Paclitaxel nanosuspensions coated with P-gp inhibitory surfactants: I. Acute toxicity and pharmacokinetics studies

Colloids and Surfaces B: Biointerfaces

Volumn 111, Issue , 2013, Pages 277-281

  Gao, Lei ^a   Liu, Guiyang ^a   Kang, Jiarui ^a   Niu, Meng ^a   Wang, Zhe ^a   Wang, Hongwei ^a   Ma, Jianli ^a   Wang, Xiaoqing ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Acute toxicity; Colloidal drug delivery system; Nanosuspensions; Paclitaxel; Pharmacokinetics

Indexed keywords

ACUTE TOXICITY; COLLOIDAL DRUGS; INTRAVENOUS ADMINISTRATION; INTRAVENOUS INJECTIONS; NANO-SUSPENSIONS; PACLITAXEL; PHARMACOKINETIC PROPERTIES; TRANSMISSION ELECTRON MICROSCOPE;

COMMERCE; DRUG DELIVERY; MAMMALS; PARTICLE SIZE; TOXICITY; TRANSMISSION ELECTRON MICROSCOPY;

PHARMACOKINETICS;

NANOPARTICLE; PACLITAXEL; TOCOFERSOLAN; ALPHA TOCOPHEROL; ALPHA-TOCOPHERYL POLYETHYLENE GLYCOL SUCCINATE; BIOMATERIAL; MACROGOL DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; SURFACTANT; SUSPENSION;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; FREEZE DRYING; LD 50; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PARTICLE SIZE; PLASMA HALF LIFE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHEMISTRY; METABOLISM; SUSPENSION; TOXICITY TESTING; ULTRASTRUCTURE;

ANIMALS; COATED MATERIALS, BIOCOMPATIBLE; MICE; NANOPARTICLES; P-GLYCOPROTEIN; PACLITAXEL; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SURFACE-ACTIVE AGENTS; SUSPENSIONS; TOXICITY TESTS, ACUTE; VITAMIN E;

EID: 84880387478     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2013.06.004     Document Type: Article

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