.1    Laquintana, V.2    Latrofa, A.3    Trapani, G.4    Torchilin, V.P.5
  • 95
    • 8144225129 scopus 로고    scopus 로고
    • Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system
    • Zhang, C.; Qineng, P.; Zhang, H., Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system. Colloids Surf. B Biointerfaces, 2004, 39, 69-75.
    • (2004) Colloids Surf. B Biointerfaces , vol.39 , pp. 69-75
    • Zhang, C.1    Qineng, P.2    Zhang, H.3
  • 96
    • 34548270126 scopus 로고    scopus 로고
    • Polymeric micelles with glycolipid-like structure and multiple hydrophobic domains for mediating molecular target delivery of paclitaxel
    • You, J.; Hu, F.-Q.; Du, Y.-Z.; Yuan, H. Polymeric micelles with glycolipid-like structure and multiple hydrophobic domains for mediating molecular target delivery of paclitaxel. Biomacromolecules, 2007, 8, 2450-2456.
    • (2007) Biomacromolecules , vol.8 , pp. 2450-2456
    • You, J.1    Hu, F.-Q.2    Du, Y.-Z.3    Yuan, H.4
  • 97
    • 74849097084 scopus 로고    scopus 로고
    • Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA–PCL–PDMAEMA triblock copolymers
    • Zhu, C.; Jung, S.; Luo, S.; Meng, F.; Zhu, X.; Park, T. G.; Zhong, Z. Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA–PCL–PDMAEMA triblock copolymers. Biomaterials, 2010, 31, 2408-2416.
    • (2010) Biomaterials , vol.31 , pp. 2408-2416
    • Zhu, C.1    Jung, S.2    Luo, S.3    Meng, F.4    Zhu, X.5    Park, T.G.6    Zhong, Z.7
  • 99
    • 84876701245 scopus 로고    scopus 로고
    • Preparation and evaluation of copolymeric micelles with high paclitaxel contents and sustained drug release
    • Li, Y.; Xu, X.; Shen, Y.; Qian, C.; Lu, F.; Guo, S. Preparation and evaluation of copolymeric micelles with high paclitaxel contents and sustained drug release. Colloids Surf. A. Physicochem. Eng. Asp., 2013, 429, 12-18.
    • (2013) Colloids Surf. A. Physicochem. Eng. Asp , vol.429 , pp. 12-18
    • Li, Y.1    Xu, X.2    Shen, Y.3    Qian, C.4    Lu, F.5    Guo, S.6
  • 100
    • 84867799211 scopus 로고    scopus 로고
    • Nano-formulation of Paclitaxel by Vitamin E succinate Functionalized Pluronic Micelles for Enhanced Encapsulation, Stability and Cytotoxicity
    • Tao, Y.; Han, J.; Wang, X.; Dou, H. Nano-formulation of Paclitaxel by Vitamin E succinate Functionalized Pluronic Micelles for Enhanced Encapsulation, Stability and Cytotoxicity. Colloids and Surfaces B: Biointerfaces, 2013, 102, 604-610.
    • (2013) Colloids and Surfaces B: Biointerfaces , vol.102 , pp. 604-610
    • Tao, Y.1    Han, J.2    Wang, X.3    Dou, H.4
  • 101
    • 84899035872 scopus 로고    scopus 로고
    • Selective tissue distribution and long circulation endowed by paclitaxel loaded PEGylated poly(Epsiloncaprolactone- co-L-lactide) micelles leading to improved anti-tumor effects and low systematic toxicity
    • Wang, F.; Shen, Y.; Xu, X.; Lv, L.; Li, Y.; Liu, J.; Li, M.; Guo, A.; Guo, S.; Jin, F. Selective tissue distribution and long circulation endowed by paclitaxel loaded PEGylated poly(epsiloncaprolactone- co-L-lactide) micelles leading to improved anti-tumor effects and low systematic toxicity. Int. J. Pharm., 2013, 456(1), 101-112.
    • (2013) Int. J. Pharm , vol.456 , Issue.1 , pp. 101-112
    • Wang, F.1    Shen, Y.2    Xu, X.3    Lv, L.4    Li, Y.5    Liu, J.6    Li, M.7    Guo, A.8    Guo, S.9    Jin, F.10
  • 102
    • 84856452267 scopus 로고    scopus 로고
    • Liposomal drug formulations in cancer therapy: 15 years along the road
    • Slingerland, M.; Guchelaar, H.-J.; Gelderblom, H. Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Discov. Today, 2012, 17, 160-166.
    • (2012) Drug Discov. Today , vol.17 , pp. 160-166
    • Slingerland, M.1    Guchelaar, H.-J.2    Gelderblom, H.3
  • 103
    • 33750715718 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer
    • Allen, T. M.; Cheng, W. W.; Hare, J. I.; Laginha, K. M. Pharmacokinetics and pharmacodynamics of lipidic nano-particles in cancer. Anticancer Agents Med. Chem., 2006, 6, 513-523.
    • (2006) Anticancer Agents Med. Chem , vol.6 , pp. 513-523
    • Allen, T.M.1    Cheng, W.W.2    Hare, J.I.3    Laginha, K.M.4
  • 104
    • 0027137936 scopus 로고
    • Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model
    • Sharma, A.; Mayhew, E.; Straubinger, R. M. Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model. Cancer Res., 1993, 53, 5877-5881.
    • (1993) Cancer Res , vol.53 , pp. 5877-5881
    • Sharma, A.1    Mayhew, E.2    Straubinger, R.M.3
  • 105
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino, M. L.; Dosio, F.; Cattel, L. Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential. Int. J. Nanomed., 2006, 1, 297-315.
    • (2006) Int. J. Nanomed , vol.1 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 106
    • 68049142557 scopus 로고    scopus 로고
    • Clinical overview on Lipoplatin™: A successful liposomal formulation of cisplatin
    • Boulikas, T., Clinical overview on Lipoplatin™: A successful liposomal formulation of cisplatin. Expert Opin. Investig. Drugs, 2009, 18, 1197-1218.
    • (2009) Expert Opin. Investig. Drugs , vol.18 , pp. 1197-1218
    • Boulikas, T.1
  • 107
    • 0033964804 scopus 로고    scopus 로고
    • Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes
    • Crosasso, P.; Ceruti, M.; Brusa, P.; Arpicco, S.; Dosio, F.; Cattel, L. Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes. J. Control Release, 2000, 63, 19-30.
    • (2000) J. Control Release , vol.63 , pp. 19-30
    • Crosasso, P.1    Ceruti, M.2    Brusa, P.3    Arpicco, S.4    Dosio, F.5    Cattel, L.6
  • 108
    • 77955668144 scopus 로고    scopus 로고
    • Antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX): In vitro and in vivo
    • Huang, Y.; Chen, X. M.; Zhao, B. X.; Ke, X. Y.; Zhao, B. J.; Zhao, X.; Wang, Y.; Zhang, X.; Zhang, Q. Antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX): In vitro and in vivo. AAPs. Pharm. Sci. Tech., 2010, 11, 752-759.
    • (2010) Aaps. Pharm. Sci. Tech , vol.11 , pp. 752-759
    • Huang, Y.1    Chen, X.M.2    Zhao, B.X.3    Ke, X.Y.4    Zhao, B.J.5    Zhao, X.6    Wang, Y.7    Zhang, X.8    Zhang, Q.9
  • 109
    • 70349679107 scopus 로고    scopus 로고
    • Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases
    • Maywood
    • Latimer, P.; Menchaca, M.; Snyder, R. M.; Yu, W.; Gilbert, B. E.; Sanders, B. G.; Kline, K. Aerosol delivery of liposomal formulated paclitaxel and vitamin E analog reduces murine mammary tumor burden and metastases. Exp. Biol. Med. (Maywood), 2009, 234, 1244-1252.
    • (2009) Exp. Biol. Med , vol.234 , pp. 1244-1252
    • Latimer, P.1    Menchaca, M.2    Snyder, R.M.3    Yu, W.4    Gilbert, B.E.5    Sanders, B.G.6    Kline, K.7
  • 110
    • 33646894333 scopus 로고    scopus 로고
    • Folate receptor-targeted liposomal formulation for paclitaxel
    • Wu, J.; Liu, Q.; Lee, R. J. A folate receptor-targeted liposomal formulation for paclitaxel. Int. J. Pharm., 2006, 316, 148-153.
    • (2006) Int. J. Pharm , vol.316 , pp. 148-153
    • Wu, J.1    Liu, Q.2    Lee, R.3
  • 111
    • 35848961893 scopus 로고    scopus 로고
    • Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells
    • Yang, T.; Choi, M. K.; Cui, F. D.; Lee, S. J.; Chung, S. J.; Shim, C. K.; Kim, D. D. Antitumor effect of paclitaxel-loaded PEGylated immunoliposomes against human breast cancer cells. Pharm. Res., 2007, 24, 2402-2411.
    • (2007) Pharm. Res , vol.24 , pp. 2402-2411
    • Yang, T.1    Choi, M.K.2    Cui, F.D.3    Lee, S.J.4    Chung, S.J.5    Shim, C.K.6    Kim, D.D.7
  • 112
  • 113
    • 51649088789 scopus 로고    scopus 로고
    • Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin
    • Strieth, S.; Eichhorn, M. E.; Werner, A.; Sauer, B.; Teifel, M.; Michaelis, U.; Berghaus, A.; Dellian, M. Paclitaxel encapsulated in cationic liposomes increases tumor microvessel leakiness and improves therapeutic efficacy in combination with Cisplatin. Clin. Cancer Res., 2008, 14, 4603-4611.
    • (2008) Clin. Cancer Res , vol.14 , pp. 4603-4611
    • Strieth, S.1    Eichhorn, M.E.2    Werner, A.3    Sauer, B.4    Teifel, M.5    Michaelis, U.6    Berghaus, A.7    Dellian, M.8
  • 114
    • 80055027137 scopus 로고    scopus 로고
    • Liposomes as multicompartmental carriers for multidrug delivery in anticancer chemotherapy
    • Cosco, D.; Paolino, D.; Maiuolo, J.; Russo, D.; Fresta, M. Liposomes as multicompartmental carriers for multidrug delivery in anticancer chemotherapy. Drug Deliv. Transl., Res., 2011, 1, 66-75.
    • (2011) Drug Deliv. Transl., Res , vol.1 , pp. 66-75
    • Cosco, D.1    Paolino, D.2    Maiuolo, J.3    Russo, D.4    Fresta, M.5
  • 115
    • 77955473762 scopus 로고    scopus 로고
    • Paclitaxel-loaded, folic-acid-targeted and TAT-peptide-conjugated polymeric liposomes: In vitro and in vivo evaluation
    • Zhao, P.; Wang, H.; Yu, M.; Cao, S.; Zhang, F.; Chang, J.; Niu, R. Paclitaxel-loaded, folic-acid-targeted and TAT-peptide-conjugated polymeric liposomes: In vitro and in vivo evaluation. Pharm. Res., 2010, 27, 1914-1926.
    • (2010) Pharm. Res , vol.27 , pp. 1914-1926
    • Zhao, P.1    Wang, H.2    Yu, M.3    Cao, S.4    Zhang, F.5    Chang, J.6    Niu, R.7
  • 116
    • 79958191520 scopus 로고    scopus 로고
    • Localized delivery of paclitaxel using elastic liposomes: Formulation development and evaluation
    • Utreja, P.; Jain, S.; Tiwary, A. Localized delivery of paclitaxel using elastic liposomes: Formulation development and evaluation. Drug Deliv., 2011, 18, 367-376.
    • (2011) Drug Deliv , vol.18 , pp. 367-376
    • Utreja, P.1    Jain, S.2    Tiwary, A.3
  • 117
    • 34347405909 scopus 로고    scopus 로고
    • Liposome formulation of paclitaxel with enhanced solubility and stability
    • Yang, T.; Cui, F.-D.; Choi, M. K.; Lin, H.; Chung, S. J.; Shim, C. K.; Kim, D. D., Liposome formulation of paclitaxel with enhanced solubility and stability. Drug Deliv., 2007, 14, 301-308.
    • (2007) Drug Deliv , vol.14 , pp. 301-308
    • Yang, T.1    Cui, F.-D.2    Choi, M.K.3    Lin, H.4    Chung, S.J.5    Shim, C.K.6    Kim, D.D.7
  • 118
    • 79957473802 scopus 로고    scopus 로고
    • PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
    • Yoshizawa, Y.; Kono, Y.; Ogawara, K. I..; Kimura, T.; Higaki, K. PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy. Int. J. Pharm., 2011, 412, 132-141.
    • (2011) Int. J. Pharm , vol.412 , pp. 132-141
    • Yoshizawa, Y.1    Kono, Y.2    Ogawara, K.I.3    Kimura, T.4    Higaki, K.5
  • 119
    • 78650320003 scopus 로고    scopus 로고
    • Preparation and the in[1]vivo evaluation of paclitaxel liposomes for lung targeting delivery in dogs
    • Zhao, L.; Ye, Y.; Li, J.; Wei, Y. M. Preparation and the in[1]vivo evaluation of paclitaxel liposomes for lung targeting delivery in dogs. J. Pharm. Pharmacol., 2011, 63, 80-86.
    • (2011) J. Pharm. Pharmacol , vol.63 , pp. 80-86
    • Zhao, L.1    Ye, Y.2    Li, J.3    Wei, Y.M.4
  • 120
    • 65849245222 scopus 로고    scopus 로고
    • RGDbased strategies for improving antitumor activity of paclitaxelloaded liposomes in nude mice xenografted with human ovarian cancer
    • Zhao, H.; Wang, J.-C.; Sun, Q.-S.; Luo, C.-L.; Zhang, Q. RGDbased strategies for improving antitumor activity of paclitaxelloaded liposomes in nude mice xenografted with human ovarian cancer. J. Drug Target., 2009, 17, 10-18.
    • (2009) J. Drug Target , vol.17 , pp. 10-18
    • Zhao, H.1    Wang, J.-C.2    Sun, Q.-S.3    Luo, C.-L.4    Zhang, Q.5
  • 121
    • 79251483489 scopus 로고    scopus 로고
    • Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: In vitro drug release, cell cytotoxicity, and uptake studies
    • Nie, S.; Hsiao, W. W.; Pan, W.; Yang, Z. Thermoreversible Pluronic® F127-based hydrogel containing liposomes for the controlled delivery of paclitaxel: In vitro drug release, cell cytotoxicity, and uptake studies. Int. J. Nanomed., 2011, 6, 151-166.
    • (2011) Int. J. Nanomed , vol.6 , pp. 151-166
    • Nie, S.1    Hsiao, W.W.2    Pan, W.3    Yang, Z.4
  • 122
    • 77956318180 scopus 로고    scopus 로고
    • PH-sensitive mPEG-Hz-cholesterol conjugates as a liposome delivery system
    • Chen, D.; Jiang, X.; Huang, Y.; Zhang, C.; Ping, Q. pH-sensitive mPEG-Hz-cholesterol conjugates as a liposome delivery system. J. Bioact. Compat. Polym., 2010, 25, 527-542.
    • (2010) J. Bioact. Compat. Polym , vol.25 , pp. 527-542
    • Chen, D.1    Jiang, X.2    Huang, Y.3    Zhang, C.4    Ping, Q.5
  • 123
    • 84873475880 scopus 로고    scopus 로고
    • Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers
    • Yan, F.; Li, L.; Deng, Z.; Jin, Q.; Chen, J.; Yang, W.; Yeh, C. K.; Wu, J.; Shandas, R.; Liu, X. Paclitaxel-liposome-microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers. J. Control. Release, 2013, 166, 246-255.
    • (2013) J. Control. Release , vol.166 , pp. 246-255
    • Yan, F.1    Li, L.2    Deng, Z.3    Jin, Q.4    Chen, J.5    Yang, W.6    Yeh, C.K.7    Wu, J.8    Shandas, R.9    Liu, X.10
  • 124
    • 27744508956 scopus 로고    scopus 로고
    • Paclitaxel-loaded PLGA nanoparticles: Potentiation of anticancer activity by surface conjugation with wheat germ agglutinin
    • Mo, Y.; Lim, L.-Y. Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin. J. Control Release, 2005, 108(2), 244-262.
    • (2005) J. Control Release , vol.108 , Issue.2 , pp. 244-262
    • Mo, Y.1    Lim, L.-Y.2
  • 125
    • 0020545039 scopus 로고
    • Otagiri, M. Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation
    • Uekama, K.; Narisawa, S.; Hirayama, F.; Otagiri, M. Improvement of dissolution and absorption characteristics of benzodiazepines by cyclodextrin complexation. Int. J. pharm., 1983, 16(3), 327-338.
    • (1983) Int. J. Pharm , vol.16 , Issue.3 , pp. 327-338
    • Uekama, K.1    Narisawa, S.2    Hirayama, F.3
  • 127
    • 0025250651 scopus 로고
    • Non-surfactant formulation for alfaxalone based on an amorphous cyclodextrin: Activity studies in rats and dogs
    • Estes, K.; Brewster, M.; Webb, A.; Bodor, N. A non-surfactant formulation for alfaxalone based on an amorphous cyclodextrin: Activity studies in rats and dogs. Int. J. Pharm., 1990, 65 (1), 101-107.
    • (1990) Int. J. Pharm , vol.65 , Issue.1 , pp. 101-107
    • Estes, K.1    Brewster, M.2    Webb, A.3    Bodor, N.A.4
  • 128
    • 0033104290 scopus 로고    scopus 로고
    • Cyclodextrin-based controlled drug release system
    • Hirayama, F.; Uekama, K. Cyclodextrin-based controlled drug release system. Advanced drug delivery reviews 1999, 36, (1), 125-141.
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.1 , pp. 125-141
    • Hirayama, F.1    Uekama, K.2
  • 129
    • 0037020525 scopus 로고    scopus 로고
    • Paclitaxel-loaded PLGA nanoparticles: Preparation, physicochemical characterization and in vitro anti-tumoral activity
    • Fonseca, C.; Simoes, S.; Gaspar, R. Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J. Control. Release, 2002, 83, 273-286.
    • (2002) J. Control. Release , vol.83 , pp. 273-286
    • Fonseca, C.1    Simoes, S.2    Gaspar, R.3
  • 130
    • 77956934839 scopus 로고    scopus 로고
    • Application of rotatable central composite design in the preparation and optimization of poly (Lactic-co-glycolic acid) nanoparticles for controlled delivery of paclitaxel
    • Kollipara, S.; Bende, G.; Movva, S.; Saha, R. Application of rotatable central composite design in the preparation and optimization of poly (lactic-co-glycolic acid) nanoparticles for controlled delivery of paclitaxel. Drug Dev. Ind. Pharm., 2010, 36, 1377-1387.
    • (2010) Drug Dev. Ind. Pharm , vol.36 , pp. 1377-1387
    • Kollipara, S.1    Bende, G.2    Movva, S.3    Saha, R.4
  • 131
    • 77957732045 scopus 로고    scopus 로고
    • Combined chemo-immunotherapy as a prospective strategy to combat cancer: A nanoparticle based approach
    • Roy, A.; Singh, M. S.; Upadhyay, P.; Bhaskar, S. Combined chemo-immunotherapy as a prospective strategy to combat cancer: A nanoparticle based approach. Mol. Pharm., 2010, 7, 1778-1788.
    • (2010) Mol. Pharm , vol.7 , pp. 1778-1788
    • Roy, A.1    Singh, M.S.2    Upadhyay, P.3    Bhaskar, S.4
  • 132
    • 70449527465 scopus 로고    scopus 로고
    • Comparison of anti-tumor efficacy of paclitaxel delivered in nano-and microparticles
    • Chakravarthi, S. S.; De, S.; Miller, D. W.; Robinson, D. H. Comparison of anti-tumor efficacy of paclitaxel delivered in nano-and microparticles. Int. J. Pharm., 2010, 383, 37-44.
    • (2010) Int. J. Pharm , vol.383 , pp. 37-44
    • Chakravarthi, S.S.1    De, S.2    Miller, D.W.3    Robinson, D.H.4
  • 133
    • 33747688383 scopus 로고    scopus 로고
    • Electrohydrodynamic atomization for biodegradable polymeric particle production
    • Xie, J.; Lim, L. K.; Phua, Y.; Hua, J.; Wang, C. H. Electrohydrodynamic atomization for biodegradable polymeric particle production. J. Colloid Interface Sci., 2006, 302, 103-112.
    • (2006) J. Colloid Interface Sci , vol.302 , pp. 103-112
    • Xie, J.1    Lim, L.K.2    Phua, Y.3    Hua, J.4    Wang, C.H.5
  • 134
    • 0035914220 scopus 로고    scopus 로고
    • Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers
    • Mu, L.; Feng, S. Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers. J. Control. Release, 2001, 76, 239-254.
    • (2001) J. Control. Release , vol.76 , pp. 239-254
    • Mu, L.1    Feng, S.2
  • 136
    • 84874941640 scopus 로고    scopus 로고
    • Nanoparticle mediated co-delivery of Paclitaxel and a TLR-4 agonist results in tumor regression and enhanced immune response at the tumor microenvironment in mouse model
    • Roy, A.; Singh, M. S.; Upadhyay, P.; Bhaskar, S. Nanoparticle mediated co-delivery of Paclitaxel and a TLR-4 agonist results in tumor regression and enhanced immune response at the tumor microenvironment in mouse model. Int. J. Pharm., 2013, 445, 171-180.
    • (2013) Int. J. Pharm , vol.445 , pp. 171-180
    • Roy, A.1    Singh, M.S.2    Upadhyay, P.3    Bhaskar, S.4
  • 137
  • 138
    • 84887132067 scopus 로고    scopus 로고
    • Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery
    • Koo, H.; Min, K.H.; Lee, S. C.; Park, J.H.; Park, K.; Jeong, S.Y.; Choi, K.; Kwon, I.C.; Kim, K. Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery. J. Control. Release., 2013, 172 (3), 823-831.
    • (2013) J. Control. Release , vol.172 , Issue.3 , pp. 823-831
    • Koo, H.1    Min, K.H.2    Lee, S.C.3    Park, J.H.4    Park, K.5    Jeong, S.Y.6    Choi, K.7    Kwon, I.C.8    Kim, K.9
  • 140
    • 0028919413 scopus 로고
    • Interaction of taxol and other anticancer drugs with α-cyclodextrin
    • Cserháti, T.; Forgács, E.; Holló, J., Interaction of taxol and other anticancer drugs with α-cyclodextrin. J. Pharm. Biomed. Anal. 1995, 13(4), 533-541.
    • (1995) J. Pharm. Biomed. Anal , vol.13 , Issue.4 , pp. 533-541
    • Cserháti, T.1    Forgács, E.2    Holló, J.3
  • 141
    • 0028838372 scopus 로고
    • Pharmaceutical and physical properties of paclitaxel (Taxol) complexes with cyclodextrins
    • Sharma, U.S.; Balasubramanian, S.V.; Straubinger, R.M. Pharmaceutical and physical properties of paclitaxel (Taxol) complexes with cyclodextrins. J. Pharm. Sci., 1995, 84(10), 1223-1230.
    • (1995) J. Pharm. Sci , vol.84 , Issue.10 , pp. 1223-1230
    • Sharma, U.S.1    Balasubramanian, S.V.2    Straubinger, R.M.3
  • 142
    • 0029978562 scopus 로고    scopus 로고
    • Solubility and stability of taxol: Effects of buffers and cyclodextrins
    • Dordunoo, S. K.; Burt, H. M. Solubility and stability of taxol: effects of buffers and cyclodextrins. Int. J. Pharm., 1996, 133(1), 191-201.
    • (1996) Int. J. Pharm , vol.133 , Issue.1 , pp. 191-201
    • Dordunoo, S.K.1    Burt, H.M.2
  • 144
    • 24144490885 scopus 로고    scopus 로고
    • Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention
    • Sahoo, S. K.; Labhasetwar, V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol. Pharm., 2005, 2, 373-383.
    • (2005) Mol. Pharm , vol.2 , pp. 373-383
    • Sahoo, S.K.1    Labhasetwar, V.2
  • 145
    • 77950515941 scopus 로고    scopus 로고
    • Conjugated poly (Ethylene glycol)-co-poly (lactic acid) micelle enhances paclitaxel anti-glioblastoma effect
    • Zhan, C.; Gu, B.; Xie, C.; Li, J.; Liu, Y.; Lu, W. Cyclic RGD conjugated poly (ethylene glycol)-co-poly (lactic acid) micelle enhances paclitaxel anti-glioblastoma effect. J. Control. Release, 2010, 143, 136-142.
    • (2010) J. Control. Release , vol.143 , pp. 136-142
    • Zhan, C.1    Gu, B.2    Xie, C.3    Li, J.4    Liu, Y.5    Lu, W.6    Cyclic, R.7
  • 146
    • 79959514159 scopus 로고    scopus 로고
    • Improved therapeutic effect of folate-decorated PLGA–PEG nanoparticles for endometrial carcinoma
    • Liang, C.; Yang, Y.; Ling, Y.; Huang, Y.; Li, T.; Li, X. Improved therapeutic effect of folate-decorated PLGA–PEG nanoparticles for endometrial carcinoma. Bioorg. Med. Chem., 2011, 19, 4057-4066.
    • (2011) Bioorg. Med. Chem , vol.19 , pp. 4057-4066
    • Liang, C.1    Yang, Y.2    Ling, Y.3    Huang, Y.4    Li, T.5    Li, X.6
  • 147
    • 77952357790 scopus 로고    scopus 로고
    • Paclitaxel- loaded stabilizer-free poly (D, l-lactide-co-glycolide) nanoparticles conjugated with quantum dots for reversion of anti-cancer drug resistance and cancer cellular imaging
    • Kuo, W. S.; Ku, Y. C.; Sei, H. T.; Cheng, F. Y.; Yeh, C. S. Paclitaxel- loaded stabilizer-free poly (d, l-lactide-co-glycolide) nanoparticles conjugated with quantum dots for reversion of anti-cancer drug resistance and cancer cellular imaging. J. Chin. Chem. Soc., 2009, 56, 923-934.
    • (2009) J. Chin. Chem. Soc , vol.56 , pp. 923-934
    • Kuo, W.S.1    Ku, Y.C.2    Sei, H.T.3    Cheng, F.Y.4    Yeh, C.S.5
  • 148
    • 77957673052 scopus 로고    scopus 로고
    • Nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells
    • Wang, C.; Ho, P. C.; Lim, L. Y., Wheat germ agglutininconjugated PLGA nanoparticles for enhanced intracellular delivery of paclitaxel to colon cancer cells. Int. J. Pharm., 2010, 400, 201-210.
    • (2010) Int. J. Pharm , vol.400 , pp. 201-210
    • Wang, C.1    Ho, P.C.2    Lim, L.Y.3    Wheat Germ Agglutininconjugated, P.4
  • 150
    • 76749138904 scopus 로고    scopus 로고
    • The formulation of aptamer- coated paclitaxel–polylactide nanoconjugates and their targeting to cancer cells
    • Tong, R.; Yala, L.; Fan, T. M.; Cheng, J. The formulation of aptamer- coated paclitaxel–polylactide nanoconjugates and their targeting to cancer cells. Biomaterials, 2010, 31, 3043-3053.
    • (2010) Biomaterials , vol.31 , pp. 3043-3053
    • Tong, R.1    Yala, L.2    Fan, T.M.3    Cheng, J.4
  • 152
    • 24344471360 scopus 로고    scopus 로고
    • Preparation and in vitro anticancer activity of wheat germ agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and isopropyl myristate
    • Mo, Y.; Lim, L.-Y., Preparation and in vitro anticancer activity of wheat germ agglutinin (WGA)-conjugated PLGA nanoparticles loaded with paclitaxel and isopropyl myristate. J. Control. Release, 2005, 107, 30-42.
    • (2005) J. Control. Release , vol.107 , pp. 30-42
    • Mo, Y.1    Lim, L.-Y.2
  • 153
    • 35348919484 scopus 로고    scopus 로고
    • Preparation and characterization of paclitaxel- loaded PLGA nanoparticles coated with cationic SM5-1 single- chain antibody
    • Kou, G.; Gao, J.; Wang, H.; Chen, H.; Li, B.; Zhang, D.; Wang, S.; Hou, S.; Qian, W.; Dai, J. Preparation and characterization of paclitaxel- loaded PLGA nanoparticles coated with cationic SM5-1 single- chain antibody. J. Biochem. Mol. Biol., 2007, 40, 731-739.
    • (2007) J. Biochem. Mol. Biol , vol.40 , pp. 731-739
    • Kou, G.1    Gao, J.2    Wang, H.3    Chen, H.4    Li, B.5    Zhang, D.6    Wang, S.7    Hou, S.8    Qian, W.9    Dai, J.10
  • 154
    • 41049089702 scopus 로고    scopus 로고
    • The preparation and characterization of anti-VEGFR2 conjugated, paclitaxel-loaded PLLA or PLGA microspheres for the systemic targeting of human prostate tumors
    • Lu, J.; Jackson, J. K.; Gleave, M. E.; Burt, H. M. The preparation and characterization of anti-VEGFR2 conjugated, paclitaxel-loaded PLLA or PLGA microspheres for the systemic targeting of human prostate tumors. Cancer Chemother. Pharmacol., 2008, 61, 997-1005.
    • (2008) Cancer Chemother. Pharmacol , vol.61 , pp. 997-1005
    • Lu, J.1    Jackson, J.K.2    Gleave, M.E.3    Burt, H.M.4
  • 155
    • 84881669479 scopus 로고    scopus 로고
    • Transferrinconjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment
    • Cui, Y.; Xu, Q.; Chow, P. K.; Wang, D.; Wang, C. H. Transferrinconjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment. Biomaterials, 2013, 34(33), 8511-8520.
    • (2013) Biomaterials , vol.34 , Issue.33 , pp. 8511-8520
    • Cui, Y.1    Xu, Q.2    Chow, P.K.3    Wang, D.4    Wang, C.H.5
  • 157
    • 33751247035 scopus 로고    scopus 로고
    • Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins
    • Hamada, H.; Ishihara, K.; Masuoka, N.; Mikuni, K.; Nakajima, N. Enhancement of water-solubility and bioactivity of paclitaxel using modified cyclodextrins. J. Biosci. Bioeng., 2006, 102, 369-371.
    • (2006) J. Biosci. Bioeng , vol.102 , pp. 369-371
    • Hamada, H.1    Ishihara, K.2    Masuoka, N.3    Mikuni, K.4    Nakajima, N.5
  • 158
    • 0142124208 scopus 로고    scopus 로고
    • Inclusion complexation and solubilization of paclitaxel by bridged bis (β-cyclodextrin) s containing a tetraethylenepentaamino spacer
    • Liu, Y.; Chen, G.-S.; Li, L.; Zhang, H.-Y.; Cao, D. X.; Yuan, Y. J., Inclusion complexation and solubilization of paclitaxel by bridged bis (β-cyclodextrin) s containing a tetraethylenepentaamino spacer. J. Med. Chem., 2003, 46, 4634-4637.
    • (2003) J. Med. Chem , vol.46 , pp. 4634-4637
    • Liu, Y.1    Chen, G.-S.2    Li, L.3    Zhang, H.-Y.4    Cao, D.X.5    Yuan, Y.J.6
  • 159
    • 70349840419 scopus 로고    scopus 로고
    • Combined hydroxypropyl-β- cyclodextrin and poly (Anhydride) nanoparticles improve the oral permeability of paclitaxel
    • Agüeros, M.; Ruiz-Gatón, L.; Vauthier, C.; Bouchemal, K.; Espuelas, S.; Ponchel, G.; Irache, J. Combined hydroxypropyl-β- cyclodextrin and poly (anhydride) nanoparticles improve the oral permeability of paclitaxel. Eur. J. Pharm. Sci., 2009, 38, 405-413.
    • (2009) Eur. J. Pharm. Sci , vol.38 , pp. 405-413
    • Agüeros, M.1    Ruiz-Gatón, L.2    Vauthier, C.3    Bouchemal, K.4    Espuelas, S.5    Ponchel, G.6    Irache, J.7
  • 160
    • 36549018670 scopus 로고    scopus 로고
    • Safety and efficacy of amphiphilic ß-cyclodextrin nanoparticles for paclitaxel delivery
    • Bilensoy, E.; Gürkaynak, O.; Doğan, A. L.; Hıncal, A. A. Safety and efficacy of amphiphilic ß-cyclodextrin nanoparticles for paclitaxel delivery. Int. J. Pharm., 2008, 347, 163-170.
    • (2008) Int. J. Pharm , vol.347 , pp. 163-170
    • Bilensoy, E.1    Gürkaynak, O.2    Doğan, A.L.3    Hıncal, A.A.4
  • 161
    • 79551649572 scopus 로고    scopus 로고
    • Paclitaxel loaded nanosponges: In-vitro characterization and cytotoxicity study on MCF-7 cell line culture
    • Ansari, K.A.; J Torne, S.; Vavia, P.R.; Trotta, F.; Cavalli, R. Paclitaxel loaded nanosponges: In-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Curr. Drug Deliv., 2011, 8, 194-202.
    • (2011) Curr. Drug Deliv , vol.8 , pp. 194-202
    • Ansari, K.A.1    J Torne, S.2    Vavia, P.R.3    Trotta, F.4    Cavalli, R.5
  • 162
    • 35649016184 scopus 로고    scopus 로고
    • Solubilization of hydropropyl-beta-cyclodextrin to paclitaxel and its relative molecular inclusion mechanism
    • Zhang, X.N.; Tang, L.H.; Yan, X.Y.; Zhang, Q. Solubilization of hydropropyl-beta-cyclodextrin to paclitaxel and its relative molecular inclusion mechanism. Chin. Trad. Herb. Drug, 2007, 38, 1317-1319.
    • (2007) Chin. Trad. Herb. Drug , vol.38 , pp. 1317-1319
    • Zhang, X.N.1    Tang, L.H.2    Yan, X.Y.3    Zhang, Q.4
  • 163
    • 77953360626 scopus 로고    scopus 로고
    • Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly (Anhydride) nanoparticles
    • Agueros, M.; Zabaleta, V.; Espuelas, S.; Campanero, M.; Irache, J. Increased oral bioavailability of paclitaxel by its encapsulation through complex formation with cyclodextrins in poly (anhydride) nanoparticles. J. Control. Release, 2010, 145, 2-8.
    • (2010) J. Control. Release , vol.145 , pp. 2-8
    • Agueros, M.1    Zabaleta, V.2    Espuelas, S.3    Campanero, M.4    Irache, J.5
  • 164
    • 71049139855 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: A modern formulation approach in drug delivery system
    • Mukherjee, S.; Ray, S.; Thakur, R. S. Solid lipid nanoparticles: A modern formulation approach in drug delivery system. Ind. J. Pharm. Sci., 2009, 71, 349-358.
    • (2009) Ind. J. Pharm. Sci , vol.71 , pp. 349-358
    • Mukherjee, S.1    Ray, S.2    Thakur, R.S.3
  • 165
    • 84878380072 scopus 로고    scopus 로고
    • Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells
    • Miao, J.; Du, Y.-Z.; Yuan, H.; Zhang, X.-g.; Hu, F. Q. Drug resistance reversal activity of anticancer drug loaded solid lipid nanoparticles in multi-drug resistant cancer cells. Colloids Surf. B. Biointerfaces, 2013, 110, 74-80.
    • (2013) Colloids Surf. B. Biointerfaces , vol.110 , pp. 74-80
    • Miao, J.1    Du, Y.-Z.2    Yuan, H.3    Zhang, X.-G.4    Hu, F.Q.5
  • 166
    • 84875781324 scopus 로고    scopus 로고
    • Cell uptake of paclitaxel solid lipid nanoparticles modified by cellpenetrating peptides in A549 cells
    • Zhang, Y. L.; Zhang, Z. H.; Jiang, T. Y.; Lv, H. X.; Zhou, J. P. Cell uptake of paclitaxel solid lipid nanoparticles modified by cellpenetrating peptides in A549 cells. Pharmazie, 2013, 68, 47-53.
    • (2013) Pharmazie , vol.68 , pp. 47-53
    • Zhang, Y.L.1    Zhang, Z.H.2    Jiang, T.Y.3    Lv, H.X.4    Zhou, J.P.5
  • 167
    • 79953302226 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of paclitaxel loaded in pegylated solid lipid nanoparticles after intravenous administration
    • Li, R.; Eun, J. S.; Lee, M. K. Pharmacokinetics and biodistribution of paclitaxel loaded in pegylated solid lipid nanoparticles after intravenous administration. Arch. Pharm. Res., 2011, 34, 331-337.
    • (2011) Arch. Pharm. Res , vol.34 , pp. 331-337
    • Li, R.1    Eun, J.S.2    Lee, M.K.3
  • 168
    • 70350393672 scopus 로고    scopus 로고
    • Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation
    • Bansal, T.; Akhtar, N.; Jaggi, M.; Khar, R. K.; Talegaonkar, S. Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov. Today, 2009, 14, 1067-1074.
    • (2009) Drug Discov. Today , vol.14 , pp. 1067-1074
    • Bansal, T.1    Akhtar, N.2    Jaggi, M.3    Khar, R.K.4    Talegaonkar, S.5
  • 169
    • 28744445460 scopus 로고    scopus 로고
    • Dendrimer biocompatibility and toxicity
    • Duncan, R.; Izzo, L. Dendrimer biocompatibility and toxicity. Adv. Drug Deliv. Rev., 2005, 57, 2215-2237.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 2215-2237
    • Duncan, R.1    Izzo, L.2
  • 170
    • 84872799173 scopus 로고    scopus 로고
    • Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier
    • Teow, H. M.; Zhou, Z.; Najlah, M.; Yusof, S. R.; Abbott, N. J.; D'Emanuele, A. Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int. J. Pharm., 2013, 441,701-711.
    • (2013) Int. J. Pharm , vol.441 , pp. 701-711
    • Teow, H.M.1    Zhou, Z.2    Najlah, M.3    Yusof, S.R.4    Abbott, N.J.5    D'emanuele, A.6
  • 171
    • 49749126336 scopus 로고    scopus 로고
    • Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumorspecific treatment and imaging
    • Saad, M.; Garbuzenko, O. B.; Ber, E.; Chandna, P.; Khandare, J. J.; Pozharov, V. P.; Minko, T. Receptor targeted polymers, dendrimers, liposomes: Which nanocarrier is the most efficient for tumorspecific treatment and imaging? J. Control. Release, 2008, 130, 107-114.
    • (2008) J. Control. Release , vol.130 , pp. 107-114
    • Saad, M.1    Garbuzenko, O.B.2    Ber, E.3    Chandna, P.4    Khandare, J.J.5    Pozharov, V.P.6    Minko, T.7
  • 172
    • 84896698030 scopus 로고    scopus 로고
    • Biodegradable Implants Efficiently Deliver Combination of Paclitaxel and Temozolomide to Glioma C6 Cancer Cells In Vitro
    • Ni, S.; Fan, X.; Wang, J.; Qi, H.; Li, X. Biodegradable Implants Efficiently Deliver Combination of Paclitaxel and Temozolomide to Glioma C6 Cancer Cells In Vitro. Ann. Biomed. Eng., 2014, 42(1), 214-221.
    • (2014) Ann. Biomed. Eng , vol.42 , Issue.1 , pp. 214-221
    • Ni, S.1    Fan, X.2    Wang, J.3    Qi, H.4    Li, X.5
  • 173
    • 42749094325 scopus 로고    scopus 로고
    • Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma
    • Ranganath, S. H.; Wang, C.-H., Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma. Biomaterials, 2008, 29(20), 2996-3003.
    • (2008) Biomaterials , vol.29 , Issue.20 , pp. 2996-3003
    • Ranganath, S.H.1    Wang, C.-H.2
  • 174
    • 0030003465 scopus 로고    scopus 로고
    • Development of a polymeric surgical paste formulation for taxol
    • Winternitz, C. I.; Jackson, J. K.; Oktaba, A. M.; Burt, H. M. Development of a polymeric surgical paste formulation for taxol. Pharm. Res., 1996, 13, 368-375.
    • (1996) Pharm. Res , vol.13 , pp. 368-375
    • Winternitz, C.I.1    Jackson, J.K.2    Oktaba, A.M.3    Burt, H.M.4
  • 176
    • 64649095837 scopus 로고    scopus 로고
    • Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme
    • Ong, B.; Ranganath, S. H.; Lee, L. Y.; Lu, F.; Lee, H. S.; Sahinidis, N.V.; Wang, C.H., Paclitaxel delivery from PLGA foams for controlled release in post-surgical chemotherapy against glioblastoma multiforme. Biomaterials, 2009, 30, 3189-3196.
    • (2009) Biomaterials , vol.30 , pp. 3189-3196
    • Ong, B.1    Ranganath, S.H.2    Lee, L.Y.3    Lu, F.4    Lee, H.S.5    Sahinidis, N.V.6    Wang, C.H.7
  • 177
    • 0030604694 scopus 로고    scopus 로고
    • Development of biodegradable polymeric paste formulations for taxol: An in vitro and in vivo study
    • Zhang, X.; Jackson, J. K.; Wong, W.; Min, W.; Cruz, T.; Hunter, W. L.; Burt, H. M. Development of biodegradable polymeric paste formulations for taxol: An in vitro and in vivo study. Int. J. Pharm., 1996, 137, 199-208.
    • (1996) Int. J. Pharm , vol.137 , pp. 199-208
    • Zhang, X.1    Jackson, J.K.2    Wong, W.3    Min, W.4    Cruz, T.5    Hunter, W.L.6    Burt, H.M.7
  • 178
    • 0028896964 scopus 로고
    • Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D, l-lactic acid)
    • Burt, H. M.; Jackson, J. K.; Bains, S. K.; Liggins, R. T.; Oktaba, A. M. C.; Arsenault, A.L.; Hunter, W.L. Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d, l-lactic acid). Cancer Lett., 1995, 88, 73-79.
    • (1995) Cancer Lett , vol.88 , pp. 73-79
    • Burt, H.M.1    Jackson, J.K.2    Bains, S.K.3    Liggins, R.T.4    Oktaba, A.5    Arsenault, A.L.6    Hunter, W.L.7
  • 179
    • 0034893953 scopus 로고    scopus 로고
    • Kinetics of P-glycoproteinmediated efflux of paclitaxel
    • Jang, S.H.; Wientjes, M.G.; Au, J. L. S. Kinetics of P-glycoproteinmediated efflux of paclitaxel. J. Pharmacol. Exp. Ther., 2001, 298, 1236-1242.
    • (2001) J. Pharmacol. Exp. Ther , vol.298 , pp. 1236-1242
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.3
  • 180
    • 0037426719 scopus 로고    scopus 로고
    • Novel controlled release formulation for the anticancer drug
    • Mu, L.; Feng, S. A novel controlled release formulation for the anticancer drug. J. Control. Release, 2003, 86, 33-48.
    • (2003) J. Control. Release , vol.86 , pp. 33-48
    • Mu, L.1    Feng, S.A.2
  • 181
    • 77955108815 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of paclitaxel formulated in vitamin E[1]TPGS emulsified nanoparticles of biodegradable polymers: In vitro and in vivo studies
    • Zhao, L.; Feng, S. S. Enhanced oral bioavailability of paclitaxel formulated in vitamin E[1]TPGS emulsified nanoparticles of biodegradable polymers: In vitro and in vivo studies. J. Pharm. Sci., 2010, 99, 3552-3560.
    • (2010) J. Pharm. Sci , vol.99 , pp. 3552-3560
    • Zhao, L.1    Feng, S.S.2
  • 182
    • 46749107462 scopus 로고    scopus 로고
    • In vitro and in vivo investigation on PLA–TPGS nanoparticles for controlled and sustained small molecule chemotherapy
    • Zhang, Z.; Lee, S. H.; Gan, C. W.; Feng, S. S. In vitro and in vivo investigation on PLA–TPGS nanoparticles for controlled and sustained small molecule chemotherapy. Pharm. Res., 2008, 25, 1925-1935.
    • (2008) Pharm. Res , vol.25 , pp. 1925-1935
    • Zhang, Z.1    Lee, S.H.2    Gan, C.W.3    Feng, S.S.4
  • 183
    • 28844438726 scopus 로고    scopus 로고
    • In vitro and in vivo studies on vitamin E TPGS-emulsified poly (D, L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation
    • [183] Win, K. Y.; Feng, S. S. In vitro and in vivo studies on vitamin E TPGS-emulsified poly (D, L-lactic-co-glycolic acid) nanoparticles for paclitaxel formulation. Biomaterials, 2006, 27, 2285-2291.
    • (2006) Biomaterials , vol.27 , pp. 2285-2291
    • Win, K.Y.1    Feng, S.S.2
  • 184
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • Yin, W.K.; Feng, S. S. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials, 2005, 26, 2713-2722.
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Yin, W.K.1    Feng, S.S.2
  • 185
    • 33749663431 scopus 로고    scopus 로고
    • Self-assembled nanoparticles of poly (Lactide)– vitamin E TPGS copolymers for oral chemotherapy
    • Zhang, Z.; Feng, S. S. Self-assembled nanoparticles of poly (lactide)– vitamin E TPGS copolymers for oral chemotherapy. Int. J. Pharm., 2006, 324, 191-198.
    • (2006) Int. J. Pharm , vol.324 , pp. 191-198
    • Zhang, Z.1    Feng, S.S.2
  • 186
    • 67349243616 scopus 로고    scopus 로고
    • Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar over comes tumor drug resistance
    • Patil, Y.; Sadhukha, T.; Ma, L.; Panyam, J. Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar over comes tumor drug resistance. J. Control. Release, 2009,136 (1), 21-29.
    • (2009) J. Control. Release , vol.136 , Issue.1 , pp. 21-29
    • Patil, Y.1    Sadhukha, T.2    Ma, L.3    Panyam, J.4
  • 187
  • 188
    • 0344012523 scopus 로고    scopus 로고
    • Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability
    • Gao, P.; Rush, B. D.; Pfund, W. P.; Huang, T.; Bauer, J. M.; Morozowich, W.; Kuo, M. S.; Hageman, M. J. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J. Pharm. Sci., 2003, 92, 2386-2398.
    • (2003) J. Pharm. Sci , vol.92 , pp. 2386-2398
    • Gao, P.1    Rush, B.D.2    Pfund, W.P.3    Huang, T.4    Bauer, J.M.5    Morozowich, W.6    Kuo, M.S.7    Hageman, M.J.8
  • 189
    • 0344443710 scopus 로고    scopus 로고
    • Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system
    • Gursoy, N.; Garrigue, J. S.; Razafindratsita, A.; Lambert, G.; Benita, S. Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system. J. Pharm. Sci., 2003, 92, 2411-2418.
    • (2003) J. Pharm. Sci , vol.92 , pp. 2411-2418
    • Gursoy, N.1    Garrigue, J.S.2    Razafindratsita, A.3    Lambert, G.4    Benita, S.5
  • 190
    • 33845798299 scopus 로고    scopus 로고
    • Nanoemulsions as versatile formulations for paclitaxel delivery: Peroral and dermal delivery studies in rats
    • Khandavilli, S.; Panchagnula, R. Nanoemulsions as versatile formulations for paclitaxel delivery: Peroral and dermal delivery studies in rats. J. Invest. Dermatol., 2006, 127, 154-162.
    • (2006) J. Invest. Dermatol , vol.127 , pp. 154-162
    • Khandavilli, S.1    Panchagnula, R.2
  • 191
    • 0037261361 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of paclitaxel by coadministration of the Pglycoprotein inhibitor KR30031
    • Woo, J. S.; Lee, C. H.; Shim, C. K.; Hwang, S. J. Enhanced oral bioavailability of paclitaxel by coadministration of the Pglycoprotein inhibitor KR30031. Pharm. Res., 2003, 20, 24-30.
    • (2003) Pharm. Res , vol.20 , pp. 24-30
    • Woo, J.S.1    Lee, C.H.2    Shim, C.K.3    Hwang, S.J.4
  • 192
    • 84880387478 scopus 로고    scopus 로고
    • Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies
    • Gao, L.; Liu, G.; Kang, J.; Niu, M.; Wang, Z.; Wang, H.; Ma, J.; Wang, X. Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies. Colloids Surf. B Biointerfaces., 2013, 111, 277-281.
    • (2013) Colloids Surf. B Biointerfaces , vol.111 , pp. 277-281
    • Gao, L.1    Liu, G.2    Kang, J.3    Niu, M.4    Wang, Z.5    Wang, H.6    Ma, J.7    Wang, X.8
  • 194
    • 66149129222 scopus 로고    scopus 로고
    • Albumin- bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer
    • Miele, E.; Spinelli, G. P.; Miele, E.; Tomao, F.; Tomao, S. Albumin- bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer. Int. J. Nanomed., 2009, 4, 99-105.
    • (2009) Int. J. Nanomed , vol.4 , pp. 99-105
    • Miele, E.1    Spinelli, G.P.2    Miele, E.3    Tomao, F.4    Tomao, S.5
  • 195
    • 54549097056 scopus 로고    scopus 로고
    • Conjugated chitosan as a novel platform for oral delivery of paclitaxel
    • Lee, E.; Lee, J.; Lee, I.-H.; Yu, M.; Kim, H.; Chae, S. Y.; Jon, S. Conjugated chitosan as a novel platform for oral delivery of paclitaxel. J. Med. Chem., 2008, 51, 6442-6449.
    • (2008) J. Med. Chem , vol.51 , pp. 6442-6449
    • Lee, E.1    Lee, J.2    Lee, I.-H.3    Yu, M.4    Kim, H.5    Chae, S.Y.6    Jon, S.7
  • 196
    • 33845216424 scopus 로고    scopus 로고
    • Dendrimer versus linear conjugate: Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel
    • Khandare, J. J.; Jayant, S.; Singh, A.; Chandna, P.; Wang, Y.; Vorsa, N.; Minko, T. Dendrimer versus linear conjugate: Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel. Bioconjug. Chem., 2006, 17, 1464-1472.
    • (2006) Bioconjug. Chem , vol.17 , pp. 1464-1472
    • Khandare, J.J.1    Jayant, S.2    Singh, A.3    Chandna, P.4    Wang, Y.5    Vorsa, N.6    Minko, T.7
  • 197
    • 70350187071 scopus 로고    scopus 로고
    • Folatemediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system
    • Dosio, F.; Arpicco, S.; Stella, B.; Brusa, P.; Cattel, L. Folatemediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system. Int. J. Pharm., 2009, 382, 117-123.
    • (2009) Int. J. Pharm , vol.382 , pp. 117-123
    • Dosio, F.1    Arpicco, S.2    Stella, B.3    Brusa, P.4    Cattel, L.5
  • 200
    • 0035002363 scopus 로고    scopus 로고
    • Paclitaxel immunoconjugate for the specific treatment of ovarian cancer in vitro
    • Jaime, J.; Pagé, M. Paclitaxel immunoconjugate for the specific treatment of ovarian cancer in vitro. Anticancer Res., 2001, 21, 1119-1128.
    • (2001) Anticancer Res , vol.21 , pp. 1119-1128
    • Jaime, J.1    Pagé, M.2
  • 201
    • 78349308871 scopus 로고    scopus 로고
    • Development and in vivo evaluation of an oral drug delivery system for paclitaxel
    • Iqbal, J.; Sarti, F.; Perera, G.; Bernkop-Schnurch, A. Development and in vivo evaluation of an oral drug delivery system for paclitaxel. Biomaterials 2011, 32, 170-175.
    • (2011) Biomaterials , vol.32 , pp. 170-175
    • Iqbal, J.1    Sarti, F.2    Perera, G.3    Bernkop-Schnurch, A.4
  • 202
    • 84872799173 scopus 로고    scopus 로고
    • Delivery of Paclitaxel Across Cellular Barriers Using a Dendrimer-based Nanocarrier
    • Teow, H. M.; Zhou, Z.; Najlah, M.; Yusof, S. R.; Abbott, N. J.; Emanuele, A. Delivery of Paclitaxel Across Cellular Barriers Using a Dendrimer-based Nanocarrier. Int. J. Pharm., 2013, 441, 701-711.
    • (2013) Int. J. Pharm , vol.441 , pp. 701-711
    • Teow, H.M.1    Zhou, Z.2    Najlah, M.3    Yusof, S.R.4    Abbott, N.J.5    Emanuele, A.6
  • 203
    • 84884148401 scopus 로고    scopus 로고
    • Preparation and characterization of novel poly(Ethylene glycol) paclitaxel derivatives
    • Arpicco, S.; Stella, B.; Schiavon, O.; Milla, P.; Zonari, D.; Cattel, L. Preparation and characterization of novel poly(ethylene glycol) paclitaxel derivatives. Int. J. Pharm., 2013, 454(2), 653-659.
    • (2013) Int. J. Pharm , vol.454 , Issue.2 , pp. 653-659
    • Arpicco, S.1    Stella, B.2    Schiavon, O.3    Milla, P.4    Zonari, D.5    Cattel, L.6
  • 204
    • 84884674473 scopus 로고    scopus 로고
    • Paclitaxel-hyaluronan hydrosoluble bioconjugate: Mechanism of action in human bladder cancer cell lines
    • Montagner, I. M.; Banzato, A.; Zuccolotto, G.; Renier, D.; Campisi, M.; Bassi, P.; Zanovello, P.; Rosato, A. Paclitaxel-hyaluronan hydrosoluble bioconjugate: mechanism of action in human bladder cancer cell lines. Urol. Oncol., 2013, 31(7), 1261-1269.
    • (2013) Urol. Oncol , vol.31 , Issue.7 , pp. 1261-1269
    • Montagner, I.M.1    Banzato, A.2    Zuccolotto, G.3    Renier, D.4    Campisi, M.5    Bassi, P.6    Zanovello, P.7    Rosato, A.8
  • 205
    • 84874996157 scopus 로고    scopus 로고
    • Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression
    • Wei, W.; Lv, P.-P.; Chen, X.-M.; Yue, Z.-G.; Fu, Q.; Liu, S.-Y.; Yue, H.; Ma, G.-H., Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression. Biomaterials, 2013, 34 (15), 3912-3923.
    • (2013) Biomaterials , vol.34 , Issue.15 , pp. 3912-3923
    • Wei, W.1    Lv, P.-P.2    Chen, X.-M.3    Yue, Z.-G.4    Fu, Q.5    Liu, S.-Y.6    Yue, H.7    Ma, G.-H.8
  • 207
    • 84864140974 scopus 로고    scopus 로고
    • Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression
    • Jang, Y.L.; Yun, U.J.; Lee, M.S.; Kim, M.G.; Son, S.; Lee, K.; Chae, S. Y.; Lim, D. W.; Kim, H. T.; Kim, S. H. Cell-penetrating peptide mimicking polymer-based combined delivery of paclitaxel and siRNA for enhanced tumor growth suppression. Int. J. Pharm., 2012, 434 (1), 488-493.
    • (2012) Int. J. Pharm , vol.434 , Issue.1 , pp. 488-493
    • Jang, Y.L.1    Yun, U.J.2    Lee, M.S.3    Kim, M.G.4    Son, S.5    Lee, K.6    Chae, S.Y.7    Lim, D.W.8    Kim, H.T.9    Kim, S.H.10
  • 208
    • 84926391807 scopus 로고    scopus 로고
    • Accessed June 14
    • www.clinicaltrials.gov (Accessed June 14, 2013).
    • (2013)


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